Prevalence and Risk Factors of Schistosoma haematobium Infections among Primary School Children in Yola North Local Government, Adamawa State, Nigeria

Schistosomiasis, also known as snail fever or bilharzia, is a disease caused by parasitic flatworms called Schistosomes. The disease is spread by contact with fresh water contaminated with these schistosomes. This study was conducted to determine the prevalence, in relation to gender, age and risk factors associated with Schistosoma haematobium infections among primary school children in Jimeta-Yola. Each child was administered a semi-structured questionnaire to collect socio-demographic data. Urine samples were collected from 150 pupils for microscopic analysis for the detection of S. haematobium eggs. The prevalence of S. haematobium eggs in Yelwa Primary School, showed that females had the highest prevalence rate with 12 (40.0%) infection while male had a prevalence rate of 8 (17.78%) infection. The infection in relation to age showed that the age range 8-10 years had the highest infection with 11 (44.0%), the age range 14> years had the least prevalence with 2 (10.00%). The prevalence in Limawa Primary School, showed that males had a prevalence rate of 9 (19.15%) infection while female had a prevalence rate of 7 (25.00%) infection. The infection in relation to age showed that the age range <8 years had the highest infection with 7 (28.00%), while nothing was recorded in the age 14 > years. In general, the prevalence rate of urinary schistosomiasis infection among primary school children in jimeta-yola, adamawa state is fairly low with a prevalence of 24.0 % among active school children. No significant difference was found between gender, age, source of water, and urinary schistosomiasi

Physical characteristics underpinning repetitive lunging in fencing

Given the repetitive demand to execute lunging and changes in direction within fencing, the ability to sustain these at maximal capacity is fundamental to performance. The aim of this study was threefold. Firstly to provide normative values for this variable referred to as repeat lunge ability (RLA) and secondly to identify the physical characteristics that underpin it. Thirdly, was to establish if a cause and effect relationship existed by training the associated characteristics. Assessment of lower body power, reactive strength, speed, change of direction speed (CODS) and a sport specific RLA were conducted on senior and junior elite male fencers (n = 36). Fencers were on average (± SD) 18.9 ± 3.2 years of age, 174.35 ± 10.42 cm tall, 70.67 ± 7.35 kg in mass, and 8.5 ± 4.2 years fencing experience. The RLA test had average work times of 16.03 s ± 1.40 and demonstrated "large" to "very large" associations with all tested variables, but in particular CODS (r = .70) and standing broad jump (SBJ; r = -68). Through linear regression analysis, these also provided a two-predictor model accounting for 61% of the common variance associated with RLA. A cause and effect relationship with SBJ and CODS was confirmed by the training group, where RLA performance in these fencers improved from 15.80 ± 1.07 s to 14.90 ± 0.86 s, with the magnitude of change reported as "moderate" (ES = 0.93). Concurrent improvements were also noted in both SBJ (216.86 cm ± 17.15 vs. 221.71 ± 17.59 cm) and CODS (4.44 ± 0.29 s s. 4.31 ± 0.09 s) and while differences were only significant in SBJ, magnitudes of change were classed as "small" (ES = 0.28) and "moderate" (ES = 0.61)respectively. In conclusion, to improve RLA strength and conditioning coaches should focus on improving lower-body power and reactive strength, noting that jump training and plyometrics designed to enhance horizontal propulsion may be most effective, and translate to improvement in CODS also

On the Evolution of and High-Energy Emission from GHz-Peaked-Spectrum Sources

Here we discuss evolution and broad-band emission of compact (< kpc) lobes in young radio sources. We propose a simple dynamical description for these objects, consisting of a relativistic jet propagating into a uniform gaseous medium in the central parts of an elliptical host. In the framework of the proposed model, we follow the evolution of ultrarelativistic electrons injected from a terminal hotspot of a jet to expanding lobes, taking into account their adiabatic energy losses as well as radiative cooling. This allows us to discuss the broad-band lobe emission of young radio sources. In particular, we argue that the observed spectral turnover in the radio synchrotron spectra of these objects cannot originate from the synchrotron self-absorption process but is most likely due to free-free absorption effects connected with neutral clouds of interstellar medium engulfed by the expanding lobes and photoionized by active centers. We also find a relatively strong and complex high-energy emission component produced by inverse-Compton up-scattering of various surrounding photon fields by the lobes' electrons. We argue that such high energy radiation is strong enough to account for several observed properties of GHz-peaked-spectrum (GPS) radio galaxies at UV and X-ray frequencies. In addition, this emission is expected to extend up to GeV (or possibly even TeV) photon energies and can thus be probed by several modern gamma-ray instruments. In particular, we suggest that GPS radio galaxies should constitute a relatively numerous class of extragalactic sources detected by GLAST.Comment: 32 pages, 3 figures included. Revised version, accepted for publication in Ap

Low energy atomic collision with dipole interactions

We apply quantum defect theory to study low energy ground state atomic collisions including aligned dipole interactions such as those induced by an electric field. Our results show that coupled even ($l$) relative orbital angular momentum partial wave channels exhibit shape resonance structures while odd ($l$) channels do not. We analyze and interpret these resonances within the framework of multichannel quantum defect theory (MQDT).Comment: 27 pages, 17 figures, an inadvertent typo correcte

Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver

Developmental changes in the liver can significantly impact drug disposition. Due to the emergence of microRNAs (miRNAs) as important regulators of drug disposition gene expression, we studied age-dependent changes in miRNA expression. Expression of 533 miRNAs was measured in 90 human liver tissues (fetal, pediatric [1-17 years], and adult [28-80 years]; n = 30 each). In all, 114 miRNAs were upregulated and 72 were downregulated from fetal to pediatric, and 2 and 3, respectively, from pediatric to adult. Among the developmentally changing miRNAs, 99 miRNA-mRNA interactions were predicted or experimentally validated (e.g., hsa-miR-125b-5p-CYP1A1; hsa-miR-34a-5p-HNF4A). In human liver samples (n = 10 each), analyzed by RNA-sequencing, significant negative correlations were observed between the expression of >1,000 miRNAs and mRNAs of drug disposition and regulatory genes. Our data suggest a mechanism for the marked changes in hepatic gene expression between the fetal and pediatric developmental periods, and support a role for these age-dependent miRNAs in regulating drug disposition

How the Kano model contributes to Kansei engineering in services

Recent studies show that products and services hold great appeal if they are attractively designed to elicit emotional feelings from customers. Kansei engineering (KE) has good potential to provide a competitive advantage to those able to read and translate customer affect and emotion in actual product and services. This study introduces an integrative framework of the Kano model and KE, applied to services. The Kano model was used and inserted into KE to exhibit the relationship between service attribute performance and customer emotional response. Essentially, the Kano model categorises service attribute quality into three major groups (must-be [M], one-dimensional [O] and attractive [A]). The findings of a case study that involved 100 tourists who stayed in luxury 4- and 5-star hotels are presented. As a practical matter, this research provides insight on which service attributes deserve more attention with regard to their significant impact on customer emotional needs. Statement of Relevance: Apart from cognitive evaluation, emotions and hedonism play a big role in service encounters. Through a focus on delighting qualities of service attributes, this research enables service providers and managers to establish the extent to which they prioritise their improvement efforts and to always satisfy their customer emotions beyond expectation. Keywords: Kansei engineering, emotional feelings, Kano model, service

Replication stress by Py–Im polyamides induces a non-canonical ATR-dependent checkpoint response

Pyrrole–imidazole polyamides targeted to the androgen response element were cytotoxic in multiple cell lines, independent of intact androgen receptor signaling. Polyamide treatment induced accumulation of S-phase cells and of PCNA replication/repair foci. Activation of a cell cycle checkpoint response was evidenced by autophosphorylation of ATR, the S-phase checkpoint kinase, and by recruitment of ATR and the ATR activators RPA, 9-1-1, and Rad17 to chromatin. Surprisingly, ATR activation was accompanied by only a slight increase in single-stranded DNA, and the ATR targets RPA2 and Chk1, a cell cycle checkpoint kinase, were not phosphorylated. However, ATR activation resulted in phosphorylation of the replicative helicase subunit MCM2, an ATR effector. Polyamide treatment also induced accumulation of monoubiquitinated FANCD2, which is recruited to stalled replication forks and interacts transiently with phospho-MCM2. This suggests that polyamides induce replication stress that ATR can counteract independently of Chk1 and that the FA/BRCA pathway may also be involved in the response to polyamides. In biochemical assays, polyamides inhibit DNA helicases, providing a plausible mechanism for S-phase inhibition