1,920 research outputs found
The Effect of Doping Process Route on LiNiO Cathode Material Properties
The pursuit of higher energy density in lithium-ion batteries has driven the increase of the nickel content in lithium nickel cobalt manganese oxide cathode active materials (CAMs), ultimately approaching LiNiO (LNO). The downside of the high specific capacity of LNO is more severe degradation of the CAM during battery operation. A common approach to increase structural stability is the introduction of dopants. Various dopants are discussed and compared with each other when integrated into the CAM and tested against undoped materials in the literature, but little attention is given to the role of the process route of their introduction. In this work, we demonstrate with a series of nominally equally Zr-doped LNO samples that effects on various physico- and electrochemical properties are due not to the dopant itself, as one would assume in comparison to an undoped sample, but to the process route and the resulting particle morphology. Dopant, concentration and process routes (co-precipitation, impregnation and co-calcination) were chosen based on their significance for industrial application
Populist alternative news use and its role for elections: Web-tracking and survey evidence from two campaign periods
This study explores voters' populist alternative news use during (different types of) democratic elections and investigates starting points for preventing potentially harmful effects. We draw from two combined data sets of web-tracking and survey data which were collected during the 2017 German Bundestag campaign (1523 participants) and the 2019 European Parliamentary election campaign in Germany (1009 participants). Results indicate that while populist alternative news outlets drew more interest during the first-order election campaign, they reached only 16.5% of users even then. Moreover, most users visited their websites rather seldom. Nonetheless, our data suggest that alternative news exposure is strongly linked to voting for (right-wing) populist parties. Regarding the origins of exposure, our analyses punctuate the role of platforms in referring users to populist alternative news. About 40% of website visits originated from Facebook alone in both data sets and another third of visits from search engines. This raises questions about algorithmic accountability
Over-optimism in unsupervised microbiome analysis: Insights from network learning and clustering
In recent years, unsupervised analysis of microbiome data, such as microbial network analysis and clustering, has increased in popularity. Many new statistical and computational methods have been proposed for these tasks. This multiplicity of analysis strategies poses a challenge for researchers, who are often unsure which method(s) to use and might be tempted to try different methods on their dataset to look for the “best” ones. However, if only the best results are selectively reported, this may cause over-optimism: the “best” method is overly fitted to the specific dataset, and the results might be non-replicable on validation data. Such effects will ultimately hinder research progress. Yet so far, these topics have been given little attention in the context of unsupervised microbiome analysis. In our illustrative study, we aim to quantify over-optimism effects in this context. We model the approach of a hypothetical microbiome researcher who undertakes four unsupervised research tasks: clustering of bacterial genera, hub detection in microbial networks, differential microbial network analysis, and clustering of samples. While these tasks are unsupervised, the researcher might still have certain expectations as to what constitutes interesting results. We translate these expectations into concrete evaluation criteria that the hypothetical researcher might want to optimize. We then randomly split an exemplary dataset from the American Gut Project into discovery and validation sets multiple times. For each research task, multiple method combinations (e.g., methods for data normalization, network generation, and/or clustering) are tried on the discovery data, and the combination that yields the best result according to the evaluation criterion is chosen. While the hypothetical researcher might only report this result, we also apply the “best” method combination to the validation dataset. The results are then compared between discovery and validation data. In all four research tasks, there are notable over-optimism effects; the results on the validation data set are worse compared to the discovery data, averaged over multiple random splits into discovery/validation data. Our study thus highlights the importance of validation and replication in microbiome analysis to obtain reliable results and demonstrates that the issue of over-optimism goes beyond the context of statistical testing and fishing for significance
Enhanced Electron-Phonon Coupling and its Irrelevance to High T Superconductivity
It is argued that the origin of the buckling of the CuO planes in
certain cuprates as well as the strong electron-phonon coupling of the
phonon is due to the electric field across the planes induced by atoms with
different valence above and below. The magnitude of the electric field is
deduced from new Raman results on YBaCuO and
BiSr(CaY)CuO with different O and Y
doping, respectively. In the latter case it is shown that the symmetry breaking
by replacing Ca partially by Y enhances the coupling by an order of magnitude,
while the superconducting drops to about two third of its original value.Comment: 4 pages, 2 figures. This and other papers can be downloaded from
http://gwis2.circ.gwu.edu/~tp
Strukturgeologische Geländestudie im Mittleren Buntsandstein zur Nutzung als geothermisches Reservoir
Zur Nutzung von Erdwärme aus Teufen
zwischen 2–5 km werden häufig Systeme
aus einer Injektions- und Förderbohrung
(‚Dubletten-System‘) genutzt.
Dabei wird durch die Injektionsbohrung ein Fluid in den Untergrund verpresst,
welches sich erhitzt und durch
die Förderbohrung wieder an die Oberfläche
gelangt. Ein wesentlicher Parameter
für die produktive Nutzung von
solchen Dubletten-Systemen ist eine hohe
Permeabilität der Gesteine im Untergrund.
Häufig werden in solchen geothermischen
Reservoiren die Wegsamkeiten
für Fluide von Brüchen kontrolliert,
die bereits vorhanden sind oder
künstlich erzeugt werden müssen (hydraulische
Stimulation). Deshalb ist die
Kenntnis über existierende Bruchgeometrien
sowie Vernetzung der Bruchsysteme
von fundamentaler Notwendigkeit
zur Abschätzung der Permeabilität
von geothermischen Reservoiren. Seismische
Verfahren und Bohrkernanalysen
besitzen im Allgemeinen dafür eine
zu geringe Auflösung. Daher bieten sich
dreidimensionale Rekonstruktionen des
Bruchsystems aus analogen Obertageaufschlüssen
an (vgl. Philipp et al. 2005;
2006)...conferenc
Antigen-Specific vs. Neutralizing Antibodies Against Conditioned Media of Patients With Clostridioides difficile Infection: A Prospective Exploratory Study
The immunological response against Clostridioides difficile (C. difficile) is crucial for an
improved understanding of disease mechanisms and the development of novel therapeutic
strategies. From April 2014 to February 2015, adult patients with C. difficile infection (CDI)
were recruited, and the clinical course and treatment response were carefully monitored.
On day 1, 3, and 6 after diagnosis, patient plasma samples were screened for anti-GDH
(glutamate dehydrogenase), anti-TcdA, anti-TcdB, and anti-CWP84 (cell-wall protein 84)
antibodies by ELISA. Additionally, neutralization assays of toxins from conditioned media
of clinical isolates (RT010, RT014, and RT027) were performed. Most patients with CDI
(n=46) had antibodies against GDH (85%) and CWP84 (61%), but only few had antibodies
against TcdA (11%) and TcdB (28%). We found patients with neutralizing antibodies against
C. difficile toxins (conditioned media) produced by RT027 (26%). A subgroup of these
samples could neutralize both toxins from RT027 and RT014 [11%, (5/46)]; however, no
single sample neutralized only RT014. Overall, neutralizing antibody titers were low (≤1:16).
In a one week follow-up of acute infection, we never observed an early booster effect
with seroconversion or antibody increases, irrespective of disease severity. No correlation
was found between the presence of antigen-specific (ELISA) or neutralizing antibodies
and the clinical course of disease. Anti-TcdB but not anti-TcdA antibodies correlated with
the occurrence of neutralizing antibodies. In conclusion, natural antibody titers against C.
difficile toxins were absent or low and were not associated with disease severity. The
correlation between the anti-TcdB with toxin neutralization confirms the importance of
TcdB for virulence of CDI. Alternative sensitization strategies, e.g., through vaccine
development, are required to overcome the regular low-titer antibody production following
natural intestinal C. difficile exposure
Expression of SEC62 Oncogene in Benign, Malignant and Borderline Melanocytic Tumors—Unmasking the Wolf in Sheep’s Clothing?
SEC62 oncogene located at chromosomal region 3q26 encodes for a transmembrane protein
of the endoplasmic reticulum (ER) and is expressed at high levels in numerous human malignancies. SEC62 overexpression has been associated with worse prognosis and high risk for lymphatic
and distant metastases in head and neck cancer, cervical cancer, hepatocellular cancer, and lung
cancer. However, its role in the development and tumor biology of melanocytic lesions has not
been investigated so far. An immunohistochemical study including 209 patients with melanocytic
lesions (malignant melanoma (MM), n = 93; melanoma metastases (MET), n = 28; Spitz nevi (SN),
n = 29; blue nevi (BN), n = 21; congenital nevi (CN), n = 38) was conducted and SEC62 expression
was correlated with clinical data including patient survival and histopathological characteristics.
SN showed the highest SEC62 expression levels followed by MET, MM, CN, and BN. High SEC62
expression correlated with a shorter overall and progression-free survival in MM patients. Additionally, high Sec62 levels correlated significantly with higher tumor size (T stage), the presence of
tumor ulceration, and the presence of lymph node as well as distant metastases. Strikingly, SEC62
expression showed a strong correlation with Clark level. Taken together, these data demonstrate that
SEC62 is a promising prognostic marker in MM and has the potential to predict biological behavior
and clinical aggressiveness of melanocytic lesions
Cynomolgus monkey's choroid reference database derived from hybrid deep learning optical coherence tomography segmentation.
Cynomolgus monkeys exhibit human-like features, such as a fovea, so they are often used in non-clinical research. Nevertheless, little is known about the natural variation of the choroidal thickness in relation to origin and sex. A combination of deep learning and a deterministic computer vision algorithm was applied for automatic segmentation of foveolar optical coherence tomography images in cynomolgus monkeys. The main evaluation parameters were choroidal thickness and surface area directed from the deepest point on OCT images within the fovea, marked as the nulla with regard to sex and origin. Reference choroid landmarks were set underneath the nulla and at 500 µm intervals laterally up to a distance of 2000 µm nasally and temporally, complemented by a sub-analysis of the central bouquet of cones. 203 animals contributed 374 eyes for a reference choroid database. The overall average central choroidal thickness was 193 µm with a coefficient of variation of 7.8%, and the overall mean surface area of the central bouquet temporally was 19,335 µm2 and nasally was 19,283 µm2. The choroidal thickness of the fovea appears relatively homogeneous between the sexes and the studied origins. However, considerable natural variation has been observed, which needs to be appreciated
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