403 research outputs found
Testing Lorentz invariance by use of vacuum and matter filled cavity resonators
We consider tests of Lorentz invariance for the photon and fermion sector
that use vacuum and matter-filled cavities. Assumptions on the wave-function of
the electrons in crystals are eliminated from the underlying theory and
accurate sensitivity coefficients (including some exceptionally large ones) are
calculated for various materials. We derive the Lorentz-violating shift in the
index of refraction n, which leads to additional sensitivity for matter-filled
cavities ; and to birefringence in initially isotropic media. Using published
experimental data, we obtain improved bounds on Lorentz violation for photons
and electrons at levels of 10^-15 and below. We discuss implications for future
experiments and propose a new Michelson-Morley type experiment based on
birefringence in matter.Comment: 15 pages, 8 table
Field Blue Stragglers and Related Mass Transfer Issues
This chapter contains my impressions and perspectives about the current state
of knowledge about field blue stragglers (FBS) stars, drawn from an extensive
literature that I searched. I conclude my review of issues that attend FBS and
mass transfer, by a brief enumeration of a few mildly disquieting observational
facts.Comment: Chapter 4, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G.
Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe
COMAP Early Science: V. Constraints and Forecasts at
We present the current state of models for the carbon monoxide (CO)
line-intensity signal targeted by the CO Mapping Array Project (COMAP)
Pathfinder in the context of its early science results. Our fiducial model,
relating dark matter halo properties to CO luminosities, informs parameter
priors with empirical models of the galaxy-halo connection and previous CO(1-0)
observations. The Pathfinder early science data spanning wavenumbers
-Mpc represent the first direct 3D constraint on the
clustering component of the CO(1-0) power spectrum. Our 95% upper limit on the
redshift-space clustering amplitude K greatly
improves on the indirect upper limit of K reported from the CO
Power Spectrum Survey (COPSS) measurement at Mpc. The COMAP
limit excludes a subset of models from previous literature, and constrains
interpretation of the COPSS results, demonstrating the complementary nature of
COMAP and interferometric CO surveys. Using line bias expectations from our
priors, we also constrain the squared mean line intensity-bias product,
K, and the cosmic molecular gas
density, Mpc (95% upper
limits). Based on early instrument performance and our current CO signal
estimates, we forecast that the five-year Pathfinder campaign will detect the
CO power spectrum with overall signal-to-noise of 9-17. Between then and now,
we also expect to detect the CO-galaxy cross-spectrum using overlapping galaxy
survey data, enabling enhanced inferences of cosmic star-formation and
galaxy-evolution history.Comment: Paper 5 of 7 in series. 17 pages + appendix and bibliography (30
pages total); 15 figures, 6 tables; accepted for publication in ApJ; v3
reflects the accepted version with minor changes and additions to tex
COMAP Early Science: III. CO Data Processing
We describe the first season COMAP analysis pipeline that converts raw
detector readouts to calibrated sky maps. This pipeline implements four main
steps: gain calibration, filtering, data selection, and map-making. Absolute
gain calibration relies on a combination of instrumental and astrophysical
sources, while relative gain calibration exploits real-time total-power
variations. High efficiency filtering is achieved through spectroscopic
common-mode rejection within and across receivers, resulting in nearly
uncorrelated white noise within single-frequency channels. Consequently,
near-optimal but biased maps are produced by binning the filtered time stream
into pixelized maps; the corresponding signal bias transfer function is
estimated through simulations. Data selection is performed automatically
through a series of goodness-of-fit statistics, including and
multi-scale correlation tests. Applying this pipeline to the first-season COMAP
data, we produce a dataset with very low levels of correlated noise. We find
that one of our two scanning strategies (the Lissajous type) is sensitive to
residual instrumental systematics. As a result, we no longer use this type of
scan and exclude data taken this way from our Season 1 power spectrum
estimates. We perform a careful analysis of our data processing and observing
efficiencies and take account of planned improvements to estimate our future
performance. Power spectrum results derived from the first-season COMAP maps
are presented and discussed in companion papers.Comment: Paper 3 of 7 in series. 26 pages, 23 figures, submitted to Ap
COMAP Early Science: IV. Power Spectrum Methodology and Results
We present the power spectrum methodology used for the first-season COMAP
analysis, and assess the quality of the current data set. The main results are
derived through the Feed-feed Pseudo-Cross-Spectrum (FPXS) method, which is a
robust estimator with respect to both noise modeling errors and experimental
systematics. We use effective transfer functions to take into account the
effects of instrumental beam smoothing and various filter operations applied
during the low-level data processing. The power spectra estimated in this way
have allowed us to identify a systematic error associated with one of our two
scanning strategies, believed to be due to residual ground or atmospheric
contamination. We omit these data from our analysis and no longer use this
scanning technique for observations. We present the power spectra from our
first season of observing and demonstrate that the uncertainties are
integrating as expected for uncorrelated noise, with any residual systematics
suppressed to a level below the noise. Using the FPXS method, and combining
data on scales we estimate , the first direct 3D
constraint on the clustering component of the CO(1-0) power spectrum in the
literature.Comment: Paper 4 of 7 in series. 18 pages, 11 figures, as accepted in Ap
Blood Signature of Pre-Heart Failure: A Microarrays Study
International audienceBACKGROUND: The preclinical stage of systolic heart failure (HF), known as asymptomatic left ventricular dysfunction (ALVD), is diagnosed only by echocardiography, frequent in the general population and leads to a high risk of developing severe HF. Large scale screening for ALVD is a difficult task and represents a major unmet clinical challenge that requires the determination of ALVD biomarkers. METHODOLOGY/PRINCIPAL FINDINGS: 294 individuals were screened by echocardiography. We identified 9 ALVD cases out of 128 subjects with cardiovascular risk factors. White blood cell gene expression profiling was performed using pangenomic microarrays. Data were analyzed using principal component analysis (PCA) and Significant Analysis of Microarrays (SAM). To build an ALVD classifier model, we used the nearest centroid classification method (NCCM) with the ClaNC software package. Classification performance was determined using the leave-one-out cross-validation method. Blood transcriptome analysis provided a specific molecular signature for ALVD which defined a model based on 7 genes capable of discriminating ALVD cases. Analysis of an ALVD patients validation group demonstrated that these genes are accurate diagnostic predictors for ALVD with 87% accuracy and 100% precision. Furthermore, Receiver Operating Characteristic curves of expression levels confirmed that 6 out of 7 genes discriminate for left ventricular dysfunction classification. CONCLUSIONS/SIGNIFICANCE: These targets could serve to enhance the ability to efficiently detect ALVD by general care practitioners to facilitate preemptive initiation of medical treatment preventing the development of HF
COMAP Early Science: I. Overview
The CO Mapping Array Project (COMAP) aims to use line intensity mapping of
carbon monoxide (CO) to trace the distribution and global properties of
galaxies over cosmic time, back to the Epoch of Reionization (EoR). To validate
the technologies and techniques needed for this goal, a Pathfinder instrument
has been constructed and fielded. Sensitive to CO(1-0) emission from
- and a fainter contribution from CO(2-1) at -8, the
Pathfinder is surveying deg in a 5-year observing campaign to detect
the CO signal from . Using data from the first 13 months of observing,
we estimate on scales - the first direct
3D constraint on the clustering component of the CO(1-0) power spectrum. Based
on these observations alone, we obtain a constraint on the amplitude of the
clustering component (the squared mean CO line temperature-bias product) of
K - nearly an order-of-magnitude improvement
on the previous best measurement. These constraints allow us to rule out two
models from the literature. We forecast a detection of the power spectrum after
5 years with signal-to-noise ratio (S/N) 9-17. Cross-correlation with an
overlapping galaxy survey will yield a detection of the CO-galaxy power
spectrum with S/N of 19. We are also conducting a 30 GHz survey of the Galactic
plane and present a preliminary map. Looking to the future of COMAP, we examine
the prospects for future phases of the experiment to detect and characterize
the CO signal from the EoR.Comment: Paper 1 of 7 in series. 18 pages, 16 figures, submitted to Ap
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of association implicating multiple pathways including host defence, telomere maintenance, signalling and cell-cell adhesion. Objectives: To improve our understanding of factors that increase IPF susceptibility by identifying previously unreported genetic associations. Methods and measurements: We conducted genome-wide analyses across three independent studies and meta-analysed these results to generate the largest genome-wide association study of IPF to date (2,668 IPF cases and 8,591 controls). We performed replication in two independent studies (1,456 IPF cases and 11,874 controls) and functional analyses (including statistical fine-mapping, investigations into gene expression and testing for enrichment of IPF susceptibility signals in regulatory regions) to determine putatively causal genes. Polygenic risk scores were used to assess the collective effect of variants not reported as associated with IPF. Main results: We identified and replicated three new genome-wide significant (P<5×10−8) signals of association with IPF susceptibility (associated with altered gene expression of KIF15, MAD1L1 and DEPTOR) and confirmed associations at 11 previously reported loci. Polygenic risk score analyses showed that the combined effect of many thousands of as-yet unreported IPF susceptibility variants contribute to IPF susceptibility. Conclusions: The observation that decreased DEPTOR expression associates with increased susceptibility to IPF, supports recent studies demonstrating the importance of mTOR signalling in lung fibrosis. New signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility
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