Meat Quality of Lai Sind, Brahman × Lai Sind and Charolais × Lai Sind Cattle Raised in Dak Lak Province

Peer reviewe

Awareness and preparedness of healthcare workers against the first wave of the COVID-19 pandemic: A cross-sectional survey across 57 countries.

BACKGROUND: Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This study aimed to describe the level of awareness and preparedness of hospital HCWs at the time of the first wave. METHODS: This multinational, multicenter, cross-sectional survey was conducted among hospital HCWs from February to May 2020. We used a hierarchical logistic regression multivariate analysis to adjust the influence of variables based on awareness and preparedness. We then used association rule mining to identify relationships between HCW confidence in handling suspected COVID-19 patients and prior COVID-19 case-management training. RESULTS: We surveyed 24,653 HCWs from 371 hospitals across 57 countries and received 17,302 responses from 70.2% HCWs overall. The median COVID-19 preparedness score was 11.0 (interquartile range [IQR] = 6.0-14.0) and the median awareness score was 29.6 (IQR = 26.6-32.6). HCWs at COVID-19 designated facilities with previous outbreak experience, or HCWs who were trained for dealing with the SARS-CoV-2 outbreak, had significantly higher levels of preparedness and awareness (p<0.001). Association rule mining suggests that nurses and doctors who had a 'great-extent-of-confidence' in handling suspected COVID-19 patients had participated in COVID-19 training courses. Male participants (mean difference = 0.34; 95% CI = 0.22, 0.46; p<0.001) and nurses (mean difference = 0.67; 95% CI = 0.53, 0.81; p<0.001) had higher preparedness scores compared to women participants and doctors. INTERPRETATION: There was an unsurprising high level of awareness and preparedness among HCWs who participated in COVID-19 training courses. However, disparity existed along the lines of gender and type of HCW. It is unknown whether the difference in COVID-19 preparedness that we detected early in the pandemic may have translated into disproportionate SARS-CoV-2 burden of disease by gender or HCW type

Size Determination of Polystyrene Sub-Microspheres Using Transmission Spectroscopy

Nano/micro polystyrene (PS) beads have found many applications in different fields spanning from drug delivery, bio-diagnostics, and hybrid plasmonics to advanced photonics. The sizes of the PS beads are an important parameter, especially in plasmonic and photonic experiments. In this work, we demonstrate a quick and straightforward method to estimate the diameters of sub-microspheres (0.2 &mu;m to 0.8 &mu;m) using the transmission spectra of a close-packed monolayer of polystyrene beads on glass or quartz substrates. Experimental transmission spectra of the PS monolayers were verified against finite-difference time-domain (FDTD) simulation and showed good agreement. The effects of the substrates on the transmission spectra and, hence, the accuracy of the method were also studied by simulation, which showed that common transparent substrates only cause minor deviation of the PS bead sizes calculated by the proposed method

Public Policy and the Idea of the Vietnamese State: The Cultural Political Economy of Domestic Water Supply

Using Rural Water Supply (RWS) policy practices as a case study, this article shows that the disjunction between implementation as formally conceived and informally practised is not a question of ineffective policy cycle dynamics, but rather an inherent feature of Vietnam’s Cultural Political Economy. Drawing on critical realist approaches to social and state theory, we argue that formal and informal RWS policy practices, as a set of two interconnected spheres, serve as key, separate but connected, mechanisms for reproducing the distribution of material resources (primarily through the informal sphere) and the hegemony of ideas (primarily through the formal sphere) in Vietnamese society. We conclude that the formal, administrative practices of RWS policy are primarily to be understood in their function of reproducing the idea of the state and state legitimacy. RWS administrative practices function to sustain the core social and political order in Vietnam as institutionalised in “the state”, rather than being primarily oriented to improving rural water supply. The findings raise questions for donor-supported programs that focus on formal administrative institutions and practices for improving the performance of the water sector

Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability. To address these challenges, published assays to date demanded a very high-depth sequencing, resulting in an elevated price of test. Herein, we developed a multimodal assay called SPOT-MAS (screening for the presence of tumor by methylation and size) to simultaneously profile methylomics, fragmentomics, copy number, and end motifs in a single workflow using targeted and shallow genome-wide sequencing (~0.55×) of cell-free DNA. We applied SPOT-MAS to 738 non-metastatic patients with breast, colorectal, gastric, lung, and liver cancer, and 1550 healthy controls. We then employed machine learning to extract multiple cancer and tissue-specific signatures for detecting and locating cancer. SPOT-MAS successfully detected the five cancer types with a sensitivity of 72.4% at 97.0% specificity. The sensitivities for detecting early-stage cancers were 73.9% and 62.3% for stages I and II, respectively, increasing to 88.3% for non-metastatic stage IIIA. For tumor-of-origin, our assay achieved an accuracy of 0.7. Our study demonstrates comparable performance to other ctDNA-based assays while requiring significantly lower sequencing depth, making it economically feasible for population-wide screening