Les lieux historiques et leur dimension pédagogique. Le débat allemand contemporain

Cet article présente les questions qui animent le débat allemand sur les lieux historiques et leur valeur pédagogique. Dans la recherche historique, les sites de tout ordre (aménagés ou non) sont considérés comme des sources historiques ayant une valeur épistémologique propre, qui favorise l’acquisition de connaissances historiques et influence l’élaboration de représentations de l’histoire. Les anciens camps de concentration du régime national-socialiste en Allemagne qui ont été transformés en lieux de commémoration constituent une catégorie spécifique de lieux historiques, suscitant un débat sur la mémoire dans la société.Being important sources for the historian, historical places, sites, monuments and landscapes may also help students in developing historical knowledge, concepts and representations of history. This article deals with the German didactic theory on learning and teaching history by going out of the classroom and working on historical sites. Within this debate, memorials are considered as a special kind of historical places, taking an important place in public and scientific debate about memory, society and heritage education and as a topic in the didactics of history

Textkomplexität und Textverstehen. Einführende Überlegungen zu einer interdisziplinären Modellierung

Gefördert durch den Publikationsfonds der Universität Kasse

Mehrsprachigkeitspotentiale im bilingualen Sachfachunterricht

Die diesem Sammelwerk zugrunde liegenden Vorhaben wurden im Rahmen der gemeinsamen „Qualitätsoffensive Lehrerbildung“ von Bund und Ländern mit Mitteln des Bundesministeriums für Bildung und Forschung unter dem Förderkennzeichen 01JA1505 gefördert

Assessing segmental versus non-segmental features in the ventral nervous system of onychophorans (velvet worms)

Gefördert durch den Publikationsfonds der Universität Kasse

Geschichte denken statt pauken auf der Sekundarstufe II. 20 Jahre nach der friedlichen Revolution: Deutsche und europäische Perspektiven im gymnasialen Geschichtsunterricht

Didaktische Ansätze für einen kompetenzorientierten Unterricht in der gymnasialen Oberstufe; aufgezeigt am Gegenstand der friedlichen Revolution in der DDR. Diese Broschüre enthält neben theoretischen und grundlegenden Arbeiten vor allem eine umfangreiche Sammlung von Unterrichtskonzepten und Materialien für einen Geschichtsunterricht, der die Entwicklung eines reflektierten und selbstreflexiven Geschichtsbewusstseins bei den Schülern in das Zentrum stellt. (Verlag

Agrobacterium spp. nosocomial outbreak assessment using rapid MALDI-TOF MS based typing, confirmed by whole genome sequencing.

Background A number of episodes of nosocomial Agrobacterium spp. bacteremia (two cases per year) were observed at Bern University Hospital, Switzerland, from 2015 to 2017. This triggered an outbreak investigation. Methods Cases of Agrobacterium spp. bacteremias that occurred between August 2011 and February 2017 were investigated employing line lists, environmental sampling, rapid protein- (MALDI-TOF MS), and genome-based typing (pulsed field gel electrophoresis and whole genome sequencing) of the clinical isolates. Results We describe a total of eight bacteremia episodes due to A. radiobacter (n = 2), Agrobacterium genomovar G3 (n = 5) and A. pusense (n = 1). Two tight clusters were observed by WGS typing, representing the two A. radiobacter isolates (cluster I, isolated in 2015) and four of the Agrobacterium genomovar G3 isolates (cluster II, isolated in 2016 and 2017), suggesting two different point sources. The epidemiological investigations revealed two computer tomography (CT) rooms as common patient locations, which correlated with the two outbreak clusters. MALDI-TOF MS permitted faster evaluation of strain relatedness than DNA-based methods. High resolution WGS-based typing confirmed the MALDI-TOF MS clustering. Conclusions We report clinical and epidemiological characteristics of two outbreak clusters with Agrobacterium. spp. bacteremia likely acquired during CT contrast medium injection and highlight the use of MALDI-TOF MS as a rapid tool to assess relatedness of rare gram-negative pathogens in an outbreak investigation

Structural and Molecular Properties of Insect Type II Motor Axon Terminals

A comparison between the axon terminals of octopaminergic efferent dorsal or ventral unpaired median neurons in either desert locusts (Schistocerca gregaria) or fruit flies (Drosophila melanogaster) across skeletal muscles reveals many similarities. In both species the octopaminergic axon forms beaded fibers where the boutons or varicosities form type II terminals in contrast to the neuromuscular junction (NMJ) or type I terminals. These type II terminals are immunopositive for both tyramine and octopamine and, in contrast to the type I terminals, which possess clear synaptic vesicles, only contain dense core vesicles. These dense core vesicles contain octopamine as shown by immunogold methods. With respect to the cytomatrix and active zone peptides the type II terminals exhibit active zone-like accumulations of the scaffold protein Bruchpilot (BRP) only sparsely in contrast to the many accumulations of BRP identifying active zones of NMJ type I terminals. In the fruit fly larva marked dynamic changes of octopaminergic fibers have been reported after short starvation which not only affects the formation of new branches (“synaptopods”) but also affects the type I terminals or NMJs via octopamine-signaling (Koon et al., 2011). Our starvation experiments of Drosophila-larvae revealed a time-dependency of the formation of additional branches. Whereas after 2 h of starvation we find a decrease in “synaptopods”, the increase is significant after 6 h of starvation. In addition, we provide evidence that the release of octopamine from dendritic and/or axonal type II terminals uses a similar synaptic machinery to glutamate release from type I terminals of excitatory motor neurons. Indeed, blocking this canonical synaptic release machinery via RNAi induced downregulation of BRP in neurons with type II terminals leads to flight performance deficits similar to those observed for octopamine mutants or flies lacking this class of neurons (Brembs et al., 2007)