User-Centric Monitoring and Steering of the Execution of Large Job Sets

Processing of large data sets with high through put is one of the major focus of Grid computing today. If possible, data are split up into small chunks that are processed independently. Thus, job sets of hundreds > or even thousands of individual jobs are possible. For the job submitter or the resource providers such a scenario is a nightmare currently, as it is hard to keep track of such an amount of jobs or to identify failure reasons. We present a system that will support gLite users to track and monitor their jobs and their resource usage, to nd and identify failure reasons and even to steer running applications

Spritzenabszesse bei intravenös Drogenabhängigen: Häufigkeit assoziierter Komplikationen in Abhängigkeit der Lokalisation

Zusammenfassung: Hintergrund: Haut- und Weichteilabszesse sind bei intravenös Drogenabhängigen der häufigste Hospitalisationsgrund. Zu den mit Spritzenabszessen assoziierten Komplikationen gehören septische Arthritiden, septische Thrombosen und Embolien, lokale Schädigung von umliegenden Strukturen, periphere Ischämie durch intraarterielle Injektion, Pseudoaneurysmata von Venen und Arterien und die nekrotisierende Fasziitis. Material und Methode: Wir führten eine retrospektive Studie von 108Hospitalisationen bei 85Patienten mit insgesamt 130Abszessen in Hinblick auf die aufgetretenen Komplikationen durch. Ergebnisse: Fünfundfünfzig Prozent der Abszesse waren an der unteren Extremität lokalisiert. Die Komplikationsrate an dieser Lokalisation war mit 12/71 (16,9%) signifikant höher (p=0,0005) als an der oberen Extremität mit 0/55. Abszesse an der unteren Extremität führten zu einer signifikant längeren Hospitalisationsdauer als solche an der oberen Extremität (8,5 vs. 4,2Tage, p=0,005) und damit zu höheren Kosten. Schlussfolgerung: Bei der Behandlung von Spritzenabszessen der unteren Extremität muss an das erhöhte Risiko assoziierter Komplikationen gedacht werden. In den Beratungsstellen durchzuführende präventive Maßnahmen könnten durch Vermeiden von Injektionen an den unteren Extremitäten zu einer Verminderung der durch den Drogenkonsum verursachten Kosten führe

Reconstruction and architecture of medullosan pteridosperms (Pennsylvanian)

A new reconstruction of the architecture of medullosan pteridosperms is proposed on the basis of three stems preserved as compression-impression fossils: one from the Southern Anthracite Coal Field of Pennsylvania (lower part of Llewellyn Formation, Pennsylvania, Westphalian D) probably belonging to Alethopteris foliage; a second stem from the roof shale of the Eagle coal bed (Kanawha Formation, Middle Pennsylvanian, Westphalian B) of West Virginia, associated with Neuropteris foliage; and a third reported from the Stephanian of Commentry, France, in connection with Odontopteris foliage. The diameters of the Llewellyn, Eagle, and Commentry stems are 17 cm, 13 cm, and 6.5 cm, respectively. All three stems bear remnants of petioles up to several centimeters in length. The petolar remnants indicate that the living leaves grew upward at an angle of 30 - 60 degrees from the vertical, a growth habit that is common in present day tropical plants with similar overall architecture. Leaves drooped only when they were dying. After decay they broke off and left short petiolar remnants bent downward. The Llewellyn and Eagle stems represent plants with thick, straight stems, whereas the Commentry specimen shows a thin and slightly curved stem

Gallbladder Ejection Fraction is Unrelated to Gallbladder Pathology in Children and Adolescents

Objectives: Biliary dyskinesia is a common diagnosis that frequently results in cholecystectomy. In adults, most clinicians use a cut off value for the gallbladder ejection fraction (GBEF) of <35% to define the disease. This disorder is not well characterized in children. Our aim was to determine the relation between GBEF and gallbladder pathology using a large statewide medical record repository. Methods: We obtained records from all patients of 21 years and younger who underwent hepatic iminodiacetic acid (HIDA) testing within the Indiana Network for Patient Care from 2004 to 2013. GBEF results were obtained from radiology reports using data mining techniques. Age, sex, race, and insurance status were obtained for each patient. Any gallbladder pathology obtained subsequent to an HIDA scan was also obtained and parsed for mention of cholecystitis, cholelithiasis, or cholesterolosis. We performed mixed effects logistic regression analysis to determine the influence of age, sex, race, insurance status, pathologist, and GBEF on the presence of these histologic findings. Results: Two thousand eight hundred forty-one HIDA scans on 2558 patients were found. Of these, 310 patients had a full-text gallbladder pathology report paired with the HIDA scan. GBEF did not correlate with the presence of gallbladder pathology (cholecystitis, cholelithiasis, or cholesterolosis) when controlling for age, sex, race, insurance status, and pathologist using a mixed effects model. Conclusions: Hypokinetic gallbladders are no more likely to have gallbladder pathology than normal or hyperkinetic gallbladders in the setting of a patient with both a HIDA scan and a cholecystectomy. Care should be used when interpreting the results of HIDA scans in children and adolescents

Extent of hypoattenuation on CT angiography source images in Basilar Artery occlusion: prognostic value in the Basilar Artery International Cooperation Study

&lt;p&gt;&lt;b&gt;Background and Purpose:&lt;/b&gt; The posterior circulation Acute Stroke Prognosis Early CT Score (pc-ASPECTS) quantifies the extent of early ischemic changes in the posterior circulation with a 10-point grading system. We hypothesized that pc-ASPECTS applied to CT angiography source images predicts functional outcome of patients in the Basilar Artery International Cooperation Study (BASICS).&lt;/p&gt; &lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; BASICS was a prospective, observational registry of consecutive patients with acute symptomatic basilar artery occlusion. Functional outcome was assessed at 1 month. We applied pc-ASPECTS to CT angiography source images of patients with CT angiography for confirmation of basilar artery occlusion. We calculated unadjusted and adjusted risk ratios (RRs) of pc-ASPECTS dichotomized at &#8805;8 versus &#60;8. Primary outcome measure was favorable outcome (modified Rankin Scale scores 0–3). Secondary outcome measures were mortality and functional independence (modified Rankin Scale scores 0–2).&lt;/p&gt; &lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Of 158 patients included, 78 patients had a CT angiography source images pc-ASPECTS ≥8. Patients with a pc-ASPECTS ≥8 more often had a favorable outcome than patients with a pc-ASPECTS &#60;8 (crude RR, 1.7; 95% CI, 0.98–3.0). After adjustment for age, baseline National Institutes of Health Stroke Scale score, and thrombolysis, pc-ASPECTS &#8805;8 was not related to favorable outcome (RR, 1.3; 95% CI, 0.8–2.2), but it was related to reduced mortality (RR, 0.7; 95% CI, 0.5–0.98) and functional independence (RR, 2.0; 95% CI, 1.1–3.8). In post hoc analysis, pc-ASPECTS dichotomized at &#8805;6 versus &#60;6 predicted a favorable outcome (adjusted RR, 3.1; 95% CI, 1.2–7.5).&lt;/p&gt; &lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; pc-ASPECTS on CT angiography source images independently predicted death and functional independence at 1 month in the CT angiography subgroup of patients in the BASICS registry.&lt;/p&gt

Cysteinyl Leukotriene Levels in Esophageal Mucosal Biopsies of Children with Eosinophilic Inflammation: Are They All the Same?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75498/1/j.1572-0241.2006.00557.x.pd

Individual Response to Risk As a Function of Normative Social Pressure: A Pilot Study of Seat Belt Use

The authors attempt to clarify some of the variables that influence whether people act appropriately when a Risk is substantial and subject to individual control. They do so by reporting results of a pilot study of seat belt use. Also, the authors believe their approach to be generalizable to problems such as encouraging people to test for radon, to use condoms to prevent AIDS or to quit smoking

Acute Effects of Enteral Nutrition on Protein Turnover in Adolescents with Crohn Disease

ABSTRACT: Adults with inactive Crohn disease have been shown to have normal rates of protein turnover when compared with healthy adults. It is not known whether this is true for adolescents with inactive Crohn disease, when rate of protein synthesis must be greater than that of breakdown for normal development. The objective of this study was to determine whether enteral nutrition acutely suppresses proteolysis and increases protein synthesis in adolescents with inactive Crohn disease. Six adolescents (five males/one female; mean age, 15.8 Ϯ 1.9 y; range, 13.2-17.6 y; mean bone age, 14.6 Ϯ 1.8 y; range, 12.5-17 y) participated. Leucine (Leu) and phenylalanine (Phe) kinetics were measured using stable isotopes under fasted and fed conditions during a single study visit. In response to enteral nutrition, the endogenous rates of appearance (R a ) of Leu and Phe (reflecting proteolysis) decreased significantly by 40%. The percentages of splanchnic uptake of Leu and Phe were 35 Ϯ 10% and 13 Ϯ 12%, respectively. Under fed conditions, utilization of Phe for protein synthesis increased significantly. We conclude that in clinically stable adolescents with Crohn disease, enteral nutrition promotes anabolism by suppressing proteolysis and increasing protein synthesis. Rates of suppression of proteolysis were similar to those reported previously in normal children