High-contrast imaging of HD 29992 and HD 196385 with GPI

Based on high contrast images obtained with the Gemini Planet Imager (GPI), we report the discovery of two point-like sources at angular separations of $\rho\sim0.18''$ and $\rho\sim0.80''$ from the stars HD 29992 and HD 196385. A combined analysis of the new GPI observations and images from the literature indicates that the source close to HD 29992 could be a companion to the star. Concerning HD 196385, the small number of contaminants ($\sim0.5$) suggests that the detected source may be gravitationally bound to the star. For both systems, we discarded the presence of other potential companions with $m>75$ M$_{\rm Jup}$ at $\rho\sim0.3 - 1.3''$. From stellar model atmospheres and low-resolution GPI spectra, we derive masses of $\sim0.2$ - $0.3$ M$_{\odot}$ for these sources. Using a Markov-chain Monte Carlo approach, we performed a joint fit of the new astrometry measurements and published radial velocity data to characterize the possible orbits. For HD 196385B, the median dynamic mass is in agreement with that derived from model atmospheres, whilst for HD 29992B, the orbital fit favors masses close to the brown dwarf regime($\sim0.08$ M$_{\odot}$). HD 29992 and HD 196385 might be two new binary systems with M-type stellar companions. However, new high angular resolution images would help to definitively confirm whether the detected sources are gravitationally bound to their respective stars, and permit tighter constraints on the orbital parameters of both systems

Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells

Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation. Regulation of ligand expression in tumor cells mainly relays on transcriptional mechanisms, while the involvement of ubiquitin or ubiquitin-like modifiers remains largely unexplored. Here, we focused on the SUMO pathway and demonstrated that the ligand of DNAM1 activating receptor, PVR, undergoes SUMOylation in multiple myeloma. Concurrently, we found that PVR is preferentially located in intracellular compartments in human multiple myeloma cell lines and malignant plasma cells and that inhibition of the SUMO pathway promotes its translocation to the cell surface, increasing tumor cell susceptibility to NK cell-mediated cytolysis. Our findings provide the first evidence of an innate immune activating ligand regulated by SUMOylation, and confer to this modification a novel role in impairing recognition and killing of tumor cells.Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation. Regulation of ligand expression in tumor cells mainly relays on transcriptional mechanisms, while the involvement of ubiquitin or ubiquitin-like modifiers remains largely unexplored. Here, we focused on the SUMO pathway and demonstrated that the ligand of DNAM1 activating receptor, PVR, undergoes SUMOylation in multiple myeloma. Concurrently, we found that PVR is preferentially located in intracellular compartments in human multiple myeloma cell lines and malignant plasma cells and that inhibition of the SUMO pathway promotes its translocation to the cell surface, increasing tumor cell susceptibility to NK cell-mediated cytolysis. Our findings provide the first evidence of an innate immune activating ligand regulated by SUMOylation, and confer to this modification a novel role in impairing recognition and killing of tumor cells

The X-ray spectrum of a disk illuminated by ions

The X-ray spectrum from a cool disk embedded in an ion supported torus is computed. The interaction of the hot ions with the disk increases the hard X-ray luminosity of the system}. A surface layer of the disk is heated by the protons from the torus. The Comptonized spectrum produced by this layer has a shape that depends only weakly on the incident energy flux and the distance from the accreting compact object. It consists of a `blue bump' of unComptonized soft photons and a flat high energy tail, reminiscent of the observed spectra. The hard tail becomes flatter as the thermalization depth in the cool disk is increased. Further evidence for ion illumination are the Li abundance in the secondaries of low mass X-ray binaries and the 450 keV lines sometimes seen in black-hole transient spectra.Comment: 7p, to appear in Monthly Notice

Mitochondrial DNA phylogeography and population history of the grey wolf Canis lupus

The grey wolf (Canis lupus) and coyote (C. latrans) are highly mobile carnivores that disperse over great distances in search of territories and mates. Previous genetic studies have shown little geographical structure in either species. However, population genetic structure is also influenced by past isolation events and population fluctuations during glacial periods. In this study, control region sequence data from a worldwide sample of grey wolves and a more limited sample of coyotes were analysed. The results suggest that fluctuating population sizes during the late Pleistocene have left a genetic signature on levels of variation in both species. Genealogical measures of nucleotide diversity suggest that historical population sizes were much larger in both species and grey wolves were more numerous than coyotes. Currently, about 300 000 wolves and 7 million coyotes exist. In grey wolves, genetic diversity is greater than that predicted from census population size, reflecting recent historical population declines. By contrast, nucleotide diversity in coyotes is smaller than that predicted by census population size, reflecting a recent population expansion following the extirpation of wolves from much of North America. Both species show little partitioning of haplotypes on continental or regional scales. However, a statistical parsimony analysis indicates local genetic structure that suggests recent restricted gene flow.Peer Reviewe

Experimental and theoretical cross sections for positron scattering from the pentane isomers.

Isomerism is ubiquitous in chemistry, physics, and biology. In atomic and molecular physics, in particular, isomer effects are well known in electron-impact phenomena; however, very little is known for positron collisions. Here we report on a set of experimental and theoretical cross sections for low-energy positron scattering from the three structural isomers of pentane: normal-pentane, isopentane, and neopentane. Total cross sections for positron scattering from normal-pentane and isopentane were measured at the University of Trento at incident energies between 0.1 and 50 eV. Calculations of the total cross sections, integral cross sections for elastic scattering, positronium formation, and electronic excitations plus direct ionization, as well as elastic differential cross sections were computed for all three isomers between 1 and 1000 eV using the independent atom model with screening corrected additivity rule. No definitive evidence of a significant isomer effect in positron scattering from the pentane isomers appears to be present. (C) 2016 AIP Publishing LLC

Formation of the compact jets in the black hole GX 339-4

Galactic black hole binaries produce powerful outflows with emit over almost the entire electromagnetic spectrum. Here, we report the first detection with the Herschel observatory of a variable far-infrared source associated with the compact jets of the black hole transient GX 339-4 during the decay of its recent 2010-2011 outburst, after the transition to the hard state. We also outline the results of very sensitive radio observations conducted with the Australia Telescope Compact Array, along with a series of near-infrared, optical (OIR) and X-ray observations, allowing for the first time the re-ignition of the compact jets to be observed over a wide range of wavelengths. The compact jets first turn on at radio frequencies with an optically thin spectrum that later evolves to optically thick synchrotron emission. An OIR reflare is observed about ten days after the onset of radio and hard X-ray emission, likely reflecting the necessary time to build up enough density, as well as to have acceleration (e.g. through shocks) along an extended region in the jets. The Herschel measurements are consistent with an extrapolation of the radio inverted power-law spectrum, but they highlight a more complex radio to OIR spectral energy distribution for the jets.Comment: Accepted for publication in MNRAS Letter, 6 pages, 3 Figures + 1 online Tabl

Beam Test of Silicon Strip Sensors for the ZEUS Micro Vertex Detector

For the HERA upgrade, the ZEUS experiment has designed and installed a high precision Micro Vertex Detector (MVD) using single sided micro-strip sensors with capacitive charge division. The sensors have a readout pitch of 120 microns, with five intermediate strips (20 micron strip pitch). An extensive test program has been carried out at the DESY-II testbeam facility. In this paper we describe the setup developed to test the ZEUS MVD sensors and the results obtained on both irradiated and non-irradiated single sided micro-strip detectors with rectangular and trapezoidal geometries. The performances of the sensors coupled to the readout electronics (HELIX chip, version 2.2) have been studied in detail, achieving a good description by a Monte Carlo simulation. Measurements of the position resolution as a function of the angle of incidence are presented, focusing in particular on the comparison between standard and newly developed reconstruction algorithms.Comment: 41 pages, 21 figures, 2 tables, accepted for publication in NIM

A fast and long-lived outflow from the supermassive black hole in NGC 5548

Supermassive black holes in the nuclei of active galaxies expel large amounts of matter through powerful winds of ionized gas. The archetypal active galaxy NGC 5548 has been studied for decades, and high-resolution X-ray and UV observations have previously shown a persistent ionized outflow. An observing campaign in 2013 with six space observatories shows the nucleus to be obscured by a long-lasting, clumpy stream of ionized gas never seen before. It blocks 90% of the soft X-ray emission and causes simultaneous deep, broad UV absorption troughs. The outflow velocities of this gas are up to five times faster than those in the persistent outflow, and at a distance of only a few light days from the nucleus, it may likely originate from the accretion disk.Comment: 25 pages, 8 figures. This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science, electronically available at Science Express (June 19, 2014). For a brief video explaining the key results of this paper, please visit http://www.issibern.ch/teams/ngc5548/?page_id=2

Cardiovascular adverse events in modern myeloma therapy - incidence and risks. A review from European Myeloma Network (EMN) and Italian Society of Arterial Hypertension (SIIA)

Cardiovascular disease in myeloma patients may derive from factors unrelated to the disease (age, diabetes, dyslipidemia, obesity, prior cardiovascular diseases), related to the disease (cardiac AL-amyloidosis, hyperviscosity, high-output failure, arteriovenous shunting, anemia, renal dysfunction) and linked to antimyeloma treatment (anthracyclines, corticosteroids, alkylating agents, immunomodulatory drugs, proteasome inhibitors). An accurate knowledge of cardiovascular events, effective dose reductions, prevention and management of early and late cardiovascular side effects of chemotherapeutic agents are essential in current clinical practice. Myeloma experts are obliged to carefully balance drugs' efficacy and toxicity for each individual patient. This review summarizes current data and novel insights on cardiovascular adverse events of today's antimyeloma treatment, focusing on carfilzomib, which is the starting point to develop consensus recommendations on preventing and managing cardiovascular side effects in myeloma patients