Revisiting Heck-Mizoroki reactions in ionic liquids

The use of ionic liquids as an alternative to conventional organic solvents has been an important research topic in order to answer economic and environmental challenges. This critical review revisits the different approaches and achievements on the use of ionic liquids as solvents in Heck-Mizoroki coupling reactions; a brief reference to supported ionic liquids will be also highlighted

Original article UDC: 618.19-006:615-085:616.151.5 Archive of Oncology 2002;10(2):61-6. Effect of CMF-chemotherapy on blood

chemotherapy on blood coagulation were investigated in 30 patients receiving adjuvant chemotherapy and in 30 patients receiving chemotherapy for metastatic breast cancer. METHODS: In plasma samples of 60 patients (median age 49.5), we evaluated the following parameters: 1) Markers of in vivo clotting activation thrombin-antithrombin complex ( ELISA) and D-dimer (ELISA), 2) Natural anticoagulants (protein C [PC] and antithrombin III [AT III] by chromogenic methods). The coagulation studies were performed at the beginning and at the end of the first cycle of CMF protocol. RESULTS: Before CMF therapy, significant difference was observed between patients with early stage and patients with metastatic breast cancer in the PC (p<0.01), AT III (p<0.01) and TAT (p<0.01) levels. After CMF therapy, patients with stage II (adjuvant) disease manifested a significant decrease in the level of PC and AT III activity (p<0.01) and an increase in TAT level (p<0.01). In patients with disseminated breast cancer CMF therapy provoked an increased level of TAT and D-dimer with a decreased activity of protein C and antithrombin III. There was significant difference in value of TAT, D-dimer, protein C and antithrombin III between the patients with adjuvant and metastatic breast cancer patients after CMF chemotherapy. CONCLUSION: Our results suggest that the application of cytotoxic therapy provokes hypercoagulable condition in breast cancer patients. This effect should be considered when chemotherapy is employed in advanced cancer patients at high risk for thrombosis, or in patients with other risk factors

ORIGINAL ARTICLE UDC: 616.155.3:576.36:623.454.8

Positive correlation between micronuclei and necrosis of lymphocytes in medical personnel occupationally exposed to ionizing radiatio

fatal

Lobular panniculitis: A manifestation of pancreatic tumor wit

Archive of Oncology 2002;10(1):37-8. Role of endorectal ultrasonography in

olorectal cancer is the fourth most common type of cancer worldwide yet there continues to be controversy and confusion regarding the best methods and techniques for its diagnosis and management. The treatment of rectal carcinoma is mainly determined by its local extension. Preoperative staging of rectal carcinoma can be assessed by different methods: digital rectal examination, transrectal ultrasound, computed tomography, and magnetic resonance imaging. The first articles about endorectal ultrasonography (ERUS) and its application in diagnostics of anorectal diseases date since 1956. Its use in clinical practice was limited mostly because of the bad technical characteristics of probes (1,2). Over the past several years, the tremendous improvements in endorectal and endoanal ultrasonography allowed a much more accurate evaluation of both benign and malignant anorectal diseases and what is more importan

MONTENEGRO

Galectin-3 expression in medullary thyroid carcinoma in relation to tumor progressio

KAMENICA, SERBIA AND MONTENEGRO

Primary non-Hodgkin lymphoma of the jejunum associated with mesenteri

Case report UDC: 612.627-006:053.6:616-089.8:615-085 Archive of Oncology 2002;10(4):281-2. Clinical and morphological features of ovarian pure dysgerminoma: A report of a

14 years old gir

Staging of rectal cancer by endorectal ultrasonography

Endorectal ultrasonography is valuable method for accurate local staging of rectal cancer. Precise evaluation of tumor stage is essential for optimal therapy planning in patients with rectal cancer. Furthermore, it has great influence on the resectability and the risk of recurrence following resection. Endorectal ultrasonography has become the most common diagnostic tool for locally staging rectal cancer due to its advantages over magnetic resonance imaging (MRI) and computer tomography (CT). Among these diagnostic modalities ERUS has been known to be most accurate. Moreover, endorectal ultrasonography is inexpensive and quick diagnostic procedure associated with minimal discomfort to the patient. However, the use of CT, MRI, and more recently magnetic resonance imaging with endorectal coil often remains necessary. These modalities may be useful supplements in patients with suspected T4 lesion, when endorectal ultrasonography is technically unsuccessful and in cases of diagnostic dilemma. Major improvements in diagnostic and staging of rectal cancer have led to stage-oriented surgery, planning of therapy individually for each patient, reduce of local recurrences, and better overall survival. This article reviews the current use of endorectal ultrasonography in preoperative staging of rectal cancer as the most practical and accurate diagnostic modality for preoperative locoregional staging of rectal cancer at this time