Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Immediate recall as a secondary text: Referential parameters, pragmatics and propositions

Since the process of recalling combines comprehension and speech production, it is viewed as an extremely complex though understudied linguo-cognitive phenomenon. Recalls as secondary texts or text derivatives are also considered to be a good material to explore cognitive aspects of secondary texts production, information conversion procedures and types of transformations of primary texts. The notion of ‘secondary texts’ also implies multiplicity, as an original text may be retranslated into numerous secondary texts different in quality and degree of completeness. The purpose of the study is to model the propositional secondary retold texts and to identify the specifics of the recipients’ interpretation of the main event in the text. It is aimed at discriminating the differences between the primary expository text and its 134 immediate recalls produced by 15-year old native Russian speakers. In order to reveal the specifics of the propositional content of a primary expository text and its recalls, their recipients used the following methodological operations: The description and interpretation of the semantic roles of the first and second arguments aligned to predicates on the basis of the verbs’ semantic properties; the employment of the psycholinguistic model of the utterances generation; the characteristic of memory as a complex of cognitive and mnemic processes; the definition of cognitive-semantic discourse structures; and the understanding of a proposition as a stable component of an utterance independent of the surface grammar. The comparison of the original text and its recalls with the use of innovative “denotative maps” enabled us to define successful and unsuccessful expression of propositional structures and the main idea of the original text. The classification of texts includes four groups based on the number of the reproduced propositions and types (weak or successful) of the reflection of the primary text denotative card. The authors designed and successfully implemented an innovative 11 stage- algorithm of revealing patterns of a printed text comprehension and its immediate recalls including the primary visual perception of the text, its primary interpretation, reading, encoding, reflection, preparation for an oral presentation, desobjectivation (distribution of semantic roles), interpretation, reflection, oral implementation and text. The work fills in certain gaps in the research, such as the specifics of immediate recalls production, identification of changes in propositional structures of immediate recalls, and expanding the corpus of semantic roles similar to Frame Net. The findings can be successfully applied in natural language processing and linguistic didactics

Возможности прегравидарной подготовки женщин с низким овариальным резервом

Purpose: to evaluate the comprehensive preparation of women with infertility and low ovarian reserve for assisted reproductive technology (ART) programs, including with the use of the drug Melsmon, to study the effect of such therapy on asthenic syndrome, the quality of the ovarian response, endometrium and conceiving. Material and methods. For the study 18 women with primary and secondary infertility and low ovarian reserve were selected. Ten of them received the drug Melsmon in preparation for the ART programs as part of complex hormone replacement therapy. Women were examined and prepared for the ART programs in accordance with the approved protocol of the Ministry of Health of the Russian Federation. In addition, the level ofalpha-2-microglobulin of fertility (glycodelin) in menstrual blood was studied in women by immunoassay with the use ofFertitest-M kits. The work was performed on the basis of the Clinic of Modern Medicine (Ivanovo). Results. The use of the drug Melsmon in complex preparation for ART programs for women with low ovarian reserve and AMG indicators of 0.5-1.0 ng/ml led to the improvement in the ovarian response to stimulation, increased secretory activity of the endometrium and the quality of conceiving. The drug Melsmon contributed to the correction of asthenic syndrome and normalization of glycodelin level in the menstrual blood. Conclusions. Further research of the effect of the drug Melsmon on the functional activity of the ovaries and endometrium in women with reduced ovarian reserve is required.Цель исследования: оценить комплексную подготовку женщин с бесплодием и низким овариальным резервом к программам вспомогательных репродуктивных технологий (ВРТ), в том числе с использованием препарата Мэлсмон, изучить влияние такой терапии на астенический синдром, качество овариального ответа, эндометрия и частоту зачатия. Материал иметоды. В исследовании приняли участие 18 женщин с первичным и вторичным бесплодием и низким овариальным резервом. Десять из них при подготовке к программам ВРТ в составе комплексной заместительной гормональной терапии получали препарат Мэлсмон. Обследование и подготовка к программам ВРТ велись в соответствии с протоколом, утвержденным Минздравом России. Дополнительно оценивался уровень альфа-2-микроглобулина фертильности (гликоделина) в менструальной крови методом иммуноферментного анализа с использованием наборов «Фертитест-М». Работа выполнена на базе Клиники современной медицины (Иваново). Результаты. Включение препарата Мэлсмон в комплексную подготовку к программам ВРТ женщин с низким овариальным резервом иуровнем антимюллерова гормона 0,5-1,0 нг/мл приводило кулучшению овариального ответа на стимуляцию, повышению секреторной активности эндометрия и частоты зачатия. Препарат Мэлсмон способствовал коррекции астенического синдрома и нормализации уровня гликоделина в менструальной крови. Выводы. Требуется продолжение исследований по влиянию препарата Мэлсмон на функциональную активность яичников и эндометрияуженщин со сниженным овариальным резервом

The use of plant-tissue composition at hemofilter the polyserositis of pigs (illness glasser)

The purpose of the research in the article is to study a specific infectious disease – hemophilous polyserositis of pigs, its spread in the territory of the Ural region. Epizootological analysis of Piglet morbidity was shown, laboratory studies were conducted, and recommendations for the treatment and prevention of this disease were made. Evaluation of the specific effectiveness of the plant - tissue immunomodulator “Vidoral” in the treatment of hemophilous polyserositis in pigs and increasing the protective activity of vaccines. The features of the development of the epizootic process in hemophilous polyserositis of pigs in the studied agricultural enterprises of two regions of the Ural region are characterized. The role and place of porcine hemophilous polyserositis among respiratory diseases of infectious etiology in the formation of the nosological profile of infectious pathology is determined. The drug Vidoral on a plant and tissue basis was theoretically justified and studied, and the effectiveness of its use in animals with hemophilous polyserositis in pigs was determined

The role of acute respiratory infections in the pathogenesis of distal limb infections in cattle

Acute respiratory diseases of infectious etiology of cattle occupy the second place in the nosological picture after diseases of the digestive system and cause huge economic damage, which in the Russian Federation is estimated at several billion rubles annually. Very often, respiratory pathology in highly productive cows is associated with infections of the distal extremities, primarily with necrobacteriosis, streptococcosis and staphylococcosis, which cause significant economic damage by reducing the productivity of animals. An important pathogenetic factor affecting the development of diseases of the distal extremities in cattle (cattle) are infections of the respiratory tract. According to our long-term observations, all farms in which outbreaks of necrobacteriosis were recorded were unfavorable for respiratory infections of cattle, such as infectious rhinotracheitis (IRT), viral diarrhea (VD), parainfluenza type 3 (PG-3), respiratory syncytial infection (RSI), pasteurellosis, chlamydia, salmonellosis and others

Micropropagation studies and antioxidant analysis of the endangered plants of Bulgarian yellow gentian (Gentiana lutea L.)

In order to develop an efficient micropropagation system, it is essential to establish the appropriate concentration of growth regulators for seed germination, shoot formation and rooting. Nodal segments from in vitro obtained seedlings of Gentiana lutea L. were cultured in vitro in Murashige and Skoog’s medium supplemented with BAP, Thidiazuron and Zeatin (0.5, 1.0 and 2.0 mg L−1). A maximum number of shoots with the highest height was recorded at 2.0 mg L−1 BAP. For further optimization of the process, we used nutrient media containing BAP and Zeatin with a combination of low concentration of Indoleacetic acid. MS medium containing 2.0 mg L−1 Zeatin and 0.2 mg L−1 IAA resulted in maximum numbers of shoots 94.3) with shoot height 2.5 cm. The multiple plants were successfully ex vitro acclimatized with 65% survival. The presence of growth regulators (2.0 mg L−1 Zeatin and 0.2 mg L−1 IAA) in the nutrient media resulted in an effective antioxidant activity in G. Lutea determined by the low molecular antioxidant metabolites such as phenols and flavonoids and activities of antioxidant enzymes – catalase, ascorbate peroxidase, guaiacol peroxidase, and superoxide dismutase. The described protocol allows the establishment of numerous micropropaged plants of rare and endangered G. lutea

Effect of fire extinguish methods on RHA-concrete strength

During the few past years reuse these materials to enhancement the mechanical properties of concrete are one of the aims of concrete technology. The previous researches turn the rice hulls into rice husk ash by different methods. In this research, RHA were prepared by two methods which are oven burning at 200°C and exposure to direct flame. Concrete cubes with 4%, 8%, 12%, and 16% by weight of cement were prepared and tested under compression test to achieve the optimum percentage of replacement and RHA preparation method. Then, three groups of RHA concrete cubes were casted and exposed to direct fire for one hour. One group of them tested directly to study the enhancement of fire resistance of RHA concrete and act of RHA in concrete fire resistance while, the other groups extinguished by two different methods (Water, and Powder) to study the effect of fire extinguish method on concrete strength. The results found that oven burning rice husk produce RHA better than direct flam. Effect of fire extinguish method has nearly the same effect on the reduction in concrete compressive strength and flexural strength. Concrete fire resistance for RHA concrete is higher than the conventional concrete. © Published under licence by IOP Publishing Ltd