Thinning mechanisms of heterogeneous continental lithosphere

The mechanisms responsible for the formation of extremely thinned continental crust (<10 km thick) and lithosphere during rifting remains debated. Observations from present-day and fossil passive margins highlight the role of deep-seated deformation, likely controlled by heterogeneities within the continental lithosphere, such as changing lithologies, mechanical anisotropies and inherited structures. We investigate the mechanisms of lithospheric thinning by exploring the role of pre-existing heterogeneities on the architecture and evolution of rifted margins. We estimate pre-rift pressure conditions (P0) vs. depth diagrams of crustal to lithospheric sections, to quantify rift-related modifications on inherited lithostatic pressure gradients. Two field examples from the Alpine Tethys margins in the Eastern and Southern Alps (SE Switzerland and N Italy) were selected to characterize: (1) the pre-rift architecture of the continental lithosphere; (2) the localization of rift-related deformation in distinct portions of the lithosphere; and (3) the interaction between pre-existing heterogeneities of the lithosphere and rift-related structures. These observations are compared with high-resolution, two-dimensional thermo-mechanical numerical models. The design of the models takes into account pre-existing mechanical heterogeneities representing the initial pre-rift architecture of the continental lithosphere. Extensional structures consist of high-angle and low-angle normal faults, anastomosing shear-zones and decoupling horizons. Such structures accommodate the lateral extraction of mechanically stronger levels derived from the middle to lower crust. As a result, the extremely thinned continental crust in Tethyan passive margins represents the juxtaposition and amalgamation of distinct strong levels of the crust separated by major extensional structures identified by sharp pressure gradients. Future work should determine the applicability of these results to other present-day and fossil rifted margins

Journeys in Non-Classical Computation I: A Grand Challenge for computing research

A gateway event is a change to a system that leads to the possibility of huge increases in kinds and levels of complexity. It opens up a whole new kind of phase space to the systemÕs dynamics. Gateway events during evolution of life on earth include the appearance of eukaryotes (organisms with a cell nucleus), an oxygen atmosphere, multi-cellular organisms and grass. Gateway events during the development of mathematics include each invention of a new class of numbers (negative, irrational, imaginary, ...), and dropping Euclid's parallel postulate. A gateway event produces a profound and fundamental change to the system: Once through the gateway, life is never the same again. We are currently poised on the threshold of a significant gateway event in computation: That of breaking free from many of our current Òclassical computationalÓ assumptions. Our Grand Challenge for computer science is to journey through the gateway event obtained by breaking our current classical computational assumptions, and thereby develop a mature science of Non-Classical Computatio

The low-frequency radio telescope NenuFAR

International audienceNenuFAR is a new, large low-frequency radio telescope, in construction and commissioning at the Nançay Radioastronomy Observatory, that starts to provide high sensitivity observations in the 10-85 MHz range. NenuFAR’s 1938 dual polarization antennas are connected to a suite of receivers allowing the instrument to operate, simultaneously if needed, in 4 distinct modes : as a standalone beamformer, a standalone imager, a waveform snapshots recorder, and a giant low-frequency station of the LOFAR array. We provide here an overview of the antennas, receivers, data products, operation and scientific context of the instrument

The low-frequency radio telescope NenuFAR

International audienceNenuFAR is a new, large low-frequency radio telescope, in construction and commissioning at the Nançay Radioastronomy Observatory, that starts to provide high sensitivity observations in the 10-85 MHz range. NenuFAR’s 1938 dual polarization antennas are connected to a suite of receivers allowing the instrument to operate, simultaneously if needed, in 4 distinct modes : as a standalone beamformer, a standalone imager, a waveform snapshots recorder, and a giant low-frequency station of the LOFAR array. We provide here an overview of the antennas, receivers, data products, operation and scientific context of the instrument

The low-frequency radio telescope NenuFAR

International audienceNenuFAR is a new, large low-frequency radio telescope, in construction and commissioning at the Nançay Radioastronomy Observatory, that starts to provide high sensitivity observations in the 10-85 MHz range. NenuFAR’s 1938 dual polarization antennas are connected to a suite of receivers allowing the instrument to operate, simultaneously if needed, in 4 distinct modes : as a standalone beamformer, a standalone imager, a waveform snapshots recorder, and a giant low-frequency station of the LOFAR array. We provide here an overview of the antennas, receivers, data products, operation and scientific context of the instrument

The low-frequency radio telescope NenuFAR

International audienceNenuFAR is a new, large low-frequency radio telescope, in construction and commissioning at the Nançay Radioastronomy Observatory, that starts to provide high sensitivity observations in the 10-85 MHz range. NenuFAR’s 1938 dual polarization antennas are connected to a suite of receivers allowing the instrument to operate, simultaneously if needed, in 4 distinct modes : as a standalone beamformer, a standalone imager, a waveform snapshots recorder, and a giant low-frequency station of the LOFAR array. We provide here an overview of the antennas, receivers, data products, operation and scientific context of the instrument

The low-frequency radio telescope NenuFAR

International audienceNenuFAR is a new, large low-frequency radio telescope, in construction and commissioning at the Nançay Radioastronomy Observatory, that starts to provide high sensitivity observations in the 10-85 MHz range. NenuFAR’s 1938 dual polarization antennas are connected to a suite of receivers allowing the instrument to operate, simultaneously if needed, in 4 distinct modes : as a standalone beamformer, a standalone imager, a waveform snapshots recorder, and a giant low-frequency station of the LOFAR array. We provide here an overview of the antennas, receivers, data products, operation and scientific context of the instrument

Weekly high-dose liposomal amphotericin B (L-AmB) in critically ill septic patients with multiple <i>Candida</i> colonization: The AmBiDex study

<div><p>Background</p><p>To demonstrate the feasibility and safety of weekly high-dose liposomal amphotericin B (L-AmB) (as a pre-emptive antifungal treatment) for 2 weeks in patients with septic shock and Candida colonization.</p><p>Methods</p><p>Pilot, multicentre, open-label, prospective study conducted in seven French ICUs. Non-immunocompromised patients, receiving mechanical ventilation were eligible if they presented ICU-acquired severe sepsis requiring newly administered antibacterial agents and Candida colonization in at least two sites. Exclusion criteria included the need for antifungal therapy and creatinine > 220 μmol/L. All patients were to receive a high-dose L-AmB (10 mg/kg/week) for two weeks. A follow-up period of 21 days following the second administration of L-AmB was conducted. Treated patients were compared to 69 matched untreated controls admitted in the same ICUs before the study period.</p><p>Results</p><p>Twenty-one patients were included in the study, of which 20 received at least one infusion of high-dose L-AmB. A total of 24 adverse events were identified in 13(61%) patients. Fourteen adverse events were categorized as serious in 8(38%) patients. In four cases the adverse events were considered as potentially related to study drug administration and resulted in L-AmB discontinuation in one patient. Few patients experienced severe renal toxicity since no patient presented with severe hypokalemia. No patients required renal replacement therapy. Compared to matched controls, no significant increase in serum creatinine levels in patients receiving high-dose L-AmB was reported.</p><p>Conclusions</p><p>Weekly administration of high-dose L-AmB has a manageable safety profile and is feasible in patients with ICU-acquired sepsis and multiple Candida colonization. Trials of L-AmB versus other antifungal agents used as pre-emptive antifungal therapy are warranted.</p><p>Trial registration</p><p>ClinicalTrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT00697944" target="_blank">NCT00697944</a></p></div