New software for identification and evaluation of environmental and waste management in the companies

Reducing environmental pollution by finding optimal solutions for waste management is an ongoing concern both within companies and in landfills. The need to develop waste management integrated systems should have the effect of reducing the impact on the environment in the context of a sustainable development. This paper proposes a solution for waste management, which is already applied in a warehouse that collects non-hazardous types of waste in three major cities: Campina, Ploiesti and Boldesti-Scaieni. Using the software application called “mediu.conturweb” provides a comprehensive framework for monitoring the total amount of waste stored and recycled, for monitoring environmental factors like CH4 and CO2 emissions. The application achieved its goal of reducing emissions back in 2015, when it was first implemented, for a huge amount of waste of approximately 131,909.36 t to the values of 384 tons/year for CH4 and of 998 tons/year for CO2

Informatic system for identifying and evaluation of the environmental aspects and waste products management

In this paper, the authors present the instruments provided by a software package that is dedicated for the identification and evaluation of the management of environmental aspects and waste. The solution proposed, modeled as a cycle, can be adapted to any company in the manufacturing sector and involves the elaboration of a procedure for environment-related aspects, the implementation of software, training of personnel, identification, evaluation and monitoring of the significant environmental issues, preoccupation for future improvement

Quality management and social responsibility in the context of sustainable development

The authors have analyzed two major determinants of sustainable development: quality management and social responsibility. The sustainable development is a concept used not only by researchers in domains like economics or ecology, but also by managers of different types of organizations that try to transpose this concept in real life. Many organizations like corporations, public institutions or small and medium enterprises promote the goals of sustainable development in their activity through various instruments like social responsibility's programs or the use of different standards. So, the aim of this article is to analyze the relationship between quality management, social responsibility and sustainable development

Multi-Response Optimization Analysis of the Milling Process of Asphalt Layer Based on the Numerical Evaluation of Cutting Regime Parameters

The present study aimed to optimize the process parameters (milling depth and advanced speed) for an asphalt milling operation using a multi-response approach based on Taguchi design of experiments (DOE) and Grey Relational Analysis (GRA). Nine simulations tests were conducted using Discrete Element Method (DEM) in order to determine the forces acting on the cutting tooth support and tip. The considered performance characteristics were cutting forces (smaller is better category) and chip section area (larger is better category). A Grey Relational Grade (GRG) was determined from GRA, allowing to identify the optimal parameter levels for the asphalt milling process with multiple performance characteristics. It was found that that the optimal milling parameters for multi-response analysis are a milling depth of 200 mm and an advanced speed of 30 mm/min. Furthermore, analysis of variance (ANOVA) was used to determine the most significant factor influencing the performance characteristics. The analysis results revealed that the dominant factor affecting the resultant cutting force was milling depth, while the main factor affecting chip section area was the advanced speed. Optimizing milling efficiency is essential in machining operations. A key factor in this direction is comprehending the interplay between chip removal and cutting forces. This understanding is fundamental for achieving increased productivity, cost-effectiveness, and extended tool lifespan during the milling process

Determination of VEGFR-2 (KDR) 604A>G Polymorphism in Pancreatic Disorders

Pancreatic disorders have a high prevalence worldwide. Despite the fact that screening methods became more effective and the knowledge we have nowadays about pancreatic diseases has enhanced, their incidence remains high. Our purpose was to determine whether single nucleotide polymorphism (SNP) of VEGFR-2/KDR (vascular endothelial growth factor receptor 2/kinase insert domain receptor) influences susceptibility to develop pancreatic pathology. Genomic DNA was extracted from blood samples collected from patients diagnosed with acute pancreatitis (n = 110), chronic pancreatitis (n = 25), pancreatic cancer (n = 82) and healthy controls (n = 232). VEGFR-2 (KDR) 604A>G (rs2071559) polymorphism frequency was determined with TaqMan allelic discrimination assays. Statistical assessment was performed by associating genetic polymorphism with clinical and pathological data. In both pancreatic disorders and healthy control groups the polymorphism we studied was in Hardy-Weinberg equilibrium. Association between increased risk for pancreatic disorders and studied polymorphism was statistically significant. KDR 604AG and AG + GG genotypes were more prevalent in acute pancreatitis and pancreatic cancer patients than in controls. These genotypes influence disease development in a low rate. No association was found between chronic pancreatitis and KDR 604AG and AG + GG genotypes. In Romanian cohort, we found an association between the KDR 604A→G polymorphism and acute pancreatitis and pancreatic cancer. Carriers of the -604G variant allele were more frequent among acute pancreatitis and pancreatic cancer than among controls, suggesting that KDR 604G allele may confer an increased risk for these diseases. In the future, more extensive studies on larger groups are necessary, in order to clarify the role of VEGFR2 polymorphisms in pancreatic pathology

L'établissement d'Acic-Suat (commune de Baia, département de Tulcea). Méthodologie d'une enquête pluridisciplinaire

International audienceFondé sur les rives méridionales de la lagune de Goloviţa, l’établissement grec d’Acic Suat se développe dès le second quart du VIe s. av. J.-C. sur une péninsule disposée à l’entrée du golfe de Baia. Distinct des vestiges identifiés au XIXe s. par K. F. Peters, ce site peut correspondre, par sa chronologie et sa localisation, à celui désigné sous le nom de « Caraburun » dans les études consacrées au territoire d’Istros. Depuis 2011, la mission archéologique franco-roumaine à Orgamè a déployé autour de cet établissement un programme de recherche pluridisciplinaire qui permet désormais d’en esquisser la trajectoire historique, tout comme les contours. L’objet de cet article n’est pas tant de détailler l’ensemble des résultats obtenus que de présenter la méthodologie employée, laquelle offre une approche globale sur cette communauté coloniale installée à mi-chemin entre Orgamè et IstrosSituată pe malul sudic al lagunei Golovița, așezarea grecească de la Acic Suat s-a dezvoltat din al doilea sfert al secolului al VII-lea a.Chr., în peninsula situată la intrarea în golful Baia. Distinct de vestigiile identificate în secolul al XIX-lea de către K. F. Peters, acest sit poate corespunde atât din punct de vedere cronologic, cât și al localizării, cu așezarea desemnată sub numele de ”Caraburun” în studiile consacrate teritoriului histrian. Din anul 2011, misiunea arheologică franco-română de la Orgame desfășoară aici un program de cercetare pluridisciplinară care va permite acum trasarea parcursului istoric, precum și a limitelor așezării. Obiectul acestui articol nu îl constituie detalierea rezultatelor obținute, ci prezentarea metodologiei utilizate, ce oferă o abordare globală asupra comunității coloniale așezate la jumătatea drumului dintre Orgame și Istros

L’établissement d’Acic-Suat (commune de Baia, département de Tulcea). Méthodologie d’une enquête pluridisciplinaire

International audienc

L'établissement d'Acic-Suat (commune de Baia, département de Tulcea). Méthodologie d'une enquête pluridisciplinaire

International audienceFondé sur les rives méridionales de la lagune de Goloviţa, l’établissement grec d’Acic Suat se développe dès le second quart du VIe s. av. J.-C. sur une péninsule disposée à l’entrée du golfe de Baia. Distinct des vestiges identifiés au XIXe s. par K. F. Peters, ce site peut correspondre, par sa chronologie et sa localisation, à celui désigné sous le nom de « Caraburun » dans les études consacrées au territoire d’Istros. Depuis 2011, la mission archéologique franco-roumaine à Orgamè a déployé autour de cet établissement un programme de recherche pluridisciplinaire qui permet désormais d’en esquisser la trajectoire historique, tout comme les contours. L’objet de cet article n’est pas tant de détailler l’ensemble des résultats obtenus que de présenter la méthodologie employée, laquelle offre une approche globale sur cette communauté coloniale installée à mi-chemin entre Orgamè et IstrosSituată pe malul sudic al lagunei Golovița, așezarea grecească de la Acic Suat s-a dezvoltat din al doilea sfert al secolului al VII-lea a.Chr., în peninsula situată la intrarea în golful Baia. Distinct de vestigiile identificate în secolul al XIX-lea de către K. F. Peters, acest sit poate corespunde atât din punct de vedere cronologic, cât și al localizării, cu așezarea desemnată sub numele de ”Caraburun” în studiile consacrate teritoriului histrian. Din anul 2011, misiunea arheologică franco-română de la Orgame desfășoară aici un program de cercetare pluridisciplinară care va permite acum trasarea parcursului istoric, precum și a limitelor așezării. Obiectul acestui articol nu îl constituie detalierea rezultatelor obținute, ci prezentarea metodologiei utilizate, ce oferă o abordare globală asupra comunității coloniale așezate la jumătatea drumului dintre Orgame și Istros

A Survey of Empirical Results on Program Slicing

International audienceBACKGROUND:Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications.METHODS:This was a multicentre, double-blind, randomised placebo-controlled trial for which patients were recruited at 602 hospitals, clinics, or community practices from 33 countries across six continents. Eligible patients had a history of peripheral artery disease of the lower extremities (previous peripheral bypass surgery or angioplasty, limb or foot amputation, intermittent claudication with objective evidence of peripheral artery disease), of the carotid arteries (previous carotid artery revascularisation or asymptomatic carotid artery stenosis of at least 50%), or coronary artery disease with an ankle-brachial index of less than 0·90. After a 30-day run-in period, patients were randomly assigned (1:1:1) to receive oral rivaroxaban (2·5 mg twice a day) plus aspirin (100 mg once a day), rivaroxaban twice a day (5 mg with aspirin placebo once a day), or to aspirin once a day (100 mg and rivaroxaban placebo twice a day). Randomisation was computer generated. Each treatment group was double dummy, and the patient, investigators, and central study staff were masked to treatment allocation. The primary outcome was cardiovascular death, myocardial infarction or stroke; the primary peripheral artery disease outcome was major adverse limb events including major amputation. This trial is registered with ClinicalTrials.gov, number NCT01776424, and is closed to new participants.FINDINGS:Between March 12, 2013, and May 10, 2016, we enrolled 7470 patients with peripheral artery disease from 558 centres. The combination of rivaroxaban plus aspirin compared with aspirin alone reduced the composite endpoint of cardiovascular death, myocardial infarction, or stroke (126 [5%] of 2492 vs 174 [7%] of 2504; hazard ratio [HR] 0·72, 95% CI 0·57-0·90, p=0·0047), and major adverse limb events including major amputation (32 [1%] vs 60 [2%]; HR 0·54 95% CI 0·35-0·82, p=0·0037). Rivaroxaban 5 mg twice a day compared with aspirin alone did not significantly reduce the composite endpoint (149 [6%] of 2474 vs 174 [7%] of 2504; HR 0·86, 95% CI 0·69-1·08, p=0·19), but reduced major adverse limb events including major amputation (40 [2%] vs 60 [2%]; HR 0·67, 95% CI 0·45-1·00, p=0·05). The median duration of treatment was 21 months. The use of the rivaroxaban plus aspirin combination increased major bleeding compared with the aspirin alone group (77 [3%] of 2492 vs 48 [2%] of 2504; HR 1·61, 95% CI 1·12-2·31, p=0·0089), which was mainly gastrointestinal. Similarly, major bleeding occurred in 79 (3%) of 2474 patients with rivaroxaban 5 mg, and in 48 (2%) of 2504 in the aspirin alone group (HR 1·68, 95% CI 1·17-2·40; p=0·0043).INTERPRETATION:Low-dose rivaroxaban taken twice a day plus aspirin once a day reduced major adverse cardiovascular and limb events when compared with aspirin alone. Although major bleeding was increased, fatal or critical organ bleeding was not. This combination therapy represents an important advance in the management of patients with peripheral artery disease. Rivaroxaban alone did not significantly reduce major adverse cardiovascular events compared with asprin alone, but reduced major adverse limb events and increased major bleeding