Design and Construction of the 3.2 Mev High Voltage Column for Darht II

A 3.2 MeV injector has been designed and built for the Darht II Project at Los Alamos Lab. The installation of the complete injector system is nearing completion at this time. The requirements for the injector are to produce a 3.2 MeV, 2000 ampere electron pulse with a flattop width of at least 2-microseconds and emittance of less than 0.15 p cm-rad normalized. A large high voltage column has been built and installed. The column is vertically oriented, is 4.4 meters long, 1.2 meters in diameter, and weights 5700 kilograms. A novel method of construction has been employed which utilizes bonded mycalex insulating rings. This paper will describe the design, construction, and testing completed during construction. Mechanical aspects of the design will be emphasized.Comment: 3 pages, 4 figures, Linac 200

The Way We Measure: Comparison of Methods to Derive Radial Surface Brightness Profiles

The breaks and truncations in the luminosity profile of face-on spiral galaxies offer valuable insights in their formation history. The traditional method of deriving the surface photometry profile for face-on galaxies is to use elliptical averaging. In this paper, we explore the question whether elliptical averaging is the best way to do this. We apply two additional surface photometry methods, one new: principle axis summation, and one old that has become seldom used: equivalent profiles. These are compared to elliptically averaged profiles using a set of 29 face-on galaxies. We find that the equivalent profiles match extremely well with elliptically averaged profiles, confirming the validity of using elliptical averaging. The principle axis summation offers a better comparison to edge-on galaxies.Comment: Accepted for publication by Monthly Notices of the R.A.S. A hi-res version is available at http://www.astro.rug.nl/~vdkruit/Petersetal-VI.pd

Bayesian Cointegrated Vector Autoregression models incorporating Alpha-stable noise for inter-day price movements via Approximate Bayesian Computation

We consider a statistical model for pairs of traded assets, based on a Cointegrated Vector Auto Regression (CVAR) Model. We extend standard CVAR models to incorporate estimation of model parameters in the presence of price series level shifts which are not accurately modeled in the standard Gaussian error correction model (ECM) framework. This involves developing a novel matrix variate Bayesian CVAR mixture model comprised of Gaussian errors intra-day and Alpha-stable errors inter-day in the ECM framework. To achieve this we derive a novel conjugate posterior model for the Scaled Mixtures of Normals (SMiN CVAR) representation of Alpha-stable inter-day innovations. These results are generalized to asymmetric models for the innovation noise at inter-day boundaries allowing for skewed Alpha-stable models. Our proposed model and sampling methodology is general, incorporating the current literature on Gaussian models as a special subclass and also allowing for price series level shifts either at random estimated time points or known a priori time points. We focus analysis on regularly observed non-Gaussian level shifts that can have significant effect on estimation performance in statistical models failing to account for such level shifts, such as at the close and open of markets. We compare the estimation accuracy of our model and estimation approach to standard frequentist and Bayesian procedures for CVAR models when non-Gaussian price series level shifts are present in the individual series, such as inter-day boundaries. We fit a bi-variate Alpha-stable model to the inter-day jumps and model the effect of such jumps on estimation of matrix-variate CVAR model parameters using the likelihood based Johansen procedure and a Bayesian estimation. We illustrate our model and the corresponding estimation procedures we develop on both synthetic and actual data.Comment: 30 page

The clinical effectiveness and cost-effectiveness of inhaler devices used in the routine management of chronic asthma in older children: a systematic review and economic evaluation

Background: This review examines the clinical effectiveness and cost-effectiveness of hand-held inhalers to deliver medication for the routine management of chronic asthma in children aged between 5 and 15 years. Asthma is a common disease of the airways, with a prevalence of treated asthma in 5–15-year-olds of around 12% and an actual prevalence in the community as high as 23%. Treatment for the condition is predominantly by inhalation of medication. There are three main types of inhaler device, pressurised metered dose, breath actuated, and dry powder, with the option of the attachment of a spacer to the first two devices under some prescribed circumstances. Two recent reviews have examined the clinical and cost-effectiveness evidence on inhaler devices, but one was for children aged under 5 years and the comparison in the second was made between pressurised metered dose inhalers and other types only. Objectives: This review examines the clinical effectiveness and cost-effectiveness of manual pressurised metered dose inhalers, breath-actuated metered dose inhalers, and breath-actuated dry powder inhalers, with and without spacers as appropriate, to deliver medication for the routine management of chronic asthma in children aged between 5 and 15 years. Methods: Two previous HTA reviews have compared the effectiveness of inhaler devices, one focusing on asthma in children aged under 5 years and the other on asthma and chronic obstructive airways disease in all age groups. For the current review, a literature search was carried out to identify all evidence relating to the use of inhalers in older children with chronic asthma. A search of in-vitro studies undertaken for one of the previous reviews was also updated. The data sources used were: 15 electronic bibliographic databases; the reference lists of one of the previous HTA reports and other relevant articles; health services research-related internet resources; and all sponsor submissions. Studies were selected according to strict inclusion and exclusion criteria, and relevant information concerning effectiveness and patient compliance and preference was extracted directly on to an extraction/evidence table. Quality assurance was monitored. Economic evaluation was undertaken by reviewing existing cost-effective evidence. Further economic modelling was carried out, and tables constructed to determine device cost-minimisation and incremental quality-adjusted life-year (QALY) thresholds between devices. Results: Number and quality of studies, and direction of evidence: Fourteen randomised controlled studies were identified relating to the clinical effectiveness of inhaler devices for delivering β2-agonists. A further five were on devices delivering corticosteroids and one concerned the delivery of cromoglicate. Overall, there were no differences in clinical efficacy between inhaler devices, but a pressurised metered dose inhaler with a spacer would appear to be more effective than one without. These findings endorse those of a previous HTA review but extend them to other inhaler devices. Seven randomised controlled trials examined the impact on clinical effectiveness of using a nonchlorofluorocarbon (CFC) propellant in place of a CFC propellant in metered dose inhalers, both pressurised and breath activated, although only one study considered the latter type. No differences were found between inhalers containing either propellant. A further 30 studies of varying quality, from 12 randomised controlled trials to non-controlled studies, were identified that concerned the impact of use by, and preference for, inhaler type, and treatment adherence in children. Differences between the studies, and limitations in comparative data between various inhaler device types, make it difficult to draw any firm conclusions from this evidence. Summary of benefits: No obvious benefits for one inhaler device type over another for use in children aged 5–15 years were identified. Costs and cost per quality-adjusted life-year: Two approaches have been taken: cost-minimisation and QALY threshold. In the QALY threshold approach, additional QALYs that each device must produce compared with a cheaper device to achieve an acceptable cost per QALY were calculated. Using the cheapest and most expensive devices for delivering 200 μg of beclometasone per day, assuming no cost offset for any device, and a threshold of £5000, the largest QALY needed was 0.00807. With such a small QALY increase, no intervention can be categorically rejected as not cost-effective. Conclusions: Generalisability of findings: On the available evidence there are no obvious benefits for one inhaler device over another when used by children aged 5–15 years with chronic asthma. However, the evidence, in the majority of cases, was compiled on children with mild to moderate asthma and restricted to a limited number of drugs. Therefore the findings may not be generalisable to those at the more severe end of the spectrum of the disease or to inhaler devices delivering some of the drugs used in the management of asthma. Need for further research: Many of the previous studies are likely to have been underpowered. Further clinical trials with a robust methodology, sufficient power and qualitative components are needed to demonstrate any differences in clinical resource use and patients’ asthma symptoms. Further studies should also include the behavioural aspects of patients towards their medication and its delivery mechanisms. It is acknowledged that sufficient power may prove impractical owing to the large numbers of patients required

Nonconventional screening of the Coulomb interaction in FexOy clusters: An ab-initio study

From microscopic point-dipole model calculations of the screening of the Coulomb interaction in non-polar systems by polarizable atoms, it is known that screening strongly depends on dimensionality. For example, in one dimensional systems the short range interaction is screened, while the long range interaction is anti-screened. This anti-screening is also observed in some zero dimensional structures, i.e. molecular systems. By means of ab-initio calculations in conjunction with the random-phase approximation (RPA) within the FLAPW method we study screening of the Coulomb interaction in FexOy clusters. For completeness these results are compared with their bulk counterpart magnetite. It appears that the onsite Coulomb interaction is very well screened both in the clusters and bulk. On the other hand for the intersite Coulomb interaction the important observation is made that it is almost contant throughout the clusters, while for the bulk it is almost completely screened. More precisely and interestingly, in the clusters anti-screening is observed by means of ab-initio calculations

The Shape of Dark Matter Haloes IV. The Structure of Stellar Discs in Edge-on Galaxies

We present optical and near-infrared archival observations of eight edge-on galaxies. These observations are used to model the stellar content of each galaxy using the FitSKIRT software package. Using FitSKIRT, we can self-consistently model a galaxy in each band simultaneously while treating for dust. This allows us to accurately measure both the scale length and scale height of the stellar disc, plus the shape parameters of the bulge. By combining this data with the previously reported integrated magnitudes of each galaxy, we can infer their true luminosities. We have successfully modelled seven out of the eight galaxies in our sample. We find that stellar discs can be modelled correctly, but have not been able to model the stellar bulge reliably. Our sample consists for the most part of slow rotating galaxies, and we find that the average dust layer is much thicker than what is reported for faster rotating galaxies.Comment: Accepted for publication by Monthly Notices RAS. Hi-res. version available at www.astro.rug.nl/~vdkruit/Petersetal-IV.pd

The Shape of Dark Matter Haloes II. The Galactus HI Modelling & Fitting Tool

We present a new HI modelling tool called \textsc{Galactus}. The program has been designed to perform automated fits of disc-galaxy models to observations. It includes a treatment for the self-absorption of the gas. The software has been released into the public domain. We describe the design philosophy and inner workings of the program. After this, we model the face-on galaxy NGC2403, using both self-absorption and optically thin models, showing that self-absorption occurs even in face-on galaxies. It is shown that the maximum surface brightness plateaus seen in Paper I of this series are indeed signs of self-absorption. The apparent HI mass of an edge-on galaxy can be drastically lower compared to that same galaxy seen face-on. The Tully-Fisher relation is found to be relatively free from self-absorption issues.Comment: Accepted for publication by Monthly Notices RAS. Hi-res. version available at www.astro.rug.nl/~vdkruit/Petersetal-II.pd