512 research outputs found
Intraspecific Variation in Taxonomic Characteristics of the Mayfly \u3ci\u3ePotamanthus Myops\u3c/i\u3e (Walsh)
Data collected from an ecological study of the mayfly Potamanthus rnyops (Walsh) in Michigan showed intraspecific variability in taxonomic characteristics that have been employed by previous investigators for species separation. Nymphal dorsal maculation patterns varied considerably within a single population. Also, the ratio of mandibular tusk length to head length increased with successive nymphal instars. Certain adult taxonomic characteristics, particularly relative male imago eye size and distance of separation, were either too poorly defined or too variable to be conclusive in species identification
Herschel observations of EXtraordinary Sources: Analysis of the full Herschel/HIFI molecular line survey of Sagittarius B2(N)
A sensitive broadband molecular line survey of the Sagittarius B2(N)
star-forming region has been obtained with the HIFI instrument on the Herschel
Space Observatory, offering the first high-spectral resolution look at this
well-studied source in a wavelength region largely inaccessible from the ground
(625-157 um). From the roughly 8,000 spectral features in the survey, a total
of 72 isotopologues arising from 44 different molecules have been identified,
ranging from light hydrides to complex organics, and arising from a variety of
environments from cold and diffuse to hot and dense gas. We present an LTE
model to the spectral signatures of each molecule, constraining the source
sizes for hot core species with complementary SMA interferometric observations,
and assuming that molecules with related functional group composition are
cospatial. For each molecule, a single model is given to fit all of the
emission and absorption features of that species across the entire 480-1910 GHz
spectral range, accounting for multiple temperature and velocity components
when needed to describe the spectrum. As with other HIFI surveys toward massive
star forming regions, methanol is found to contribute more integrated line
intensity to the spectrum than any other species. We discuss the molecular
abundances derived for the hot core, where the local thermodynamic equilibrium
approximation is generally found to describe the spectrum well, in comparison
to abundances derived for the same molecules in the Orion KL region from a
similar HIFI survey.Comment: Accepted to ApJ. 64 pages, 14 figures. Truncated abstrac
ISO LWS Spectroscopy of M82: A Unified Evolutionary Model
We present the first complete far-infrared spectrum (43 to 197 um) of M82,
the brightest infrared galaxy in the sky, taken with the Long Wavelength
Spectrometer of the Infrared Space Observatory (ISO). We detected seven fine
structure emission lines, [OI] 63 and 145 um, [OIII] 52 and 88 um, [NII] 122
um, [NIII] 57 um and [CII] 158 um, and fit their ratios to a combination
starburst and photo-dissociation region (PDR) model. The best fit is obtained
with HII regions with n = 250 cm^{-3} and an ionization parameter of 10^{-3.5}
and PDRs with n = 10^{3.3} cm^{-3} and a far-ultraviolet flux of G_o =
10^{2.8}. We applied both continuous and instantaneous starburst models, with
our best fit being a 3-5 Myr old instantaneous burst model with a 100 M_o
cut-off. We also detected the ground state rotational line of OH in absorption
at 119.4 um. No excited level OH transitions are apparent, indicating that the
OH is almost entirely in its ground state with a column density ~ 4x10^{14}
cm^{-2}. The spectral energy distribution over the LWS wavelength range is well
fit with a 48 K dust temperature and an optical depth, tau_{Dust} proportional
to lambda^{-1}.Comment: 23 pages, 4 figures, accepted by ApJ, Feb. 1, 199
Diffuse-interface model for rapid phase transformations in nonequilibrium systems
A thermodynamic approach to rapid phase transformations within a diffuse
interface in a binary system is developed. Assuming an extended set of
independent thermodynamic variables formed by the union of the classic set of
slow variables and the space of fast variables, we introduce finiteness of the
heat and solute diffusive propagation at the finite speed of the interface
advancing. To describe the transformation within the diffuse interface, we use
the phase-field model which allows us to follow the steep but smooth change of
phases within the width of diffuse interface. The governing equations of the
phase-field model are derived for the hyperbolic model, model with memory, and
for a model of nonlinear evolution of transformation within the
diffuse-interface. The consistency of the model is proved by the condition of
positive entropy production and by the outcomes of the fluctuation-dissipation
theorem. A comparison with the existing sharp-interface and diffuse-interface
versions of the model is given.Comment: 15 pages, regular article submitted to Physical Review
Cyclin-dependent kinase 9 as a potential target for anti-TNF resistant inflammatory bowel disease
BACKGROUND AND AIMS: Resistance to single cytokine blockade, namely anti-TNF therapy, is a growing concern for patients with inflammatory bowel disease (IBD). The transcription factor T-bet is a critical regulator of intestinal homeostasis, is genetically linked to mucosal inflammation and controls the expression of multiples genes such as the pro-inflammatory cytokines IFN-Îł and TNF. Inhibiting T-bet may therefore offer a more attractive prospect for treating IBD but remains challenging to target therapeutically. In this study, we evaluate the effect of targeting the transactivation function of T-bet using inhibitors of P-TEFb (CDK9-cyclin T), a transcriptional elongation factor downstream of T-bet. METHODS: Using an adaptive immune-mediated colitis model, human colonic lymphocytes from IBD patients and multiple large clinical datasets, we investigate the effect of CDK9 inhibitors on cytokine production and gene expression in colonic CD4+ T cells and link these genetic modules to clinical response in patients with IBD. RESULTS: Systemic CDK9 inhibition led to histological improvement of immune-mediated colitis and was associated with targeted suppression of colonic CD4+ T cell-derived IFN-Îł and IL-17A. In colonic lymphocytes from IBD patients, CDK9 inhibition potently repressed genes responsible for pro-inflammatory signalling, and in particular genes regulated by T-bet. Remarkably, CDK9 inhibition targeted genes that were highly expressed in anti-TNF resistant IBD and that predicted non-response to anti-TNF therapy. CONCLUSION: Collectively, our findings reveal CDK9 as a potential target for anti-TNF resistant IBD, which has the potential for rapid translation to the clinic
Epidural Hematoma Following Cervical Spine Surgery.
STUDY DESIGN: A multicentered retrospective case series.
OBJECTIVE: To determine the incidence and circumstances surrounding the development of a symptomatic postoperative epidural hematoma in the cervical spine.
METHODS: Patients who underwent cervical spine surgery between January 1, 2005, and December 31, 2011, at 23 institutions were reviewed, and all patients who developed an epidural hematoma were identified.
RESULTS: A total of 16 582 cervical spine surgeries were identified, and 15 patients developed a postoperative epidural hematoma, for a total incidence of 0.090%. Substantial variation between institutions was noted, with 11 sites reporting no epidural hematomas, and 1 site reporting an incidence of 0.76%. All patients initially presented with a neurologic deficit. Nine patients had complete resolution of the neurologic deficit after hematoma evacuation; however 2 of the 3 patients (66%) who had a delay in the diagnosis of the epidural hematoma had residual neurologic deficits compared to only 4 of the 12 patients (33%) who had no delay in the diagnosis or treatment (P = .53). Additionally, the patients who experienced a postoperative epidural hematoma did not experience any significant improvement in health-related quality-of-life metrics as a result of the index procedure at final follow-up evaluation.
CONCLUSION: This is the largest series to date to analyze the incidence of an epidural hematoma following cervical spine surgery, and this study suggest that an epidural hematoma occurs in approximately 1 out of 1000 cervical spine surgeries. Prompt diagnosis and treatment may improve the chance of making a complete neurologic recovery, but patients who develop this complication do not show improvements in the health-related quality-of-life measurements
Reversal of infall in SgrB2(M) revealed by Herschel/HIFI observations of HCN lines at THz frequencies
To investigate the accretion and feedback processes in massive star
formation, we analyze the shapes of emission lines from hot molecular cores,
whose asymmetries trace infall and expansion motions. The high-mass star
forming region SgrB2(M) was observed with Herschel/HIFI (HEXOS key project) in
various lines of HCN and its isotopologues, complemented by APEX data. The
observations are compared to spherically symmetric, centrally heated models
with density power-law gradient and different velocity fields (infall or
infall+expansion), using the radiative transfer code RATRAN. The HCN line
profiles are asymmetric, with the emission peak shifting from blue to red with
increasing J and decreasing line opacity (HCN to HCN). This is most
evident in the HCN 12--11 line at 1062 GHz. These line shapes are reproduced by
a model whose velocity field changes from infall in the outer part to expansion
in the inner part. The qualitative reproduction of the HCN lines suggests that
infall dominates in the colder, outer regions, but expansion dominates in the
warmer, inner regions. We are thus witnessing the onset of feedback in massive
star formation, starting to reverse the infall and finally disrupting the whole
molecular cloud. To obtain our result, the THz lines uniquely covered by HIFI
were critically important.Comment: A&A, HIFI special issue, accepte
Training of Instrumentalists and Development of New Technologies on SOFIA
This white paper is submitted to the Astronomy and Astrophysics 2010 Decadal
Survey (Astro2010)1 Committee on the State of the Profession to emphasize the
potential of the Stratospheric Observatory for Infrared Astronomy (SOFIA) to
contribute to the training of instrumentalists and observers, and to related
technology developments. This potential goes beyond the primary mission of
SOFIA, which is to carry out unique, high priority astronomical research.
SOFIA is a Boeing 747SP aircraft with a 2.5 meter telescope. It will enable
astronomical observations anywhere, any time, and at most wavelengths between
0.3 microns and 1.6 mm not accessible from ground-based observatories. These
attributes, accruing from the mobility and flight altitude of SOFIA, guarantee
a wealth of scientific return. Its instrument teams (nine in the first
generation) and guest investigators will do suborbital astronomy in a
shirt-sleeve environment. The project will invest $10M per year in science
instrument development over a lifetime of 20 years. This, frequent flight
opportunities, and operation that enables rapid changes of science instruments
and hands-on in-flight access to the instruments, assure a unique and extensive
potential - both for training young instrumentalists and for encouraging and
deploying nascent technologies. Novel instruments covering optical, infrared,
and submillimeter bands can be developed for and tested on SOFIA by their
developers (including apprentices) for their own observations and for those of
guest observers, to validate technologies and maximize observational
effectiveness.Comment: 10 pages, no figures, White Paper for Astro 2010 Survey Committee on
State of the Professio
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