5-fluorouracil modulated by leucovorin, methotrexate and mitomycin: highly effective, low-cost chemotherapy for advanced colorectal cancer

We have reported that an alternating regimen of bolus and continuous infusion 5-fluorouracil (FU) was superior to bolus FU in terms of response rate and progression-free survival in advanced colorectal cancer. Biochemical modulation was an essential part of this regimen and it was selective for the schedule of FU administration: bolus FU was in fact modulated by methotrexate (MTX) while continuous infusion FU was potentiated by 6-s-leucovorin (LV). Considering the low cost and the favourable report on the activity of mitomycin C (mito) added to CI FU, we have incorporated this agent in the infusional part of our treatment programme. 105 patients with untreated, advanced, measurable colorectal cancer were accrued from 13 Italian centres and treated with the following regimen. 2 biweekly cycles of FU bolus (600 mg/m2), modulated by MTX (24 h earlier, 200 mg/m2) were alternated with a 3-week continuous infusion of FU (200 mg/m2daily), modulated by LV (20 mg/m2weekly bolus). Mito, 7 mg/m2, was given on the first day of the infusional period. After a 1 week rest, the whole cycle (8 weeks) was repeated, if indicated. 5 complete and 34 partial responses were obtained (response rate, 37% on the intention to treat basis; 95% confidence limits, 28–46%). After a median follow-up time of 26 months, 37 patients are still alive. The median progression-free survival is 7.7 months with an overall survival of 18.8 months and a 2-year survival rate of 30%. The regimen was very well tolerated with fewer than 13% of patients experiencing WHO grade III–IV toxicity. These results are consistent with those obtained by our group in 3 previous trials of schedule specific biochemical modulation of FU. They also indicate a highly active, little toxic, inexpensive regimen of old drugs to be used (a) as an alternative to the more expensive combinations including CPT-11 or oxaliplatin or (b) as the basis for combination programmes with these agents. © 2001 Cancer Research Campaign http://www.bjcancer.co

Social and cultural origins of motivations to volunteer a comparison of university students in six countries

Although participation in volunteering and motivations to volunteer (MTV) have received substantial attention on the national level, particularly in the US, few studies have compared and explained these issues across cultural and political contexts. This study compares how two theoretical perspectives, social origins theory and signalling theory, explain variations in MTV across different countries. The study analyses responses from a sample of 5794 students from six countries representing distinct institutional contexts. The findings provide strong support for signalling theory but less so for social origins theory. The article concludes that volunteering is a personal decision and thus is influenced more at the individual level but is also impacted to some degree by macro-level societal forces

Carnegie Supernova Project: Kinky i-band light curves of Type Ia supernovae

We present detailed investigation of a specific i-band light-curve feature in Type Ia supernovae (SNe Ia) using the rapid cadence and high signal-to-noise ratio light curves obtained by the Carnegie Supernova Project. The feature is present in most SNe Ia and emerges a few days after the i-band maximum. It is an abrupt change in curvature in the light curve over a few days and appears as a flattening in mild cases and a strong downward concave shape, or a 'kink', in the most extreme cases. We computed the second derivatives of Gaussian Process interpolations to study 54 rapid-cadence light curves. From the second derivatives we measure: (1) the timing of the feature in days relative to i-band maximum; tdm2(i) and (2) the strength and direction of the concavity in mag d-2; dm2(i). 76 per cent of the SNe Ia show a negative dm2(i), representing a downward concavity - either a mild flattening or a strong 'kink'. The tdm2(i) parameter is shown to correlate with the colour-stretch parameter sBV, a SN Ia primary parameter. The dm2(i) parameter shows no correlation with sBV and therefore provides independent information. It is also largely independent of the spectroscopic and environmental properties. Dividing the sample based on the strength of the light-curve feature as measured by dm2(i), SNe Ia with strong features have a Hubble diagram dispersion of 0.107 mag, 0.075 mag smaller than the group with weak features. Although larger samples should be obtained to test this result, it potentially offers a new method for improving SN Ia distance determinations without shifting to more costly near-infrared or spectroscopic observations.Fil: Pessi, Priscila Jael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Hsiao, E. Y.. Florida State University; Estados UnidosFil: Folatelli, Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Anderson, J. P.. European Southern Observatory Santiago; ChileFil: Burns, C. R.. No especifíca;Fil: Uddin, S.. Texas A&M University; Estados UnidosFil: Galbany, L.. Consejo Superior de Investigaciones Científicas; EspañaFil: Phillips, M. M.. No especifíca;Fil: Morrell, N.. No especifíca;Fil: Ashall, C.. University of Hawaii at Manoa; Estados UnidosFil: Baron, E.. No especifíca;Fil: Contreras, C.. No especifíca;Fil: Hamuy, M.. Texas A&M University; Estados UnidosFil: Hoeflich, P.. Florida State University; Estados UnidosFil: Krisciunas, K.. Texas A&M University; Estados UnidosFil: Kumar, S.. Florida State University; Estados UnidosFil: Lu, J.. Florida State University; Estados UnidosFil: Martinez, Laureano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Piro, A. L.. No especifíca;Fil: Shahbandeh, M.. Florida State University; Estados UnidosFil: Stritzinger, M. D.. University Aarhus; DinamarcaFil: Suntzeff, N. B.. Texas A&M University; Estados Unido

Transitional events in the spectrophotometric regime between stripped envelope and superluminous supernovae

KM, MRM, and SJP are supported by H2020 ERC grant no. 758638. LG acknowledges financial support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 839090, and from the Spanish Ministry of Science, Innovation and Universities (MICIU) under the 2019 Ramon y Cajal programme RYC2019-027683. TMB ´ was funded by the CONICYT PFCHA / DOCTORADOBECAS CHILE/2017-72180113. MG is supported by the EU Horizon 2020 research and innovation programme under grant agreement no. 101004719. SGG acknowledges support by FCT under Project CRISP PTDC/FIS-AST-31546/2017. MN is supported by a Royal Astronomical Society Research Fellowship and H2020 ERC grant no. 948381. T-WC acknowledges the EU Funding under Marie Skłodowska-Curie grant H2020-MSCA-IF-2018-842471. The LT is operated on the island of La Palma by Liverpool John Moores University in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias with financial support from the UK Science and Technology Facilities Council. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile, as part of ePESSTO+ (the advanced Public ESO Spectroscopic Survey for Transient Objects Survey). ePESSTO+ observations were obtained under ESO programme ID 1103.D-0328 (PI: Inserra). The WHT is operated on the island of La Palma by the Isaac Newton Group of Telescopes in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrof´ısica de Canarias. SJP thanks GPL for many insightful discussions at the bar over the last few years.The division between stripped-envelope supernovae (SE-SNe) and superluminous supernovae (SLSNe) is not well-defined in either photometric or spectroscopic space. While a sharp luminosity threshold has been suggested, there remains an increasing number of transitional objects that reach this threshold without the spectroscopic signatures common to SLSNe. In this work, we present data and analysis on four SNe transitional between SE-SNe and SLSNe; the He-poor SNe 2019dwa and 2019cri, and the He-rich SNe 2019hge and 2019unb. Each object displays long-lived and variable photometric evolution with luminosities around the SLSN threshold of Mr < -19.8 mag. Spectroscopically however, these objects are similar to SE-SNe, with line velocities lower than either SE-SNe and SLSNe, and thus represent an interesting case of rare transitional events.H2020 ERC grant no. 758638European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 839090Spanish Ministry of Science, Innovation and Universities (MICIU) under the 2019 Ramon y Cajal programme RYC2019-027683CONICYT PFCHA / DOCTORADOBECAS CHILE/2017-72180113EU Horizon 2020 research and innovation programme under grant agreement no. 101004719FCT under Project CRISP PTDC/FIS-AST-31546/2017Royal Astronomical Society Research FellowshipH2020 ERC grant no. 948381UK Science and Technology Facilities CouncilESO programme ID 1103.D-0328 (PI: Inserra

SN 2020zbf: A fast-rising hydrogen-poor superluminous supernova with strong carbon lines

SN 2020zbf is a hydrogen-poor superluminous supernova at $z = 0.1947$ that shows conspicuous C II features at early times, in contrast to the majority of H-poor SLSNe. Its peak magnitude is $M_{\rm g}$ = $-21.2$ mag and its rise time ($\lesssim 24$ days from first light) place SN 2020zbf among the fastest rising SLSNe-I. Spectra taken from ultraviolet (UV) to near-infrared wavelengths are used for the identification of spectral features. We pay particular attention to the C II lines as they present distinctive characteristics when compared to other events. We also analyze UV and optical photometric data, and model the light curves considering three different powering mechanisms: radioactive decay of Ni, magnetar spin-down and circumstellar material interaction (CSM). The spectra of SN 2020zbf match well with the model spectra of a C-rich low-mass magnetar model. This is consistent with our light curve modelling which supports a magnetar-powered explosion with a $M_{\rm ej}$ = 1.5 $M_\odot$. However, we cannot discard the CSM-interaction model as it also may reproduce the observed features. The interaction with H-poor, carbon-oxygen CSM near peak could explain the presence of C II emission lines. A short plateau in the light curve, around 30 - 40 days after peak, in combination with the presence of an emission line at 6580 \r{A} can also be interpreted as late interaction with an extended H-rich CSM. Both the magnetar and CSM interaction models of SN 2020zbf indicate that the progenitor mass at the time of explosion is between 2 - 5 $M_\odot$. Modelling the spectral energy distribution of the host reveals a host mass of 10$^{8.7}$ $M_\odot$, a star-formation rate of 0.24$^{+0.41}_{-0.12}$ $M_\odot$ yr$^{-1}$ and a metallicity of $\sim$ 0.4 $Z_\odot$.Comment: 26 pages, 22 figures, submitted to A&

Broad-emission-line dominated hydrogen-rich luminous supernovae

Hydrogen-rich Type II supernovae (SNe II) are the most frequently observed class of core-collapse SNe (CCSNe). However, most studies that analyse large samples of SNe II lack events with absolute peak magnitudes brighter than -18.5 mag at rest-frame optical wavelengths. Thanks to modern surveys, the detected number of such luminous SNe II (LSNe II) is growing. There exist several mechanisms that could produce luminous SNe II. The most popular propose either the presence of a central engine (a magnetar gradually spinning down or a black hole accreting fallback material) or the interaction of supernova ejecta with circumstellar material (CSM) that turns kinetic energy into radiation energy. In this work, we study the light curves and spectral series of a small sample of six LSNe II that show peculiarities in their H$\alpha$ profile, to attempt to understand the underlying powering mechanism. We favour an interaction scenario with CSM that is not dense enough to be optically thick to electron scattering on large scales -- thus, no narrow emission lines are observed. This conclusion is based on the observed light curve (higher luminosity, fast decline, blue colours) and spectral features (lack of persistent narrow lines, broad H$\alpha$ emission, lack of H$\alpha$ absorption, weak or nonexistent metal lines) together with comparison to other luminous events available in the literature. We add to the growing evidence that transients powered by ejecta-CSM interaction do not necessarily display persistent narrow emission lines.Comment: 27 pages, 16 figures, accepted for publication in MNRA

Transitional events in the spectrophotometric regime between stripped envelope and superluminous supernovae

The division between stripped-envelope supernovae (SE-SNe) and superluminous supernovae (SLSNe) is not well-defined in either photometric or spectroscopic space. While a sharp luminosity threshold has been suggested, there remains an increasing number of transitional objects that reach this threshold without the spectroscopic signatures common to SLSNe. In this work, we present data and analysis on four SNe transitional between SE-SNe and SLSNe; the He-poor SNe 2019dwa and 2019cri, and the He-rich SNe 2019hge and 2019unb. Each object displays long-lived and variable photometric evolution with luminosities around the SLSN threshold of Mr < -19.8 mag. Spectroscopically however, these objects are similar to SE-SNe, with line velocities lower than either SE-SNe and SLSNe, and thus represent an interesting case of rare transitional events.KM, MRM, and SJP are supported by H2020 ERC grant no. 758638. LG acknowledges financial support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 839090, and from the Spanish Ministry of Science, Innovation and Universities (MICIU) under the 2019 Ramón y Cajal programme RYC2019-027683. TMB was funded by the CONICYT PFCHA / DOCTORADOBECAS CHILE/2017-72180113. MG is supported by the EU Horizon 2020 research and innovation programme under grant agreement no. 101004719. SGG acknowledges support by FCT under Project CRISP PTDC/FIS-AST-31546/2017. MN is supported by a Royal Astronomical Society Research Fellowship and H2020 ERC grant no. 948381. T-WC acknowledges the EU Funding under Marie Skłodowska-Curie grant H2020-MSCA-IF-2018-842471. The LT is operated on the island of La Palma by Liverpool John Moores University in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias with financial support from the UK Science and Technology Facilities Council