GÓMEZ CAFFARENA, J.: El teísmo moral en Kant.

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Jacques Rousseau, una conciencia desgarrada de la Ilustración.

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Filosofía y emancipación en la Ilustración.

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Kant y la reforma del saber metafísico.

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Queimadas de cana-de-açúcar: Avaliação de efeitos na qualidade do ar e na saúde respiratória de crianças

Pesquisa em Espírito Santo do Turvo (SP) analisou poluição atmosférica causada por queima de cana-de-açúcar e saúde respiratória de crianças. Realizaram-se medições de PM10, PTS e NO2, durante safra, em 2004 e 2005, em pátio de escola, e aplicou-se questionário para avaliar morbidade respiratória referida dos alunos. No município, há cultivo de cana, queimada no pré-corte e usina próxima à área urbana. Resultados dos questionários foram comparados àqueles obtidos em Juquitiba (SP) previamente. As medições de poluentes, realizadas em dias em que havia queima de cana, estiveram abaixo dos padrões de qualidade do ar. Entretanto, foram indicadas altas prevalências de sintomas e doenças respiratórias.Research undertaken in Espírito Santo do Turvo (SP), analyzed data on air pollution caused by sugarcane burning and respiratory health of children. Measurements of PM10, TSP, and NO2 were done during harvest period, in 2004 and 2005, at a public school patio and questionnaires to evaluate respiratory symptoms were applied to the school children. The municipality has predominantly sugarcane plantations and an alcohol processing plant close to urban area. Results of questionnaires were compared to those obtained in Juquitiba (SP), previously. Air pollution levels even during burning season were always bellow Brazilian standards. However, results indicated high prevalence of symptoms and of respiratory diseases.CNP

SEUDO-MASLAMA, EL MADRILEÑO: Picatrix.

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Molecular biology of the kallikrein-kinin system: from structure to function

The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a matter of controversy. The use of different experimental set-ups in concert with the development of potent and specific inhibitors and antagonists for the system has highlighted its importance but the results still lack conclusivity. Over the last few years, transgenic and gene-targeting technologies associated with molecular biology tools have provided specific information about the elusive role of the kallikrein-kinin system in the control of blood pressure and electrolyte homeostasis. cDNA and genomic sequences for kinin receptors B2 and B1 from different species were isolated and shown to encode G-protein-coupled receptors and the structure and pharmacology of the receptors were characterized. Transgenic animals expressing an overactive kallikrein-kinin system were established to study the cardiovascular effects of these alterations and the results of these investigations further corroborate the importance of this system in the maintenance of normal blood pressure. Knockout animals for B2 and B1 receptors are available and their analysis also points to the role of these receptors in cardiovascular regulation and inflammatory processes. In this paper the most recent and relevant genetic animal models developed for the study of the kallikrein-kinin system are reviewed, and the advances they brought to the understanding of the biological role of this system are discussed.Universidade Federal de São Paulo (UNIFESP)Max-Delbrück Center for Molecular MedicineUNIFESPSciEL

La participación educativa: ¿cuestión de números o de calidad?.

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La empresa, nuevo ámbito de formación continua.

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