3,942 research outputs found

    Variable cardiac responses in rhesus macaque monkeys after discrete mediodorsal thalamus manipulations

    Get PDF
    This is the final version. Available on open access from Nature Research via the DOI in this recordData availability; All data analysed during this study are included in this article.The control of some physiological parameters, such as the heart rate, is known to have a role in cognitive and emotional processes. Cardiac changes are also linked to mental health issues and neurodegeneration. Thus, it is not surprising that many of the brain structures typically associated with cognition and emotion also comprise a circuit-the central automatic network-responsible for the modulation of cardiovascular output. The mediodorsal thalamus (MD) is involved in higher cognitive processes and is also known to be connected to some of the key neural structures that regulate cardiovascular function. However, it is unclear whether the MD has any role in this circuitry. Here, we show that discrete manipulations (microstimulation during anaesthetized functional neuroimaging or localized cytotoxin infusions) to either the magnocellular or the parvocellular MD subdivisions led to observable and variable changes in the heart rate of female and male rhesus macaque monkeys. Considering the central positions that these two MD subdivisions have in frontal cortico-thalamocortical circuits, our findings suggest that MD contributions to autonomic regulation may interact with its identified role in higher cognitive processes, representing an important physiological link between cognition and emotion.Wellcome TrustFWOCost Action Primtrai

    Poincare Invariant Algebra From Instant to Light-Front Quantization

    Get PDF
    We present the Poincare algebra interpolating between instant and light-front time quantizations. The angular momentum operators satisfying SU(2) algebra are constructed in an arbitrary interpolation angle and shown to be identical to the ordinary angular momentum and Leutwyler-Stern angular momentum in the instant and light-front quantization limits, respectively. The exchange of the dynamical role between the transverse angular mometum and the boost operators is manifest in our newly constructed algebra.Comment: 21 pages, 3 figures, 1 tabl

    Walk well:a randomised controlled trial of a walking intervention for adults with intellectual disabilities: study protocol

    Get PDF
    Background - Walking interventions have been shown to have a positive impact on physical activity (PA) levels, health and wellbeing for adult and older adult populations. There has been very little work carried out to explore the effectiveness of walking interventions for adults with intellectual disabilities. This paper will provide details of the Walk Well intervention, designed for adults with intellectual disabilities, and a randomised controlled trial (RCT) to test its effectiveness. Methods/design - This study will adopt a RCT design, with participants allocated to the walking intervention group or a waiting list control group. The intervention consists of three PA consultations (baseline, six weeks and 12 weeks) and an individualised 12 week walking programme. A range of measures will be completed by participants at baseline, post intervention (three months from baseline) and at follow up (three months post intervention and six months from baseline). All outcome measures will be collected by a researcher who will be blinded to the study groups. The primary outcome will be steps walked per day, measured using accelerometers. Secondary outcome measures will include time spent in PA per day (across various intensity levels), time spent in sedentary behaviour per day, quality of life, self-efficacy and anthropometric measures to monitor weight change. Discussion - Since there are currently no published RCTs of walking interventions for adults with intellectual disabilities, this RCT will examine if a walking intervention can successfully increase PA, health and wellbeing of adults with intellectual disabilities

    Neural correlates of sexual cue reactivity in individuals with and without compulsive sexual behaviours

    Get PDF
    Although compulsive sexual behaviour (CSB) has been conceptualized as a "behavioural" addiction and common or overlapping neural circuits may govern the processing of natural and drug rewards, little is known regarding the responses to sexually explicit materials in individuals with and without CSB. Here, the processing of cues of varying sexual content was assessed in individuals with and without CSB, focusing on neural regions identified in prior studies of drug-cue reactivity. 19 CSB subjects and 19 healthy volunteers were assessed using functional MRI comparing sexually explicit videos with non-sexual exciting videos. Ratings of sexual desire and liking were obtained. Relative to healthy volunteers, CSB subjects had greater desire but similar liking scores in response to the sexually explicit videos. Exposure to sexually explicit cues in CSB compared to non-CSB subjects was associated with activation of the dorsal anterior cingulate, ventral striatum and amygdala. Functional connectivity of the dorsal anterior cingulate-ventral striatum-amygdala network was associated with subjective sexual desire (but not liking) to a greater degree in CSB relative to non-CSB subjects. The dissociation between desire or wanting and liking is consistent with theories of incentive motivation underlying CSB as in drug addictions. Neural differences in the processing of sexual-cue reactivity were identified in CSB subjects in regions previously implicated in drug-cue reactivity studies. The greater engagement of corticostriatal limbic circuitry in CSB following exposure to sexual cues suggests neural mechanisms underlying CSB and potential biological targets for interventions

    Nuclear dependence of the transverse single-spin asymmetry in the production of charged hadrons at forward rapidity in polarized p+pp+p, p+p+Al, and p+p+Au collisions at sNN=200\sqrt{s_{_{NN}}}=200 GeV

    Get PDF
    We report on the nuclear dependence of transverse single-spin asymmetries (TSSAs) in the production of positively-charged hadrons in polarized p+pp^{\uparrow}+p, p+p^{\uparrow}+Al and p+p^{\uparrow}+Au collisions at sNN=200\sqrt{s_{_{NN}}}=200 GeV. The measurements have been performed at forward rapidity (1.4<η<2.41.4<\eta<2.4) over the range of 1.8<pT<7.01.8<p_{T}<7.0 GeV/c/c and 0.1<xF<0.20.1<x_{F}<0.2. We observed a positive asymmetry ANA_{N} for positively-charged hadrons in \polpp collisions, and a significantly reduced asymmetry in pp^{\uparrow}+AA collisions. These results reveal a nuclear dependence of charged hadron ANA_N in a regime where perturbative techniques are relevant. These results provide new opportunities to use \polpA collisions as a tool to investigate the rich phenomena behind TSSAs in hadronic collisions and to use TSSA as a new handle in studying small-system collisions.Comment: 303 authors from 66 institutions, 9 pages, 2 figures, 1 table. v1 is version accepted for publication in Physical Review Letters. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

    Measurements of double-helicity asymmetries in inclusive J/ψJ/\psi production in longitudinally polarized p+pp+p collisions at s=510\sqrt{s}=510 GeV

    Full text link
    We report the double helicity asymmetry, ALLJ/ψA_{LL}^{J/\psi}, in inclusive J/ψJ/\psi production at forward rapidity as a function of transverse momentum pTp_T and rapidity y|y|. The data analyzed were taken during s=510\sqrt{s}=510 GeV longitudinally polarized pp++pp collisions at the Relativistic Heavy Ion Collider (RHIC) in the 2013 run using the PHENIX detector. At this collision energy, J/ψJ/\psi particles are predominantly produced through gluon-gluon scatterings, thus ALLJ/ψA_{LL}^{J/\psi} is sensitive to the gluon polarization inside the proton. We measured ALLJ/ψA_{LL}^{J/\psi} by detecting the decay daughter muon pairs μ+μ\mu^+ \mu^- within the PHENIX muon spectrometers in the rapidity range 1.2<y<2.21.2<|y|<2.2. In this kinematic range, we measured the ALLJ/ψA_{LL}^{J/\psi} to be 0.012±0.0100.012 \pm 0.010~(stat)~±\pm~0.0030.003(syst). The ALLJ/ψA_{LL}^{J/\psi} can be expressed to be proportional to the product of the gluon polarization distributions at two distinct ranges of Bjorken xx: one at moderate range x0.05x \approx 0.05 where recent RHIC data of jet and π0\pi^0 double helicity spin asymmetries have shown evidence for significant gluon polarization, and the other one covering the poorly known small-xx region x2×103x \approx 2\times 10^{-3}. Thus our new results could be used to further constrain the gluon polarization for x<0.05x< 0.05.Comment: 335 authors, 10 pages, 4 figures, 3 tables, 2013 data. Version accepted for publication by Phys. Rev. D. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm
    corecore