Vortex lattice structures and pairing symmetry in Sr2RuO4

Recent experimental results indicate that superconductivity in Sr2RuO4 is described by the p-wave E_u representation of the D_{4h} point group. Results on the vortex lattice structures for this representation are presented. The theoretical results are compared with experiment.Comment: 4 pages, 3 figures, M2S-HTSC-VI proceeding

Atmosphere Revitalization Technology Development for Crewed Space Exploration

As space exploration objectives extend human presence beyond low Earth orbit, the solutions to technological challenges presented by supporting human life in the hostile space environment must build upon experience gained during past and present crewed space exploration programs. These programs and the cabin atmosphere revitalization process technologies and systems developed for them represent the National Aeronautics and Space Administration s (NASA) past and present operational knowledge base for maintaining a safe, comfortable environment for the crew. The contributions of these programs to the NASA s technological and operational working knowledge base as well as key strengths and weaknesses to be overcome are discussed. Areas for technological development to address challenges inherent with the Vision for Space Exploration (VSE) are presented and a plan for their development employing unit operations principles is summarize

Practical Guidance for Including Future Costs in Economic Evaluations in the Netherlands: Introducing and Applying PAID 3.0

Objectives: A consensus has been reached in The Netherlands that all future medical costs should be included in economic evaluations. Furthermore, internationally, there is the recognition that in countries that adopt a societal perspective estimates of future nonmedical consumption are relevant for decision makers as much as production gains are. The aims of this paper are twofold: (1) to update the tool Practical Application to Include Future Disease Costs (PAID 1.1), based on 2013 data, for the estimation of future unrelated medical costs and introduce future nonmedical consumption costs, further standardizing and facilitating the inclusion of future costs; and (2) to demonstrate how to use the tool in practice, showing the impact of including future unrelated medical costs and future nonmedical consumption in a case-study where a life is hypothetically saved at different ages and 2 additional cases where published studies are updated by including future costs. Methods: Using the latest published cost of illness data from the year 2017, we model future unrelated medical costs as a function of age, sex, and time to death, which varies per disease. The Household Survey from Centraal Bureau Statistiek is used to estimate future nonmedical consumption by age. Results: The updated incremental cost-effectiveness ratios (ICERs) from the case studies show that including future costs can have a substantial effect on the ICER, possibly affecting choices made by decision makers. Conclusion: This article improves upon previous work and provides the first tool for the inclusion of future nonmedical consumption in The Netherlands

The mechanism of disaster capitalism and the failure to build community resilience:learning from the 2009 earthquake in L'Aquila, Italy

This paper reflects on what materialised during recovery operations following the earthquake in L'Aquila, Italy, on 6 April 2009. Previous critiques have focused on the actions of the Government of Italy and the Department of Civil Protection (Protezione Civile), with little attention paid to the role of local authorities. This analysis sheds light on how the latter used emergency powers, the command-and-control approach, and top-down planning to manage the disaster context, especially in terms of removal of rubble, implementing safety measures, and allocating temporary accommodation. It discusses how these arrangements constituted the mechanism via which ‘disaster capitalism’ took hold at the local and national level, and how it violated human rights, produced environmental and social impacts, hindered local communities from learning, transforming, and building resilience, and facilitated disaster capitalism and corruption. To make the disaster risk reduction and resilience paradigm more effective, a shift from centralised civil protection to decentralised, inclusive community empowerment systems is needed

Caribbean Current variability and the influence of the Amazon and Orinoco freshwater plumes

Author Posting. © Elsevier, 2007. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Deep Sea Research Part I: Oceanographic Research Papers 54 (2007): 1451-1473, doi:10.1016/j.dsr.2007.04.021.The variability of the Caribbean Current is studied in terms of the influence on its dynamics of the freshwater inflow from the Orinoco and Amazon rivers. Sea-surface salinity maps of the eastern Caribbean and SeaWiFS color images show that a freshwater plume from the Orinoco and Amazon Rivers extends seasonally northwestward across the Caribbean basin, from August to November, 3 to 4 months after the peak of the seasonal rains in northeastern South America. The plume is sustained by two main inflows from the North Brazil Current and its current rings. The southern inflow enters the Caribbean Sea south of Grenada Island and becomes the main branch of the Caribbean Current in the southern Caribbean. The northern inflow (14°N) passes northward around the Grenadine Islands and St. Vincent. As North Brazil Current rings stall and decay east of the Lesser Antilles, between 14°N and 18°N, they release freshwater into the northern part of the eastern Caribbean Sea merging with inflow from the North Equatorial Current. Velocity vectors derived from surface drifters in the eastern Caribbean indicate three westward flowing jets: (1) the southern and fastest at 11°N; (2) the center and second fastest at 14°N; (3) the northern and slowest at 17°N. The center jet (14°N) flows faster between the months of August and December and is located near the southern part of the freshwater plume. Using the MICOM North Atlantic simulation, it is shown that the Caribbean Current is seasonally intensified near 14°N, partly by the inflow of river plumes. Three to four times more anticyclonic eddies are formed during August-December, which agrees with a pronounced rise in the number of anticyclonic looper days in the drifter data then. A climatology-forced regional simulation embedding only the northern (14°N) Caribbean Current (without the influence of the vorticity of the NBC rings), using the ROMS model, shows that the low salinity plume coincides with a negative potential vorticity anomaly that intensifies the center jet located at the salinity front. The jet forms cyclones south of the plume, which are moved northwestward as the anticyclonic circulation intensifies in the eastern Caribbean Sea, north of 14°N. Friction on the shelves of the Greater Antilles also generates cyclones, which propagate westward and eastward from 67°W.The study was supported by National Science Foundation grants OCE 03-271808 and OCE 01-36477

Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.

While aspirin is generally effective for prevention of cardiovascular disease, considerable variation in drug response exists, resulting in some individuals displaying high on-treatment platelet reactivity. We used pharmacometabolomics to define pathways implicated in variation of response to treatment. We profiled serum samples from healthy subjects pre- and postaspirin (14 days, 81 mg/day) using mass spectrometry. We established a strong signature of aspirin exposure independent of response (15/34 metabolites changed). In our discovery (N = 80) and replication (N = 125) cohorts, higher serotonin levels pre- and postaspirin correlated with high, postaspirin, collagen-induced platelet aggregation. In a third cohort, platelets from subjects with the highest levels of serotonin preaspirin retained higher reactivity after incubation with aspirin than platelets from subjects with the lowest serotonin levels preaspirin (72 ± 8 vs. 61 ± 11%, P = 0.02, N = 20). Finally, ex vivo, serotonin strongly increased platelet reactivity after platelet incubation with aspirin (+20%, P = 4.9 × 10(-4), N = 12). These results suggest that serotonin is implicated in aspirin response variability.Analytical BioScience

Molecular and translational advances in meningiomas.

Meningiomas are the most common primary intracranial neoplasm. The current World Health Organization (WHO) classification categorizes meningiomas based on histopathological features, but emerging molecular data demonstrate the importance of genomic and epigenomic factors in the clinical behavior of these tumors. Treatment options for symptomatic meningiomas are limited to surgical resection where possible and adjuvant radiation therapy for tumors with concerning histopathological features or recurrent disease. At present, alternative adjuvant treatment options are not available in part due to limited historical biological analysis and clinical trial investigation on meningiomas. With advances in molecular and genomic techniques in the last decade, we have witnessed a surge of interest in understanding the genomic and epigenomic landscape of meningiomas. The field is now at the stage to adopt this molecular knowledge to refine meningioma classification and introduce molecular algorithms that can guide prediction and therapeutics for this tumor type. Animal models that recapitulate meningiomas faithfully are in critical need to test new therapeutics to facilitate rapid-cycle translation to clinical trials. Here we review the most up-to-date knowledge of molecular alterations that provide insight into meningioma behavior and are ready for application to clinical trial investigation, and highlight the landscape of available preclinical models in meningiomas