Letter from Bliss Perry to John Muir, 1902 Sep 18.

[1]September 18, 1902,My dear Mr. Muir,By the request of Messrs. Houghton, Mifflin and Company I take pleasure in sending you by express today the advance sheets of Volumes XIII. and XIV. of Sargent\u27s Silva of North America. I am under the strong impression that you were good enough to promise some years ago to review this work for the Atlantic whenever it should be completed. As the thirteenth volume, and the Supplement and Index, making Volume XIV., are now so nearly ready for publication, we wish to express the earnest hope that you may find time within the next few weeks to write a review of the Silva for the magazine. I need not say that no one could do it so acceptably to[03054][2]the readers of the Atlantic. Professor Sargent, as you may be interested to know, called at the office the other day, and expressed, as he has repeatedly on former occasions, his strong desire that you might undertake this task. Will you not do so ? I should like to take advantage of this opportunity to suggest another matter, which I must ask you to treat for the present as a matter of confidence. We are thinking of issuing during 1903 a California number of the Atlantic Monthly in which every article shall be written by a Californian. It is really surprising to see what a strong list of Atlantic writers we have upon the Pacific coast, and I feel sure that such a number will be of interest to our readers throughout the Union as indicating the literary activity of a single section pf the country. But it goes without saying that a California number of the Atlantic which did not contain a contribution [3]from you would be very unsatisfactory to us and to all of our readers. Have you not something in mind in addition to the review of the Silva which you can place in our hands during the coming winter ? Pray do your best to oblige us in this matter out of state pride as well as your old willingness to be of service to the magazine.It is a matter of constant regret to me that during a very brief visit to San-Francisco last spring I could not avail myself of that opportunity to call upon you. I hope to be in California again sometime and shall look forward to the pleasure of making your acquaintance if I may be allowed to do so.Very truly yours, [illegible]John Muir, Esq. [03054

Letter from Bliss Perry to John Muir, 1904 Jul 15.

EDITORIAL OFFICE OF **THE** ATLANTIC MONTHLY 4 PARK ST. * BOSTONJuly 15, 1904.Dear Mr. Muir,Before you went to Asia with professor Sargent, you were good enough to say that you would bear in mind the possibility of writing out for the Atlantic some of your impressions of the Journey. Now that you are comfortably settled at home again, I hope you have already begun to take your pen in hand. It will be a great pleasure to learn, at your convenience, that you are inclined to serve the Atlantic once more.Sincerely yours,[Illegible]Mr. John Muir.0340

Letter from Bliss Perry to John Muir, 1903 Jan 6.

EDITORIAL OFFICE OF $$THE$$ ATLANTIC MONTHLY 4 PARK ST. $ BOSTONJanuary 6, 1903. Dear Mr, Muir. You may remember that in writing to you several weeks ago about your review of professor Sargent\u27s Silva , I mentioned the fact that we are planning to issue one number of the Atlantic in which every article shall be written by a Californian.We have now decided to issue this California number in July of the present year. Owing to the time required for getting proofs back from the authors, we are anxious to have all the material for the number in hand by the first of April,Now I need not say that if we were to issue a California number of the magazine without a Contribution from you, we should be condemned by every Californian, to saynothing of every other reader of the Atlantic, and I am sure you will wish to do your part toward helping us to bring out this notable number of the magazine.---We have some of the material already in hand, and are greately interested in making the July issue as much of a success as possible. Will you not be good enough to tell me at as early a date as possible what the nature of your contribution will be?---We wish to have you write about anything in the world that interests you, but preferably, of course, from the point of view of this number, about something which would fit in well with that particular issue of the magazine. I hope that you are in good health and heart, and that this letter may find you in such a good-natured mood that you will sit down and tell me what you will do for us. Sincerely yours, [illigible] Mr. John Muir.[03132

Letter from Bliss Perry to John Muir, 1905 Aug 30.

EDITORIALOFFICE OFTHEATLANTICMONTHLY4 PARK ST.BOSTONAugust 30, 1905.Dear Mr. Muir,I have written to you once or twice about that half promise of yours to write for the Atlantic some articles about your experiences in the forests of Asia. Before you started on your journey with Professor Sargent, you were good enough to say that you might be inclined to write some articles about the journey for the Atlantic. We hope very earnestly that the time has now come when you will . feel like putting together your notes and allowing the readers of this magazine to share something of the pleasure which the journey must have afforded you.I know that you hate to write under the compulsion of an insistent editor but we feel here that you have many things to say which no other living man can say equally well, and we shall feel very keenly disappointed if you do not persuade yourself to gird up your loins for this particular task. Will you not be good- enough, to send me a line about it at your early convenience ?Sincerely yours,[illegible]Mr. John Muir.0362

Letter from Bliss Perry to John Muir, 1903 Feb 4.

February 4, 1903.Dear Mr. Muir:You scare me by what you say in your letter of January 25th. Really, it would he absurd to publish a California Number of the Atlantic without a contribution from you in it. Of course I hare no light to urge you in the matter and I dare- say you are getting up as early in the morning and going to bed as late at night as is at all wise, but it does seem to us as If we must have that article. Pray give us every possible opportunity for it, and remember that there will be thousands of other people as much disappointed as we in case you do not write it.Sincerely[illegible]John Muir, Esq.[03159

Letter from Bliss Perry to John Muir, 1899 Sep 7.

answer as you are now able to give us as to the time when all the papers may be expected here. I amVery sincerely yours, [illegible] PerryMr. John Muir. September 7, 1899. My dear Mr. Muir, Among the memoranda left for me by Mr. Walter H. Page, the retiring Editor of the Atlantic, I note with very great pleasure your promise to contribute three more articles, one to be on ”Trees, Shrubs, Gardens etc., of the Yosemite”, one on The Lakes, Streams, Canons, etc., etc.”of the same region, and one on the Sequoia National Park . I write now simply to express our pleasurable anticipation in being able to print these contributions from you, and to ask if the next article has not sufficiently progressed to allow you to inform us when we may expect to see it. We wish to announce this group of articles among the leading features of the magazine for 1900, and I should appreciate very much as definite an0261

Bostonia. Volume 10

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Illustrations and guidelines for selecting statistical methods for quantifying spatial pattern in ecological data

This paper aims to provide guidance to ecologists with limited experience in spatial analysis to help in their choice of techniques, It uses examples to compare methods of spatial analysis for ecological field data. A taxonomy of different data types is presented, including point- and area-referenced data, with and without attributes. Spatially and non-spatially explicit data are distinguished. The effects of sampling and other transformations that convert one data type to another are discussed; the possible loss of spatial information is considered. Techniques for analyzing spatial pattern, developed in plant ecology, animal ecology, landscape ecology, geostatistics and applied statistics are reviewed briefly and their overlap in methodology and philosophy noted. The techniques are categorized according to their output and the inferences that may be drawn from them, in a discursive style without formulae. Methods are compared for four case studies with field data covering a range of types. These are: 1) percentage cover of three shrubs along a line transect 2) locations and volume of a desert plant in a I ha area: 3) a remotely-sensed spectral index and elevation from 10(5) km(2) of a mountainous region; and 4) land cover from three rangeland types within 800 km2 of a coastal region. Initial approaches utilize mapping, frequency distributions and variance-mean indices. Analysis techniques we compare include: local quadrat variance, block, quadrat variance, correlograms, variograms, angular correlation, directional variograms, wavelets, SADIE, nearest neighbour methods, Ripley's L(t), and various landscape ecology metrics. Our advice to ecologists is to use simple visualization techniques for initial analysis, and subsequently to select methods that are appropriate for the data type and that answer their specific questions of interest, It is usually prudent to employ several different techniques

Alcohol-Induced Blackout

For a long time, alcohol was thought to exert a general depressant effect on the central nervous system (CNS). However, currently the consensus is that specific regions of the brain are selectively vulnerable to the acute effects of alcohol. An alcohol-induced blackout is the classic example; the subject is temporarily unable to form new long-term memories while relatively maintaining other skills such as talking or even driving. A recent study showed that alcohol can cause retrograde memory impairment, that is, blackouts due to retrieval impairments as well as those due to deficits in encoding. Alcoholic blackouts may be complete (en bloc) or partial (fragmentary) depending on severity of memory impairment. In fragmentary blackouts, cueing often aids recall. Memory impairment during acute intoxication involves dysfunction of episodic memory, a type of memory encoded with spatial and social context. Recent studies have shown that there are multiple memory systems supported by discrete brain regions, and the acute effects of alcohol on learning and memory may result from alteration of the hippocampus and related structures on a cellular level. A rapid increase in blood alcohol concentration (BAC) is most consistently associated with the likelihood of a blackout. However, not all subjects experience blackouts, implying that genetic factors play a role in determining CNS vulnerability to the effects of alcohol. This factor may predispose an individual to alcoholism, as altered memory function during intoxication may affect an individual’s alcohol expectancy; one may perceive positive aspects of intoxication while unintentionally ignoring the negative aspects. Extensive research on memory and learning as well as findings related to the acute effects of alcohol on the brain may elucidate the mechanisms and impact associated with the alcohol-induced blackout

Results of the c-TRAK TN trial: a clinical trial utilising ctDNA mutation tracking to detect molecular residual disease and trigger intervention in patients with moderate and high-risk early stage triple negative breast cancer.

BACKGROUND: Post-treatment detection of circulating tumour DNA (ctDNA) in early-stage triple negative breast cancer (TNBC) patients predicts high risk of relapse. c-TRAK-TN assessed the utility of prospective ctDNA surveillance in TNBC and the activity of pembrolizumab in patients with ctDNA detected (ctDNA+). PATIENTS AND METHODS: c-TRAK-TN, a multi-centre phase II trial, with integrated prospective ctDNA surveillance by digital PCR, enrolled patients with early-stage TNBC and residual disease following neoadjuvant chemotherapy, or, stage II/III with adjuvant chemotherapy. ctDNA surveillance comprised three monthly blood sampling to 12 months (18 months if samples were missed due to COVID), and ctDNA+ patients were randomised 2:1; intervention:observation. ctDNA results were blinded unless patients were allocated to intervention, when staging scans were done and those free of recurrence were offered pembrolizumab. A protocol amendment (16/09/2020) closed the observation group; all subsequent ctDNA+ patients were allocated to intervention. Co-primary endpoints were i) ctDNA detection rate ii) sustained ctDNA clearance rate on pembrolizumab (NCT03145961). RESULTS: 208 patients registered between 30/01/18 - 06/12/19, 185 had tumour sequenced, 171 (92·4%) had trackable mutations, and 161 entered ctDNA surveillance. Rate of ctDNA detection by 12 months was 27·3% (44/161,95%CI:20·6-34·9). Seven patients relapsed without prior ctDNA detection. 45 patients entered the therapeutic component (intervention n=31; observation n=14; 1 observation patient was re-allocated to intervention following protocol amendment). Of patients allocated intervention, 72% (23/32) had metastases on staging at time of ctDNA+, and 4 patients declined pembrolizumab. Of the five patients who commenced pembrolizumab, none achieved sustained ctDNA clearance. CONCLUSION: c-TRAK-TN is the first prospective study to assess whether ctDNA assays have clinical utility in guiding therapy in TNBC. Patients had a high rate of metastatic disease on ctDNA detection. Findings have implications for future trial design, emphasising the importance of commencing ctDNA testing early, with more sensitive and/or frequent ctDNA testing regimes