Selective gas phase hydrogenation of nitroarenes over Mo2C-supported Au–Pd

Open Access via RSC Gold 4 Gold Financial support to Dr. X. Wang through the Overseas Research Students Award Scheme (ORSAS) is acknowledged. Dr. N. Perret also acknowledges financial support from COST Action MP0903 Nanoalloys.Peer reviewedPublisher PD

Sonho de arquivo

O presente artigo busca analisar as noções de arquivo e de prática dearquivo a partir das reflexões de Walter Benjamin. Buscaremos compreender a novidade do método benjaminiano mostrando sua forma de exposição da obra do poeta Charles Baudelaire. A partir da correspondência entre Benjamin e Adorno, apresentaremos o dispositivo desenvolvido por Benjamin e que se trata não de interpretar a obra de Baudelaire, mas antes de expô-la. Expor essa obra significa, para Benjamin, um engajamento histórico-político do teórico-analista-arquivista e a tensão de suas contradições enquanto sujeito singular histórico. Essas contradições não são resolvidas, mas identificadas e imobilizadas como tal

Le facteur humain au coeur de l'intelligence collective

Pour que l’Intelligence collective soit pleinement efficiente, la reconnaissance individuelle dans le groupe doit être privilégiée. En effet, l’Intelligence collective qui a pour fin ultime, la performance, dépend étroitement de la bonne coopération de l’homme. Ainsi les paramètres de la communication doivent aider à mieux appréhender l’homme pour qu’il se sente pleinement reconnu et par conséquent motivé à oeuvrer pour une véritable coopération et plus encore pour une co construction avec autrui d’un savoir. For collective intelligence to be effective, individual recognition within the group must be privileged. Indeed, collective intelligence has as its ultimate objective performance, and this depends on good cooperation between humans.So the criterion for communication must help humans to understand each other better so that they feel recognized and thus motivated to work in full cooperation and to create knowledge with others

Übertragung «gegen» das Politische: Grenz-Fälle in der institutionellen Praxis der Psychoanalyse

Der Artikel behandelt Zusammenhänge zwischen individuellen und institutionellen Aspekten der Übertragungsdynamik und spezifischen strukturellen und situationsbedingten Charakteristiken der psychoanalytischen Behandlung von politisch verfolgten und gefolterten Menschen, die in einem Pariser Zentrum (Centre Primo Levi) von einem multidisziplinären Team ambulant betreut werden. Der Begriff des klinischen «Grenz-Falles» wird hier, im Kontext spezifischer, situationsgebundener und das Symptom betreffender Eigenschaften erörtert, die die Analyse wie auch die Institution unter gewissen Umständen an ihre Grenzen bringen können. Darüber hinaus wird das der analytischen Behandlungsstruktur eigene Machtgefälle, welches unter Umständen das Risiko einer erneuten Traumatisierung des Patienten beinhaltet, hinsichtlich seiner Verknüpfung mit der strukturellen Dynamik der Foltersituation erörtert.Wegen der aus ethischen Gründen nicht möglichen Veröffentlichung des in der ursprünglichen Vortragssituation präsentierten klinischen Fallmaterials bleiben die theoretischen Überlegungen hier leider ohne kasuistische Illustration. Dieser Artikel ist die Transkription des ersten Teils unseres Vortrags. Der zweite Teil, der eine Falldarstellung beinhaltete, kann hier aus Gründen der Vertraulichkeit und wegen der auffälligen Symptomcharakteristik leider nicht berücksichtigt werden

LKB1 signaling is activated in CTNNB1 -mutated HCC and positively regulates β-catenin-dependent CTNNB1 -mutated HCC

International audienceCTNNB1‐mutated HCC. They were found to be well‐differentiated, almost never steatotic, and often cholestatic, with a microtrabecular or acinar growth pattern. Here, we investigated whether LKB1, which controls energy metabolism, cell polarity, and cell growth, mediates the specific phenotype of CTNNB1‐mutated HCC. The LKB1 protein was overexpressed in CTNNB1‐mutated HCC and oncogenic activation of β‐catenin in human HCC cells induced the post‐transcriptional accumulation of the LKB1 protein encoded by the LKB1 (STK11) gene. Hierarchical clustering, based on the expression of a murine hepatic liver Lkb1 (Stk11) signature in a human public dataset, identified a HCC cluster, composed of almost all the CTNNB1‐mutated HCC, that expresses a hepatic liver LKB1 program. This was confirmed by RT‐qPCR of an independent cohort of CTNNB1‐mutated HCC and the suppression of the LKB1‐related profile upon β‐catenin silencing of CTNNB1‐mutated human hepatoma cell lines. Previous studies described an epistatic relationship between LKB1 and CTNNB1 in which LKB1 acts upstream of CTNNB1. Thus, we also analyzed the consequences of Lkb1 deletion on the zonation of hepatic metabolism, known to be the hallmark of β‐catenin signaling in the liver. Lkb1 was required for the establishment of metabolic zonation in the mouse liver by positively modulating β‐catenin signaling. We identified positive reciprocal cross talk between the canonical Wnt pathway and LKB1, both in normal liver physiology and during tumorigenesis that likely participates in the amplification of the β‐catenin signaling by LKB1 and the distinctive phenotype of the CTNNB1‐mutated HCC

Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFβ signaling pathways

Intrahepatic malignant tumours include hepatocellular carcinomas (HCC), cholangiocarcinomas (CC) and combined hepatocholangiocarcinomas (cHCC-CC), a group of rare and poorly characterized tumours that exhibit both biliary and hepatocytic differentiation. The aim of the study was to characterize the molecular pathways specifically associated with cHCC-CC pathogenesis. We performed a genome-wide transcriptional analysis of 20 histologically defined cHCC-CC and compared them with a series of typical HCC and of CC. Data were analysed by gene set enrichment and integrative genomics and results were further validated in situ by tissue microarray using an independent series of 152 tumours. We report that cHCC-CC exhibit stem/progenitor features, a down-regulation of the hepatocyte differentiation program and a commitment to the biliary lineage. TGFβ and Wnt/β-catenin were identified as the two major signalling pathways activated in cHCC-CC. A β-catenin signature distinct from that observed in well-differentiated HCC with mutant β-catenin was found in cHCC-CC. This signature was associated with microenvironment remodelling and TGFβ activation. Furthermore, integrative genomics revealed that cHCC-CC share characteristics of poorly differentiated HCC with stem cell traits and poor prognosis. The common traits displayed by CC, cHCC-CC and some HCC suggest that these tumours could originate from stem/progenitor cell(s) and raised the hypothesis of a potential continuum between intrahepatic CC, cHCC-CC and poorly differentiated HC

New Symmetrically Esterified m-Bromobenzyl Non-Aminobisphosphonates Inhibited Breast Cancer Growth and Metastases

1 - ArticleBACKGROUND: Although there was growing evidence in the potential use of Bisphosphonates (BPs) in cancer therapy, their strong osseous affinities that contrast their poor soft tissue uptake limited their use. Here, we developed a new strategy to overcome BPs hydrophilicity by masking the phosphonic acid through organic protecting groups and introducing hydrophobic functions in the side chain. METHODOLOGY/PRINCIPAL FINDINGS: We synthesized non-nitrogen BPs (non N-BPs) containing bromobenzyl group (BP7033Br) in their side chain that were symmetrically esterified with hydrophobic 4-methoxphenyl (BP7033BrALK) and assessed their effects on breast cancer estrogen-responsive cells (T47D, MCF-7) as well as on non responsive ones (SKBR3, MDA-MB-231 and its highly metastatic derived D3H2LN subclone). BP7033Br ALK was more efficient in inhibiting tumor cell proliferation, migration and survival when compared to BP7033Br. Although both compounds inhibited tumor growth without side effects, only BP7033Br ALK abrogated tumor angiogenesis and D3H2LN cells-induced metastases formation. CONCLUSION/SIGNIFICANCE: Taken together these data suggest the potential therapeutic use of this new class of esterified Bisphosphonates (BPs) in the treatment of tumor progression and metastasis without toxic adverse effects