Serving for a Better World : Selected Proceedings of the 2012 Michigan Teachers of English to Speakers of Other Languages Conference

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\u3ci\u3eTransforming Learning: Teaching & Advocacy\u3c/i\u3e and \u3ci\u3eESL at the Crossroads\u3c/i\u3e: Selected Proceedings of Both the 2009 and 2010 Michigan Teachers of English Speakers of Other Languages Conferences Grand Rapids,Michigan, October 9-10, 2009 and Ypsilanti, Michigan, October 1-2, 2010

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\u3ci\u3e“New Horizons: Striding into the Future”\u3c/i\u3e: Selected Proceedings of the 2011 Michigan Teachers of English to Speakers of Other Languages Conference, October 7- 8, 2011

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Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival

Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited. We aimed to identify the role of matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) during tumor development and metastasis. Patients and Methods: Tissue samples were obtained from surgically treated patients. Expression of the EC-cell marker, vesicular monoamine transporter-1 (VMAT-1), was used to verify ileal carcinoids. We investigated the differential expression of MMP-2, 7, 9, 11, and 13 and their endogenous inhibitors (TIMP-1, 2, and 3) by quantitative real-time RT-PCR in 25 primary tumors, their corresponding lymph node metastases and/or liver metastases and matched normal mucosa. Results: Significantly increased expression of VMAT-1, MMP-2, MMP-11, TIMP-1 and TIMP-3 was determined by quantitative RT-PCR in EC-cell carcinoids compared to normal intestinal mucosa (p < 0.05). In contrast, MMP-2 and MMP-9 as well as TIMP-1, TIMP-2, and TIMP-3 expression in primary tumors of patients with liver metastases (M1) was significantly lower than in patients lacking liver metastases (M0). EC-cell tumors were significantly larger in the M1 group of tumors, while VMAT-1 expression was significantly decreased. We found an inverse correlation between tumor size and prognosis. Univariate analysis further revealed that decreased expression of VMAT-1, MMP-2 and TIMP-3 in primary tumors was significantly associated with a reduced survival time of the patients. Conclusion: Our data reveal that MMP-2 and TIMP-3 expression together with VMAT-1 expression are of potential prognostic and clinical value in ileal carcinoids. Copyright (C) 2008 S. Karger AG, Base

Die kondyläre Metastasierung: Literaturrecherche und ein Fallbericht

Zusammenfassung: Hintergrund: Kondyläre Metastasen sind eine Rarität. In der Literaturrecherche entsprachen nur 23 der insgesamt 69 gefundenen Fälle den Kriterien von Meyer u. Shklar. Fallbericht: Bei einem 48-jährigen Mann mit Schmerzen im linken Kiefergelenk wurde im linken Kondylus eine solitäre Metastase eines kurz zuvor operierten Lungenkarzinoms gefunden. Aufgrund der ausgedehnten Umgebungsinfiltration erfolgte eine kurative Radiatio. Im Verlauf traten weitere Skelettmetastasen auf. Diskussion: Kieferköpfchenmetastasen unterscheiden sich bezüglich ihres Verlaufs kaum von den Metastasen des extraartikulären Kieferbereiches. Unter den metastasierenden Tumoren rangiert das Mammakarzinom als Primärtumor an erster Stelle, gefolgt vom Lungenkarzinom. Klinisch und radiologisch können keine spezifischen Parameter für eine Diagnosestellung angegeben werden. Bei der Differenzialdiagnostik der Gelenkserkrankungen sollte jedoch insbesondere bei Patienten mit bekannten Primärtumoren und Gelenksbeschwerden sowie radiologischen Auffälligkeiten eine mögliche Metastasierung berücksichtigt werden. Die Diagnose sollte für eine entsprechende Therapieplanung histologisch gesichert werden. Das therapeutische Vorgehen ist in der Regel palliativ, da die Grunderkrankung bei Diagnosestellung einer Kieferköpfchenmetastase zumeist weit fortgeschritten is

Problemas cuantitativos y comprensión de conceptos

Los docentes de química a nivel universitario usamos «problemas», habitualmente de tipo cuantitativo, para enseñar y para evaluar. En este trabajo ponemos en duda de que lo hagamos en forma eficaz. Se muestra, a partir de pruebas diagnósticas de pares de problemas (uno cuantitativo y otro cualitativo similar), que muchos estudiantes pueden resolver los problemas cuantitativos sin una adecuada comprensión conceptual.Chemistry professors at university level make use of «problems», usually of a quantitative type, to teach and evaluate. In this article we question the fact of whether they do it in an efficient way. From diagnostic test of pairs of problems (a quantitative and a similar qualitative one) it is shown that many students can solve quantitative problems without an appropriate conceptual comprehension

The value of computed tomographic (CT) scan surveillance in the detection and management of brain metastases in patients with small cell lung cancer.

One hundred and twenty-seven consecutive patients presenting with small cell lung cancer were entered into a whole-brain CT scan surveillance study, starting at presentation and repeating at 3-monthly intervals for 2 years as an alternative to prophylactic cranial irradiation (PCI). The aim of the study was to detect CNS metastases at an early asymptomatic stage in the hope that prompt CNS radiotherapy could achieve long-term control; at the same time unnecessary PCI with its potential long-term morbidity could be avoided. CNS metastases were found in 56 patients (44%) including 16 (13%) at diagnosis and 40 at a median of 4 months (range 1-27 months) after completing chemotherapy. No patient developed CNS disease while on chemotherapy. Thirty-six patients were asymptomatic at diagnosis (group A) but 20 developed clinical CNS relapse between scans (group B) (interval relapse). Despite prompt radiotherapy 56% of patients in group A and 60% of patients in group B died with active CNS disease. Likewise, there was no survival difference between patients in group A, group B or those who never developed CNS disease. Regular 3-month CT scan surveillance is therefore not an effective substitute for PCI

Dementia caregiving in spousal relationships: a dyadic perspective

Objectives: The number of couples facing a dementia diagnosis for one partner of the spousal dyad increases. Spousal caregiving can be a highly stressful experience associated with negative caregiver outcomes such as depression and poorer immune function. However, surprisingly little is known about how the illness and the required care effects patient’s well-being and relational changes experienced by afflicted couples. The aim of this study was to provide a literature review on how the dyadic perspective is taken into account and on how dementia effects both parts of the dyad. Methods: In order to outline findings about individual and dyadic well-being of affected couples, we conducted a literature search to review the three types of studies. First, studies focusing on one partner’s perspective, usually the perspective of the caregiver; second, studies including the caregiver’s and partially the care receiver’s view; third, studies directly referring to both partners’ perspectives. Results: The majority of studies neglect the individual with dementia by exclusively assessing caregiver variables or only indirectly including patients’ characteristics. Very few studies embrace dyadic and relational variables to execute how both partners experience the illness, spousal caregiving, and changes in the relationship. Despite the arguable validity of self reports of individuals with dementia, some studies demonstrated the usefulness of including both partners’ perspectives. Discussion: Results indicate the urgent need of integrating the perspective of the individual with dementia to improve the understanding of the effects of dementia caregiving

Stress analysis of a simplified compression plate fixation system for fractured bones

AbstractA three-dimensional finite element model was generated of a plexiglass tube with an attached six-hole stainless steel compression plate to study the mechanics of internal fixation of fractured long bones. To demonstrate the importance of the plate-bone interface, this interface was represented three different ways in the finite element model. A plated tube with a uniform transverse osteotomy gap was also examined to study the mechanics of plated fractured bones. To validate the model, the results for the intact plated tube were compared to composite beam theory and strain gauge data from an instrumented physical model. Applications of the finite element model data included the prediction of screw failure modes, plate-induced osteopenia, and multi-axial strains in an interfragmentary region. The addition of sliding motion between the plate and tube resulted in a deviation from composite beam theory and improved correspondence with strain gage data when compared to a model having the plate and tube securely bonded. Sliding motion resulted in a much smaller region of bone subjected to reduced axial stress levels, which may decrease the extent of plate-induced osteopenia. The complex nature of induced strains in an osteotomy gap was also demonstrated, along with the tendency for failure of the screws nearest the fracture site