Atomicity and non-anonymity in population-like games for the energy efficiency of hybrid-power HetNets

© 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.In this paper, the user–base station (BS) association problem is addressed to reduce grid consumption in heterogeneous cellular networks (HetNets) powered by hybrid energy sources (grid and renewable energy). The paper proposes a novel distributed control scheme inspired by population games and designed considering both atomicity and non-anonymity – i.e., describing the individual decisions of each agent. The controller performance is considered from an energy–efficiency perspective, which requires the guarantee of appropriate qualityof-service (QoS) levels according to renewable energy availability. The efficiency of the proposed scheme is compared with other heuristic and optimal alternatives in two simulation scenarios. Simulation results show that the proposed approach inspired by population games reduces grid consumption by 12% when compared to the traditional best-signal-level association policy.Peer ReviewedPostprint (author's final draft

Atomicity and non-anonymity in population-like games for the energy efficiency of hybrid-power HetNets

© 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.In this paper, the user–base station (BS) association problem is addressed to reduce grid consumption in heterogeneous cellular networks (HetNets) powered by hybrid energy sources (grid and renewable energy). The paper proposes a novel distributed control scheme inspired by population games and designed considering both atomicity and non-anonymity – i.e., describing the individual decisions of each agent. The controller performance is considered from an energy–efficiency perspective, which requires the guarantee of appropriate qualityof-service (QoS) levels according to renewable energy availability. The efficiency of the proposed scheme is compared with other heuristic and optimal alternatives in two simulation scenarios. Simulation results show that the proposed approach inspired by population games reduces grid consumption by 12% when compared to the traditional best-signal-level association policy.Peer ReviewedPostprint (author's final draft

β-thalassemia Intermedia In A Brazilian Patient With - 101 (c > T) And Codon 39 (c > T) Mutations

Context: We verified molecular alterations in a 72-year-old Brazilian male patient with a clinical course of homozygous β-thalassemia intermedia, who had undergone splenectomy and was surviving without regular blood transfusions. The blood cell count revealed microcytic and hypochromic anemia (hemoglobin = 6.5 g/dl, mean cell volume = 74 ft, mean cell hemoglobin = 24 pg) and hemoglobin electrophoresis showed fetal hemoglobin = 1.3%, hemoglobin A 2 = 6.78% and hemoglobin A = 79.4%. Objective: To identify mutations in a patient with the symptoms of β-thalassemia intermedia. Design: Molecular inquiry into the mutations possibly responsible for the clinical picture described. Setting: The structural molecular biology and genetic engineering center of the Universidade Estadual de Campinas, Campinas, Brazil. Procedures: DNA extraction was performed on the patient's blood samples. The polymerase chain reaction (PCR) was done using five specific primers that amplified exons and the promoter region of the β globin gene. The samples were sequenced and then analyzed via computer programs. Results: Two mutations that cause the disease were found: -101 (C > T) and codon 39 (C > T). Conclusions: This cases represents the first description of -101 (C > T) mutation in a Brazilian population and it is associated with a benign clinical course.12112830Baysal, E., Carver, M.F.H., The beta and delta-thalassemia repository (1995) Hemoglobin., 19 (3-4), pp. 213-236Zago, M.A., Costa, F., Bottura, C., Beta-thalassemia in Brazil (1981) Braz. J. Med. Biol. Res., 14 (6), pp. 383-388Ewing, B., Green, P., Base-calling of automated sequencer traces using Phred. II Error probabilities (1998) Genome Res., 8 (3), pp. 186-194Green, P., (2002), http://bozeman.genome.washington.edu/phrap.docs/phrap.html, The Phred/Phrap/Consed System Home Page. Phrap Assembler. Available at URL September 30Gordon, D., Abajian, C., Green, P., Consed: A graphical tool for sequence finishing (1998) Genome Res., 8 (3), pp. 195-20

D* Production in Deep Inelastic Scattering at HERA

This paper presents measurements of D^{*\pm} production in deep inelastic scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The data have been taken with the ZEUS detector at HERA. The decay channel $D^{*+}\to (D^0 \to K^- \pi^+) \pi^+$ (+ c.c.) has been used in the study. The $e^+p$ cross section for inclusive D^{*\pm} production with $5<Q^2<100 GeV^2$ and $y<0.7$ is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region {$1.3<p_T(D^{*\pm})<9.0$ GeV and $| \eta(D^{*\pm}) |<1.5$}. Differential cross sections as functions of p_T(D^{*\pm}), $\eta(D^{*\pm}), W$ and $Q^2$ are compared with next-to-leading order QCD calculations based on the photon-gluon fusion production mechanism. After an extrapolation of the cross section to the full kinematic region in p_T(D^{*\pm}) and $\eta$(D^{*\pm}), the charm contribution $F_2^{c\bar{c}}(x,Q^2)$ to the proton structure function is determined for Bjorken $x$ between 2 $\cdot$ 10$^{-4}$ and 5 $\cdot$ 10$^{-3}$.Comment: 17 pages including 4 figure

Observation of Scaling Violations in Scaled Momentum Distributions at HERA

Charged particle production has been measured in deep inelastic scattering (DIS) events over a large range of $x$ and $Q^2$ using the ZEUS detector. The evolution of the scaled momentum, $x_p$, with $Q^2,$ in the range 10 to 1280 $GeV^2$, has been investigated in the current fragmentation region of the Breit frame. The results show clear evidence, in a single experiment, for scaling violations in scaled momenta as a function of $Q^2$.Comment: 21 pages including 4 figures, to be published in Physics Letters B. Two references adde

Resource-use Patterns In Swidden Farming Communities: Implications For The Resilience Of Cassava Diversity

Resource-use patterns, especially through exchanges among farmers, may ultimately confer resilience to the local agrobiodiversity. We investigated the use of cassava ethnovarieties by swidden farming communities in Brazil, exploring the structure of networks depicting farmers and the varieties they cultivate. The emergent nested resource-use pattern indicated that all farmers shared a core of top-ranked ethnovarieties (most common/abundant) while some farmers also cultivate rarer varieties. This pattern may result of individual preferences. Due to the current loss of interest and cultivation area for traditional agriculture, we simulated the extinction of crop fields to evaluate whether nestedness conferred robustness to cassava diversity. The diversity of ethnovarieties of cassava tended to be conserved when farmers were randomly removed from the network than when we preferentially removed farmers with more diverse crop fields. Stem cuttings of ethnovarieties are commonly exchanged among farmers, thus the extinction of ethnovarieties within crop fields could be restored. Therefore, we suggest that the interplay between the farmer's resource-use patterns and exchange system strengthens the resilience of cassava diversity, which is an important staple resource for such communities. © 2014 Springer Science+Business Media New York.424605616Adams, C., As roças e o manejo da mata atlântica pelos caiçaras: Uma revisão (2000) Interciência, 25 (3), pp. 143-150Adger, W.N., Social and ecological resilience: are they related? (2000) Progress in Human Geography, 24 (3), pp. 347-364Albert, R., Jeong, H., Barabasi, A.L., Error and attack tolerance of complex networks (2000) Nature, 406, pp. 378-382Almeida-Neto, M., Guimarães, P., Guimarães Jr., P.R., Loyola, R.D., A consistent metric for nestedness analysis in ecological systems: reconciling concept and measurement (2008) Oikos, 117, pp. 1227-1239Araújo, M.S., Guimarães, P.R., Svanbäck, R., Pinheiro, A., Guimarães, P., Reis, S.F., Bolnick, D.I., Network analysis reveals contrasting effects of intraspecific competitions on individual vs. population diets (2008) Ecology, 89, pp. 1981-1993Araújo, M.S., Martins, E.G., Cruz, L.D., Fernandez, F.R., Linhares, A.X., Reis, S.F., Guimarães Jr., P.R., Nested diets: a novel pattern of individual-level resource use (2010) Oikos, 119, pp. 81-88Arroyo-Kalin, M., The Amazonian formative: crop domestication and anthropogenic soils (2010) Diversity, 2, pp. 473-504Assis, A.L.A.A., (2007) Os agricultores tradicionais do Sertão do Ribeirão (Florianópoli, SC) e a conservação de diversidade de mandioca (Manihot esculenta Crantz Euphorbiacea), , PhD. Dissertation, University of Santa Catarina (UFSC), BrazilBailey, K., (1994) Methods of Social Research, , 4th edn., New York: The Free Pass, New York, USABalée, W., The research program of historical ecology (2006) Annual Review Anthropology, 35, pp. 75-98Bascompte, J., Jordano, P., Melián, C.J., Olesen, J.M., The nested assembly of plant-animal mutualistic networks (2003) Ecology, 100 (16), pp. 9383-9387Bastolla, U., Fortuna, M.A., Pascual-Garcia, A., Ferrera, A., Luque, B., The architecture of mutualistic networks minimizes competition and increases biodiversity (2009) Nature, 458, pp. 1018-1091Begossi, A., The ethnoecology of Caiçara metapopulations (Atlantic Flores, Brazil): ecological concepts and questions (2006) Journal of Ethnobiology and Ethnomedicine, 2, p. 40Begossi, A., Hanazaki, N., Peroni, N., Silvano, R.A.M., Estudos de ecologia humana e Etnobiologia: uma revisão sobre usos e conservação (2006) Biologia da Conservação. Estadual University of Rio de Janeiro (UERJ), pp. 537-652. , In: Rocha, C. F. D., Bergalho, H. G., Alves, M. A. S., and van Sluys, M. (Org.), BRABegossi, A., May, P.H., Lopes, P.F., Oliveira, L.E.C., Vinha, V., Silvano, R.A.M., Compensation for environmental services from artisanal fisheries in SE Brazil: policy and technical strategies (2011) Ecological Economics, 71, pp. 25-32Berkes, F., Ross, H., Community resilience: toward an integrated approach (2013) Society & Natural Resources, 26 (1), pp. 5-20Bodin, Ö., Prell, C., (2011) Social Networks and Natural Resource Management: Uncovering the Social Fabric of Environmental Governance, , UK: Cambridge University PressBodin, Ö., Crona, B., Ernstson, H., Social networks in natural resource management: what is there to learn from a structural perspective? (2006) Ecology and Society, 11 (2), pp. r2Borgatti, S.P., (1992) ANTHROPAC 4.0 Reference Manual, , Natick: Analytic TechnologiesBoster, J.S., Selection for perceptual distinctiveness: evidence from Aguaruna cultivars of Manihot esculenta (1985) Economic Botany, 39 (3), pp. 310-325Calvet-Mir, L., Calvet-Mir, M., Molina, J.S., Reyes-García, V., Seed exchange as an agrobiodiversity conservation mechanism. a case study in Vall Fosca, Catalan Pyrenees, Iberian Península (2012) Ecology and Society, 179 (1), p. 29Cavechia, L.A., (2011) Manejo das paisagem por populações litorâneas e conservação da agrobiodiversidade, , PhD. Dissertation, Florianópolis, Santa Catarina, BrazilClement, C.R., Cristo-Araujo, M., Eeckenbrugge, G.C., Pereira, A.A., Picanço-Rodrigues, D., Origin and domestication of native Amazonian crops (2010) Diversity, 2, pp. 72-106DeBlasis, P., Kneip, A., Scheel-Ybert, R., Gianini, P.C., Gaspar, M.D., Sambaquis e paisagem: Dinâmica natural e arqueologia no litoral sul do Brasil (2007) Arqueologia Sul Americana, 3 (1), pp. 29-61Deletrê, M., McKey, D.B., Hodkinson, T.R., Marriage exchanges, seed exchanges, and the dynamics of manioc diversity (2011) Proceedings of the National Academy of Sciences of the U.S.A., 108 (45), pp. 18249-18254Dormann, C.F., Gruber, B., Fründ, J., Introducing the bipartite Package: analysing Ecological Networks (2008) R News Vol, 8 (2), pp. 8-11Emperaire, L., Eloy, L., A cidade, um foco de diversidade agrícola no Rio Negro (Amazonas, Brasil)? (2008) Boletim Do Museu Paraense Emílio Goeldi Ciências Humanas, 3 (2), pp. 195-211Emperaire, L., Peroni, N., Traditional management of agrobiodiversity in Brazil: a case study of manioc (2007) Human Ecology, 35, pp. 761-768Emperaire, L., Robert, P., Santilli, J., Eloy, L., Velthem, L., Katz, E., Lopez, C., Almeida, M., Diversité agricole et patrimoine dans le moyen Rio Negro (Amazonie brésilienne) (2008) Les Actes Du BRG, 7, pp. 139-153Ferreira, S.L., (2006) "Nós não somos de origem": Populares de ascendência açoriana e africana numa freguesia do sul do Brasil (1780-1960), , Dissertation, University of Santa Catarina (UFSC), BrazilFolke, C., Carpenter, S.R., Walker, B., Scheffer, M., Chapin, T., Rockström, J., Resilience thinking: integrating resilience, adaptability and transformability (2010) Ecology and Society, 15 (4), p. 20Fraser, J.A., Clements, C.R., Dark Earths and manioc cultivation in Central Amazonia: a window on pre-Columbian agricultural systems? (2008) Boletim Do Museu Paraense Emílio Goeldi Ciências Humanas, 3 (2), pp. 175-194Fu, Y.N., Guo, H., Chen, A., Cui, J., Fallow agroecossystem dynamics and socioeconomic development in China: Two case studies in Xishuangbanna Prefecture, Yunnan Province (2005) Mountain Research and Development, 25 (4), pp. 365-371Guimarães, P.R., Guimarães, P., Improving the analyses of nestedness for large sets of matrices (2006) Environmetal. Modelling & Software, 21, pp. 1512-1513Guimarães, P.R., Rico-Gray, V., dos Reis, S.F., Thompson, J.N., Asymmetries in specialization in ant-plant mutualistic networks (2006) Proceedings of the Royal Society of London B, 273, pp. 2041-2047Guimerà, R., Amaral, L.A.N., Functional cartography of complex metabolic networks (2005) Nature, 433, pp. 895-900Guimerà, R., Amaral, L.A.N., Cartography of complex networks: modules and universal roles (2005) Journal of Statistical Mechanics: Theory and Experiment, , P02001Guimerà, R., Sales-Pardo, M., Amaral, L.A.N., Modularity from fluctuations in random graphs and complex networks (2004) Physical Review E, 70, p. 025101Hanazaki, N., Castro, F., Oliveira, V.G., Peroni, N., Between the sea and the land: the livelihood of estuarine people in southeastern Brazil (2007) Ambiente E Sociedade, 10 (1), pp. 121-136Holling, C.S., Understanding the complexity of economic, ecological and social system (2001) Ecossystem, 4, pp. 390-405Holling, C.S., Gunderson, L.H., Resilience and adaptive cycles (2001) Panarchy, pp. 25-63. , L. H. Gunderson and C. S. Holling (Eds.), Covelo: Island PressIsaac, M.I., Dawoe, E., Agrarian communication networks: consequences for agroforestry (2011) Social Networks and Natural Resource Management: Uncovering the Social Fabric of Environmental Governance, pp. 322-344. , ÖBodin and C. Prell (Eds.), UK: Cambridge University PressJanssen, M.A., Bodin, O., Anderies, J.M., Elmqvist, T., Ernstson, E., McAllister, R.R.J., Olsson, P., Ryan, P., A network perspective on the resilience of social-ecological systems (2006) Ecology and Society, 11 (1), p. 15Lacerda, E.P., (2003) O Atlântico Açoriano: Uma antropologia dos contextos globais e locais da Açorianidade, , Dissertation, Universidade Federal de Santa Catarina, BrazilLopes, P.F., O pescador artesanal da Baía da Ilha Grande (2009) Ecologia De Pescadores Artesanais Da Baía Da Ilha Grande, pp. 15-61. , A. Begossi, P. F. Lopes, L. E. C. Oliveirade, and H. Nakano (Eds.), Brazil: RIMA, execução: Associação para Pesca, Diversidade e Segurança Alimentar (FIFO)Lopes, P.L.M., Rosa, E.M., Salyvonchyk, S., Nora, V., Begossi, A., Suggestions for fixing top-down coastal fisheries management through participatory approaches (2013) Marine Policy, 40, pp. 100-110Louette, D., Traditional management of seed and genetic diversity: what is a landrace (2000) Genes in the Field: On-Farm Conservation of Crop Diversity, pp. 109-142. , S. B. Brush (Ed.), USA: Roma: IPGRI/IDRC/Lewis PublishersMarshall, N.A., Marshall, P.A., Conceptualizing and operationalizing social resilience within commercial fisheries in northern Australia (2007) Ecology and Society, 12 (1), p. 1Martins, P.S., Dinâmica evolutiva em roças de cablocos amazônicos (2005) Estudos Avançados, 19 (53), pp. 209-220Mello, M., Marquitti Jr., F.M.D., Guimarães, P.R., Kalko, E.K.V., Jordano, P., Aguiar, M.A.M., The missing part of seed dispersal networks: structure and robustness of bat-fruit interactions (2011) PLoS ONE, 6 (2), pp. e17395Memmott, A., Waser, N.M., Price, M.V., Tolerance of pollination network to species extinctions (2004) Proceedings of Royal Society B, 271, pp. 2605-2611Nautiyal, S., Bisht, V., Rao, K.S., Maikhuri, R.K., The role of cultural values in agrobiodiversity conservation: a case study from Uttarakhand, Himalaya (2008) Journal of Human Ecology, 23 (1), pp. 1-6Nolin, D.A., Food-sharing networks in Lamalera, Indonesia: reciprocity, kinship, and distance (2010) Human Nature, 21 (3), pp. 243-268Olesen, J.M., Bascompte, J., Dupont, Y.L., Jordano, P., The modularity of pollination networks (2007) Proceedings of the National Academy of Sciences, 104, pp. 19891-19896Parrott, L., Chion, C., Gonzalès, R., Latombe, G., Agents, individuals, and networks: modeling methods to inform natural resource management in regional landscapes (2012) Ecology and Society, 17 (3), p. 32Pautasso, M., Aistara, G., Barnaud, A., Caillon, S., Pascal, C., Coomes, O.T., Deletrê, M., Tramontini, S., Seed exchange networks for agrobiodiversity conservation: a review (2012) Agronomy for Sustainable Development, 33 (1), pp. 151-175Peroni, N., Agricultura de pescadores (2004) Ecologia Humana De Pescadores Da Mata Atlântica E Da Amazônia, pp. 59-87. , A. Begossi (Ed.), São Paulo: Editora HUCITECPeroni, N., Hanazaki, N., Current and lost diversity of cultivated varieties, especially cassava, under swidden cultivation systems in the Brazilian Atlantic Forest (2002) Agriculture, Ecossystems and Environment, 92, pp. 171-183Peroni, N., Martins, P.S., Influência da dinâmica agrícola itinerante na geração de diversidade de etnovariedades cultivadas vegetativamente (2000) Interciência, 25, pp. 22-29Piazzon, M., Larrinaga, A.R., Santamaría, L., Are nested networks more robust to disturbance? A test using epiphyte-tree, comensalistic networks (2011) PLoS ONE, 6 (5), pp. e19637Piperno, D.R., Pearsall, D.M., (1998) The Origins of Agriculture in the Lowland Neotropics, , San Diego: AcademicPires, M.M., Guimarães Jr., P.R., Araújo, M.S., Giaretta, A.A., Costa, J.C.L., dos Reis, S.F., The nested assembly of individual-resource networks (2011) Journal of Animal Ecology, 80 (4), pp. 896-903Pujol, B., Renoux, F., Elias, M., Rival, L., McKey, D., The unappreciated ecology of landrace populations: conservation consequences of soil seed bank in cassava (2007) Biological Conservation, 36, pp. 541-551(2010) R: A language and environment for statistical computing, , http://www.R-project.org, R Development Core Team, R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URLRamirez-Sanchez, S., Pinkerton, E., The impact of resource scarcity on bonding and bridging social capital: the case of fisher's information-sharing networks in Loreto, BCS, Mexico (2009) Ecology and Society, 14 (1), p. 22Schouten, M., Opdam, P., Polman, N., Westerhof, E., Resilience-based governance in rural landscapes: Experiments with agri-environment schemes using a spatially explicit agent-based model (2013) Land Use Policy, 30 (1), pp. 934-943Thijssen, M., de Boef, W., Subedi, A., Peroni, N., O'Keeffe, E., Community biodiversity management: general introduction (2013) Community Biodiversity Management: Promoting Resilience and the Conservation of Plant Genetic Resources (Issues in Agricultural Biodiversity), , W. Boefde (Ed.), New York: Earthscan from RoutledgeThompson, E.C., Juan, Z., Comparative cultural salience: measures using free-list data (2006) Field Methods, 18 (4), pp. 398-412Veloso, H.P., Rangel Filho, A.L.R., Lima, J.V.A., (1991) Classificação Da vegetação Brasileira Adaptada a Um Sistema Universal, , Rio de Janeiro: IBGE, Departamento de Recursos Naturais e Estudos Ambientai

The Influence Of Type I Diabetes Mellitus On The Expression And Activity Of Gelatinases (matrix Metalloproteinases-2 And -9) In Induced Periodontal Disease

Background and Objective: Periodontal disease corresponds to a group of lesions that affect the tooth-supporting tissues present in the dental follicle. Although bacterial plaque is important, the immune response also contributes to the destruction of periodontal tissues. Diabetes mellitus is closely associated with the development, progression and severity of periodontal disease because it not only affects extracellular matrix organization but also the tissue response to inflammation. The objective of the present investigation was to study the influence of diabetes on experimental periodontal disease by evaluating the degradation of extracellular matrix through the analysis of matrix metalloproteinase (MMP)-2 and MMP-9 expression and activity, using immunofluorescence, zymography and real-time reverse transcription-polymerase chain reaction. Material and Methods: Wistar rats were divided into normal and diabetic groups and evaluated 0, 15 and 30 d after the induction of periodontal disease by ligature. Results: MMP-2 and -9 were detected in epithelial cells, in the blood vessel endothelium and in connective tissue cells. The same profile of enzymatic expression of MMP-2 and -9 was observed in normal and diabetic animals, with a peak in activity at day 15 of inflammation. However, in diabetic animals, MMP-2 gelatinolytic activity was reduced after the inflammatory stimulus, whereas that of MMP-9 was increased. MMP-2 gene expression decreased with inflammation in both normal groups and groups with diabetes. In contrast, MMP-9 expression increased in normal animals and decreased in diabetic animals after inflammation. Conclusion: The results suggest the involvement of MMP-2 and -9 in the dynamics of periodontal disease and that variation in their expression levels results in differences in tissue organization and wound healing in normal and diabetic animals. © 2007 Blackwell Munksgaard.4314854Lindhe, J., (1999) Tratado de Periodontologia Clínica e Implantologia Oral, 3rd Edn., pp. 46-67. , Rio de Janeiro: Rio de JaneiroGarlet, G.P., Avila-Campos, M.J., Milanezi, C.M., Ferreira, B.R., Silva, J.S., Actinobacillus actinomycetemcomitans-induced periodontal disease in mice: Patterns of cytokine, chemokine and chemokine receptor expression and leukocyte migration (2005) Microbes Infect, 7, pp. 738-747Potempa, J., Banbula, A., Travis, J., Role of bacterial proteinases in matrix destruction and modulation of host responses (2000) Periodontol 2000, 24, pp. 153-192Page, R.C., Schroeder, H.E., Pathogenesis of inflammatory periodontal disease. A summary of current work (1976) Lab Invest, 34, pp. 223-228Listgarten, M.A., Pathogenesis of periodontitis (1986) J Clin Periodontol, 13, pp. 418-425Seguier, S., Godeau, G., Brousse, N., Collagen fibers and inflammatory cells in healthy and diseased human gingival tissues: A comparative and quantitative study by immunohistochemistry and automated image analysis (2000) J Periodontol, 71, pp. 1079-1085Seguier, S., Gogly, B., Bodineau, A., Godeau, G., Brousse, N., Is collagen breakdown during periodontitis linked to inflammatory cells and expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gingival tissue? (2001) J Periodontol, 72, pp. 1398-1406Liu, R.K., Cao, C.F., Meng, H.X., Gao, Y., Polymorphonuclear neutrophils and their mediators in gingival tissues from generalized aggressive periodontitis (2001) J Periodontol, 72, pp. 1545-1553Ejeil, A.-L., Gaultier, F., Igondjo-Tchen, S., Are cytokines linked to collagen breakdown during periodontal disease progression? (2003) J Periodontol, 74, pp. 196-201Györfi, A., Fazekas, Á., Fehér, E., Ender, F., Rosivall, L., Effects of streptozotocin-induced diabetes on neurogenic inflammation of gingivomucosal tissue in rat (1996) J Periodont Res, 31, pp. 249-255Birkedal-Hansen, H., Moore, W.G.I., Bodden, M.K., Matrix metalloproteinases: A review (1993) Crit Rev Oral Biol Med, 4, pp. 197-250Sternlicht, M.D., Werb, Z., How matrix metalloproteinases regulate cell behavior (2001) Annu Rev Cell Dev Biol, 17, pp. 463-516Bok, R.A., Hansell, E.J., Nguyen, T.P., Greeberg, N.M., McKerrow, J.H., Shuman, M.A., Patterns of protease production during prostate cancer progression: Proteomic evidence for cascades in a transgenic model (2003) Prostate Cancer Prostatic Dis, 6, pp. 272-280Björklund, M., Koivunen, E., Gelatinase-mediated migration and invasion of cancer cells (2005) Biochim Biophys Acta, 1755, pp. 37-69Wiseman, B.S., Sternlicht, M.D., Lund, L.R., Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis (2003) J Cell Biol, 162, pp. 1123-1133De Vicente, J.C., Fresno, M.F., Villalain, L., Vega, J.A., Hernandez-Vallejo, G., Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma (2005) Oral Oncol, 41, pp. 283-293Kato, K., Hara, A., Kuno, T., Matrix metalloproteinases 2 and 9 in oral squamous cell carcinomas: Manifestation and local localization of their activity (2005) J Cancer Res Clin Oncol, 131, pp. 340-346Patel, B.P., Shah, P.M., Rawal., U.M., Activation of MMP-2 and MMP-9 in patients with oral squamous cell carcinoma (2005) J Surg Oncol, 90, pp. 81-88Souza, A.P., Trevilatto, P.C., Scarel-Caminaga, R.M., Brito Jr., R.B., Barros, S.P., Line, S.R.P., Analysis of the MMP-9 (C-1562T) and TIMP-2 (G-418C) gene promoter polymorphisms in patients with chronic periodontitis (2005) J Clin Periodontol, 32, pp. 207-211Xue, M., Thompson, P.J., Clifton-Bligh, R., Fulcher, G., Gallery, E.D.M., Jackson, C., Leukocyte matrix metalloproteinase-9 is elevated and contributes to lymphocyte activation in type i diabetes (2005) Int J Biochem Cell Biol, 37, pp. 2406-2416Bender, I.B., Bender, A.B., Diabetes mellitus and the dental pulp (2003) J Endod, 29, pp. 383-389Robbins, S.L., Doenças Sistêmicas, T.N., Diabetes Mellitus (1989) Patologia Estrutural e Funcional, pp. 238-250. , In: Cotran, R.S., Kumar, V.Y., Collins, T. 3rd ednConget, I., Diagnosis, classification and pathogenesis of diabetes mellitus (2002) Rev Esp Cardiol, 55, pp. 528-538Wada, L.Y., (2002) Contagem de Carboidratos: Mais Fácil Que Contar Até 3, 1st Edn., pp. 3-25. , São Paulo: São PauloMaxwell, P.R., Timms, P.M., Chandran, S., Gordon, D., Peripheral blood level alterations of TIMP-1, MMP-2 and MMP-9 in patients with type i diabetes (2001) Diabet Med, 18, pp. 777-780Kadoglou, N.P., Daskalopoulou, S.S., Perrea, D., Liapis, C.D., Matrix metalloproteinases and diabetic vascular complications (2005) Angiology, 56, pp. 173-189Diabetes and periodontal disease (2000) J Periodontol, 71, pp. 664-678. , Position PaperPersson, R.E., Hollender, L.G., MacEntee, M.I., Wyatt, C.C.L., Kiyak, H.A., Persson, G.R., Assessment of periodontal conditions and systemic disease in older subjects - Focus on diabetes mellitus (2003) J Clin Periodontol, 30, pp. 207-213Silva, J.A.F., (2006), Análise da influência do diabetes tipo I induzido na progressão da doença periodontal experimental em ratos. Campinas, SP: State University of Campinas, DissertationCarson, K.A., (1979) Cytochemical and Cytopathological Studies of Nerve, Vascular and Salivary Gland Tissues in An Hereditary Mouse Model for Diabetes Mellitus, , Chapel Hill, NC: University of North Carolina, DissertationJohnson, I.H., Effects of local irritation and dextran sulphate administration on the periodontium of the rat (1975) J Periodont Res, 10, pp. 332-345Bradford, M.M., A rapid and sensitive method of quantification of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Anal Biochem, 72, pp. 248-254Ponte, E., Tabaj, D., Maglione, M., Melato, M., Diabetes mellitus and oral disease (2001) Acta Diabetol, 38, pp. 57-62Southerland, J.H., Taylor, G.W., Moss, K., Beck, J.D., Offenbacher, S., Commonality in chronic inflammation diseases: Periodontitis, diabetes, and coronary artery disease (2006) Periodontol 2000, 40, pp. 130-143Taylor, G.W., Bidirectional interrelationships between diabetes and periodontal diseases: An epidemiologic perspective (2001) Ann Periodontol, 6, pp. 99-112Holzhausen, M., Garcia, D.F., Pepato, M.T., Marcantonio Jr., E., The influence of short-term diabetes mellitus and insulin therapy on alveolar bone loss in rats (2004) J Periodont Res, 39, pp. 188-193Makela, M., Sato, T., Uitto, V., Larjava, H., Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: Cellular origin and relationship to periodontal status (1994) J Dent Res, 73, pp. 1397-1406Aiba, T., Akeno, N., Kawane, T., Okamoto, H., Horiuchi, N., Matrix metalloproteinases-1 and -8 and TIMP-1 mRNA levels in normal and diseased human gingivae (1996) Eur J Oral Sci, 104, pp. 562-569Garlet, G.P., Cardoso, C.R., Silva, T.A., Cytokine pattern determines the progression of experimental periodontal disease induced by Actinobacillus actinomycetemcomitans through the modulation of MMPs, RANKL, and their physiological inhibitors (2006) Oral Microbiol Immunol, 21, pp. 12-20Ingman, T., Tervahartala, T., Ding, Y., Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients (1996) J Clin Periodontol, 23, pp. 1127-1132Zhou, J., Windsor, J., Porphyromonas gingivalis affects host collagen degradation by affecting expression, activation, and inhibition of matrix metalloproteinases (2006) J Periodont Res, 41, pp. 47-54Saito, T., Shimazaki, Y., Kiyohaba, Y., The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: The Hisama study (2004) J Dent Res, 83, pp. 485-490Bartold, P.M., Narayanan, A.S., Molecular and cell biology of healthy and diseased periodontal tissues (2006) Periodontol 2000, 40, pp. 29-4