7,131 research outputs found
An example of resonance saturation at one loop
We argue that the large-Nc expansion of QCD can be used to treat a Lagrangian
of resonances in a perturbative way. As an illustration of this we compute the
L_10 coupling of the Chiral Lagrangian by integrating out resonance fields at
one loop. Given a Lagrangian and a renormalization scheme, this is how in
principle one can answer in a concrete and unambiguous manner questions such as
at what scale resonance saturation takes place.Comment: 9 pages, 5 figures. Enlarged discussion, results unchanged. To be
published in Phys. Rev.
Reunion overseas: introduced wild boars and cultivated orange trees interact in the Brazilian Atlantic forest
Little is known concerning novel interactions between species that typically
interact in their native range but, as a consequence of human activity, are also interacting out of their original
distribution under new ecological conditions. Objective: We investigate the interaction between the orange tree
and wild boar, both of which share Asian origins and have been introduced to the Americas (i.e. the overseas).
Methods: Specifically, we assessed whether i) wild boars consume orange (Citrus sinensis) fruits and seeds
in orchards adjacent to a remnant of the Atlantic Forest of Brazil, ii) the orange seeds are viable after passing
through boarâs digestive tract and iii) whether the orange tree may naturalise in the forest remnant assisted by
wild boars. Results: Our camera surveys indicated that wild boar was by far the most frequent consumer of
orange fruits (40.5 % of camera trap-days). A considerable proportion of sown orange seeds extracted from fresh
boar feces emerged seedlings (27.8 %, N = 386) under controlled greenhouse conditions. Further, 37.6 % of sown
seeds (N = 500) in the forest remnant emerged seedlings in July 2015; however, after ~4 years (March 2019)
only 9 seedlings survived (i.e. 4.8 %, N = 188). Finally, 52 sweet orange seedlings were found during surveys
within the forest remnant which is intensively used by wild boars. This study indicates a high potential of boars
to act as effective seed dispersers of the sweet orange. However, harsh competition with native vegetation and
the incidence of lethal diseases, which quickly kill sweet orange trees under non-agricultural conditions, could
seriously limit orange tree establishment in the forest. Conclusions: Our results have important implications not
only because the wild boar could be a vector of potential invasive species, but also because they disperse seeds
of some native species (e.g. the queen palm, Syagrus romanzofiana) in defaunated forests, where large native
seed dispersers are missing; thus, wild boars could exert critical ecological functions lost due to human activityinfo:eu-repo/semantics/publishedVersio
Novel Therapeutic Strategies in the Topical Treatment of Atopic Dermatitis
Topical agents that are currently available for the treatment of atopic dermatitis may represent a valid approach in the management of mild or mildâmoderate cases, whereas they are often supplemented with systemic therapies for handling more complex or unresponsive cases. The most used compounds include topical corticosteroids and calcineurin inhibitors, although their use might be burdened by side effects, poor response, and low patient compliance. Consequently, new innovative drugs with higher efficacy and safety both in the short and long term need to be integrated into clinical practice. A deeper understanding of the complex pathogenesis of the disease has led to identifying new therapeutic targets and to the development of innovative therapeutics. This narrative review aims to collect data on selected promising topical drugs that are in an advanced stage of development
Long-distance dimension-eight operators in B_K
Besides their appearance at short distances \gtrsim 1/M_W, local
dimension-eight operators also contribute to kaon matrix elements at long
distances of order \gtrsim 1/mu_ope, where mu_ope is the scale controlling the
Operator Product Expansion in pure QCD, without weak interactions. This comes
about in the matching condition between the effective quark Lagrangian and the
Chiral Lagrangian of mesons. Working in dimensional regularization and in a
framework where these effects can be systematically studied, we calculate the
correction from these long-distance dimension-eight operators to the
renormalization group invariant B_K factor of K^0-K^0bar mixing, to
next-to-leading order in the 1/Nc expansion and in the chiral limit. The
correction is controlled by the matrix element <0|\bar s_L \tilde{G}_{mu
nu}gamma^mu d_L|K^0>, is small, and lowers B_K.Comment: 14 pages, LaTeX. Explanatory comments added to match version in
journa
Interactive-predictive neural multimodal systems
[EN] Despite the advances achieved by neural models in sequence
to sequence learning, exploited in a variety of tasks, they still make errors.
In many use cases, these are corrected by a human expert in a posterior
revision process. The interactive-predictive framework aims to minimize
the human effort spent on this process by considering partial corrections
for iteratively refining the hypothesis. In this work, we generalize the
interactive-predictive approach, typically applied in to machine translation field, to tackle other multimodal problems namely, image and video
captioning. We study the application of this framework to multimodal
neural sequence to sequence models. We show that, following this framework, we approximately halve the effort spent for correcting the outputs
generated by the automatic systems. Moreover, we deploy our systems
in a publicly accessible demonstration, that allows to better understand
the behavior of the interactive-predictive framework.The research leading to these results has received funding from MINECO under grant
IDIFEDER/2018/025 Sistemas de fabricacion inteligentes para la industria 4.0,
action co-funded by the European Regional Development Fund 2014-2020 (FEDER),
and from the European Commission under grant H2020, reference 825111 (DeepHealth). We also acknowledge NVIDIA Corporation for the donation of GPUs used
in this work.Peris, Ă.; Casacuberta Nolla, F. (2019). Interactive-predictive neural multimodal systems. Springer. 16-28. https://doi.org/978-3-030-31332-6_2S162
A relativistic chiral quark model for pseudoscalar emission from heavy mesons
The amplitudes for one-pion mediated transitions between heavy meson excited
states are obtained in the framework of the relativistic chiral quark model.
The effective coupling constants to pions and the decay widths of excited heavy
mesons with l<=2 for non-radially excited, and the l=0 radially excited mesons
are presented for both charmed and beauty mesons. We also discuss the allowed
decays of strange excited heavy mesons by emission of a K-meson.Comment: 20 pages, revte
Overview of Atopic Dermatitis in Different Ethnic Groups
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a high prevalence worldwide, including countries from Asia, Africa, and Latin America, and in different ethnic groups. In recent years, more attention has been placed on the heterogeneity of AD associated with multiple factors, including a patientâs ethnic background, resulting in an increasing body of clinical, genetic, epidemiologic, and immune-phenotypic evidence that delineates differences in AD among racial groups. Filaggrin (FLG) mutations, the strongest genetic risk factor for the development of AD, are detected in up to 50% of European and 27% of Asian AD patients, but very rarely in Africans. Th2 hyperactivation is a common attribute of all ethnic groups, though the Asian endotype of AD is also characterized by an increased Th17-mediated signal, whereas African Americans show a strong Th2/Th22 signature and an absence of Th1/Th17 skewing. In addition, the ethnic heterogeneity of AD may hold important therapeutic implications as a patientâs genetic predisposition may affect treatment response and, thereby, a tailored strategy that better targets the dominant immunologic pathways in each ethnic subgroup may be envisaged. Nevertheless, white patients with AD represent the largest ethnicity enrolled and tested in clinical trials and the most treated in a real-world setting, limiting investigations about safety and efficacy across different ethnicities. The purpose of this review is to describe the heterogeneity in the pathophysiology of AD across ethnicities and its potential therapeutic implications
Investigational systemic drugs for moderate to severe plaque psoriasis: Whatâs new?
Introduction: The therapeutic armamentarium for the treatment of psoriasis, a chronic inflammatory skin disease, is now reasonably broad and structured, with several therapeutic agents that demonstrated a successful long-term control of this condition. However, there are still unfulfilled gaps resulting from the inherent limitations of existing therapies, which have paved the way for the identification of new therapeutic strategies or the improvement of the existing ones. Areas covered: The aim of this review is to thoroughly explore new therapeutic strategies and novel drugs that are currently in the pipeline for the treatment of psoriasis, focusing primarily on agents that are currently in phase I/II of clinical development. Some of which retrace already existing therapeutic approaches, such as the IL23/Th17 pathway inhibition, while others unveil new and yet unexplored ones. Expert opinion: Since the therapeutic landscape of psoriasis is wide, it is not yet clear whether novel agents will fill the remaining gaps in the context of a broader and more diversified set of oral and biologic therapies. Nevertheless, with the development of precision medicine approaches, the development of innovative targeted drugs will still have a therapeutic rationale in psoriasis
Conceptos bĂĄsicos de mecĂĄnica en biomecĂĄnica
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