SCIENCEFRICTION: OF THE POSTHUMAN SUBJECT, ABJECTION, AND THE BREACH IN MIND/BODY DUALISM

This thesis investigates the multiple readings that arise when the division between the biological and technological is interrupted--here abjection is key because the binary between abjection and gadgetry gives multiple meanings to other binaries, including male/female. Using David Cronenberg’s Videodrome and eXistenZ, I argue that multiple readings arise because of people’s participation with electronically mediated technology. Indeed, abjection is salient because Cronenberg’s films present an ambivalent relationship between people and technology; this relationship is often an uneasy one because technology changes people on both a somatic and cognitive level

Postcategorical auditory distraction in short-term memory: Insights from increased task load and task type

Task-irrelevant speech impairs short-term serial recall appreciably. On the interference-by-process account, the processing of physical (i.e., pre-categorical) changes in speech yields order cues that conflict with the serial-ordering process deployed to perform the serial recall task. In this view, the post-categorical properties (e.g., phonology, meaning) of speech play no role. The present study reassessed the implications of recent demonstrations of auditory post-categorical distraction in serial recall that have been taken as support for an alternative, attentional-diversion, account of the irrelevant speech effect. Focusing on the disruptive effect of emotionally valent compared to neutral words on serial recall, we show that the distracter-valence effect is eliminated under conditions—high task-encoding load—thought to shield against attentional diversion whereas the general effect of speech (neutral words compared to quiet) remains unaffected (Experiment 1). Furthermore, the distracter-valence effect generalizes to a task that does not require the processing of serial order—the missing-item task—while the effect of speech per se is attenuated in this task (Experiment 2). We conclude that post-categorical auditory distraction phenomena in serial short-term memory are incidental: they are observable in such a setting but, unlike the acoustically driven irrelevant speech effect, are not integral to it. As such, the findings support a duplex-mechanism account over a unitary view of auditory distraction

The Categorical Deviation Effect May Be Underpinned by Attentional Capture: Preliminary Evidence from the Incidental Recognition of Distracters

The performance of a visual focal task is appreciably disrupted by an unexpected change (or deviation) in the properties of a task irrelevant auditory background. A vast amount of evidence suggests that a change in the acoustic properties of sound disrupts performance via attentional capture. However, an emerging body of evidence suggests that the disruption of task performance by a change in semantic category within a stream of sounds does not behave the same and is therefore not produced by attentional capture. This preliminary study aimed to further investigate whether the disruption produced by a categorical deviant was underpinned by attentional capture. In a single experiment, participants were presented with an irrelevant sound stream while they memorized a categorized list for free recall. We examined whether free recall performance was disrupted by an unexpected change in category within the sound and later investigated, via a surprise recognition test, whether participants had superior memory for deviant items as compared to items from the same positions in control sequences. Results revealed that the categorical deviation effect manifested in poorer free recall performance. Additionally, post-study, participants demonstrated better recognition memory for deviant items compared to control items. On the assumption that explicit recognition requires attentional encoding of deviant items, our results yield evidence that the categorical deviation effect may indeed be produced via attentional capture

Macromolecular crowding modulates folding mechanism of alpha/beta protein apoflavodoxin

Protein dynamics in cells may be different from that in dilute solutions in vitro since the environment in cells is highly concentrated with other macromolecules. This volume exclusion due to macromolecular crowding is predicted to affect both equilibrium and kinetic processes involving protein conformational changes. To quantify macromolecular crowding effects on protein folding mechanisms, here we have investigated the folding energy landscape of an alpha/beta protein, apoflavodoxin, in the presence of inert macromolecular crowding agents using in silico and in vitro approaches. By coarse-grained molecular simulations and topology-based potential interactions, we probed the effects of increased volume fraction of crowding agents (phi_c) as well as of crowding agent geometry (sphere or spherocylinder) at high phi_c. Parallel kinetic folding experiments with purified Desulfovibro desulfuricans apoflavodoxin in vitro were performed in the presence of Ficoll (sphere) and Dextran (spherocylinder) synthetic crowding agents. In conclusion, we have identified in silico crowding conditions that best enhance protein stability and discovered that upon manipulation of the crowding conditions, folding routes experiencing topological frustrations can be either enhanced or relieved. The test-tube experiments confirmed that apoflavodoxin's time-resolved folding path is modulated by crowding agent geometry. We propose that macromolecular crowding effects may be a tool for manipulation of protein folding and function in living cells.Comment: to appear in Biophysical Journal (2009). to appear in Biophysical Journal (2009

Boundaries of Semantic Distraction: Dominance and Lexicality Act at Retrieval

Three experiments investigated memory for semantic information with the goal of determining boundary conditions for the manifestation of semantic auditory distraction. Irrelevant speech disrupted the free recall of semantic category-exemplars to an equal degree regardless of whether the speech coincided with presentation or test phases of the task (Experiment 1) and occurred regardless of whether it comprised random words or coherent sentences (Experiment 2). The effects of background speech were greater when the irrelevant speech was semantically related to the to-be-remembered material, but only when the irrelevant words were high in output dominance (Experiment 3). The implications of these findings in relation to the processing of task material and the processing of background speech is discussed

Cohort profile: The UK COVID-19 Public Experiences (COPE) prospective longitudinal mixed-methods study of health and well-being during the SARSCoV2 coronavirus pandemic

Public perceptions of pandemic viral threats and government policies can influence adherence to containment, delay, and mitigation policies such as physical distancing, hygienic practices, use of physical barriers, uptake of testing, contact tracing, and vaccination programs. The UK COVID-19 Public Experiences (COPE) study aims to identify determinants of health behaviour using the Capability, Opportunity, Motivation (COM-B) model using a longitudinal mixed-methods approach. Here, we provide a detailed description of the demographic and self-reported health characteristics of the COPE cohort at baseline assessment, an overview of data collected, and plans for follow-up of the cohort. The COPE baseline survey was completed by 11,113 UK adult residents (18+ years of age). Baseline data collection started on the 13th of March 2020 (10-days before the introduction of the first national COVID-19 lockdown in the UK) and finished on the 13th of April 2020. Participants were recruited via the HealthWise Wales (HWW) research registry and through social media snowballing and advertising (Facebook®, Twitter®, Instagram®). Participants were predominantly female (69%), over 50 years of age (68%), identified as white (98%), and were living with their partner (68%). A large proportion (67%) had a college/university level education, and half reported a pre-existing health condition (50%). Initial follow-up plans for the cohort included in-depth surveys at 3-months and 12-months after the first UK national lockdown to assess short and medium-term effects of the pandemic on health behaviour and subjective health and well-being. Additional consent will be sought from participants at follow-up for data linkage and surveys at 18 and 24-months after the initial UK national lockdown. A large non-random sample was recruited to the COPE cohort during the early stages of the COVID-19 pandemic, which will enable longitudinal analysis of the determinants of health behaviour and changes in subjective health and well-being over the course of the pandemic

Bon Mua

This collection is titled Bon Mua, literally meaning four seasons; however, in the authors use, the term indicates four movements delineating the progression of my oeuvre. Bon Mua is presented in the form of a drama -- a dramatic monologue, featuring the many voices that inhabit us all, divided into canh, or scenes. The poems in Bon Mua serve as a means of not only surviving abuse but finding a way to create something beautiful. The collection of poetry, which is composed of four sections, is a dialectic between language and experience

Review of The Fluctuation of Attention.

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