48 research outputs found
Learning associations between clinical information and motion-based descriptors using a large scale MR-derived cardiac motion atlas
The availability of large scale databases containing imaging and non-imaging
data, such as the UK Biobank, represents an opportunity to improve our
understanding of healthy and diseased bodily function. Cardiac motion atlases
provide a space of reference in which the motion fields of a cohort of subjects
can be directly compared. In this work, a cardiac motion atlas is built from
cine MR data from the UK Biobank (~ 6000 subjects). Two automated quality
control strategies are proposed to reject subjects with insufficient image
quality. Based on the atlas, three dimensionality reduction algorithms are
evaluated to learn data-driven cardiac motion descriptors, and statistical
methods used to study the association between these descriptors and non-imaging
data. Results show a positive correlation between the atlas motion descriptors
and body fat percentage, basal metabolic rate, hypertension, smoking status and
alcohol intake frequency. The proposed method outperforms the ability to
identify changes in cardiac function due to these known cardiovascular risk
factors compared to ejection fraction, the most commonly used descriptor of
cardiac function. In conclusion, this work represents a framework for further
investigation of the factors influencing cardiac health.Comment: 2018 International Workshop on Statistical Atlases and Computational
Modeling of the Hear
The Effect of Endurance Training on Pulmonary VËO2 Kinetics in Solid Organs Transplanted Recipients
BACKGROUND: We investigated the effects of single (SL-ET) and double leg (DL-ET) high-intensity interval training on O2 deficit (O2Def) and mean response time (MRT) during square-wave moderate-intensity exercise (DL-MOD), and on the amplitude of VËO2p slow component (SCamp), during heavy intensity exercise (DL-HVY), on 33 patients (heart transplant = 13, kidney transplanted = 11 and liver transplanted = 9). METHODS: Patients performed DL incremental step exercise to exhaustion, two DL-MOD tests, and a DL-HVY trial before and after 24 sessions of SL-ET (n = 17) or DL-ET (n = 16). RESULTS: After SL-ET, O2Def, MRT and SCamp decreased by 16.4% ± 13.7 (p = 0.008), by 15.6% ± 13.7 (p = 0.004) and by 35% ± 31 (p = 0.002), respectively. After DL-ET, they dropped by 24.9% ± 16.2 (p < 0.0001), by 25.9% ± 13.6 (p < 0.0001) and by 38% ± 52 (p = 0.0003), respectively. The magnitude of improvement of O2Def, MRT, and SCamp was not significantly different between SL-ET and DL-ET after training. CONCLUSIONS: We conclude that SL-ET is as effective as DL-ET if we aim to improve VËO2p kinetics in transplanted patients and suggest that the slower, VËO2p kinetics is mainly caused by the impairment of peripherals exchanges likely due to the immunosuppressive medications and disuse
PV-0531: Multi-centre evaluation of atlas-based and deep learning contouring using a modified Turing Test
Fermionic Dispersion Relations in the Standard Model at Finite Temperature
We compute the one-loop dispersion relations at finite temperature for
quarks, charged leptons and neutrinos in the Minimal Standard Model. The
dispersion relations are calculated in two different plasma situations: for a
vacuum expectation value of the Higgs field
(broken electroweak symmetry) and for (unbroken electroweak
symmetry). The flavour and chiral non-degeneracy of the quasi-particle spectrum
is studied. Numerical results show that the thermal effective masses for
fermions in the broken phase have a smaller value than those in the unbroken
phase. The temperature dependence of the top quark and electron neutrino
thermal effective masses is also presented. Gauge invariance of one-loop
dispersion relations is studied.Comment: 40 pages, LaTex, 10 compressed, tarred and uuencoded figures in a
separate fil
Signatures of Right-Handed Majorana neutrinos and gauge bosons in Collisions
The process is studied in the framework of
the Left-Right symmetric model. It is shown that this reaction and for the arbitrary final lepton are likely to be discovered for
CLIC collider option.
For relatively light doubly charged Higgs boson its mass does not have much
influence on the discovery potential, while for heavier values the probability
of the reaction increases.Comment: 18 pages, 7 figures, LaTe