POBREZA E GÊNERO: A MARGINALIZAÇÃO DE TRAVESTIS E TRANSEXUAIS PELO DIREITO

O presente trabalho tem por objetivo analisar a relação entre pobreza e gênero, a partir da situação de marginalização vivenciada por travestis e transexuais. Trata-se de uma investigação de vertente jurídico-teórica e de tipo jurídico-propositivo, que busca trabalhar bases normativas e doutrinárias, para a formulação de novos enquadramentos relativos à matéria. O percurso investigativo é iniciado com uma análise de natureza conceitual, apoiando-se, principalmente, nas construções teóricas de Judith Butler sobre gênero, performatividade e abjeção. Em seguida, o tema da pobreza é abordado, buscando verificar como se dá o seu enquadramento e como se relaciona com a atual situação em que se encontram travestis e transexuais no Brasil. Por fim, as noções de reconhecimento e justiça social, formuladas por Axel Honneth, são apresentadas como subsídios para a proteção dos trangêneros, tendo em vista que o nosso Direito acaba por, muitas vezes, perpetuar mecanismos de manutenção da pobreza, quando deveria se apoiar em instrumentos que permitissem a emancipação de grupos sociais minoritários. Somente por meio do reconhecimento e da justiça social poder-se-ia efetivamente implementar direitos fundamentais no contexto da nossa atual democracia

OS DESAFIOS DO ENFRENTAMENTO DA COVID-19 NA ASSISTÊNCIA FARMACÊUTICA

Theme: the challenges of pharmaceutical assistance in times of pandemic. Problem: how can pharmaceutical assistance collaborate in the fight against Covid-19? Objectives: to carry out an analysis of coping with the Covid-19 pandemic through pharmaceutical assistance interventions in the context of the SUS. We also sought to analyze the execution of the pharmaceutical care cycle, in the face of severe cases of patients infected with the new coronavirus. Hypothesis: pharmacists have all the prerogatives to exercise their profession in times of pandemic. Justification: the pandemic has taken the death of countless lives; fear is in the whole society. In specific treatments, the pharmacist through comprehensive care can minimize the suffering of the population. Results: pharmaceutical care during the Covid-19 pandemic is extremely important, as the pharmacist plays a key role in controlling the transmission of the disease and meeting the needs of the populationTema: os desafios da assistência farmacêutica em tempos de pandemia. Problema: de que maneira a assistência farmacêutica pode colaborar no enfrentamento à Covid-19? Objetivos: realizar uma análise do enfrentamento da pandemia da Covid-19 por meio das intervenções da assistência farmacêutica no contexto do SUS. Buscou-se também analisar a execução do ciclo da assistência farmacêutica, frente a casos graves de pacientes contaminados com o novo coronavívrus. Hipótese: os farmacêuticos tem todas as prerrogativas para exercer sua profissão em tempos de pandemia. Justificativa: a pandemia tem levado a morte inúmeras vidas, o medo está em toda a sociedade. Nos tratamentos específicos o farmacêutico por meio de uma assistência integral pode minimizar o sofrimento da população. Resultados: a assistência farmacêutica durante a pandemia de Covid-19 é de extrema importância, pois o farmacêutico desempenha um papel fundamental no controle da transmissão da doença e no atendimento às necessidades da populaçã

Nesting Behaviour of a Neotropical Social Wasp Mischocyttarus saussurei Zikán, 1949 (Hymenoptera, Vespidae)

Mischocyttarus saussurei nests show a curious architectural pattern which could be related to colony camouflage. Since information on that species is scarce in literature, this study aimed to record ecological data on M. saussurei, as well as morphometric data on its nests. Data was collected at the Parque Estadual do Ibitipoca state park and at the municipalities of Barroso and Inconfidentes, Minas Gerais state, Southeastern Brazil. Seven colonies were located, exclusively in conserved environments. Five nests were dissected for morphometric analysis and for the assessment of the vegetal matter incorporated to comb walls. Nests showed comb cells opening towards the substrate and covered by vegetal layers, in which three families of mosses and three of liverworts could be identified. We deduct that the nests’ morphometry and the incorporation of vegetal layers to the combs are related to the camouflaging of colonies amidst their substrate

Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. SBMA is caused by expansions of a polyglutamine tract in the gene coding for androgen receptor (AR). Expression of polyglutamine-expanded AR causes damage to motor neurons and skeletal muscle cells. Here we investigated the effect of β-agonist stimulation in SBMA myotube cells derived from mice and patients, and in knock-in mice. We show that treatment of myotubes expressing polyglutamine-expanded AR with the β-agonist clenbuterol increases their size. Clenbuterol activated the phosphatidylinositol-3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway and decreased the accumulation of polyglutamine-expanded AR. Treatment of SBMA knock-in mice with clenbuterol, which was started at disease onset, ameliorated motor function and extended survival. Clenbuterol improved muscle pathology, attenuated the glycolytic-to-oxidative metabolic alterations occurring in SBMA muscles and induced hypertrophy of both glycolytic and oxidative fibers. These results indicate that β-agonist stimulation is a novel therapeutic strategy for SBMA

Polyamines, Gelling Agents in Tissue Culture, Micropropagation of Medicinal Plants and Bioreactors

Currently, tissue cultures of species of agricultural importance have wide applicability in industrial production processes. Tissue culture is a name given to a set of techniques that allow the regeneration of cells, tissues and organs of plants, from segments of plant organs or tissues, using nutrient solutions in aseptic and controlled environment. This regeneration is based on the totipotency of plant cells. Totipotency is a capability indicating that plant cells, in different times, may express the potential to form a new multicellular individual. Tissue culture appears to be a good alternative to conventional propagation, requiring less physical space, with high multiplication rate, without incidence of pests and diseases during cultivation, and enabling higher control of the variables involved. Thus, in the in vitro environment, with the required stimuli and appropriate conditions, different cell types express different behaviors, possibly leading to cell multiplication and differentiation into a specific tissue, characterized by a form and a function, which may lead to the regeneration of a new individual

Revolução budista ou apocalipse zumbi? Discussões sobre mindfulness a partir de uma perspectiva gestáltica

A busca por práticas meditativas orientais como tecnologia promotora de saúde e qualidade de vida tem aumentado significativamente nos últimos anos. Contudo percebe-se que a falta de compreensão dos conceitos e princípios dos quais emergem tais técnicas produzem propostas que podem ser tanto uma saída revolucionária quanto distópica. Propomos neste texto uma breve discussão sobre o movimento de mindfulness a partir de uma perspectiva gestáltica de influência goodmaniana. Assim, (a) apresentamos de maneira resumida a transmissão destas práticas desde tradições budistas até a ciência ocidental contemporânea; (b) destacamos alguns aspectos teóricos que aproximam e distanciam a Gestalt-terapia de pressupostos budistas; e (c) discutimos a apropriação dessas tradições, seus valores e suas tecnologias por um paradigma neoliberal utilitarista

Glycerol Acetylation with Propionic Acid Using Iron and Cobalt Oxides in Al-MCM-41 Catalysts

In this work, Al-MCM-41 molecular sieves were synthesized, containing iron and/or cobalt oxides, impregnated by incipient wetness method, characterized and applied as catalysts in the acetylation reaction of glycerol with propionic acid to produce green glyceryl propionate molecules of high commercial value. According to this, X-ray Diffraction (XRD), X-ray Fluorescence (XRF), Fourier Transform Infra Red (FT-IR), adsorption/desorption N2 isotherms, textural analysis, and Scanning Electron Microscope (SEM) analysis were recorded to evaluate the main characteristics of materials. The presence of Lewis and Brønsted acidic sites and catalysts surface area were observed as important key points to functionalize acetylation reaction. Thus, time reaction, temperature, and glycerol / propionic acid ratio varied to improve the most suitable reaction conditions and behaviors. As a result, glycerol conversion was above 96%, followed by 68% of selectivity to glyceryl monopropionate as well as the formation of glyceryl di- and tri- propionate and a small amount of ethylene glycol dipropionate as an undesired product. Copyright © 2021 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)

Major aspects of the use of bisphosphonates for dental implants in patients with or without osteoporosis:: a systematic review of clinical studies

Introduction: In the setting of Medication-Related Osteonecrosis of the Jaw (MRONJ) it was first reported in association with the use of bisphosphonates (BP) by maxillofacial surgeons. The potency and route of administration of BPs are identified as important risk factors. Objective: It was to evaluate the use of bisphosphonates and their side effects in patients with or without osteoporosis, with emphasis on osteonecrosis of the jaws, for dental implants. Methods: The systematic review rules of the PRISMA Platform were followed. The search was carried out from October to December 2022 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using articles from 2005 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed accordingly. according to the Cochrane instrument. Results and Conclusion: A total of 120 articles were found, and 55 articles were evaluated in full and 34 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 15 studies with a high risk of bias and 32 studies that did not meet GRADE. For patients with established osteoporosis, there are drugs that, in general, act directly on the bone remodeling process, seeking to reduce bone resorption, including BP, which are drugs of proven efficacy that act in the prevention and treatment of several bone diseases. Osteoporosis is a factor that delays the regeneration of the maxillary bone in patients submitted to implant surgery, prolonging the normal recovery time of the maxillary bone, which can vary from three to six months. Alendronate sodium is used to decrease bone resorption, the drug should be considered an adjuvant therapeutic agent for the treatment of osteoporosis. However, studies have shown that there is a risk of osteonecrosis with the use of bisphosphonates