675 research outputs found
Exclusion of Class III malocclusion candidate loci in Brazilian families
The role played by genetic components in the etiology of the Class III phenotype, a class of dental malocclusion, is not yet understood. Regions that may be related to the development of Class III malocclusion have been suggested previously. The aim of this study was to search for genetic linkage with 6 microsatellite markers (D1S234, D4S3038, D6S1689, D7S503, D10S1483, and D19S566), near previously proposed candidate regions for Class III. We performed a two-point parametric linkage analysis for 42 affected individuals from 10 Brazilian families with a positive Class III malocclusion segregation. Analysis of our data indicated that there was no evidence for linkage of any of the 6 microsatellite markers to a Class III locus at = zero, with data supporting exclusion for 5 of the 6 markers evaluated. The present work reinforces that Class III is likely to demonstrate locus heterogeneity, and there is a dependency of the genetic background of the population in linkage studies
On the inner Double-Resonance Raman scattering process in bilayer graphene
The dispersion of phonons and the electronic structure of graphene systems
can be obtained experimentally from the double-resonance (DR) Raman features by
varying the excitation laser energy. In a previous resonance Raman
investigation of graphene, the electronic structure was analyzed in the
framework of the Slonczewski-Weiss-McClure (SWM) model, considering the outer
DR process. In this work we analyze the data considering the inner DR process,
and obtain SWM parameters that are in better agreement with those obtained from
other experimental techniques. This result possibly shows that there is still a
fundamental open question concerning the double resonance process in graphene
systems.Comment: 5 pages, 3 figure
Klein tunneling in graphene: optics with massless electrons
This article provides a pedagogical review on Klein tunneling in graphene,
i.e. the peculiar tunneling properties of two-dimensional massless Dirac
electrons. We consider two simple situations in detail: a massless Dirac
electron incident either on a potential step or on a potential barrier and use
elementary quantum wave mechanics to obtain the transmission probability. We
emphasize the connection to related phenomena in optics, such as the
Snell-Descartes law of refraction, total internal reflection, Fabry-P\'erot
resonances, negative refraction index materials (the so called meta-materials),
etc. We also stress that Klein tunneling is not a genuine quantum tunneling
effect as it does not necessarily involve passing through a classically
forbidden region via evanescent waves. A crucial role in Klein tunneling is
played by the conservation of (sublattice) pseudo-spin, which is discussed in
detail. A major consequence is the absence of backscattering at normal
incidence, of which we give a new shorten proof. The current experimental
status is also thoroughly reviewed. The appendix contains the discussion of a
one-dimensional toy model that clearly illustrates the difference in Klein
tunneling between mono- and bi-layer graphene.Comment: short review article, 18 pages, 14 figures; v3: references added,
several figures slightly modifie
Preparation and scale up of extended-release tablets of bromopride
Reproducibility of the tablet manufacturing process and control of its pharmaceutics properties depends on the optimization of formulation aspects and process parameters. Computer simulation such as Design of Experiments (DOE) can be used to scale up the production of this formulation, in particular for obtaining sustained-release tablets. Bromopride formulations are marketed in the form of extended-release pellets, which makes the product more expensive and difficult to manufacture. The aim of this study was to formulate new bromopride sustained release formulations as tablets, and to develop mathematical models to standardize the scale up of this formulation, controlling weight and hardness of the tablets during manufacture according to the USP 34th edition. DOE studies were conducted using Minitab(tm) software. Different excipient combinations were evaluated in order to produce bromopride sustained-release matrix tablets. In the scale-up study, data were collected and variations in tableting machine parameters were measured. Data were processed by Minitab(tm) software, generating mathematical equations used for prediction of powder compaction behavior, according to the settings of the tableting machine suitable for scale-up purposes. Bromopride matrix tablets with appropriate characteristics for sustained release were developed. The scale-up of the formulation with the most suitable sustained release profile was established by using mathematical models, indicating that the formulation can be a substitute for the pellets currently marketed
Differential cross section and recoil polarization measurements for the gamma p to K+ Lambda reaction using CLAS at Jefferson Lab
We present measurements of the differential cross section and Lambda recoil
polarization for the gamma p to K+ Lambda reaction made using the CLAS detector
at Jefferson Lab. These measurements cover the center-of-mass energy range from
1.62 to 2.84 GeV and a wide range of center-of-mass K+ production angles.
Independent analyses were performed using the K+ p pi- and K+ p (missing pi -)
final-state topologies; results from these analyses were found to exhibit good
agreement. These differential cross section measurements show excellent
agreement with previous CLAS and LEPS results and offer increased precision and
a 300 MeV increase in energy coverage. The recoil polarization data agree well
with previous results and offer a large increase in precision and a 500 MeV
extension in energy range. The increased center-of-mass energy range that these
data represent will allow for independent study of non-resonant K+ Lambda
photoproduction mechanisms at all production angles.Comment: 22 pages, 16 figure
Tensor Correlations Measured in 3He(e,e'pp)n
We have measured the 3He(e,e'pp)n reaction at an incident energy of 4.7 GeV
over a wide kinematic range. We identified spectator correlated pp and pn
nucleon pairs using kinematic cuts and measured their relative and total
momentum distributions. This is the first measurement of the ratio of pp to pn
pairs as a function of pair total momentum, . For pair relative
momenta between 0.3 and 0.5 GeV/c, the ratio is very small at low and
rises to approximately 0.5 at large . This shows the dominance of
tensor over central correlations at this relative momentum.Comment: 4 pages, 4 figures, submitted to PR
Measurement of the nuclear multiplicity ratio for hadronization at CLAS
The influence of cold nuclear matter on lepto-production of hadrons in
semi-inclusive deep inelastic scattering is measured using the CLAS detector in
Hall B at Jefferson Lab and a 5.014 GeV electron beam. We report the
multiplicity ratios for targets of C, Fe, and Pb relative to deuterium as a
function of the fractional virtual photon energy transferred to the
and the transverse momentum squared of the . We find that the
multiplicity ratios for are reduced in the nuclear medium at high
and low , with a trend for the transverse momentum to be
broadened in the nucleus for large .Comment: Submitted to Phys. Lett.
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