El Feto, un Paciente que Espera

La preocupación sobre la salud fetal surge en nuestra sociedad a medida que se conoce que una de las causas fundamentales de las muertes prenatales es debida a las malformaciones y enfermedades fetales. En este artículo, se entrega información relevante sobre este tema que es de alta complejidad. Las preguntas que surgen frente a estos hechos son:¿Cómo y cuando enferma un feto?, ¿Cómo se pueden prevenir estas enfermedades o bien curarlas?, ¿Que se puede hacer frente a un feto enfermo? El objetivo de nuestro artículo es aportar información sobre un tema no bien conocido pero que, de una u otra forma, interesa a cada uno de nosotros

Densities and phase equilibria of hydrogen, propane and vegetable oil mixtures. Experimental data and thermodynamic modeling

Heterogeneous catalytic gas-liquid reactions are intensified when carried out in the homogenous fluid phase by means of a supercritical co-solvent. For instance, supercritical propane is used to enhance yield in the hydrogenation of vegetable oils. Besides phase equilibrium knowledge, volumetric information is also needed to elucidate kinetic mechanisms and design continuous supercritical reactors. In this work, we report new experimental PvT data of the reactive mixture H2+sunflower oil+propane using the isochoric method. In addition, the phase equilibria and PvT data are modeled with the GCA and RK-PR equations of state, respectively. The isochoric method not only provides PvT information under the reaction conditions, but also the reactive system compressibility, key variable to attain enhanced transport properties in the supercritical reactors.Fil: Hegel, Pablo Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Cotabarren, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Pereda, Selva. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. University of KwaZulu-Natal; Sudáfric

Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion

Meningiomas are tumours derived from the arachnoid and pia mater. During embryogenesis, these membranes develop from the migrating craniofacial neural crest. We have previously demonstrated that meningiomas have characteristic features of embryonic meninges. Craniofacial neural crest derivatives are affected during normal development and migration by retinoic acid. We speculated, therefore, that meningioma cell migration and invasion would be affected in a similar way. In this study we investigated the mechanisms of invasion and migration in meningiomas and the effects of retinoic acid (RA). We found that low doses of RA inhibit in vitro invasion in meningioma cells, without affecting cell proliferation or viability. The matrix metalloproteinases MMP-2 (72 kDa gelatinase) and MMP-9 (92 kDa gelatinase), which play a key role in invasion in other tumours, are not affected by RA. RA inhibits cell migration on collagen I and fibronectin. A possible mechanism for these effects is provided by the fact that RA strongly stimulates adhesion of meningioma cells to extracellular matrix substrates. As in vitro invasion, migration and decreased adhesion to the extracellular matrix correlate with the clinical manifestation of tumour invasion, we conclude that RA induces a non-invasive phenotype in meningioma cells. © 1999 Cancer Research Campaig

A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold

\u27\u27This project was a collaboration with labs at the University of Pennsylvania, North Carolina State University, University of Wisconsin at Madison, and Albert Einstein College of Medicine, and featured senior thesis work by Haverford Biology alum Ben Miltenberg \u2717.\u27\u27 -- author-supplied abstract

Classification of Dairy Farms and Identification of their Weaknesses by the PRAGACC System

Fourteen dairy farms from the Basic Unit of Cooperative Production (UBPC) Patria o Muerte in Camagüey, Cuba, were classified by the PRAGACC system and their principal weaknesses were detected in order to implement mitigation measures. In all farms, deficiencies concerning management of ecosystem elements were detected (subsystem I, natural resources); out of them, five farms were impaired in two variables, six in three variables, and three in four variables. Among the principal deficiencies identified for this subsystem, water availability and its inadequate use, lack of trees on grasslands, and insufficient endogenous sources as alternatives for cattle feeding were the most evident. Regarding subsystem II (others resources), six farms showed an inefficient production process mainly associated with absence of initiatives in finding energy sources and the non-utilization of certain materials for biofertilizers manufacturing. Two other farms were identified as the most affected, thus demanding a higher priority in measures implementation. PRAGACC also increased the likelihood of a priority arrangement for the remaining farms

Vol. 1 Núm. 02 (2021): Lenguas Radicales. El Lenguaje Como Espacio de Tensión

Lenguas Radicales, revista de lingüística, que esta actualmente alojada en la Vicerrectoría de Investigación y Posgrado (VRIP) de la Universidad de Atacama. Es una revista digital de libre acceso, sometida a revisión de pares, cuyo objetivo es promover la reflexión y el debate interdisciplinario en torno al lenguaje como objeto de debate, estudio, conflicto y problematización en contextos diversos por medio de investigaciones originales nacionales e internacionales. Sus líneas de investigaciones se enfocan en áreas de la lingüística y las disciplinas que contribuyen a la comprensión de ella, como lo son la filosofía, la educación, las ciencias sociales, las humanidades, la historia, la literatura, entre otras. Se aceptan contribuciones que provean una crítica sistemática a las actuales estructuras de poder sobre las lenguas, desafíos hacia él o convenciones previas de él. Lenguas Radicales acepta artículos y reseñas bibliográficas, estudios de caso, análisis teóricos, propuestas metodológicas, estados del arte y editoriales en español e inglés para su publicación semestral

Angiotensinogen gene G-6A polymorphism influences idiopathic pulmonary fibrosisdisease progression

Angiotensin II is a growth factor that plays a key role in the physiopathology of idiopathic pulmonary fibrosis (IPF). A nucleotide substitution of an adenine instead of a guanine (G-6A) in the proximal promoter region of angiotensinogen (AGT), the precursor of angiotensin II, has been associated with an increased gene transcription rate. In order to investigate whether the G-6A polymorphism of the AGT gene is associated with IPF development, severity and progression, the present study utilised a case–control study design and genotyped G-6A in 219 patients with IPF and 224 control subjects. The distribution of G-6A genotypes and alleles did not significantly differ between cases and controls. The G-6A polymorphism of the AGT gene was not associated with disease severity at diagnosis. The presence of the A allele was strongly associated with increased alveolar arterial oxygen tension difference during follow-up, after controlling for the confounding factors. Higher alveolar arterial oxygen tension changes over time were observed in patients with the AA genotype (0.37¡0.7 mmHg (0.049¡0.093 kPa) per month) compared to GA genotype (0.12¡1 mmHg (0.016¡0.133 kPa) per month) and GG genotype (0.2¡0.6 mmHg (0.027¡0.080 kPa) per month). G-6A polymorphism of the angiotensinogen gene is associated with idiopathic pulmonary fibrosis progression but not with disease predisposition. This polymorphism could have a predictive significance in idiopathic pulmonary fibrosis patients.Supported by grants from FIS-PI; FISPI060064, FIS-IDIBAPS CM05/00118, Sociedad Española de Neumologia y Cirugia Torácica (SEPAR)-Fundación Respira and Faculdade Capivari, Spain.Peer reviewe

PRIMER REGISTRO DE UNA ABERRACIÓN MARRÓN PARA EL CORMORÁN NEOTROPICAL NANNOPTERUM BRASILIANUM DE MÉXICO

En esta nota, reportamos un caso de aberración del plumaje en el cormorán neotropical Nannopterum brasilianum. Se registró la presencia de un color atípico en el plumaje de un individuo observado en un humedal del norte de México. El ave presentaba una aberración marrón, en la que el color negro original fue sustituido por tonos marrón claro y beige pálido. Observamos el ave alimentándose junto a otros cormoranes con una coloración normal y no mostró comportamientos diferentes. La documentación de fenotipos aberrantes es importante para determinar su frecuencia y patrones geográficos de aparición, especialmente en aves acuáticas con distribuciones geográficas extensas como N. brasilianum. Esta observación representa el primer reporte de aberración de plumaje marrón en esta especie

Comparative study of nonlinear properties of EEG signals of a normal person and an epileptic patient

Background: Investigation of the functioning of the brain in living systems has been a major effort amongst scientists and medical practitioners. Amongst the various disorder of the brain, epilepsy has drawn the most attention because this disorder can affect the quality of life of a person. In this paper we have reinvestigated the EEGs for normal and epileptic patients using surrogate analysis, probability distribution function and Hurst exponent. Results: Using random shuffled surrogate analysis, we have obtained some of the nonlinear features that was obtained by Andrzejak \textit{et al.} [Phys Rev E 2001, 64:061907], for the epileptic patients during seizure. Probability distribution function shows that the activity of an epileptic brain is nongaussian in nature. Hurst exponent has been shown to be useful to characterize a normal and an epileptic brain and it shows that the epileptic brain is long term anticorrelated whereas, the normal brain is more or less stochastic. Among all the techniques, used here, Hurst exponent is found very useful for characterization different cases. Conclusions: In this article, differences in characteristics for normal subjects with eyes open and closed, epileptic subjects during seizure and seizure free intervals have been shown mainly using Hurst exponent. The H shows that the brain activity of a normal man is uncorrelated in nature whereas, epileptic brain activity shows long range anticorrelation.Comment: Keywords:EEG, epilepsy, Correlation dimension, Surrogate analysis, Hurst exponent. 9 page