9 research outputs found
Trends in the epidemiology of catheter-related bloodstream infections; towards a paradigm shift, Spain, 2007 to 2019
- Author
- Agusti Carme
- Aliu Teresa
- Almirante Gragera Benito
- Andrés Marta
- Andrés Marta
- Ardanuy Tisaire Carmen
- Armario FernĂĄndez Mar
- Badia-Cebada Laia
- Barbadillo Sandra
- Barrufet MÂȘ Pilar
- BenĂtez Rosa
- Berbel Palau DĂ maris
- BesolĂ Anna
- Bisbe Josep
- Blancas David
- BlascĂł Montse
- Bosch Ros NĂșria
- Brugués Montse
- Calaf Elisabet
- Calbo Esther
- Campins MartĂ Magda
- Camps Susana
- Carrera Raquel
- Casas Garcia Irma
- Castander David
- Castellana Dolors
- Castro Salom Antoni
- ClarĂłs MercĂš
- Coll Colell MÂȘ Rosa
- Coloma Ana Guadalupe
- Cuquet Jordi
- Cusco Maria
- CĂ mara Jordi
- De la Cruz Sol Pilar
- de la Roca Toda Maria
- Diaz-Brito Vicens
- DomĂšnech Dolors
- DomĂšnech MÂȘ France
- Duch Mireia
- Eito Navasal M. Carmen
- Espinach AlvarĂłs Joan
- Farguell Carrera Josep
- FernĂĄndez Engracia
- Ferrer Carme
- Ferrer Lourdes
- Ferrer Roser
- Ferrer Roser
- Garcia Flores Ăngels
- Garcia Ramirez MarĂa Gracia
- GarcĂa Flores Ăngels
- GarcĂa Penche Sanches Rosa
- GarcĂa Pino Antonia
- Gasch Blasi Oriol
- Gonzalez Cristina
- Grau Palafox Laura
- Horcajada Juan Pablo
- Hornero Ana
- JimĂ©nez Zarate Ana MÂȘ
- JimĂ©nez-MartĂnez Emili
- Jover Alfredo
- Juan Serra Natalia
- Laplace Enguinados M.Rosa
- LimĂłn Enric
- Linares Laura
- LĂ©rida Ana
- LĂłpez Ana Felisa
- LĂłpez Lucrecia
- LĂłpez-Contreras JoaquĂn
- Maldonado LĂłpez Demelsa Maria
- Maraver Encarna
- MarimĂłn MarilĂł
- MarrĂłn Anna
- Martin Lydia
- MartĂnez Ana
- MartĂnez JosĂ© Antonio
- MartĂnez Sara
- Masats Ărsula
- Meije Yolanda
- Milian Sanz Marta
- Moise Alexandra
- Montardit Irene
- Moreno Encarna
- Moreno Encarna
- Moreno Esther
- Moreno MÂȘ JosĂ©
- Olona Montserrat
- Ortega Montserrat
- Palau Eva
- Perea Garcia Miquel
- Perez Ăngels
- Peñafiel Judit
- Pomar Virginia
- Porta Carolina
- Porta Roser
- Pujol Miquel
- Pujol Miquel
- PĂ©rez Rafael
- Rebull Fatsini Josep
- Redon Eva
- Salgado Xavier
- Saliba Patrick
- Santana Gemina
- Serrats Pepi
- Smithson Alex
- Sopena Nieves
- Tricas Josep Maria
- Universitat AutĂČnoma de Barcelona
- Vaqué Montserrat
- Vaqué Montserrat
- Vidal Elena
- Vila Blanca
- Villalba Naiara
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Departament de Salut. Generalitat de Catalunya ("Pla estratĂšgic de recerca i innovaciĂł en salut (PERIS) 2019-2021"); Ministerio de Asuntos EconĂłmicos y TransformaciĂłn Digital; Red Española de InvestigaciĂłn en PatologĂa Infecciosa (REIPI).Background: Catheter-related bloodstream infections (CRBSI) are frequent healthcare-associated infections and an important cause of death. Aim: To analyse changes in CRBSI epidemiology observed by the Infection Control Catalan Programme (VINCat). Methods: A cohort study including all hospital-acquired CRBSI episodes diagnosed at 55 hospitals (2007-2019) in Catalonia, Spain, was prospectively conducted. CRBSI incidence rates were adjusted per 1,000patientdays. To assess the CRBSI rate trend per year, negative binomial models were used, with the number of events as the dependent variable, and the year as the main independent variable. From each model, the annual rate of CRBSI diagnosed per 1,000patientdays and the incidence rate ratio (IRR) with its 95% confidence intervals (CI) were reported. Results: During the study, 9,290 CRBSI episodes were diagnosed (mean annual incidence rate:0.20episodes/1,000patientdays). Patients' median age was 64.1years; 36.6% (3,403/9,290) were female. In total, 73.7% (n=6,845) of CRBSI occurred in non-intensive care unit (ICU) wards, 62.7% (n=5,822) were related to central venous catheter (CVC), 24.1% (n=2,236) to peripheral venous catheters (PVC) and 13.3% (n=1,232) to peripherally-inserted central venous catheters (PICVC). Incidence rate fell over the study period (IRR:0.94;95%CI:0.93-0.96), especially in the ICU (IRR:0.88;95%CI:0.87-0.89). As a whole, while episodes of CVC CRBSI fell significantly (IRR:0.88;95%CI:0.87-0.91), peripherally-inserted catheter CRBSI (PVC and PICVC) rose, especially in medical wards (IRR PICVC:1.08;95%CI:1.05-1.11; IRR PVC: 1.03; 95% 1.00-1.05). Conclusions: Over the study, CRBSIs associated with CVC and diagnosed in ICUs decreased while episodes in conventional wards involving peripherally-inserted catheters increased. Hospitals should implement preventive measures in conventional wards
Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
- Author
- 't Hart Ellen P.
- ?a?inkovĂĄ Pavla
- Aaserud Olaf
- Abbruzzese Giovanni
- Acharya T.
- Akhtar Shahbana
- Albanese Alberto
- Alegre Javier
- Alegre Javier
- Allain Philippe
- Alusi Sundus
- Amico Enrico
- Andrade Carlos
- Andrews S. C.
- Andrews Thomasin
- Andrews Thomasin
- Anheim Mathieu
- Antczak Jakub
- Armstrong Matthew
- Armstrong Richard
- Arques Penelope Navas
- Arran N.
- Arran Natalie
- Artiga MarĂa JosĂ© Saiz
- Axelson E.
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachoud-LĂ©vi Anne-Catherine
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Bardinet E.
- Barker Roger A.
- Barrero Francisco
- Barth Katrin
- Barth Katrin
- Barthélémy Rekha
- Bas Jordi
- Bascuñana Mónica
- Bechtel N.
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Bentivoglio Anna Rita
- Bentivoglio Rita
- Berglund Peter
- Berna C.
- Berrissoul Hassan
- Bertini Elisabetta
- Betz Sabrina
- Biunno Ida
- BjĂžrgo Kathrine
- BjĂžrnevoll Inga
- Blaszcyk Magdalena
- Blin Stéphanie
- Bocwinska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen S.
- Bohlen Stefan
- Bojakowska-Jaremek Kamila
- Bolwijn J. J. W.
- Bonelli Raphael
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- Borowsky B.
- Bos Reineke
- Bos Reineke
- Bosca Maria E.
- Bosredon Cecile
- Bost Marie
- Boukbiza Ouhaid Lagha
- Bourne Colin
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burrows Liz
- Busquets NĂșria
- Busse Monica
- Butcher Cynthia
- BĂŒrk Katrin
- C Jan Frich
- Caldentey Juan Garcia
- Callaghan J.
- Callaghan Jenny
- Callaghan Jenny
- Callaghan Jenny
- Calmeyn Godelinde
- Calopa Matilde
- Campbell C.
- Campbell C.
- Campbell M.
- Campos Anabel
- Capellari Sabina
- Capetian Philipp
- Carette Maryline Cabaret Anne-Sophie
- Carrillo FĂĄtima
- Carruesco Gemma Tome
- Cash D. M.
- Castaldo Anna
- Catena Judit LĂłpez
- Chu Carol
- Chu Carol
- Chu Carol
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Clapton Jackie
- Clayton Carole
- Clenaghan Catherine
- Coelho Miguel
- Coleman A.
- Come Adrien
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Cortegana Hermoso Eva Pacheco
- Cortelli Pietro
- Coulthard Elizabeth
- Courtin Françoise
- Craufurd D.
- Craufurd David
- Crawford H.
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- CĂĄceres MarĂa Teresa
- D'Alessio Barbara
- da Silva Wildson Vieira
- Damas Fatima
- Davies Rhys
- De Bruycker Christelle
- De Michele Giuseppe
- de Souza Jenny
- de Tommaso Marina
- de Weert A. Marit
- de YĂ©benes Justo GarcĂa
- de YĂ©benes Justo GarcĂa
- Debruxelles Sabrina
- Dec Malgorzata
- Decolongon J.
- Defebvre Eric Decorte Luc
- Dekker M.
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Delvaux Isabelle
- Descals AsunciĂłn MartĂnez
- Destee Alain
- Di Bella Daniela
- Di Donato Stefano
- Di Maio Luigi
- Di Pietro Anna
- di Poggio Monica Bandettini
- Di Renzo Martina
- Diercks Gabriele
- Dipple Heather
- Dixon Kathryn
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Dressler Dirk
- Duché Charlotte
- Dujardin Kathy
- Dumas E. M.
- Dumas Eve M.
- Dunnett Stephen
- Dunnett Stephen
- Dupuit Michel
- Durr Alexandra
- Duru CĂ©cile
- Dziadkiewicz Artur
- Ecker Daniel
- Ecker Daniel
- Edwards Maureen
- Ellrichmann Gisa
- Esposito Chiara
- Eusebio Alexandre
- Evans Carole
- Fairtlough Helen
- Fannemel Madeleine
- Fasquel VĂ©ronique
- Favellato Mariagrazia
- Fenollar MarĂa
- Ferrandes Giovanna
- Ferreira Joaquim
- Ferreira Joaquim J.
- Ferrer Pilar Quiléz
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Fletcher Amy
- Fluchere Frédérique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Fox N. C.
- Foy Kevin
- Frajman E.
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frontali Marina
- Frost C.
- Fullam Ruth
- Fullam Ruth
- Fullam Ruth
- Gago Miguel
- Galassi Roberto
- Gallantrae Deena
- Gallentrae Deena
- Ganos Christos
- Garcia Patrocinio Moreno
- GarcĂa RocĂo GarcĂa-Ramos
- Garde Monica Bascuñana
- Garrett Carolina
- Gaston Itziar
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Gerrans Emily
- Gethin Louise
- Ghelli Elena
- Gibbard C.
- Gill Paul
- Gilling Mette
- Ginestroni Andrea
- Godefroy Olivier
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- Golding Charlotte
- Gonzenbach Roman
- GonzĂĄlez GonzĂĄlez Sonia
- Goodman Anna
- Gorospe AranzazĂș
- Gorzkowska Agnieszka
- Gorzolla Heike
- Grant Janet
- Griguoli Annamaria
- Gross Diana
- Guedes Leonor Correia
- Guedes Leonor Correia
- Guerra Maria RosĂĄlia
- Guerrero Rosa
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guisasola Luis Menéndez
- Gustafsson Lena
- Guzman Natalie Valle
- Guérid Marie-Anne
- GĂžrvell Per F.
- Haider Salman
- Hallam Caroline
- Hamer Stephanie
- Hamer Stephanie
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia
- Handley Olivia
- Handley Olivia J.
- Harding Alison
- Hare Marianne
- Harrison David
- Hauer Maria
- Hayward Beverley
- Hecht Karen
- Heiberg Arvid
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Held Christine
- Hensman Moss Davina J.
- Hensman Davina
- Hepperger Caroline
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen DurĂĄn
- Herrmann Lennard
- Hicks S.
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena E.
- Ho Carrie
- Hobbs N.
- Hobson Emma
- Hoffmann Rainer
- Holas Christiane
- Holl Anna
- Holmans Peter
- Hotter Anna
- Howard Liz
- Hughes Max
- Hughes Teresa
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hyppönen Hannele
- Hölzner Eva
- HĂžsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago JesĂșs Miguel Ruiz
- Illmann Torsten
- Jachinska Katarzyna
- Jack Roisin
- Jacobsen Oda
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Jasinska-Myga Barbara
- Johns Nicola
- Johnson H.
- Johnson Liz
- Jones Lesley
- Jones Lesley
- Jones Mary
- Jones R.
- Jones Una
- Julié Celine
- Jung Hans H.
- Jurgens C.
- Justo D.
- Kaelin Alain
- Kaminski Barbara
- Kapfhammer Hans-Peter
- Kavalier Fred
- Kazoka Mbombe
- Keenan S.
- Kennard C.
- Kershaw Ann
- Kesse Andrea
- Khalil Hanan
- KlempĂr JirĂ
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Klöppel Stefan
- Koivisto Susana Pro
- Koivisto Susana Pro
- Koivisto Susana Pro
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kotz Peter
- Kraus Alison
- Kraus Alison
- Kraus Alison
- Kraus P.
- Krawczyk Malgorzata
- Kremer B.
- Kremer Berry
- Krysa Wioletta
- Krystkowiak Pierre
- Kwiecinski Hubert
- Labuschagne I.
- LafoucriĂšre Danielle
- Lahiri N.
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer B.
- Landwehrmeyer Bernhard
- Landwehrmeyer G. Bernhard
- Lang Christina
- Langbehn Douglas
- Lange Herwig
- Lange Herwig
- Larsen Ida Unmack
- Lashwood Alison
- Lau Puay Ngoh
- LaurĂ Matilde
- Laver Fiona
- Leavitt Blair R.
- Lee S.
- Leenders K. L.
- Lehericy S.
- Lemaire Marie-HĂ©lĂšne
- Levey Jamie
- Lewerenz Jan
- Lewerenz Jan
- Lewis Monica
- Lewis Monica
- LeythÀuser Gabriele
- Lezius Franziska
- Liessens Dirk
- Lilek Sabine
- Linnsand Petra
- Lo Kitty
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera MĂłnica Rodriguez
- Lorentzen Eirin
- Loutfi Ghada
- Lucena Carolina Mendez
- Löhle Matthias
- Maass Antonia
- Magnet Markus
- Maiwald Robert
- MajerovĂĄ Veronika
- Malone I.
- Man A. Hoff
- Mandich Paola
- Manouvrier Sylvie
- Mantaux BĂ©atrice
- Manzanares Salvadora
- Marchese Roberta
- Marcinkowski Jerzy
- Marelli C.
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Markova Ivana
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martinez-Horta SaĂŒl
- Martinez-Jaurrieta Maria Dolores
- MartĂn Esther SuarĂ©z San
- MartĂnez-Descals AsunciĂłn
- Mason Sarah
- Massarelli Marco
- Massaro Francesca
- Matheson Kirsty
- Mazzante Irene
- McGill Marie
- McKenzie Sue
- Mead Simon
- Mechi Claudia
- Mendes Tiago
- Mestre Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milchman C.
- Milkereit Eva
- Minet CĂ©cile
- Minster Sara
- Minster Sara
- Mir Pablo
- Monaco W.
- Monza Daniela
- Monza Daniela
- Morales Blas
- Moreau Laura Vivancos
- Moreno Jose Manuel Garcia
- Moreno José Luis López-Sendón
- Mundler Laura
- Murch Ann
- Murphy Helen
- Musgrave Hannah
- Möller Jens Carsten
- MĂŒhlau Mark
- MĂŒller Christoph
- MĂŒller Nicole
- MĂŒnchau Alexander
- MĂŒtze Lisanne
- Nanetti Lorenzo
- Neleborn-LingefjÀrd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Nielsen JĂžrgen
- Nielsen JĂžrgen E.
- Niess Anke
- Nigaud K.
- Novak Marianne
- Nowak Malgorzata
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Regan A.
- Oehmen Martin
- Olivier Audrey
- Olofsson Carina
- Opala Gregorz
- Ordidge R.
- Ortega Paloma
- Orth Michael
- Orth Michael
- Orth Michael
- Otti Daniela
- Oughton Emma
- Owen G.
- Owen Michael
- Padieu HĂ©lĂšne
- Paganini Marco
- Painold Annamaria
- Pardiñas Antonio F.
- Paridi Dominga
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Pate Louise
- Patel A.
- Patel Aakta
- Paterski Laurent
- Paterson Nicole
- Pearson Pauline
- Peinemann Alexander
- Peluso Silvio
- Peppa Nadia
- Peppa Nadia
- Pepple T.
- Perea MarĂa Fuensanta Noguera
- Peter Mireille
- Petersen Jens
- Petrollini Martina
- Peña José Chacón
- Piacentini Silvia
- Piano Carla
- Pica Emmanul
- Piedad John
- Plomhouse Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pourchot C.
- Pradella Silvia
- Prehn Christian
- Price Kathleen
- Priller Josef
- Probst Daniela
- Prundean Adriana
- PrĂŒĂ Harald
- PÀivÀrinta Markku
- Quarrell Oliver
- Queller S.
- Raab Tina
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Raman Ashok
- Raman Ashok
- Ramirez Inés Legarda
- Ramos-Arroyo Maria A.
- Ramos-Arroyo Maria A.
- Raymond Lucy
- Read J.
- Redondo Luis
- Reetz Kathrin
- REGISTRY investigators
- Reilmann R.
- Reilmann Ralf
- Reinante Gema
- Reisinger Karin
- Ret C. Jauff
- RetterstĂžl Lars
- Rialland Amandine
- Riballo Antonio Villa
- Ribas Guillermo GarcĂa
- RibaĂŻ Pascale
- Ribbat Michael
- Richter Przemyslaw
- Rickards Hugh
- Rissling Ida
- Rivadeneyra Perez Jessica
- Rizzo Giovanni
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- RodrĂguez MarĂa JosĂ© Torres
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Romano Silvia
- Romero Irene
- Romoli Anna Maria
- Roos Raymund
- Roos Raymund A. C.
- Roos Raymund A. C.
- Rosas H. D.
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzinska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- RuĂz Pedro J. GarcĂa
- Ryglewicz Danuta
- RĂžren Niini
- SablonniĂšre Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santhouse Alastair
- Santos R. Dar
- Sass Christian
- Say M.
- Scaglione Cesa
- Scahill R.
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schrader Christoph
- Schwenk Daniela
- Schöggl Helmut
- SchĂŒpbach Michael
- Sciruicchio Vittorio
- SebastiĂĄn A. Rojo
- SebastiĂĄn Ana Rojo
- Sempolowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Silva Mark
- Simonin Clémence
- Simpson Sheila A.
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smith Paul
- Snowden Julie
- Soleti Francesco
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Somers Nele
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike Jakob
- Squitieri Ferdinando
- Stattin Eva-Lena
- Stebler Yanik
- Stepniak Iwona
- Stokke Bodil
- Stompel Daniel
- Stopford C.
- Stopford Cheryl
- Storch Alexander
- Stout J.
- Stubbe Lars
- Sturrock A.
- StĂĄrkovĂĄ Irena
- StÀdtler Michael
- Suarez MarĂa JosĂ© Lama
- Sulek Anna
- Summers Fiona
- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- SĂĄnchez Vicenta
- SĂŒĂmuth Sigurd
- t'Hart E. P.
- Tabrizi Sarah
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
- Tan Louis
- Taylor Cat
- Taylor Rachel
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Catherine
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Tobin A.
- Tomasello Chiara
- Torres MarĂa Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- TRACK-HD investigators
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tuuha Katri
- Uhrova Tereza
- Ullah Jasmin
- Ure Alexandra
- ValabrĂšgue R.
- Valadas Anabela
- Valentine Ruth
- van den Bogaard S. J. A.
- van den Bogaard Simon J. A.
- van der Grond J.
- van Hout Monique S. E.
- van Oostrom J. C. H.
- van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen R.
- van Walsem Marleen R.
- Vandenberghe Wim
- Vandenberghe Wim
- Vargas-GonzĂĄlez Laura
- Vaughan Vivien
- Ventura Marta FatĂĄs
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verhoeven Marloes E.
- Verny Christophe
- Verstappen C. C. P.
- Verstraelen Nichola
- Viladrich Celia Mareca
- Vilaplana Garcia Carmen PeirĂł
- Villanueva Clara
- Vinther-Jensen Tua
- Vuillaume Isabelle
- Wahlström Jan
- Wahlström Jan
- Wang C.
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Zaugg Sabine
- Weber Natalia
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wentzel Magnus
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Whalstedt Carina
- Whitehead D.
- Whitlock K.
- Wiedemann Alexandra
- Wikström Birgitta
- Wild E.
- Wild Edward
- Wild Sue
- Wild Sue
- Winkelmann Juliane
- Witjes-Ane M.-N.
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wright Abigail
- Wright Abigail
- Wright Jan
- WĂłjcik Magdalena
- Yardumian Pam
- Yardumian Pam
- Yates Shona
- Zaremba Jacek
- Zaremba Jacek
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zieora-Jakutowicz Karolina
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008â11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003â13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 Ă 10â10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 Ă 10â8 DHFR p=8·37 Ă 10â7 MTRNR2L2 p=2·15 Ă 10â9) and to a lesser extent in REGISTRY (MSH3 p=9·36 Ă 10â4 DHFR p=8·45 Ă 10â4 MTRNR2L2 p=1·20 Ă 10â3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 Ă 10â8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16â0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06â0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation
Helminthofauna of
- Publication venue
- 'EDP Sciences'
- Publication date
- 17/08/2016
- Field of study
Faunistic and ecological study of parasitic helminths of Microtus (Microtus) cabrerae (Thomas, 1906) (Rodentia : Arvicolidae) in the Iberian Peninsula. 70 specimens have been dissected, coming from 8 enclaves located in three Spanish provinces ; 6 species of helminths have been detected (1 Digenetic Trematode, 4 Cestodes and 1 Nematode). Structure of helminthfauna of M. (M.) cabrerae in relation to remaining Iberian Arvicolids and the most conditionating ecological factors of the helminthfauna of the Rodent are analyzed
Suicidal ideation in a European Huntington's disease population.
- Author
- 't Hart Ellen P
- Aaserud Olaf
- Abbruzzese Giovanni
- Akhtar Shahbana
- Albanese Alberto
- Alberti Silvia
- Alegre Javier
- Allain Philippe
- Alonso-Frech Fernando
- Amico Enrico
- Ammendola Sarah
- Andrade Carlos
- Andrews Thomasin
- Andrich JĂŒrgen
- Antczak Jakub
- Armstrong Richard
- Arques Penelope Navas
- Arran Natalie
- Artiga MarĂa JosĂ© Saiz
- Avarvarei Luminita Dinca
- Azulay Jean-Philippe
- Babiloni Blandine
- Bachoud-LĂ©vi A-C
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A
- Barrero Francisco
- Barth Katrin
- Bas Jordi
- Bascuñana Mónica
- Bastida Antonio MartĂn
- Bek Judith
- Bellonet Marcellin
- Bentivoglio A R
- Bentivoglio Anna Rita
- Bernhard Landwehrmeyer G
- Berrissoul Hassan
- Bertini Elisabetta
- Betz Sabrina
- Bisson Jonathan
- Biunno I
- BjĂžrgo Kathrine
- Blaszcyk Magdalena
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Bolwijn J J W
- Bonelli R M
- Bonelli Raphael M
- Boogaerts Andrea
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- BoÄwiĆska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugada Francisco CasterĂĄ
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buratti Lisa
- Burguera Juan Andres
- Burgunder J-M
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets NĂșria
- Busse Monica
- Butcher Cynthia
- BĂĄrcenas Antonio Herranz
- BĂŒrk Kathrin
- Cabaret Maryline
- Caldentey Juan Garcia
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Capellari Sabina
- Capetian Philipp
- Carette Anne-Sophie
- Carrillo FĂĄtima
- Carruesco Gemma Tome
- Casado Ana GonzĂĄlez
- Catalli Claudio
- Catena Judit LĂłpez
- Cavaco Sara
- Cheriet Samia
- Chiara Piccininni
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Clayton Carole
- Clenaghan Catherine
- Coelho Miguel
- Coleman Caroline
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Correia-Guedes Leonor
- Cortelli Pietro
- Costa Cristina
- Courtin Françoise
- Craufurd David
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- CĂ rdenas Regina Ponsi
- CĂĄceres MarĂa Teresa
- da Silva Wildson Vieira
- DamĂĄsio Joana
- Davidson Jill
- De Bruycker Christelle
- De Michele Giuseppe
- de Raedt Sylvie
- Debruxelles Sabrina
- Dec MaĆgorzata
- Decorte Eric
- Defebvre Luc
- Dekker M
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Descals AsunciĂłn MartĂnez
- Destee Alain
- Di Bella Daniela
- Di Donato Stefano
- Di Giacopo Raffaella
- Di Maio Luigi
- Di Maria Emilio
- Di Pardo Alba
- Di Pietro Anna
- di Poggio Monica Bandettini
- Diercks Gabriele
- Dipple Heather
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dressler Dirk
- Duché Charlotte
- Dujardin Kathy
- Dumas Eve M
- Dunnett S B
- Dunnett Stephen
- Duru CĂ©cile
- Dziadkiewicz Artur
- Démonet Jean-François
- DĂez-AjaLĂłpez CristĂłbal
- Ecker Daniel
- Edwards Maureen
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Elorza Marina Dalmau
- Eschenbach Carolin
- Esmaeilzadeh Mona
- Eusebio Alexandre
- Fairtlough Helen
- Fannemel Madeleine
- Fasano Alfonso
- Fasquel VĂ©ronique
- Fenollar MarĂa
- Ferrandes Giovanna
- Ferreira J J
- Ferreira Joaquim J
- Ferrer Pilar Quiléz
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flamez Anja
- Fletcher Amy
- FluchÚre Frédér- ique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan
- Frontali Marina
- Fullam Ruth
- Gago Miguel
- Gallantrae Deena
- Gallassi Roberto
- Ganos Christos
- Garcia Anabel Campos
- Garcia Patrocinio Moreno
- GarcĂa RuĂz Pedro J
- GarcĂa RocĂo GarcĂa-Ramos
- GarcĂa Socorro Soriano
- Garde Monica Bascuñana
- Garrett Carolina
- Gaston Itziar
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Ghelli Elena
- Gill Paul
- Giltay Erik J
- Ginestroni Andrea
- Godefroy Olivier
- Goerendt Ines
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- GonzĂĄlez MĂłnica
- GonzĂĄlez Sonia GonzĂĄlez
- Gorospe AranzazĂș
- Gorzkowska Agnieszka
- Gorzolla Heike
- Griguoli Annamaria
- Guerra Maria RosĂĄlia
- Guerrero Rosa
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guisasola Luis Menéndez
- Guzman [Unknown]
- Guérid Marie-Anne
- Göller Marie-Louise
- GĂžrvell Per
- Haider Salman
- Hamer Stephanie
- Hametner Eva-Maria
- Handley O J
- Handley Olivia
- Harding Alison
- Hare Marianne
- Harrison David
- Hartikainen PĂ€ivi
- Hauge Erik
- Hayward Beverley
- Hecht Karen
- Heiberg A
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen DurĂĄn
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Holas Christiane
- Holl Anna
- Horta Saul Martinez
- Hotter Anna
- Howard Liz
- Hubers Anna A M
- Hughes Alis
- Hughes Max
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Höglund Arja
- Hölzner Eva
- HĂžsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago JesĂșs Miguel Ruiz
- ielewska Anna Was
- Ignatius Jaakko
- Jachinska Katarzyna
- Jack Roisin
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- JanuĂĄrio Cristina
- Jaremek Kamila Bojakowska
- Jasinska-Myga Barbara
- Johansson Anders
- Johns Nicola
- Johnson Liz
- Johnstone Catherine
- Jones Lesley
- Jones Mary
- Jones Una
- JĂșlio Filipa
- Kaelin Alain
- Kajula Outi
- Kaminska Anna
- Kaminski Barbara
- Kapfhammer Hans-Peter
- Kavalier Fred
- Kazoka Mbombe
- Khalil Hanan
- KlempĂĆ JiĆĂ
- Klimberg Aneta
- Kohl Zacharias
- Koivisto Susana Pro
- Komati Suresh
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kraus Alison
- Krawczyk Malgorzata
- Kremer H P H
- Krysa Wioletta
- Krystkowiak Pierre
- Kwiecinski Hubert
- KÀrppÀ Mikko
- KĆodowska-Duda Gabriela
- Ladurner Gunther
- LafoucriĂšre Danielle
- Lahiri Nayana
- Laing Hana
- Lambeck Johann
- Landwehrmeyer Bernhard
- Landwehrmeyer G B
- Lange Herwig
- Lashwood Alison
- LaurĂ Matilde
- Laver Fiona
- Leenders K L
- Legarda Inés
- Lemaire Marie-HĂ©lĂšne
- Levey J
- Lewerenz Jan
- Lewis Monica
- Leythaeuser Gabriele
- Lezius Franziska
- lhagen Sven E P
- Lilek Sabine
- Lilek Stefan
- Lima Joana
- Llesoy Joan Roig
- llmann T I
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lorentzen Eirin
- Loria Giovanna
- Loureiro Rui
- Loutfi Ghada
- López-Sendón Moreno José Luis
- Maass Antonia
- MagalhĂŁes Marina
- Maglione Vittorio
- Magnet Markus
- MajerovĂĄ Veronika
- Mandich Paola
- Manouvrier Sylvie
- Mantaux BĂ©atrice
- Manuel Jose
- Marcel Christophe
- Marchese Roberta
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martinez-Jaurrieta Maria Dolores
- Martino Tiziana
- Martirio MarĂa
- MartĂnez Isabel Haro
- MartĂnez Laura Martinez
- MartĂnez-Descals AsunciĂłn
- Mason Sarah
- Massano JoĂŁo
- Massarelli Marco
- Massaro Francesca
- Matheson Kirsty
- McGill Marie
- McKenzie Sue
- Mechi Claudia
- Meireles Joana
- Mendes Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Milkereit Eva
- Miller Joanne
- Minster Sara
- Mir Pablo
- Monza Daniela
- Morales Blas
- Moreau Laura Vivancos
- Moreno Garcia
- Morez V
- Morgan Karen
- Mundler Laura
- Murphy Helen
- Musgrave Hannah
- Mustonen Aki
- Möller Jens Carsten
- MĂŒhlau Mark
- MĂŒller Christoph
- MĂŒller Nicole
- MĂŒnchau Alexander
- MĂŒtze Lisanne
- Nanetti Lorenzo
- Neleborn-LingefjÀrd Liselotte
- Nemeth Andrea H
- Nepper Solveig
- Nielsen J E
- Nielsen Mette Gilling
- Niess Anke
- Noguera Perea MarĂa Fuensanta
- Novak Marianne
- Nowak Malgorzata
- O'Donovan Kirsty
- O'Keefe Deidre
- Oehmen Martin
- Olivier Audrey
- Olofsson Carina
- Opala Gregorz
- Orth Michael
- Otti Daniela
- Oughton Emma
- Overland Torborg
- Owen Michael
- Padieu Helene
- Paganini Marco
- Painold Annamaria
- Paridi Dominga
- Pariente Jérémie
- Parkinson Andrew
- Partington-Jones Lucy
- Patel Aakta
- Paterski Laurent
- Patton Michael
- Paucar Martin
- Pearson Pauline
- Peinemann Alexander
- Peppa Nadia
- Perez Maria Rabasa
- Peter Mireille
- Peterson Maria
- Petersén Asa
- Petrollini Martina
- Peña José Chacón
- Piacentini Silvia
- Piano Carla
- Plomhouse Lucie
- Poda Roberto
- Poewe Werner
- Porteous Mary
- Pradella Silvia
- Price Kathleen
- Priller Josef
- Probst Daniela
- ProKoivisto S
- Prundean Adriana
- PrĂŒĂ Harald
- PÀivÀrinta M
- PĂ„lhagen Sven
- Quaranta Davide
- Quarrell Oliver
- Quiroga Purificacion Pin
- Raab Tina
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Ramos-Arroyo Maria A
- Recio Maria FernĂĄndez
- Reetz Kathrin
- Reilmann Ralf
- Reimer Jan
- Reinante Gema
- Reisinger Karin
- RetterstĂžl Lars
- Reza- Soltani Tina Walldén
- Rialland Amandine
- Riballo Antonio Villa
- Ribas Guillermo GarcĂa
- Richter Przemyslaw
- Rickards Hugh
- Rinaldi Carlo
- Rissling Ida
- Ritchie Stuart
- Rivera Susana VĂĄzquez
- Riza-Soltani Tina WaldĂšn
- Rizzo Giovanni
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Roca Elvira
- Roedig Verena
- Rogers Dawn
- Rojo SebastiĂĄn A
- Rola Rafal
- Romano Silvia
- Romero Irene
- Romoli Anna Maria
- Roos R A C
- Roos Raymund A C
- Rose Linda Ellison
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Rossi Fabiana
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Ruddy Deborah
- Rudolf Gabrielle
- RudziĆska Monika
- Russo Cinzia Valeria
- RuĂz BelĂ©n GarzĂłn
- Ryglewicz Danuta
- RĂžren Niini
- SablonniĂšre Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- San MartĂn Esther SuarĂ©z
- Sando Botne
- Sandström Britta
- Santala Maire
- Santhouse Alastair
- Sass Christian
- Savage Lois
- Scaglione Cesa
- Scheibl Monika
- Scherer- Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schrader Christoph
- Schrenk Caroline
- Schuierer Michele
- Schwenk Daniela
- Schöggl Helmut
- SchĂŒpbach Michael
- Sciruicchio Vittorio
- SebastiĂĄn Ana Rojo
- Seliverstov Yury
- SempoĆowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Silva Mark
- Simonin Clémence
- Simpson Sheila
- Sinadinosa Daniela
- Singh Baldev
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Snowden Julie
- Soleti Francesco
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Sorbi Sandro
- Souza Jennyde
- Spadaro Maria
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike Jakob
- Squitieri Ferdinando
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz GisĂšle
- Stenwak Agata
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stubbe Lars
- StÀdtler Michael
- StÄpniak Iwona
- Suarez MarĂa JosĂ© Lama
- Summers Fiona
- Sundblom Jimmy
- SuĆek Anna
- Svennigsson Per
- Svenningsson Per
- Swain Rachel
- Szczudlik Andrzej
- SzczygieĆ ElĆŒbieta
- Szinwelski Michal
- SĂĄnchez JesĂșs
- SĂĄnchez Vicenta
- SĂĄnchez Violeta SĂĄnchez
- SĂŒĂmuth Sigurd
- Tabrizi S J
- Tabrizi Sarah
- Tacik Pawel
- Taylor Catherine
- Taylor Rachel
- Tedr- off Joakim
- Terol Santiago DurĂĄn-Sindreu
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- TimĂłteo Ăngela
- Tomasello Chiara
- Tommaso Marinade
- Torres RodrĂguez MarĂa JosĂ©
- Torres Antequera
- Toscano Jean
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tuuha Katri
- Tyvoll Hilde
- Uhrova T
- Ullah Jasmin
- Ure Alexandra
- Val Javier LĂłpezdel
- Valadas Anabela
- Valentine Ruth
- Valle Natalie
- van den Bogaard Simon J A
- van der Mast Rose C
- van Duijn Erik
- van Hout Monique S E
- van Reijen Dimphna
- van Vugt Jeroen P P
- Vandenberghe W
- Vandenberghe Wim
- Ventura Marta FatĂĄs
- Verellen- Dumoulin C
- Vergara Mar RuĂz
- Vergé Luis Redondo
- Verny Christophe
- Verstraelen Nichola
- Viladrich Celia Mareca
- Villanueva Clara
- Vives Barbara
- Vuillaume Isabelle
- Wagner Caroline
- Wahlström J
- Wahlström Jan
- Walleczek Anna Maria
- Walsem Marleen Rvan
- Wannepain Sandrine
- Warner Thomas
- Weber Sabine
- Weert A Maritde
- Wehus Raghild
- Weindl Adolf
- Wenning Gregor
- Werner Cornelius J
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Widner Hkan
- Wiklund Leif
- Wikström Birgitta
- Wild Edward
- Wild Sue
- Winkelmann Juliane
- Winkler JĂŒrgen
- Winnberg Elisabeth
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- WiĆniewski BartĆomiej
- Wolz Martin
- Wright Abigail
- Wright Jan
- WĂłjcik Magdalena
- Yarduiman Pam
- Yardumian Pam
- Yates Shona
- Yudina Elizaveta
- YĂ©benes Justo GarcĂade
- Zaremba J
- Zaremba Jacek
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zieora-Jakutowicz Karolina
- Zimmermann Marie- Agathe
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Ă man Jaana
- Ăkland Ellen
- Ć aĆĄinkovĂĄ Pavla
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2013
- Field of study
Optimization of adsorptive removal of α-toluic acid by CaO2 nanoparticles using response surface methodology
- Author
- 't Hart Ellen P.
- Aaserud Olaf
- Abbruzzese Giovanni
- Aguilar Barbera Miquel
- Albanese Alberto
- Allain Philippe
- Alonso-Frech Fernando
- Andrews Thomasin
- Andrews Thomasin
- Andrich JĂŒrgen
- Antczak Jakub
- Antequera Torres MarĂa Martirio
- Arran Natalie
- Azulay Jean-Philippe
- Babiloni Blandine
- Bachoud-LĂ©vi A. C.
- Badenes Guia Dolors
- Banaszkiewicz Krzysztof
- Bandettini di Poggio Monica
- Bandmann Oliver
- Barker Roger A.
- Barnes Kathy
- Barrero Francisco
- Barth Katrin
- Barth Katrin
- Bas Jordi
- Bascuñana Garde Mónica
- Bascuñana Garde Mónica
- Bastida Antonio MartĂn
- Bate Louise
- Bechtel Natalie
- Beckmann Heike
- Beister Antonie
- Bellonet Marcellin
- Bentivoglio A. R.
- Bentivoglio Anna Rita
- Bertini Elisabetta
- Bisson Jonathan
- Biunno I.
- Björn Yvonne
- BjĂžrgo Kathrine
- BjĂžrnevoll Inga
- Blinkenberg Ellen Ăkland
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Bolwijn J. J. W.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Boogaerts Andrea
- BorgerĂžd Nancy
- Bos Reineke
- Bos Reineke
- Bosca Maria
- Bourne Colin
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buongiorno Maria Teresa
- Buratti Lisa
- Burg Sabrina
- Burguera Juan Andrés
- Burgunder J. M.
- Burgunder Jean-Marc
- Burgunder Yvonne
- Burn John
- Burns Peter
- Burrows Liz
- Busquets NĂșria
- Busse Monica
- BĂŒrk Kathrin
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Campos Garcia Anabel
- Cannella Milena
- Capellari Sabrina
- Carette Anne-Sophie
- Carrillo FĂĄtima
- Casas Hernanz Laura
- Catalli Claudio
- Causley Aaron
- Cavaco Sara
- Chabot Christelle
- Chacón Peña José
- Cheriet Samia
- Chu Carol
- Chu Carol
- Chu Elvina
- Ciesielska Anna
- Clapton Jackie
- Clayton Carole
- Clenaghan Catherine
- Codella Valentina
- Coelho Miguel
- Coleman Caroline
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Correia Guedes Leonor
- Correia Guedes Leonor
- Cortelli Pietro
- Costa Cristina
- Craufurd David
- Crooks Jenny
- Cubo Esther
- Curtis Adrienne
- CĂĄceres MarĂa Teresa
- Dalmau Elorza Marina
- DamĂĄsio Joana
- de Bruycker Christelle
- de Gregorio Francesca
- de Michele Giuseppe
- de Nicola Nunzia
- de Raedt Sylvie
- de Souza Jenny
- de Tommaso Marina
- de Weert A. Marit
- Debruxelles Sabrina
- Dec Malgorzata
- Decorte Eric
- Dekker M.
- Delliaux Marie
- Delphini Marie
- Delval Arnaud
- di Bella Daniela
- di Donato Stefano
- di Giacopo Raffaella
- di Maio Luigi
- di Maria Emilio
- di Pietro Anna
- Diercks Gabriele
- Difruscolo Olimpia
- Dinca Avarvarei Luminita
- Dipple Heather
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Dujardin Kathy
- Dumas Eve M.
- Dunnett S. B.
- Dunnett Stephen B.
- Duru CĂ©cile
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- European Huntington's Disease Network
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- Uhrova T.
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Vale José
- van den Bogaard Simon J. A.
- van Hout Monique S.
- van Kammen D.
- van Oostrom J. C. H.
- van Reijen Dimphna
- van Vugt Jeroen P.
- van Walsem Marleen R.
- van Walsem Marlene R.
- Vandenberghe Wim
- Vandenberghe Wim
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verny Christophe
- Verstappen C. C. P.
- Verstraelen Nichola
- Verstraelen Nichola
- Villa Riballo Antonio
- Villanueva Clara
- Vivancos Moreau Laura
- Vives Barbara
- VĂĄzquez Rivera Susana
- Wagner Caroline
- Wahlström J.
- Wahlström Jan
- Walleczek Anna Maria
- Wallner M.
- Wannepain Sandrine
- Warner Thomas
- Weber Zaugg Sabine
- Wehus Raghild
- Weindl Adolf
- Wenning Gregor
- Werner Cornelius Johannes
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Widner Hakan
- Wiedemann Alexandra
- Wiklund Leif
- Wikström Birgitta
- Wild E. J.
- Wild Edward
- Wild Sue
- Winnberg Elisabeth
- Witjes-Ané Marie-Noelle
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Wolf Elisabeth
- Wolz Annett
- Wolz Martin
- Wright Abigail
- Wright Jan
- WĂłjcik Magdalena
- Yardumian Pam
- Yates Shona
- Yudina Elizaveta
- Zangerl Anja
- Zaremba J.
- Zaremba Jacek
- Zdzienicka Elzbieta
- Zeman Adam
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Ă man Jaana
- Publication venue
- Elsevier
- Publication date
- 01/01/2011
- Field of study
The present work addresses the optimization of process parameters for adsorptive removal of α-toluic acid by calcium peroxide (CaO2) nanoparticles using response surface methodology (RSM). CaO2 nanoparticles were synthesized by chemical precipitation method and confirmed by Transmission electron microscopy (TEM) and high-resolution TEM (HRTEM) analysis which shows the CaO2 nanoparticles size range of 5â15ânm. A series of batch adsorption experiments were performed using CaO2 nanoparticles to remove α-toluic acid from the aqueous solution. Further, an experimental based central composite design (CCD) was developed to study the interactive effect of CaO2 adsorbent dosage, initial concentration of α-toluic acid, and contact time on α-toluic acid removal efficiency (response) and optimization of the process. Analysis of variance (ANOVA) was performed to determine the significance of the individual and the interactive effects of variables on the response. The model predicted response showed a good agreement with the experimental response, and the coefficient of determination, (R2) was 0.92. Among the variables, the interactive effect of adsorbent dosage and the initial α-toluic acid concentration was found to have more influence on the response than the contact time. Numerical optimization of process by RSM showed the optimal adsorbent dosage, initial concentration of α-toluic acid, and contact time as 0.03âg, 7.06âg/L, and 34âmin respectively. The predicted removal efficiency was 99.50%. The experiments performed under these conditions showed α-toluic acid removal efficiency up to 98.05%, which confirmed the adequacy of the model prediction
Clinical manifestations of intermediate allele carriers in Huntington disease
- Author
- A Marit de Weert
- Aakta Patel
- Abigail Wright
- Abigail Wright
- Adriana Prundean
- Adrien Come
- Adrienne Curtis
- Agata Stenwak
- Agnieszka Gorzkowska
- Agnieszka Konkel
- Aicha Ghenam
- Alain Kaelin
- Aleksandra Kaczmarczyk
- Alessandro Roca
- Alexander MĂŒnchau
- Alexandra Ure
- Alexandre Eusebio
- Alice Seris
- Alison Kraus
- Alma Sikiric
- Alyson Andrew
- Alyson Bradbury
- Alzbeta MĂŒhlbĂ€ck
- Amaia GonzĂĄlez
- Amy Palmer
- Ana Calado
- Ana GarcĂa
- Ana Maria Finisterra
- Ana Maria Finisterra
- Ana Rojo SebastiĂĄn
- Ana Rojo SebastiĂĄn
- Ana Salgueiro
- Anabela Valadas
- Andrea Buck
- Andrea Ginestroni
- Andrea H Nemeth
- Andrea Horta-Barba
- Andrea Kesse
- Andrea Sollom
- Andrew Parkinson
- Andrzej Szczudlik
- Aneta Klimberg
- Angel MartĂnez Pueyo
- Anke Niess
- Anna Ciesielska
- Anna Gogol
- Anna Kaminska
- Anna Maria Romoli
- Anna Rita Bentivoglio
- Anna Rita Dellomonaco
- Anna SuĆek
- Anna Wasielewska
- Anne Kampstra
- Anne Rosser
- Anne Schoonderbeek
- Anne-Catherine Bachoud-LĂ©vi
- Annunziata De Nicola
- Antonella Muroni
- Antonia Campolongo
- Antonio Herranz BĂĄrcenas
- Antonio Villa Riballo
- Ariane Schneider
- Artur Dziadkiewicz
- Arvid Heiberg
- Arvid Heiberg
- ArĂĄnzazu Gorospe
- Ashok Krishnamoorthy
- Ashok Raman
- AsunciĂłn MartĂnez Descals
- AsunciĂłn MartĂnez-Descals
- Audrey Olivier
- Baldev Singh
- Barbara D'Alessio
- Barbara JasiĆska-Myga
- Barbara Kaminski
- Barbara Vives Pastor
- BartĆomiej WiĆniewski
- Beate Rindal
- Beatriz Tijero Merino
- Beatriz Udaeta
- Belén Frades
- Bernhard Landwehrmeyer
- Beverley Hayward
- Beverley Soltysiak
- Bianca Kramer
- Blandine Babiloni
- Bénédicte Gohier
- Calvo S.
- Camille Genoves
- Carina Hvalstedt
- Carlo Rinaldi
- Carlos Salvador
- Carmen AntĂșnez Almagro
- Carmen DurĂĄn Herrera
- Carole Clayton
- Carolin Geitner
- Carolina Mendez Lucena
- Carolina Villa
- Caroline Hallam
- Caroline Peacy
- Carsten Saft
- Cat Taylor
- Caterina Bartoli
- Catherine Bourdet
- Catherine Clenaghan
- Catherine Taylor
- Cecilie Haggag Johannessen
- Charlotte Duché
- Charlotte Eddy
- Charlotte Golding
- Cheryl Stopford
- Chiara Esposito
- Christelle Chabot
- Christian Sass
- Christian Sass
- Christiane Schlangen
- Christina Vangsted-Hansen
- Christine Garreau
- Christine Held
- Christine Held
- Christine Leypold
- Christine Verellen-Dumoulin
- Christine Verellen-Dumoulin
- Christoph Michael Kosinski
- Christoph Schrader
- Christophe Verny
- Christos Ganos
- Cici Feliz Feliz
- Cinzia Valeria Russo
- Claire Thiriez
- Clara Villanueva
- Clarisse Scherer-Gagou
- Claudia Cormio
- Claudia Lamanna
- Claudia Mechi
- Claudia Serpino
- Cornelius J Werner
- Cristina JanuĂĄrio
- Cristina Melgar Fernandez
- Cristina Semedo
- Cubo E.
- Cynthia Butcher
- Cyril Goizet
- CĂšlia Mareca Viladrich
- CĂ©cile Focseneanu
- CĂ©cile Minet
- Daniel Ecker
- Daniel Ecker
- Daniel Stompel
- Daniel Zielonka
- Daniel Zielonka
- Daniela Monza
- Daniela Probst
- Daniela Rae
- Daniela Schwenk
- Danielle LafoucriĂšre
- Danuta Ryglewicz
- David Craufurd
- David Harrison
- Davina Hensman
- Dawn Freire- Patino
- Dawn Rogers
- Dawn Rogers
- Deena Gallantree
- Dirk Dressler
- Dolors Badenes Guia
- Dominique Bonneau Marie Bost
- Dominique Van Paemel
- Dorota BoÄwiĆska
- Edward Wild
- Elena Bellosta Diago
- Elena Ghelli
- Elena LĂłpez
- Elena Salvatore
- Elisabeth Dramstad
- Elisabeth Rosser
- Elisabetta Bertini
- Elizabeth Coulthard
- Elizaveta Yudina
- Ellen P 't Hart
- Elvina Chu
- Elvira Roca
- Elzbieta Zdzienicka
- ElĆŒbieta SzczygieĆ
- Emilia Sitek
- Emma Hobson
- Emma Oughton
- Erika Timewell
- Esther Cubo
- Eugeniusz Zielonka
- Eva Hölzner
- Eva Milkereit
- Eva Pacheco Cortegana
- Eve M Dumas
- Ewa NaroĆŒaĆska
- Ewelina Ciach-Wysocka
- Ewelina Kubowicz
- Fabienne Calvas
- Farideh Badei
- Ferdinando Squitieri
- Fernanda Fortunato
- Fernando Alonso Frech
- Fernando Alonso-Frech
- Filipa JĂșlio
- Fiona Summers
- Flverly Francis
- Francesca De Gregorio
- Francesca Elifani
- Francesca Lovo
- Francesco Marrosu
- Francisco Castera Brugada Carmen PeirĂł Vilaplana
- Franziska Lezius
- Frédérique Fluchere
- Fuensanta Noguera Perea
- FĂĄtima Damas Hermoso
- G Bernhard Landwehrmeyer
- Gabriela KĆodowska-Duda
- Gabriele Diercks
- Gareth Thomas
- Gemma Tome Carruesco
- Gil-Polo CAnne-Catherine Bachoud-LĂ©vi
- Gill Siuda
- Ginette Cass
- Gioia Jacopini
- Giovanni Franco
- Giovanni Ristori
- Gisa Ellrichmann
- Giulia Coarelli
- Giuseppe De Michele
- Graça Morgado
- Grzegorz Opala
- Grzegorz Witkowski
- Grzegorz Witkowski
- Guillermo GarcĂa Ribas
- Gunnel Fredlund
- Halina Sienkiewicz-Jarosz
- Hanan Khalil
- Hannah Musgrave
- Hannele Hypponen
- Heather Dipple
- Heike Beckmann
- Heike Gorzolla
- Helen Fairtlough
- Helen Gundersen
- Helen Murphy
- Helene Padieu
- Heli Hiivola
- Herwig Lange
- Hubert Kwiecinski
- Hugh Rickards
- Husam Samara
- HĂ©lĂšne Grosjean
- Ida Biunno
- Ida Unmack Larsen
- Idaira MartĂn
- Ines Goerendt
- Inés Legarda Ramirez
- Irene Mazzante
- Irene Romero
- Iris Trender-Gerhard
- Isabella Foustanos
- Itziar Gaston
- Ivana Markova
- Iwona StÄpniak
- Jacek AnioĆa Anna Bryl
- Jacek Zaremba
- Jacek Zaremba
- Jaime Kulisevsky Bojarsky
- Jakub Antczak
- Jamie Levey
- Jan Coebergh
- Jan Frich
- Jan Lewerenz
- Jan Lewerenz
- Jan Wahlström
- Jan Wahlström
- Jan Wright
- Jaroslaw Slawek
- Javier Del Val Fernandez
- Javier LĂłpez Del Val
- Javier Pagonabarraga
- Jean Rothery
- Jean Toscano
- Jean-Marc Burgunder
- Jean-Marc Burgunder
- Jean-Philippe Azulay
- Jennifer Thompson
- Jenny Callaghan
- Jenny Callaghan
- Jenny Callaghan
- Jenny Crooks
- Jenny de Souza
- Jenny Schmalfeld
- Jenny Townhill
- Jenny Townhill
- Jeremy Cosgrove
- Jeroen P P van Vugt
- Jerzy Marcinkowski
- Jesus Perez Perez
- JesĂșs Miguel Ruiz Idiago
- Jette Stockholm
- Jill Davison
- Jillian Foster
- Joana Morgado
- Joaquim J Ferreira
- Joaquim J Ferreira
- Johannes Schiefer
- John O Donovan
- John Piedad
- Jordi Bas
- Josh Williams
- Josh Wood
- José Chacón Peña
- José Luis López-Sendón Moreno
- JosĂ© Manuel GarcĂa Moreno
- JosĂ© MatĂas Arbelo
- Joy Read
- Juan Andres Burguera
- Juan Carlos Gomez Esteban
- Juan GarcĂa Caldentey
- Juan GarcĂa Caldentey
- Juan GarcĂa Caldentey
- Juan Manuel Periañez
- Juan MarĂn Muñoz
- Juan Pablo Tartari DĂaz-Zorita
- Judit LĂłpez Catena
- Judith Bek
- Julia Connemann
- Julia Middleton
- Julie Frost
- Julie Prouzet
- Julie Snowden
- Justo GarcĂa de YĂ©benes
- Justyna SempoĆowicz
- Jutta Rummel
- Jérémie Pariente
- JĂžrgen E Nielsen
- JĂžrgen Nielsen
- Kai Boelmans
- Kamila Bojakowska-Jaremek
- Karen Doherty
- Karen Morgan
- Karolina Ziora-Jakutowicz
- Kasia Sieradzan
- Katarzyna Jachinska
- Katherine Tidswell
- Kathleen Fuller
- Kathleen Price
- Kathrin Reetz
- Kathrine BjĂžrgo
- Kathrine Haggag
- Kathryn Dixon
- Katia Youssov
- Katri Tuuha
- Katrin Barth
- Katrin Barth
- Katrina Holmes
- Kay Fillingham
- Kerstin Koppers
- Kerstin Nöth
- Kingsley Powell
- Kirsti Martikainen
- Kirsty Matheson
- Kirsty O'Donovan
- Kirsty O'Donovan
- Koldo Berganzo Corrales
- Krzysztof Banaszkiewicz
- Laetitia Jameau
- Laetitia Vervoitte
- Lars RetterstĂžl
- Lars Stubbe
- Laura Casas Hernanz
- Laura Martinez Martinez
- Laura Mundler
- Laura Vivancos Moreau
- Laurent Cléret
- Laurent Marquine
- Laurent Paterski
- Laurie Lemoine
- Leann Westmoreland
- Leanne Timings
- Lena Hjermind
- Lennard Herrmann
- Leonor Correia Guedes
- Leonor Correia Guedes
- Lesley Gowers
- Lesley Jones
- Lisanne MĂŒtze
- Lisbeth Regeur
- Liselotte Neleborn-LingefjÀrd
- Liv Barnett
- Liz Howard
- Liz Johnson
- Liz Rowett
- Lois Savage
- Lorna Downie
- Lotfi Boudali
- Louise Gethin
- Louise Nevitt
- Lucy Partington-Jones
- Luigi Di Maio
- Luis Menéndez Guisasola
- Luis Redondo
- Lynn Davidson
- Madeleine Fannemel
- Magdalena Boczarska-Jedynak
- Magdalena BĆaszczyk
- Magdalena WĂłjcik
- Maite Paredes Mata
- Malgorzata Krawczyk
- Malgorzata Nowak
- Mandy Longthorpe
- Manuel Almeida
- Marco Massarelli
- Marco Paganini
- Margarida Dias
- Maria Angeles Acera Gil
- Maria Antonia Ramos-Arroyo
- Maria Ascension Zea Sevilla
- Maria Bosca
- Maria Dolores Martinez-Jaurrieta
- Maria Dolores Romero Lemos
- Maria Peterson
- Maria Ramos-Arroyo
- Maria Simonelli
- Marianne Hare
- Marianne Novak
- Marie Delfini
- Marie-Anne Guérid
- Marie-Noelle Witjes-Ané
- Marielle Nowak
- Marina de Tommaso
- Marina Frontali
- Marina Ăvila Villanueva
- Markku PÀivÀrinta
- Marleen R van Walsem
- Marleen van Walsem
- Marloes Verhoeven
- Marta FatĂĄs Ventura
- Marta Para Prieto
- Martin Oehmen
- Martina Di Renzo
- Martina Petrollini
- Martinez-Descalls A.
- Martinez-Horta S.
- Mary Jones
- Maryla Rakowicz
- Maryline Couette
- MarĂa Del Mar Fenollar
- MarĂa JosĂ© Sainz Artiga
- MarĂa Martirio Antequera Torres
- Matilde Calopa
- Matilde LaurĂ
- Matthias Dose
- Maurizio Vezza
- Max Hughes
- Maïté Bertrand
- MaĆgorzata Dec
- Mbombe Kazoka
- Mehdi Sebaiti
- Melisa Vacca
- Meriel McEntagart
- Mette Gilling
- Michael Bachmeier
- Michael Orth
- Michael Orth
- Michael Owen
- Michael Patton
- Michael SchĂŒpbach
- Michal Szinwelski
- Michalina Malec-Litwinowicz
- MichaĆ Arkuszewski
- Michela Ferraldeschi
- Michela Figorilli
- Michelle Phillips
- MichĂšle Pierre
- Miguel Coelho
- Milena Cannella
- Milou Jacobs
- Miquel Aguilar Barbera
- Misericordia Floriach Robert
- Monica Bascuñana Garde
- Monica Busse
- Monica Lewis
- Monica Rodriguez Lopera
- Monika RudziĆska
- Monika RudziĆska
- Monique S E van Hout
- MĂĄrio Miguel Rosa
- Mónica Bascuñana
- Nadia Peppa
- Nadia Peppa
- Nadia RodrĂguez DedichĂĄ
- Nancy BorgerĂžd
- Natalia Grabska
- Natalie Arran
- Natalie Bechtel
- Nathalia Weber
- Natividad Mariscal
- Nayana Lahiri
- Nayana Lahiri
- Neil Fullerton
- Nichola Verstraelen
- Nicola Johns
- Nicola Robertson
- Nicole Göpfert
- Niini RĂžren
- Nils Olav Aanonsen
- Nina Hofstetter
- Noelia RodrĂguez MartĂnez
- Noemi Calzado
- NĂșria Busquets
- Oda Jacobsen
- Oddveig Rosby
- Olaf Aaserud
- Olga Solberg
- Olimpia Difruscolo
- Oliver Bandmann
- Oliver Quarrell
- Olivia J Handley
- Olivia J Handley
- Pablo SĂĄnchez Lozano
- Pam Yardumian
- Pamela Bethwaite
- Paola Zinzi
- Paola Zinzi
- Pascale RibaĂŻ
- Patricia Trigo Cubillo
- Patricia Trigo Cubillo
- Patrick Weydt
- Patrocinio Garcia Moreno
- Paul Gill
- Pavla Ć aĆĄinkovĂĄ
- Pawel Tacik
- Pedro JosĂ© GarcĂa RuĂz
- Penelope Navas Arques
- Per GĂžrvell
- Peter Berglund
- Peter Brockie
- Philippe Allain
- Pia Eklund
- Pierpaolo Sorrentino
- Pilar Quiléz Ferrer
- Piotr Janik
- Piotr Robowski
- Przemyslaw Richter
- Rachel Edwards
- Rachel Taylor
- Radu Constantinescu
- Rafal Rola
- Ragnhild Wehus
- Rainer Hoffmann
- Ralf Marquard
- Ralf Reilmann
- Ramon Fernandez de Bobadilla
- Ramos-Arroyo M. A.
- Raphael M Bonelli
- Raymund A C Roos
- Raymund A C Roos
- Rebecca Minschke
- Reineke Bos
- Reineke Bos
- René Ribacoba
- Richard Armstrong
- RocĂo GarcĂa-Ramos GarcĂa
- RocĂo Malo de Molina
- Roisin Jack
- Roland Raseta
- Rosa Guerrero LĂłpez
- Rupert Noad
- Ruth Fullam
- Ruth Fullam
- Ruth Fullam
- Ruth Valentine
- Sabine Gayde-Stephan
- Sabine Weber Zaugg
- Sabrina Betz
- Sabrina Debruxelles
- Salman Haider
- Salvadora Manzanares
- Samia Cheriet
- Sandra Gutierrez Romero
- Sandra Large
- Sandrine Rolland
- Sandro Sorbi
- Sara Minster
- Sara Minster
- Sarah Hunt
- Sarah J Tabrizi
- Sarah Rose
- Sarah Tabrizi
- Saul Martinez-Horta
- Saul Martinez-Horta
- Selene Capodarca
- Serge JaumĂ Classen
- Shahbana Akhtar
- Sharon McDonnell
- Sheila A Simpson
- Shona Yates
- Sigrun Schepers
- Sigurd SĂŒssmuth
- Silke Rumpf
- Silvia Piacentini
- Silvia Pradella
- Silvia Romano
- Silvio Peluso
- Simon J A van den Bogaard
- Simone Zittel
- Solveig Nepper
- Sonia Arribas Pardo
- Sonia GonzĂĄlez
- Sonja Trautmann
- Stefan Bohlen
- Stefania Bruno
- Stefanie Brown
- Stefanie Rohm
- Stephan Klebe
- Stephanie Hamer
- Stephen B Dunnett
- Stephen Dunnett
- Stuart Jamieson
- Sue McKenzie
- Sue Wild
- Suresh Komati
- Susan Huson
- Susana Pro Koivisto
- Susana Pro Koivisto
- Suzanne Lindquist
- SĂ©bastien Charpentier
- Tecla Tucci
- Tereza Uhrova
- Thomas Musacchio
- Thomas Warner
- Thomasin Andrews
- Tiago Mendes
- Tiago Mestre
- Tiago Mestre
- Tiziana Martino
- Torsten Illmann
- Tua Vinther-Jensen
- Ulrika HĂžsterey-Ugander
- Umberto Spampinato
- Una Jones
- Uruj Anjum
- Ute Hidding
- Valentina Codella
- Valeria Piras
- Valérie Vaquie
- Verena Baake
- Verena Baake
- Veronica Puertas Martin
- Verónica Mañanes Barral
- Vicenta SĂĄnchez
- Vittorio Sciruicchio
- Vivien Vaughn
- Walburgis Heinicke
- Wildson Vieira da Silva
- Wim Vandenberghe
- Wioletta Krysa
- Witold Soltan
- Yanik Stebler
- Yuri Seliverstov
- Zeid Mohammed
- Zosia Miedzybrodzka
- Zygmunt Jamrozik
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2016
- Field of study
Objective: There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. Methods: We assessed a cohort of participants at risk with <36 CAG repeats of the huntingtin (HTT) gene. Outcome measures were the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive, and behavior domains, Total Functional Capacity (TFC), and quality of life (Short Form-36 [SF-36]). This cohort was subdivided into IA carriers (27-35 CAG) and controls (<27 CAG) and younger vs older participants. IA carriers and controls were compared for sociodemographic, environmental, and outcome measures. We used regression analysis to estimate the association of age and CAG repeats on the UHDRS scores. Results: Of 12,190 participants, 657 (5.38%) with <36 CAG repeats were identified: 76 IA carriers (11.56%) and 581 controls (88.44%). After correcting for multiple comparisons, at baseline, we found no significant differences between IA carriers and controls for total UHDRS motor, SF-36, behavioral, cognitive, or TFC scores. However, older participants with IAs had higher chorea scores compared to controls (p 0.001). Linear regression analysis showed that aging was the most contributing factor to increased UHDRS motor scores (p 0.002). On the other hand, 1-year follow-up data analysis showed IA carriers had greater cognitive decline compared to controls (p 0.002). Conclusions: Although aging worsened the UHDRS scores independently of the genetic status, IAs might confer a late-onset abnormal motor and cognitive phenotype. These results might have important implications for genetic counseling. ClinicalTrials.gov identifier: NCT01590589
Cognitive decline in Huntington's disease expansion gene carriers
- Author
- Aanonsen Nils Olaf
- Aaserud Olaf
- Abbruzzese Giovanni
- Akhtar Shahbana
- AlarcĂłn Moreau MarĂa Dolores
- Albanese Alberto
- Allain Philippe
- Almagro Carmen AntĂșnez
- Alonso-Frech Fernando
- Andrade Carlos
- Andrews Thomasin
- Andrich JĂŒrgen
- Anheim Mathieu
- Anjum Uruj
- Annic AgnĂšs
- Antczak Jakub
- Arbelo JosĂ© MatĂas
- Arkuszewski MichaĆ
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Artiga MarĂa JosĂ© Sainz
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-LĂ©vi Anne-Catherine
- Badei Farideh
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barral Verónica Mañanes
- Barrero Francisco
- Barth Katrin
- Barthélémy Recka
- Bartoli Caterina
- Barun Nadia
- Bas Jordi
- Bascuñana Mónica
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benoit Alexandra
- Bentivoglio Anna Rita
- Bentivoglio Anna-Rita
- Berglund Maria
- Berglund MĂ„ns
- Berglund Peter
- Bergmann Ulrike
- Bernard TomĂĄĆĄ
- Berrisoul Hassan
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bioux Sandrine
- Biunno Ida
- BjĂžrgo Kathrine
- BjĂžrnevoll Inga
- Bliaux Evangeline
- Blin Stéphanie
- Blinkenberg Ellen Ăkland
- Blondeau Leily
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boissé Marie-Françoise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonneau Dominique
- BorgeĂžd Nancy
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boster Sarah
- Boudali Lotfi
- Bove Francesco
- BoÄwiĆska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brown Pauline
- Brown Stefanie
- Brugger Florian
- Bruno Stefania
- Bruycker Christelle De
- Bryl Jacek AnioĆa Anna
- Buchanan Lindsay
- Buck Andrea
- Buongiorno MarĂa Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burrows Liz
- Busquets NĂșria
- Busse Monica
- Butcher Cynthia
- BĂĄrcenas Antonio Herranz
- Böringer Regina
- BĂŒrk Katrin
- BĆaszczyk Magdalena
- Cabaret Maryline
- Calandra-Buonaura Giovanna
- Caldentey Juan GarcĂa
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Calzado Noemi
- Campolongo Antonia
- Cannella Milena
- Capellari Sabina
- Capetian Philipp
- Capodarca Selene
- Carette Anne-Sophie
- CarriĂšre Nicolas
- Carruesco Gemma Tome
- Cass Ginette
- Castagliuolo Simona
- Castaldo Anna
- Catalli Claudio
- Catena Judit LĂłpez
- Cavaco Sara
- Cação Gonçalo
- Chabot Christelle
- Charles Perrine
- Cheriet Samia
- Chiara Piccininni
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Classen Serge JaumĂ
- Clayton Carole
- Clenaghan Catherine
- Coarelli Giulia
- Codella Valentina
- Coebergh Jan
- Coelho Miguel
- Come Adrien
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Cortegana Eva MarĂa Pacheco
- Cortelli Pietro
- Cosgrove Jeremy
- Costa Andreia
- Coulthard Elizabeth
- Courtin Françoise
- Couttier Julien
- Craufurd David
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D'Alessio Barbara
- Da Silva Vieira
- DamĂĄsio Joana
- Das Purkayastha Debasish
- Davidson Lynn
- Davison Jill
- De Bobadilla Ramon Fernandez
- De Gregorio Francesca
- De La Cerda Santa MarĂa AndrĂ©s
- De Langavant Laurent Cleret
- De Michele Giuseppe
- De Molina RocĂo Malo
- De Nicola Annunziata
- De Souza Jenny
- De Tommaso Marina
- De Weert A. Marit
- Debilly BĂ©rengĂšre
- Debruxelles Sabrina
- Dec MaĆgorzata
- Decorte Eric
- DedichĂĄ Nadia RodrĂguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Del Mar Fenollar MarĂa
- Del Val Fernandez Javier
- Del ValleLoarte MarĂa
- Delabaere HelĂšne
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Demonet Jean-François
- Depelchin Alizé
- Descals AsunciĂłn MartĂnez
- Destee Alain
- Dewulf-Pasz Nelly
- Deyebenes Justo GarcĂa
- Di Bella Daniela
- Di Donato Stefano
- Di Giacopo Raffaella
- Di Maio Luigi
- Di Maria Emilio
- Di Poggio Monica Bandettini
- Di Renzo Martina
- Dieguez Esther
- Diercks Gabriele
- Difruscolo Olimpia
- Dipple Heather
- Dixon Kathryn
- Doherty Karen
- Dondaine Thibaut
- Donovan John O.
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dramstad Elisabeth
- Dressler Dirk
- Duché Charlotte
- Duda Gabriela KĆodowska E.
- Dugauquier Florence
- Duits Annelien
- Dujardin Kathy
- Dumas Eve M.
- Dunnett Stephen
- Dunnett Stephen B.
- Dupuis Michel
- Durif Franck
- Durr Alexandra
- Duru CĂ©cile
- Dziadkiewicz Artur
- DĂaz-Zorita Juan Pablo Tartari
- Ecker Daniel
- Eddy Charlotte
- Edwards Maureen
- Edwards Rachel
- Eklund Pia
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Esposito Chiara
- Eusebio Alexandre
- Evans Carole
- Ewenczyk Claire
- Fairtlough Helen
- Fannemel Madeleine
- Fasano Alfonso
- Fasquel VĂ©ronique
- Feliz Cici Feliz
- Fernandes Joana
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J.
- Ferrer Pilar Quiléz
- Figuerola Begoña Jeweinat
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flament MĂ©lanie
- Fletcher Amy
- Fluchere Frédérique
- Fortuna Lorenza
- Fortunato Fernanda
- Foster Jillian
- Foustanos Isabella
- Frades Belén
- Francis Flverly
- Francisque HĂ©lĂšne
- Franco Giovanni
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan
- Frich Jan C.
- Frontali Marina
- Fullam Ruth
- Fuller Kathleen
- Fullerton Neil
- Gago Miguel
- Gallantree Deena
- Gallassi Roberto
- Gallentree Deena
- Ganos Christos
- Garcia-Amigot Fermin
- GarcĂa Ana
- GarcĂa RocĂo GarcĂa-Ramos
- Garreau Christine
- Garrett Carolina
- Gaston Itziar
- Gayde-Stephan Sabine
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Genoves Camille
- Gerrtiz Anna
- Gethin Louise
- Ghelli Elena
- Gill Paul
- Gilling Mette
- Ginestroni Andrea
- Girard Carole
- Giuliano Joe
- Godefroy Olivier
- Goerendt Ines
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- GonzĂĄlez Sonia
- Goodman Anna
- Gorospe ArĂĄnzazu
- Gorzkowska Agnieszka
- Gorzolla Heike
- Goudie David
- Gowers Lesley
- Grabska Natalia
- Grosjean HĂ©lĂšne
- Guedes Leonor Correia
- Guenam Aicha
- Guia Dolors Badenes
- Guidubaldi Arianna
- GuimarĂŁes Joana
- Guisasola Luis Menéndez
- Guyant-Maréchal Lucie
- Guzman Natalie Valle
- Guérid Marie-Anne
- Göller Marie-Lousie
- Göpfert Nicole
- GĂžrvell Per F.
- Haggag Kathrine
- Haider Salman
- Hallam Caroline
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Hannequin Didier
- Hannier VĂ©ronique
- Harding Alison
- Hare Marianne
- Harrison David
- Harrower Timothy
- Hartikainen Paivi
- Haug Marte GjĂžl
- Hauge Erik
- Hayward Beverley
- Hecht Karen
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hermoso FĂĄtima Damas
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Duran
- Herrmann Lennard
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Hofstetter Nina
- Holas Christiane
- Holl Anna
- Holmes Katrina
- Hopes Lucie
- Hotter Anna
- Howard Liz
- Hughes Max
- Hunger Ulrike
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hyppönen Hannele
- Hölzner Eva
- HĂžsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago JesĂșs Miguel Ruiz
- Illarioshkin Sergey
- Illmann Torsten
- Ireland Jane
- Irvine Sarah
- Jachinska Katarzyna
- Jack Roisin
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- JanuĂĄrio Cristina
- JasiĆska-Myga Barbara
- Jauffret CĂ©line
- Johannessen Cecilie Haggag
- Johns Nicola
- Johnson Liz
- Jones Lesley
- Jones Mary
- Jones Una
- Jourdain SĂ©verine
- Jung Hans H.
- Justo Damian
- JĂșlio Filipa
- Kaczmarczyk Aleksandra
- Kaelin Alain
- Kaminska Anna
- Kaminski Barbara
- Kammel Gerit
- Kampstra Anne
- Kapfhammer Hans-Peter
- Kassar Abdulrahman
- Kavalier Fred
- Kazoka Mbombe
- Kesse Andrea
- Khalil Hanan
- Klebe Stephan
- KlempĂr JirĂ
- Klimberg Aneta
- Klooster Jesper
- Knight Caroline
- Kohl Zacharias
- Koivisto Susana Pro
- Komati Suresh
- Konkel Agnieszka
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kozay Christina
- Kramer Bianca
- Kraus Alison
- Kraus Peter
- Krawczyk Malgorzata
- Kremer Berry
- Krishnamoorthy Ashok
- Krysa Wioletta
- Krystkowiak Pierre
- Kubowicz Ewelina
- Kwiecinski Hubert
- Ladurner Gunther
- LafoucriĂšre Danielle
- Lagha-Boukbiza Ouhaid
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer Bernhard
- Landwehrmeyer G. Bernhard
- Lange Herwig
- Larcher Barbara
- Large Sandra
- Lashwood Alison
- Lau Puay Ngoh
- LaurĂ Matilde
- Laver Fiona
- Leenders Nico
- Legendre Perrine
- Lemaire Marie-Helene
- Lemoine Laurie
- Lesne Fabien
- Levey Jamie
- Lewerenz Jan
- Lewin Kajsa
- Lewis Monica
- Lezius Franziska
- Ligon-Auer Maria
- Lilek Sabine
- Lilek Stefan
- Linnsand Petra
- Loiseau Sylvie
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera Monica Rodriguez
- Loria Giovanna
- Loureiro Rui
- Loutfi Ghada
- Lovo Francesca
- Lozano Pablo SĂĄnchez
- Lucena Carolina Mendez
- LĂłpez Rosa Guerrero
- Löhle Matthias
- LĂŒsebrink Antje
- Maass Antonia
- MagalhĂŁes Marina
- Magnet Markus
- Mahlknecht Philipp
- Maiwald Robert
- Majeed Tahir
- MajerovĂĄ Veronika
- Malec-Litwinowicz Michalina
- MaltĂȘte David
- Mandich Paola
- Manouvrier Sylvie
- Mantaux BĂ©atrice
- Manzanares Salvadora
- Marcel Christophe
- Marchese Roberta
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martin Veronica Puertas
- Martinez-Horta Saul
- Martinez-Jaurrieta Maria Dolores
- Martino Tiziana
- MartĂn Idaira
- MartĂnez Noelia RodrĂguez
- MartĂnez-Descals AsunciĂłn
- Mason Sarah
- Massano JoĂŁo
- Massarelli Marco
- Matheson Kirsty
- Mazzante Irene
- Mcdonnell Sharon
- Mcentagart Meriel
- Mcfadyen Paula
- Mcgill Marie
- Mckenzie Sue
- Mclean Tim
- Mechi Claudia
- Meier Simone
- Meireles Joana
- Mendes Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milani Paolo
- Milkereit Eva
- Minet CĂ©cile
- Minschke Rebecca
- Minster Sara
- Modoni Anna
- Mohammed Zeid
- Monin Marie-Lorraine
- Monteiro Ana
- Monza Daniela
- Morales Blas
- Moreira InĂȘs
- Moreno José Luis Lópeze-Sendón
- Moreno JosĂ© Manuel GarcĂa
- Moreno Patrocinio Garcia
- Morgado Graca
- Morgan Karen
- Mundler Laura
- Murphy Helen
- Musgrave Hannah
- Mutez Eugénie
- Muñoz Esteban
- Muñoz Juan MarĂn
- MĂ€chtel Miriam
- Möller Carsten
- MĂŒhlau Mark
- MĂŒhlbĂ€ck Alzbeta
- MĂŒller Christoph
- MĂŒller Nicole
- MĂŒnchau Alexander
- MĂŒnkel Kristina
- MĂŒtze Lisanne
- Nanetti Lorenzo
- NarozaĆska Ewa
- Neleborn-LingefjÀrd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Nevitt Louise
- Nielsen JĂžrgen E.
- NiemelÀ Valter
- Niess Anke
- Novak Marianne
- Nowak Malgorzata
- Nowak Marielle
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Neill Mari
- Oehmen Martin
- Olivier Audrey
- Ollokainen Mari
- Olofsson Carina
- Oosterloo Mayke
- Opala Grzegorz
- Orth Michael
- Ossig Christiana
- Otti Daniela
- Oughton Emma
- Owen Michael
- Padieu Helene
- Paganini Marco
- Pagonabarraga Javier
- Painold Annamaria
- Palanca Paloma Millan
- Palmer Amy
- Panzeri Marta
- Pardo Sonia Arribas
- Paridi Dominga
- Pariente Jérémie
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Patel Aakta
- Paterski Laurent
- Patton Michael
- Peacy Caroline
- Pearson Pauline
- Peinemann Alexander
- Peluso Silvio
- Peppa Nadia
- Perea Fuensanta Noguera
- Perez Jesus Perez
- Periañez Juan Manuel
- Peter Mireille
- Petersen Jens A.
- Peterson Maria
- Petersén à sa
- Petracca Martina
- Petrollini Martina
- Peña José Chacón
- Phillipps Clélie
- Phillips Michelle
- Piacentini Silvia
- Piano Carla
- Pica Emmanuel
- Piedad John
- Pierre MichĂšle
- Pinter Bernadette
- Playe Alicia
- Plomhause Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pouliquen Dorothée
- Powell Kingsley
- Pradella Silvia
- Price Kathleen
- Prieto Marta Para
- Priller Josef
- Probst Daniela
- Prouzet Julie
- Prundean Adriana
- PrĂŒĂ Harald
- Pueyo Angel MartĂnez
- PÀivÀrinta Markku
- PĂ„lhagen Sven
- Quaranta Davide
- Quarrell Oliver
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Ramirez Inés Legarda
- Ramos-Arroyo Maria
- Ramos-Arroyo Maria Antonia
- Raseta Rolland
- Redondo Luis
- Reetz Kathrin
- Reijntjes Robert H. A. M.
- Reilmann Ralf
- Reimer Jan
- Reisinger Karin
- Reiter Eva-Magdalena
- RetterstĂžl Lars
- Ribacoba René
- Riballo Antonio Villa
- Ribas Guillermo GarcĂa
- RibaĂŻ Pascale
- Ribbat Michael
- Ribosa Roser
- Richter Przemyslaw
- Rickards Hugh
- Rijntjes Michel
- Rinaldi Carlo
- Rindal Beate
- Ristori Giovanni
- Ritchie Stuart
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Roca Elvira
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Rolland Sandrine
- Romano Silvia
- Romero Irene
- Romero Sandra Gutierrez
- Romoli Anna Maria
- Roos Raymund A. C.
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Roze Emmanuel
- Ruddy Deborah
- Rudolf Gabrielle
- RudziĆska Monika
- Rummel Jutta
- Rumpf Silke
- Russo Cinzia Valeria
- RuĂz Pedro JosĂ© GarcĂa
- Ryglewicz Danuta
- RĂžren Niini
- RĂžsby Oddveig
- SablonniĂšre Bernard
- Saft Carsten
- Salgueiro Ana
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santacruz Pilar
- Santala Maire
- Santhouse Alastair
- Sass Christian
- Savage Lois
- Scaglione Cesa
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schoonderbeek Anne
- Schrader Christoph
- Schwenk Daniela
- Schöggl Helmut
- SchĂŒler BĂ©atrice
- SchĂŒpbach Michael
- Sciruicchio Vittorio
- SebastiĂĄn Ana Rojo
- SempoĆowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sevilla Maria Ascension Zea
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Sikiric Alma
- Silva Mark
- Simonelli Maria
- Simonin Clémence
- Simpson Sheila A.
- Sinadinosa Daniela
- Singh Baldev
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Snowden Julie
- Soleti Francesco
- Solito Marcella
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- SolĂs Pilar
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spagnolo Francesca
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike
- Squitieri Ferdinando
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz GisĂšle
- Stenwak Agata
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stubbe Lars
- StÀdtler Michael
- StĂžrseth Hanna Haugan
- Stȩpniak Iwona
- Summers Fiona
- Sundblom Jimmy
- SuĆek Anna
- Swain Rachel
- Szczudlik Andrzej
- SzczygieĆ Elzbieta
- Szejko Natalia
- Szinwelski Michal
- SĂĄnchez Vicenta
- SĂĄnchez Violeta SĂĄnchez
- SĂŒssmuth Sigurd
- T Hart Ellen P.
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
- Tan Louis
- Tard CĂ©line
- Taroni Franco
- Tataru Alina
- Taylor Anne-Marie
- Taylor Cat
- Taylor Rachel
- Tchikviladzé Maya
- Thibault-Tanchou Stéphanie
- Thiel Silvia
- Thomas Gareth
- Thompson Jennifer
- Thompson Jennifer C.
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Timings Leanne
- Tir MĂ©lissa
- Tomasello Chiara
- Tonner Alison
- Torlizzi Flavia
- Torres MarĂa Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Udaeta Beatriz
- Uhrova Tereza
- Ulla Miguel
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Valentine Ruth
- Van Den Bogaard Simon J. A.
- Van Hout Monique S. E.
- Van Oostrom Joost
- Van Paemel Dominique
- Van Vugt Jeroen P. P.
- Van Walsem Marleen
- Van Walsem Marleen R
- Vandenberghe Wim
- Vaughan Vivien
- Ventura Marta FatĂĄs
- Verellen-Dumoulin Christine
- Verhoeven Marloes
- Verny Christophe
- Verstraelen Nichola
- Verstraelen Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Viladrich CĂšlia Mareca
- Vilaplana Francisco Castera Brugada Carmen PeirĂł
- Villa Carolina
- Villanueva Clara
- Villanueva Marina Ăvila
- Vivancos Laura
- Vogel Melanie
- Vuillaume Isabelle
- Waber Mirella
- Wagner Caroline
- Wahlström Jan
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Widner HĂ„kan
- Wikström Birgitta
- Wild Edward
- Wild Sue
- Wildson SĂ©bastien Charpentier
- Williams Josh
- Winkelmann Juliane
- Winkler JĂŒrgen
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- WiĆniewski BartĆomiej
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wright Abigail
- Wright Jan
- WĂłjcik Magdalena
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zucker Birgit
- Ć aĆĄinkovĂĄ Pavla
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study
- Author
- \u160a\u161inkov\ue1 Pavla
- \u160enk\ue1rov\ue1 Zuzana
- \uc5man Jaana
- Aaserud Olaf
- Abbruzzese Giovanni
- Agarwal Veena
- Akhtar Shahbana
- Alarc\uf3n Moreau Mar\ueda Dolores
- Albanese Alberto
- Allain Philippe
- Almagro Carmen Ant\ufanez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrich J\ufcrgen
- Angeles Maria
- Aniola Jacek
- Anjum Uruj
- Annic Agn\ue8s
- Antczak Jakub
- Arbelo Jos\ue9 Mat\uedas
- Arkuszewski Michal
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Artiga Mar\ueda Jos\ue9 Sainz
- Azulay Jean-Philippe
- B\ue1rcenas Antonio Herranz
- B\uf6ringer Regina
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-L\ue9vi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barral Ver\uf3nica Ma\uf1anes
- Barrero Francisco
- Barth Katrin
- Barth\ue9l\ue9my Recka
- Bas Jordi
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benoit Alexandra
- Bentivoglio Anna Rita
- Berglund Maria
- Berglund Peter
- Bergmann Ulrike
- Berrisoul Hassan
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bioux Sandrine
- Biunno Ida
- Bj\uf6rnsson Elisabeth
- Bj\uf8rgo Kathrine
- Bj\uf8rnevoll Inga
- Blaszczyk Magdalena
- Bliaux Evangeline
- Blin St\ue9phanie
- Blinkenberg Ellen 8kland
- Blondeau Leily
- Bo\u107wi\u144ska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boiss\ue9 Marie-Fran\ue7oise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Borge\uf8d Nancy
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boudali Lotfi
- Bove Francesco
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buchanan Lindsay
- Buck Andrea
- Buongiorno Mar\ueda Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets N\ufaria
- Busse Monica
- Butcher Cynthia
- Cabaret Maryline
- Calado Ana
- Calandra-Buonaura Giovanna
- Caldentey Juan Garc\ueda
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Calzado Noemi
- Campolongo Antonia
- Cannella Milena
- Capellari Sabina
- Capetian Philipp
- Capodarca Selene
- Cardoso Helena
- Carette Anne-Sophie
- Carri\ue8re Nicolas
- Carrillo F\ue1tima
- Carruesco Gemma Tome
- Casado Roc\uedo Villagr\ue1n
- Cass Ginette
- Castagliuolo Simona
- Castaldo Anna
- Catalli Claudio
- Catena Judit L\uf3pez
- Chabot Christelle
- Charles Perrine
- Charpentier S\ue9bastien
- Cheriet Samia
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Classen Serge Jaum\ue1
- Clayton Carole
- Clenaghan Catherine
- Coarelli Giulia
- Codella Valentina
- Coebergh Jan
- Coelho Miguel
- Coleman Caroline
- Come Adrien
- Connemann Julia
- Constant Eric
- Constantinescu Radu
- Cormio Claudia
- Corrales Koldo Berganzo
- Cortegana Eva Mar\ueda Pacheco
- Cortelli Pietro
- Costa Andreia
- Costa Cristina
- Coulthard Elizabeth
- Courtin Fran\ue7oise
- Couttier Julien
- Craufurd David
- Craven Janet
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D\ucdaz-Zorita Juan Pablo Tartari
- Da Silva Wildson Vieira
- Das Purkayastha Debasish
- Davidson Lynn
- Davies Rhys
- Davison Jill
- De Bobadilla Ramon Fernandez
- De Bruycker Christelle
- De Gregorio Francesca
- De La Cerda Santa Mar\ueda Andr\ue9s
- De Langavant Laurent Cleret
- De Michele Giuseppe
- De Molina Roc\uedo Malo
- De Nicola Annunziata
- De Souza Keylock Jenny
- De Tommaso Marina
- De Weert A. Marit
- De Y\ue9benes Justo Garc\ueda
- Debilly B\ue9reng\ue8re
- Debruxelles Sabrina
- Dec Malgorzata
- Decorte Eric
- Dedich\ue1 Nadia Rodr\uedguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Del Mar Fenollar Mar\ueda
- Del Valle Loarte Mar\ueda
- Delabaere Hel\ue8ne
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Demonet Jean-Fran\ue7ois
- Depelchin Aliz\ue9
- Destee Alain
- Dewulf-Pasz Nelly
- DI Bella Daniela
- DI Donato Stefano
- DI Giacopo Raffaella
- DI Maio Luigi
- DI Maria Emilio
- DI Pietro Anna Gerrtiz
- DI Poggio Monica Bandettini
- DI Renzo Martina
- DI\ue9guez Esther
- DIas Margarida
- DIercks Gabriele
- DIfruscolo Olimpia
- DIpple Heather
- Doherty Karen
- Dondaine Thibaut
- Donovan John O
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dramstad Elisabeth
- Dressler DIrk
- Duch\ue9 Charlotte
- Dugauquier Florence
- Duits Annelien
- Dujardin Kathy
- Dumas Eve M.
- Dunnett Stephen
- Dupuis Michel
- Durif Franck
- Durr Alexandra
- Duru C\ue9cile
- Dziadkiewicz Artur
- Ecker Daniel
- Eddy Charlotte
- Edwards Maureen
- Edwards Rachel
- Eklund Pia
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Esposito Federica
- Esteban Juan Carlos Gomez
- Eusebio Alexandre
- Evans Carole
- Ewenczyk Claire
- Fairtlough Helen
- Fannemel Madeleine
- Farewell Daniel
- Fasano Alfonso
- Fasquel V\ue9ronique
- Fernandez Cristina Melgar
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J
- Ferrer Pilar Quil\ue9z
- Figuerola Bego\uf1a Jeweinat
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flament M\ue9lanie
- Fletcher Amy
- Fluchere Fr\ue9d\ue9rique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Foy Kevin
- Frades Bel\ue9n
- Francis Flverly
- Francisque H\ue9l\ue8ne
- Franco Giovanni
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan C.
- Frontali Marina
- Frost Julie
- Fullam Ruth
- Fuller Kathleen
- G\uf6ller Marie-Lousie
- G\uf6pfert Nicole
- G\uf8rvell Per F.
- Gago Miguel
- Gallassi Roberto
- Gallentree Deena
- Ganos Christos
- Garc\ueda Ana
- Garc\ueda Roc\uedo Garc\ueda-Ramos
- Garcia-Amigot Fermin
- Garde M\uf3nica Bascu\uf1ana
- Garrett Carolina
- Gaston Itziar
- Gayde-Stephan Sabine
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Genoves Camille
- Gerrans Emily
- Ghelli Elena
- Gil Acera
- Gill Paul
- Gillardin Anne-Fran\ue7oise
- Gilling Mette
- Ginestroni Andrea
- Girard Carole
- Giuliano Joe
- Godefroy Olivier
- Goerendt Ines
- Gogol Anna
- Gohier B\ue9n\ue9dicte
- Goizet Cyril
- Golding Charlotte
- Gonz\ue1lez Amaia
- Gonz\ue1lez Laura Vargas
- Gonz\ue1lez Sonia
- Good Jean-Marc
- Goodman Anna
- Gorzkowska Agnieszka
- Gorzolla Heike
- Goudie David
- Gowers Lesley
- Grabska Natalia
- Grosjean H\ue9l\ue8ne
- Gu\ue9rid Marie-Anne
- Guedes Leonor Correia
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guimar\ue3es Joana
- Guisasola Luis Men\ue9ndez
- Gunner Kerry
- Guyant-Mar\ue9chal Lucie
- Guzman Natalie Valle
- H\uf6lzner Eva
- H\uf8sterey-Ugander Ulrika
- Haider Salman
- Haig-Brown DIane
- Hallam Caroline
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Hannequin DIdier
- Hannier V\ue9ronique
- Harding Alison
- Hare Marianne
- Harris Kayla
- Harrison David
- Harrower Timothy
- Hart't Ellen P.
- Hartikainen Paivi
- Haug Marte Gj\uf8l
- Hauge Erik
- Hayward Beverley
- Hayward Elaine
- Hecht Karen
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hermoso F\ue1tima Damas
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Dur\ue1n
- Herrmann Lennard
- Heywood Melanie
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Hofstetter Nina
- Holas Christiane
- Holl Anna
- Holmans Peter
- Hopes Lucie
- Hotter Anna
- Howard Liz
- Hughes Alis
- Hughes Max
- Hunger Ulrike
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hypp\uf6nen Hannele
- Ialongo Tamara
- Idiago Jes\ufas Miguel Ruiz
- Ignatius Jaakko
- Illarioshkin Sergey
- Illmann Torsten
- Ireland Jane
- Irvine Sarah
- J\ue4\ue4skalainen Outi
- J\ufalio Filipa
- Jachinska Katarzyna
- Jack Roisin
- Jacobsen Oda
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Janu\ue1rio Cristina
- Jasi\u144ska-Myga Barbara
- Jauffret C\ue9line
- Johns Nicola
- Johnson Liz
- Jones Lesley
- Jones Mary
- Jones Una
- Jourdain S\ue9verine
- Jung Hans H.
- Justo Damian
- K\ue4rpp\ue4 Mikko
- Kaczmarczyk Aleksandra
- Kaelin Alain
- Kaiserova Michaela
- Kajula Outi
- Kaminska Anna
- Kaminski Barbara
- Kammel Gerit
- Kampstra Anne
- Kapfhammer Hans-Peter
- Kassar Abdulrahman
- Kavalier Fred
- Kazoka Mbombe
- Kesse Andrea
- Keys Liane
- Khalil Hanan
- Kipps Christopher
- Klebe Stephan
- Klemp\ued\u159 Ji\u159\ued
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Klooster Jesper
- Knight Caroline
- Kohl Zacharias
- Koivisto Susana Pro
- Komati Suresh
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kozay Christina
- Kramer Bianca
- Kraus Alison
- Kraus Peter
- Krawczyk Malgorzata
- Kremer Berry
- Krishnamoorthy Ashok
- Krysa Wioletta
- Krystkowiak Pierre
- Kubowicz Ewelina
- Kwiecinski Hubert
- L\ue9onard Marie-Claude
- L\uf3pez Rosa Guerrero
- L\uf6hle Matthias
- L\ufcsebrink Antje
- Ladurner Gunther
- Lafoucri\ue8re Danielle
- Lagha-Boukbiza Ouhaid
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer Bernhard
- Lange Herwig
- Larcher Barbara
- Large Sandra
- Larsen Ida Unmack
- Lashwood Alison
- Laur\ue1 Matilde
- Laver Fiona
- Leenders Nico
- Legendre Perrine
- Lemaire Marie-H\ue9l\ue8ne
- Lemoine Laurie
- Lemos Mar\ueda Dolores Romero
- Lesne Fabien
- Levey Jamie
- Lewerenz Jan
- Lewis Monica
- Leypold Christine
- Lezius Franziska
- Ligon-Auer Maria
- Lilek Sabine
- Lilek Stefan
- Lindquist Suzanne
- Linnsand Petra
- Loiseau Sylvie
- Lolk Annette
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera Monica Rodriguez
- Loria Giovanna
- Loutfi Ghada
- Lovo Francesca
- Lozano Pablo S\ue1nchez
- Lucena Carolina Mendez
- Lundsgaard Marianne
- M\ue4chtel Miriam
- M\uf8ller Anette Torvin
- M\ufchlau Mark
- M\ufchlb\ue4ck Alzbeta
- M\ufcller Christoph
- M\ufcller Nicole
- M\ufcnchau Alexander
- M\ufcnkel Kristina
- M\ufctze Lisanne
- Maass Antonia
- MacKinnon Lesley
- Madsen Louise Hasselstr\uf8m
- Magnet Markus
- Mahlknecht Philipp
- Maiwald Robert
- Majeed Tahir
- Majerov\ue1 Veronika
- Malec-Litwinowicz Michalina
- Malt\ueate David
- Mandich Paola
- Mandich Paola
- Manouvrier Sylvie
- Mantaux B\ue9atrice
- Manzanares Salvadora
- Marcel Christophe
- Marchese Roberta
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Marquard Ralf
- Mart\uedn Idaira
- Mart\uednez Noelia Rodr\uedguez
- Mart\uednez-Descals Asunci\uf3n
- Martikainen Kirsti
- Martin Veronica Puertas
- Martinez-Horta Saul
- Martinez-Jaurrieta Maria Dolores
- Martino Tiziana
- Mason Sarah
- Massano Jo\ue3o
- Massarelli Marco
- Mata Maite Paredes
- Matheson Kirsty
- Mazzante Irene
- McDonnell Sharon
- McEntagart Meriel
- McFadyen Paula
- McGill Marie
- McKenzie Sue
- McLean Tim
- McNulty Paul
- Mechi Claudia
- Meier Simone
- Meireles Joana
- Mendes Tiago
- Merino Beatriz Tijero
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milani Paolo
- Milkereit Eva
- Minet C\ue9cile
- Minschke Rebecca
- Minster Sara
- Mir Pablo
- Modoni Anna
- Mohammed Zeid
- Moilanen Jukka
- Monin Marie-Lorraine
- Monteiro Ana
- Monza Daniela
- Morales Blas
- Moreno Jos\ue9 Luis L\uf3pez-Send\uf3n
- Moreno Jose Manuel Garc\ueda
- Moreno Patrocinio Garcia
- Morgado Graca
- Morgado Joana
- Morgan Karen
- Mu\uf1oz Esteban
- Mu\uf1oz Juan Mar\uedn
- Mundler Laura
- Murphy Helen
- Musacchio Thomas
- Musgrave Hannah
- Mustonen Aki
- Mutez Eug\ue9nie
- N\uf6th Kerstin
- Nanetti Lorenzo
- Necuiniate Renata
- Neleborn-Lingefj\ue4rd Liselotte
- Nemeth Andrea H
- Nepper Solveig
- Nevitt Louise
- Nielsen J\uf8rgen
- Niess Anke
- Noad Rupert
- Novak Marianne
- Nowak Malgorzata
- Nowak Marielle
- Nyberg Clara
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Neill Mari
- Oehmen Martin
- Olivier Audrey
- Ollokainen Mari
- Olofsson Carina
- Oosterloo Mayke
- Opala Grzegorz
- Orth Michael
- Ossig Christiana
- Otti Daniela
- Oughton Emma
- Owen Michael
- P\ue4iv\ue4rinta Markku
- P\ue5lhagen Sven
- Padieu Helene
- Paganini Marco
- Pagonabarraga Javier
- Painold Annamaria
- Palanca Paloma Millan
- Palmer Amy
- Panzeri Marta
- Pardo Sonia Arribas
- Paridi Dominga
- Pariente J\ue9r\ue9mie
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Pate Louise
- Patel Aakta
- Paterski Laurent
- Patton Michael
- Paucar Martin
- Paus Karin
- Pe\uf1a Jos\ue9 Chac\uf3n
- Peacy Caroline
- Pearson Pauline
- Peinemann Alexander
- Peippo Maarit
- Peluso Silvio
- Peppa Nadia
- Perea Fuensanta Noguera
- Perez Jesus Perez
- Peria\uf1ez Juan Manuel
- Peter Mireille
- Petersen Jens A.
- Peterson Maria
- Petracca Martina
- Petrollini Martina
- Phillipps Cl\ue9lie
- Phillips Michelle
- Piacentini Silvia
- Piano Carla
- Piccininni Chiara
- Pierre Mich\ue8le
- Pilcher Richard
- Pinter Bernadette
- Playe Alicia
- Plomhause Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pouliquen Doroth\ue9e
- Powell Kingsley
- Pr\ufc f Harald
- Pradella Silvia
- Price Kathleen
- Prieto Marta Para
- Priller Josef
- Probst Daniela
- Prouzet Julie
- Prundean Adriana
- Pueyo Angel Mart\uednez
- Quaranta Davide
- Quarrell Oliver
- R\uf8ren Niini
- R\uf8sby Oddveig
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Ramesh Raviram
- Ramirez In\ue9s Legarda
- Ramos-Arroyo Maria Antonia
- Raseta Rolland
- Redondo Luis
- Redondo Mar\ueda Teresa C\ue1ceres
- Reetz Kathrin
- Regeur Lisbeth
- Reilmann Ralf
- Reisinger Karin
- Reiter Eva-Magdalena
- Retterst\uf8l Lars
- Riba\uef Pascale
- Ribacoba Ren\ue9
- Ribas Guillermo Garc\ueda
- Ribbat Michael
- Ribosa Roser
- Richter Przemyslaw
- Rickards Hugh
- Rijntjes Michel
- Rinaldi Carlo
- Rindal Beate
- Ristori Giovanni
- Ritchie Stuart
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Roca Elvira
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Rolland Sandrine
- Romano Silvia
- Romero Irene
- Romero Sandra Gutierrez
- Romoli Anna Maria
- Roos Raymund A. C.
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Roze Emmanuel
- Ru\uedz Pedro Jos\ue9 Garc\ueda
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzi\u144ska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- Ryglewicz Danuta
- S\ue1nchez Vicenta
- S\ue1nchez Violeta S\ue1nchez
- S\ufcssmuth Sigurd
- Sablonni\ue8re Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santacruz Pilar
- Santala Maire
- Santhouse Alastair
- Sass Christian
- Savage Lois
- Scaglione Cesa
- Sch\uf6ggl Helmut
- Sch\ufcler B\ue9atrice
- Sch\ufcpbach Michael
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schoonderbeek Anne
- Schrader Christoph
- Schwenk Daniela
- Sciruicchio Vittorio
- Sebasti\ue1n Ana Rojo
- Seliverstov Yury
- Semedo Cristina
- Sempolowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sevilla Maria Ascension Zea
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Sikiric Alma
- Silva Mark
- Simonelli Maria
- Simonin Cl\ue9mence
- Simpson Sheila A
- Simpson Steve
- Sinadinosa Daniela
- Singh Baldev
- Sipponen Marjett
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smalley Sarah
- Snowden Julie
- Sol\ueds Pilar
- Soleti Francesco
- Solito Marcella
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spagnolo Francesca
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike
- Squitieri Ferdinando
- St 9pniak Iwona
- St\ue4dtler Michael
- St\uf8rseth Hanna Haugan
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz Gis\ue9le
- Stenwak Agata
- Stockholm Jette
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stubbe Lars
- Sulek Anna
- Summers Fiona
- Sundblom Jimmy
- Svenningsson Per
- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- Tabrizi Sarah
- Tacik Pawel
- Tard C\ue9line
- Taroni Franco
- Tataru Alina
- Taylor Anne-Marie
- Taylor Cat
- Taylor Rachel
- Tchikviladz\ue9 Maya
- Thibault-Tanchou St\ue9phanie
- Thiel Silvia
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Timings Leanne
- Tir M\ue9lissa
- Tomasello Chiara
- Tonner Alison
- Torlizzi Flavia
- Torres Mar\ueda Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Udaeta Beatriz
- Uhrova Tereza
- Ulla Miguel
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Valentine Ruth
- Van De Wyngaerde Fran\ue7oise
- Van Den Bogaard Simon J. A.
- Van Hout Monique S. E.
- Van Oostrom Joost
- Van Paemel Dominique
- Van Reijen Dimphna
- Van Vugt Jeroen P. P.
- Van Walsem Marleen
- Vandenberghe Wim
- Vangsted-Hansen Christina
- Vaughan Vivien
- Ventura Marta Fat\ue1s
- Verellen-Dumoulin Christine
- Verhoeven Marloes
- Vernon Nathan
- Verny Christophe
- Verstappen Carla
- Verstraelen Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Viladrich C\ue8lia Mareca
- Vilaplana Carmen Peir\uf3
- Villa Riballo Antonio
- Villa Carolina
- Villanueva Clara
- Villanueva Marina \uc1vila
- Vingerhoets Francois
- Vinther-Jensen Tua
- Vivancos Laura
- Vogel Melanie
- Vuillaume Isabelle
- W\uf3jcik Magdalena
- Waber Mirella
- Wagner Caroline
- Wahlstr\uf6m Jan
- Wallden Tina
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Weekes Rebecca
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wermuth Lene
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Wi\u15bniewski Bartlomiej
- Wider Christian
- Wikstr\uf6m Birgitta
- Wild Edward
- Wild Sue
- Williams Josh
- Winkelmann Juliane
- Winkler J\ufcrgen
- Witjes-An\ue9 Marie-Noelle
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wright Abigail
- Wright Jan
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Yudina Elizaveta
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'IOS Press'
- Publication date
- 01/01/2018
- Field of study
Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis
Clinical and genetic characteristics of late-onset Huntington's disease
- Author
- Aanonsen Nils Olaf
- Aaserud Olaf
- Abbruzzese Giovanni
- Acera Gil Maria Angeles
- Ackermann Oda
- Adarmes Astrid
- Agarwal Veena
- Agosti Chiara
- Akhtar Shahbana
- Alaerts Nick
- AlarcĂłn MarĂa Dolores
- Albanese Alberto (ORCID:0000-0002-5864-0006)
- Allain Philippe
- Almagro Carmen AntĂșnez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrews Thomasin
- Andrich JĂŒrgen
- Anheim Mathieu
- Anjum Uruj
- Anna Bryl Jacek AnioĆa
- Annic AgnĂšs
- Antczak Jakub
- Antequera Torres MarĂa Martirio
- Antonova Victoria
- Arbelo JosĂ© MatĂas
- Arkuszewski MichaĆ
- Armstrong Richard
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-LĂ©vi Anne-Catherine
- Bachoud-LĂ©vi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandettini di Poggio Monica
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barlati Sergio
- Barral Verónica Mañanes
- Barrero Francisco
- Barrett Wendy
- Barth Katrin
- Barth Katrin
- Barthélémy Recka
- Bartoli Caterina
- Barun Nadia
- Bas Jordi
- Bascuñana Mónica
- Becanovic Kristina
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benaminov Stanislav
- Benito Dolors Moragues
- Bentivoglio Anna Rita (ORCID:0000-0002-9663-095X)
- Bentivoglio Anna-Rita
- Berglund Maria
- Berglund MĂ„ns
- Berglund Peter
- Bergmann Ulrike
- Bernal-Escudero Maravilla
- Bernard TomĂĄĆĄ
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- BezdĂÄek OndĆej
- Bijlsma Emilia K.
- Bioux Sandrine
- Biunno Ida
- Björnsson Elisabeth
- BjĂžrgo Kathrine
- BjĂžrnevoll Inga
- Bled DĂ©borah
- Bliaux Evangeline
- Blin Stéphanie
- Blinkenberg Ellen Ăkland
- Blondeau Leily
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boissé Marie-Françoise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- BorgerĂžd Nancy
- Bos Reineke
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boster Sarah
- Boudali Lotfi
- Bove Francesco
- BoÄwiĆska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brown Pauline
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bruun Anu
- Buchanan Lindsay
- Buck Andrea
- Buongiorno MarĂa Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets NĂșria
- Busse Monica
- Butcher Cynthia
- BĂĄrcenas Antonio Herranz
- Böringer Regina
- BĂŒrk Katrin
- BĆaszczyk Magdalena
- Cabaret Maryline
- Calado Ana
- Calandra-Buonaura Giovanna
- Caldentey Juan GarcĂa
- Caldentey Juan GarcĂa
- Caldentey Juan GarcĂa
- Callaghan Jenny
- Callaghan Jenny
- Callaghan Jenny
- Calmeyn Godelinde
- Calopa Matilde
- Calvas Fabienne
- Calzado Noemi
- Campolongo Antonia
- Cannella Milena
- Capellari Sabina
- Capetian Philipp
- Capodarca Selene
- Cardoso Helena
- Carette Anne-Sophie
- Carrillo FĂĄtima
- CarriĂšre Nicolas
- Carruesco Gemma Tome
- Casado RocĂo VillagrĂĄn
- Cass Ginette
- Castagliuolo Simona
- Castaldo Anna
- Catalli Claudio
- Catena Judit LĂłpez
- Cavaco Sara
- Cação Gonçalo
- Charles Perrine
- Charpentier SĂ©bastien
- Chen Simone
- Cheriet Samia
- Chiara Piccininni
- Chu Carol
- Chu Elvina
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Classen Serge JaumĂ
- Clayton Carole
- Clenaghan Catherine
- Cleret de Langavant Laurent
- Coarelli Giulia
- Codella Valentina
- Coebergh Jan
- Coelho Miguel
- Coleman Caroline
- Come Adrien
- Compostella Silvia
- Connemann Julia
- Constant Eric
- Constantinescu Radu
- Cormio Claudia
- Corrales Koldo Berganzo
- Cortelli Pietro
- Cosgrove Jeremy
- Costa Andreia
- Costa Cristina
- Coulthard Elizabeth
- Couttier Julien
- Craufurd David
- Craven Janet
- Craven Janet
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D'Alessio Barbara
- DamĂĄsio Joana
- Davidson Lynn
- Davies Rhys
- Davison Jill
- De Bruycker Christelle
- de Die-Smulders Christine EM.
- De Gregorio Francesca
- De Michele Giuseppe
- De Nicola Annunziata
- de Raedt Sylvie
- de Souza (Keylock) Jenny
- de Tommaso Marina
- Debilly BĂ©rengĂšre
- Debruxelles Sabrina
- Dec MaĆgorzata
- Decorte Eric
- DedichĂĄ Nadia RodrĂguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Delabaere HelĂšne
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Delvaux Isabelle
- Demonet Jean-François
- Depelchin Alizé
- Derost Philippe
- Descals AsunciĂłn MartĂnez
- Destee Alain
- Dewulf-Pasz Nelly
- Di Bella Daniela
- Di Donato Stefano
- Di Giacopo Raffaella
- Di Maio Luigi
- Di Maria Emilio
- Di Renzo Martina
- Diago Elena Bellosta
- Dias Margarida
- Diercks Gabriele
- Difruscolo Olimpia
- Dipple Heather
- Dixon Kathryn
- Dixon Kathryn
- Diéguez Esther
- Doherty Karen
- Dondaine Thibaut
- Donovan John O.
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dramstad Elisabeth
- Dressler Dirk
- Duché Charlotte
- Duffell Allison
- Dugauquier Florence
- Duits Annelien
- Dujardin Kathy
- Dumas Eve M.
- Dunnett Stephen
- Dunnett Stephen B.
- Duport Sophie
- Dupuis Michel
- Durif Franck
- Durr Alexandra
- Dziadkiewicz Artur
- Ecker Daniel
- Ecker Daniel
- Eddy Charlotte
- Edwards Maureen
- Edwards Rachel
- Eklund Pia
- Ekwall Camilla
- El-Nimr George
- Elifani Francesca
- Ellrichmann Gisa
- Esmaeilzadeh Mouna
- Esposito Chiara
- Esposito Federica
- Eusebio Alexandre
- Evans Carole
- Ewenczyk Claire
- Fairtlough Helen
- Fannemel Madeleine
- Fasano Alfonso
- Feliz Cici
- Fenollar MarĂa del Mar
- Fernandes Joana
- Fernandez de Bobadilla Ramon
- Fernandez Cristina Melgar
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J.
- Ferreira Joaquim J.
- Ferrer Pilar Quiléz
- Figorilli Michela
- Figuerola Begoña Jeweinat
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flamez Anja
- Fletcher Amy
- Fluchere Frédérique
- Fortuna Lorenza
- Fortunato Fernanda
- Foster Jillian
- Foustanos Isabella
- Foy Kevin
- Frades Belén
- Fraisse Sonia
- Francis Flverly
- Francisque HĂ©lĂšne
- Franco Giovanni
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan
- Frich Jan C.
- Frontali Marina
- Frontali Marina
- Frost Julie
- Fullam Ruth
- Fullam Ruth
- Fullam Ruth
- Fuller Kathleen
- Fullerton Neil
- Gago Miguel
- Gallantree Deena
- Gallassi Roberto
- Gallentree Deena
- Ganos Christos
- Ganos Christos
- Garcia-Amigot Fermin
- GarcĂa de YĂ©benes Justo
- GarcĂa Moreno JosĂ© Manuel
- GarcĂa RuĂz Pedro JosĂ©
- GarcĂa Ana
- GarcĂa-Ramos GarcĂa RocĂo
- Garde Monica Bascuñana
- Garrett Carolina
- Gaston Itziar
- Gayde-Stephan Sabine
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Genoves Camille
- Germain VĂ©ronique
- Gerrans Emily
- Gerrtiz (nee Di Pietro) Anna
- Gethin Louise
- Ghelli Elena
- Gill Paul
- Gillardin Anne-Françoise
- Gilling Mette
- Ginestroni Andrea
- Girard Carole
- Giuliano Joe
- Goerendt Ines
- Gogol (formerly Kalbarczyk) Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- Golding Charlotte
- Gomez Esteban Juan Carlos
- GonzĂĄlez Amaia
- GonzĂĄlez Sonia
- Gonçalves Alexandra
- Good Jean-Marc
- Goodman Anna
- Gorzkowska Agnieszka
- Gorzolla Heike
- Gosling (nee Brown) Stefanie
- Goudie David
- Gowers Lesley
- Grabska Natalia
- Guedes Leonor Correia
- Guedes Leonor Correia
- Guenam Aicha
- Guia Dolors Badenes
- Guidubaldi Arianna
- GuimarĂŁes Joana
- Guisasola Luis Menéndez
- Gunner Kerry
- Guyant-Maréchal Lucie
- Guzman Natalie Valle
- Guérid Marie-Anne
- Göller Marie-Lousie
- Göpfert Nicole
- GĂžrvell Per F.
- Haggag Kathrine
- Haider Salman
- Haig-Brown Diane
- Haig-Brown Diane
- Hallam Caroline
- Hamer Stephanie
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Handley Olivia J.
- Hannequin Didier
- Hannier VĂ©ronique
- Harding Alison
- Hare Marianne
- Hare Marianne
- Harris Kayla
- Harrison David
- Harrison Kaye
- Harrower Timothy
- Harrower Timothy
- Hartikainen Paivi
- Haug Marte GjĂžl
- Hauge Erik
- Hayward Beverley
- Hayward Elaine
- Hecht Karen
- Heiberg Arvid
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hermoso FĂĄtima Damas
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen DurĂĄn
- Herrmann Lennard
- Heywood Melanie
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena
- Ho Aileen
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Hofstetter Nina
- Hogenboom Marye
- Holas Christiane
- Holl (formerly Hödl) Anna
- Holmes Katrina
- Hopes Lucie
- Horta Andrea
- Horta Andrea
- Hotter Anna
- Howard Liz
- Hughes Max
- Hunger Ulrike
- Hunt Sarah
- Huson Susan
- Hussain Hasina
- Hussl Anna
- Hvalstedt Carina
- Hyppönen Hannele
- Hölzner Eva
- HĂžsterey-Ugander Ulrika
- Ialongo Tamara
- Ignatius Jaakko
- Illarioshkin Sergey
- Illarioshkin Sergey
- Illmann Torsten
- Ireland Jane
- Irvine Sarah
- Jacek (formerly Rödig
- Jachinska Katarzyna
- Jack Roisin
- Jacobs Milou
- Jacobsen Oda
- Jacopini Gioia
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- JanuĂĄrio Cristina
- Jaramillo Javier Abril
- JasiĆska-Myga Barbara
- Jauffret CĂ©line
- JesĂșs Silvia
- Johannessen Cecilie Haggag
- Johansson Anders
- Johns Nicola
- Johnson Liz
- Jones Lesley
- Jones Mary
- Jones Una
- Jourdain SĂ©verine
- Jung Hans H.
- Jurgens Caroline
- Justo Damian
- JÀÀskelÀinen Outi
- JĂșlio Filipa
- Kaczmarczyk Aleksandra
- Kaelin Alain
- Kaiserova Michaela
- Kajula Outi
- Kaminska Anna
- Kaminski Barbara
- Kammel Gerit
- Kampstra Anne
- Kapfhammer Hans-Peter
- Kassar Abdulrahman
- Kavalier Fred
- Kazoka Mbombe
- Kennedy (nee Smith) Karen
- Kesse Andrea
- Keys Liane
- Khalil Hanan
- Khasanova Diana
- Kipps Christopher
- Klebe Stephan
- Klebe Stephan
- Klempir Jiri
- KlempĂĆ JiĆĂ
- KlempĂĆovĂĄ Olga
- Klimberg Aneta
- Klooster Jesper
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- Koivisto Susana Pro
- Komati Suresh
- Konkel Agnieszka
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- Koppers Kerstin
- Koppitz Michael
- Korotysh Maria
- Kosinski Christoph Michael
- Kozay Christina
- Kramer Bianca
- Kraus Alison
- Kraus Alison
- Kraus Peter
- Krawczyk Malgorzata
- Kremer Berry
- Kremer Berry
- Krishnamoorthy Ashok
- Krysa Wioletta
- Krystkowiak Pierre
- Krystkowiak Pierre
- Kubowicz Ewelina
- Kurbatov Sergey
- Kwiecinski+ Hubert
- KÀrppÀ Mikko
- KĆodowska â Duda Gabriela
- Ladurner Gunther
- LafoucriĂšre Danielle
- Lagha-Boukbiza Ouhaid
- Lahiri Nayana
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer Bernhard
- Landwehrmeyer G. Bernhard
- Lange Herwig
- Lange Herwig
- Larcher Barbara
- Large Sandra
- Larsen Ida Unmack
- Lashwood Alison
- Lau Puay Ngoh
- LaurĂ Matilde
- Laver Fiona
- Leenders Nico
- Legaz Agustina
- Legendre Perrine
- Lemaire Marie-HĂ©lĂšne
- Lemoine Laurie
- Lesne Fabien
- Levey Jamie
- Lewerenz Jan
- Lewerenz Jan
- Lewin Kajsa
- Lewis Monica
- Leypold Christine
- Lezius Franziska
- Liessens Dirk
- Ligon-Auer Maria
- Lilek Sabine
- Lilek Stefan
- Linder Christoph
- Lindquist Suzanne
- Linnsand Petra
- Loarte MarĂa del Valle
- Loiseau Sylvie
- Lolk Annette
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera Monica Rodriguez
- Loria Giovanna
- Loureiro Rui
- Loutfi Ghada
- Lovo Francesca
- Lozano Pablo SĂĄnchez
- Lucena Carolina Mendez
- Lundsgaard Marianne
- LĂ©onard Marie-Claude
- LĂłpez del Val Javier
- LĂłpez Elena
- LĂłpez Rosa Guerrero
- López-Sendón Moreno José Luis
- Löhle Matthias
- LĂŒsebrink Antje
- Maass Antonia
- MacKinnon Lesley
- Madsen Louise HasselstrĂžm
- MagalhĂŁes Andreia
- MagalhĂŁes Marina
- Magnet Markus
- Magzhanov Rim
- Mahlknecht Philipp
- Majeed Tahir
- MajerovĂĄ-Ibarburu Veronika
- Malec-Litwinowicz Michalina
- Malo de Molina RocĂo
- MaltĂȘte David
- Mandich Paola
- Manouvrier Sylvie
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- Marcel Christophe
- Marchese Roberta
- Marchina Eleonora
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Marit de Weert A.
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- van Vugt Jeroen P. P.
- van Walsem Marleen
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- WiĆniewski BartĆomiej
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- Zaremba
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- Zdzienicka Elzbieta
- Zea Sevilla Maria Ascension
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zouitina Yassine
- Zucker Birgit
- Ă man Jaana
- Ăstern Rune
- Ć aĆĄinkovĂĄ Pavla
- Ć enkĂĄrovĂĄ Zuzana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30â50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of â€35 or a UHDRS motor score of â€5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, â0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients