43 research outputs found
Open source and international health informatics: placebo or panacea?
The authors explore the history of open source software and how the future of this paradigm can affect global changes to healthcare informatics. They identify four key requirements:
1 to establish an international health informatics open source (IHI-OS) community
2 to develop a kernel that is broad enough but also provides sufficient detail to be usable across international boundaries and across medical disciplines
3 to develop a business case for international health informatics open source
4 to develop international standards
Timing of antiretroviral therapy and regimen for HIV-infected patients with tuberculosis: the effect of revised HIV guidelines in Malawi
Climate emergency summit III:nature-based solutions report
An RSGS & SNH report from the Climate Summit held in April 2020"The Climate Emergency is the result of burning fossils fuels and changes in the way we use the land that short-circuit global carbon and nitrogen cycles. To remain within safe climate limits (1.5-2°C), the remaining carbon budget for all people, and for all time, is now so small that stopping fossil fuel use, while essential, will not by itself address the problem. Changing the way we use the land and sea is now essential. Nature-based solutions are vital to creating a safe operating space for humanity. "Extract from the foreword by Dr Clive Mitchell, Outcome Manager: People and Nature, Scottish Natural Heritage. The report has 45 contributors for a variety of institutions
A planet within the debris disk around the pre-main-sequence star AU Microscopii
AU Microscopii (AU Mic) is the second closest pre main sequence star, at a
distance of 9.79 parsecs and with an age of 22 million years. AU Mic possesses
a relatively rare and spatially resolved3 edge-on debris disk extending from
about 35 to 210 astronomical units from the star, and with clumps exhibiting
non-Keplerian motion. Detection of newly formed planets around such a star is
challenged by the presence of spots, plage, flares and other manifestations of
magnetic activity on the star. Here we report observations of a planet
transiting AU Mic. The transiting planet, AU Mic b, has an orbital period of
8.46 days, an orbital distance of 0.07 astronomical units, a radius of 0.4
Jupiter radii, and a mass of less than 0.18 Jupiter masses at 3 sigma
confidence. Our observations of a planet co-existing with a debris disk offer
the opportunity to test the predictions of current models of planet formation
and evolution.Comment: Nature, published June 24th [author spelling name fix
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden
Leading Schools During Crisis: What School Administrators Must Know
School leadership is synonymous with challenge. However, some school leaders face true crises - situations threatening the continuing existence of their school. Leading Schools During Crisis analyzes leadership and behaviors of principals in these extraordinary circumstances. A simultaneously scholarly and practice-oriented book, Leading Schools During Crisis proposes the first school-specific model of defining and analyzing crises. Through authentic case studies, Leading Schools During Crisis offers a detailed theoretical and practical analysis of each crisis and the lessons from it for all school leaders.
Highlights of the twelve case studies include: P.S. 234, Manhattan. At nine a.m. on September 11, 2001, the thirty-seven teachers and 650 elementary students of P.S. 234 were twelve hundred feet from Ground Zero. Principal Anna Switzer states, [r]ight when the second plane crashed--that\u27s when we knew that it wasn\u27t an accident. George Washington Carver H.S., New Orleans, Louisiana. Principal Vanessa Eugene believed Katrina would be another chapter in New Orleans\u27 long history of near-miss hurricanes. Carver\u27s campus was soon under ten feet of water. Sobrante Park E.S., Oakland, California. Like many schools, Sobrante Park only slowly realized the paradigm shift associated with the No Child Left Behind Act--until the fifth year of failing to make Adequate Yearly Progress. What do you do when all the data is bad? asked Principal Marco Franco. Platte Canyon H.S, Bailey, Colorado. Principal Brian Krause was approached by a frantic student who reported: \u27[T]here\u27s a guy in the English classroom with a gun\u27 . . . . I remember thinking, okay, he said guy. He didn\u27t say student or kid or Johnny. Other case studies include the challenges inherent in starting charter schools, discovery of systemic and deliberate grade fraud, rezoning of 95 percent of a elementary school\u27s student population, and leading a school populated by changing--and often contentious--refugee groups