Longidorus israelensis sp. n. (Nematoda : Dorylaimoidea), a parasite of carrot in Israel

#Longidorus israelensis sp. n., espèce parthénogénétique associée à des dégâts sur carotte en Israël, est décrite. Cette espèce est caractérisée par une grande longueur du corps (7,1-9,1 mm), une région labiale légèrement en relief et aplatie frontalement, des poches amphidiennes non bilobées, un long odontostyle (125-135 micromètres) et une queue courte, sub-hémisphérique (36-46 micromètres). Elle présente également une disposition inhabituelle des noyaux des glandes oesophagiennes. Les carottes attaquées par #L. israelensis sp. n. voient la croissance de leurs racines stoppée, le départ de racines secondaires et l'apparition de renflements à l'extrémité des racines. Il en résulte des carottes déformées et divisées en pluseiurs parties. Le nématode est généralement rencontré à des profondeurs du sol variant de 20 à 40 cm mais il peut migrer jusqu'à 40-100 cm de profondeur de façon à survivre pendant la période estivale chaude et sèche. (Résumé d'auteur

Optical photometric and spectral study of the new FU Orionis object V2493 Cygni (HBC 722)

Aims. We present new results from optical photometric and spectroscopic observations of the eruptive pre-main sequence star V2493 Cyg (HBC 722). The object has continued to undergo significant brightness variations over the past few months and is an ideal target for follow-up observations. Methods. We carried out CCD BVRI photometric observations in the field of V2493 Cyg (“Gulf of Mexico”) from August 1994 to April 2012, i.e. at the pre-outburst states and during the phases of the outburst. We acquired high, medium, and low resolution spectroscopy of V2493 Cyg during the outburst. To study the pre-outburst variability of the target and construct its historical light curve, we searched for archival observations in photographic plate collections. Both CCD and photographic observations were analyzed using 15 comparison stars in the field of V2493 Cyg. Results. The pre-outburst photographic and CCD photometric observations of V2493 Cyg show low-amplitude light variations typical of T Tauri stars. The recent photometric data show a slow light decrease from October 2010 to June 2011 followed by an increase in brightness that continued until early 2012. The spectral observations of V2493 Cyg are typical of FU Orionis stars absorption spectra with strong P Cyg profiles of Hα and Na I D lines. On the basis of photometric monitoring performed over the past two years, the spectral properties at the maximal light, as well as the shape of long-term light curves, we confirm that the observed outburst of V2493 Cyg is of FU Orionis type

Electronic Transport Properties or Ensembles of Perylene-Substituted Poly-isocyanopeptide Arrays

Contains fulltext : 72261.pdf (publisher's version ) (Closed access)9 p

Black sea observing system

The ultimate goal of modern operational oceanography are end user oriented products with high scientific quality. Beneficiaries are the governmental services, coast and offshore based enterprises and research institutions that make use of the products generated by operational oceanography. Direct users are coastal managers, shipping, search and rescue, oil spill combat, offshore industry, ports, fishing, tourism, and recreation industry. Indirect beneficiaries, through climate forecasting based on ocean observations, are food, energy, water and medical suppliers. Availability of updated information on the actual state as well as forecast of marine environment is essential for the success and safety of maritime operations in the offshore industry. Various systems for the collection and presentation of marine data for the needs of different users have been developed and put in operation in the Black Sea. The systems are located both along the coast and in the open sea and the information they provide is used by both the maritime industry and the widest range of users. The Black Sea Monitoring and Forecasting Center in the frame of the Copernicus Marine Service is providing regular and systematic information about the physical state of the ocean, marine ecosystem and wave conditions in the Black Sea area, assimilating observations, keeping efficient operations, advanced technology and high quality modeling products. Combining and optimizing in situ, remote sensing, modeling and forecasting into a Black Sea observing system is a task that has to be solved, and that will allow to get a more complete and comprehensive picture of the state of the marine environment as well as to forecast future changes of physical and biogeochemical state of the Black Sea and the Black Sea ecosystem

Multiwavelength Intraday Variability of the BL Lac S5 0716+714

We report results from a 1 week multi-wavelength campaign to monitor the BL Lac object S5 0716+714 (on December 9-16, 2009). In the radio bands the source shows rapid (~ (0.5-1.5) day) intra-day variability with peak amplitudes of up to ~ 10 %. The variability at 2.8 cm leads by about 1 day the variability at 6 cm and 11 cm. This time lag and more rapid variations suggests an intrinsic contribution to the source's intraday variability at 2.8 cm, while at 6 cm and 11 cm interstellar scintillation (ISS) seems to predominate. Large and quasi-sinusoidal variations of ~ 0.8 mag were detected in the V, R and I-bands. The X-ray data (0.2-10 keV) do not reveal significant variability on a 4 day time scale, favoring reprocessed inverse-Compton over synchrotron radiation in this band. The characteristic variability time scales in radio and optical bands are similar. A quasi-periodic variation (QPO) of 0.9 - 1.1 days in the optical data may be present, but if so it is marginal and limited to 2.2 cycles. Cross-correlations between radio and optical are discussed. The lack of a strong radio-optical correlation indicates different physical causes of variability (ISS at long radio wavelengths, source intrinsic origin in the optical), and is consistent with a high jet opacity and a compact synchrotron component peaking at ~= 100 GHz in an ongoing very prominent flux density outburst. For the campaign period, we construct a quasi-simultaneous spectral energy distribution (SED), including gamma-ray data from the FERMI satellite. We obtain lower limits for the relativistic Doppler-boosting of delta >= 12-26, which for a BL\,Lac type object, is remarkably high.Comment: 16 pages, 15 figures, table 2; Accepted for Publication in MNRA

Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc

Bacterial cancer therapy was first trialled in patients at the end of the nineteenth century. More recently, tumour-targeting bacteria have been harnessed to deliver plasmid-expressed therapeutic interfering RNA to a range of solid tumours. A major limitation to clinical translation of this is the short-term nature of RNA interference in vivo due to plasmid instability. To overcome this, we sought to develop tumour-targeting attenuated bacteria that stably express shRNA by virtue of integration of an expression cassette within the bacterial chromosome and demonstrate therapeutic efficacy in vitro and in vivo. Results The attenuated tumour targeting Salmonella typhimurium SL7207 strain was modified to carry chromosomally integrated shRNA expression cassettes at the xylA locus. The colorectal cancer cell lines SW480, HCT116 and breast cancer cell line MCF7 were used to demonstrate the ability of these modified strains to perform intracellular infection and deliver effective RNA and protein knockdown of the target gene c-Myc. In vivo therapeutic efficacy was demonstrated using the Lgr5creERT2Apcflx/flx and BlgCreBrca2flx/flp53flx/flx orthotopic immunocompetent mouse models of colorectal and breast cancer, respectively. In vitro co-cultures of breast and colorectal cancer cell lines with modified SL7207 demonstrated a significant 50–95% (P < 0.01) reduction in RNA and protein expression with SL7207/c-Myc targeted strains. In vivo, following establishment of tumour tissue, a single intra-peritoneal administration of 1 × 106 CFU of SL7207/c-Myc was sufficient to permit tumour colonisation and significantly extend survival with no overt toxicity in control animals. Conclusions In summary we have demonstrated that tumour tropic bacteria can be modified to safely deliver therapeutic levels of gene knockdown. This technology has the potential to specifically target primary and secondary solid tumours with personalised therapeutic payloads, providing new multi-cancer detection and treatment options with minimal off-target effects. Further understanding of the tropism mechanisms and impact on host immunity and microbiome is required to progress to clinical translation