5,069 research outputs found
A multi-flow model for microquasars
We present a new picture for the central regions of Black Hole X-ray
Binaries. In our view, these central regions have a multi-flow configuration
which consists in (1) an outer standard accretion disc down to a transition
radius r_J, (2) an inner magnetized accretion disc below r_J driving (3) a non
relativistic self-collimated electron-proton jet surrounding, when adequate
conditions for pair creation are met, (4) a ultra relativistic
electron-positron beam. This accretion-ejection paradigm provides a simple
explanation to the canonical spectral states, from radio to X/gamma-rays, by
varying the transition radius r_J and disc accretion rate independently. Large
values of r_J and low accretion rate correspond to Quiescent and Hard states.
These states are characterized by the presence of a steady electron-proton MHD
jet emitted by the disc below r_J. The hard X-ray component is expect to form
at the jet basis. When r_J becomes smaller than the marginally stable orbit
r_i, the whole disc resembles a standard accretion disc with no jet,
characteristic of the Soft state. Intermediate states correspond to situations
where r_J ~ r_i. At large accretion rate, an unsteady pair cascade process is
triggered within the jet axis, giving birth to flares and ejection of
relativistic pair blobs. This would correspond to the luminous intermediate
state, with its associated superluminal motions.Comment: 12 pages, 3 figures. Proceedings of ``High Energies in the
Highlands'', Fort-William, 27 June-1 July 200
Mammalian models of extended healthy lifespan
Over the last two centuries, there has been a significant increase in average lifespan expectancy in the developed world. One unambiguous clinical implication of getting older is the risk of experiencing age-related diseases including various cancers, dementia, type-2 diabetes, cataracts and osteoporosis. Historically, the ageing process and its consequences were thought to be intractable. However, over the last two decades or so, a wealth of empirical data has been generated which demonstrates that longevity in model organisms can be extended through the manipulation of individual genes. In particular, many pathological conditions associated with the ageing process in model organisms, and importantly conserved from nematodes to humans, are attenuated in long-lived genetic mutants. For example, several long-lived genetic mouse models show attenuation in age-related cognitive decline, adiposity, cancer and glucose intolerance. Therefore, these long-lived mice enjoy a longer period without suffering the various sequelae of ageing. The greatest challenge in the biology of ageing is to now identify the mechanisms underlying increased healthy lifespan in these model organisms. Given that the elderly are making up an increasingly greater proportion of society, this focused approach in model organisms should help identify tractable interventions that can ultimately be translated to humans
Inhibition of Tendon Cell Proliferation and Matrix Glycosaminoglycan Synthesis by Non-Steroidal Anti-Inflammatory Drugs in vitro
The purpose of this study was to investigate the effects of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) on human tendon. Explants of human digital flexor and patella tendons were cultured in medium containing pharmacological concentrations of NSAIDs. Cell proliferation was measured by incorporation of 3H-thymidine and glycosaminoglycan synthesis was measured by incorporation of 35S-Sulphate. Diclofenac and aceclofenac had no significant effect either on tendon cell proliferation or glycosaminoglycan synthesis. Indomethacin and naproxen inhibited cell proliferation in patella tendons and inhibited glycosaminoglycan synthesis in both digital flexor and patella tendons. If applicable to the in vivo situation, these NSAIDs should be used with caution in the treatment of pain after tendon injury and surgery
Transport of Cosmic Rays in Chaotic Magnetic Fields
The transport of charged particles in disorganised magnetic fields is an
important issue which concerns the propagation of cosmic rays of all energies
in a variety of astrophysical environments, such as the interplanetary,
interstellar and even extra-galactic media, as well as the efficiency of Fermi
acceleration processes. We have performed detailed numerical experiments using
Monte-Carlo simulations of particle propagation in stochastic magnetic fields
in order to measure the parallel and transverse spatial diffusion coefficients
and the pitch angle scattering time as a function of rigidity and strength of
the turbulent magnetic component. We confirm the extrapolation to high
turbulence levels of the scaling predicted by the quasi-linear approximation
for the scattering frequency and parallel diffusion coefficient at low
rigidity. We show that the widely used Bohm diffusion coefficient does not
provide a satisfactory approximation to diffusion even in the extreme case
where the mean field vanishes. We find that diffusion also takes place for
particles with Larmor radii larger than the coherence length of the turbulence.
We argue that transverse diffusion is much more effective than predicted by the
quasi-linear approximation, and appears compatible with chaotic magnetic
diffusion of the field lines. We provide numerical estimates of the Kolmogorov
length and magnetic line diffusion coefficient as a function of the level of
turbulence. Finally we comment on applications of our results to astrophysical
turbulence and the acceleration of high energy cosmic rays in supernovae
remnants, in super-bubbles, and in jets and hot spots of powerful
radio-galaxies.Comment: To be published in Physical Review D, 20 pages 9 figure
Pair Plasma Dominance in the Parsec-Scale Relativistic Jet of 3C345
We investigate whether a pc-scale jet of 3C345 is dominated by a normal
plasma or an electron-positron plasma. We present a general condition that a
jet component becomes optically thick for synchrotron self-absorption, by
extending the method originally developed by Reynolds et al. The general
condition gives a lower limit of the electron number density, with the aid of
the surface brightness condition, which enables us to compute the magnetic
field density. Comparing the lower limit with another independent constraint
for the electron density that is deduced from the kinetic luminosity, we can
distinguish the matter content. We apply the procedure to the five components
of 3C345 (C2, C3, C4, C5, and C7) of which angular diameters and radio fluxes
at the peak frequencies were obtainable from literature. Evaluating the
representative values of Doppler beaming factors by their equipartition values,
we find that all the five components are likely dominated by an
electron-positron plasma. The conclusion does not depend on the lower cutoff
energy of the power-law distribution of radiating particles.Comment: 17 page
Coronary steal syndrome after coronary artery bypass for anomalous aortic origin of a coronary artery.
Anomalous aortic origin of a coronary artery found in a symptomatic 9-year-old boy was initially treated with coronary artery bypass grafting using a left internal mammary artery anastomoses to the left anterior descending coronary artery, but resulted in coronary ischemia, likely from a steal phenomenon. Subsequent transection of the proximal left internal mammary artery with anastomosis to the ascending aorta, and coronary ostial enlargement, resulted in a durable treatment. We recommend caution in choosing coronary artery bypass grafting using a left internal mammary artery pedicle graft for the treatment of anomalous aortic origin of a coronary artery
Estimating the functional form for the density dependence from life history data
Two contrasting approaches to the analysis of population dynamics are currently popular: demographic approaches where the associations between demographic rates and statistics summarizing the population dynamics are identified; and time series approaches where the associations between population dynamics, population density, and environmental covariates are investigated. In this paper, we develop an approach to combine these methods and apply it to detailed data from Soay sheep (Ovis aries). We examine how density dependence and climate contribute to fluctuations in population size via age- and sex-specific demographic rates, and how fluctuations in demographic structure influence population dynamics. Density dependence contributes most, followed by climatic variation, age structure fluctuations and interactions between density and climate. We then simplify the density-dependent, stochastic, age-structured demographic model and derive a new phenomenological time series which captures the dynamics better than previously selected functions. The simple method we develop has potential to provide substantial insight into the relative contributions of population and individual-level processes to the dynamics of populations in stochastic environments
Participatory arts interventions promote interpersonal and intergroup prosocial intentions in middle childhood
We report the results of two experiments which test the potential of arts engagement for promoting prosocial intentions. Experiment 1 (N = 216) tested the impact of a participatory arts intervention (vs. a control condition) on children's empathy and interpersonal prosocial intentions. Experiment 2 (N = 174) tested the impact of a participatory arts intervention (vs. a control condition) on children's prosocial intentions toward outgroup members under competitive and non-competitive conditions. Experiment 1 showed that the participatory arts intervention significantly increased children's interpersonal prosocial intentions, but not their empathy. Experiment 2 showed that, under competitive conditions, the participatory arts intervention significantly increased prosocial intentions toward outgroup members, an effect that persisted for six months beyond the intervention. Under non-competitive conditions, the participatory arts intervention consolidated improvements in prosocial intentions toward outgroup members. Overall, the results confirm the hypothesis that participatory arts engagement can promote prosocial intentions during middle childhood
The effects of an experimental programme to support students’ autonomy on the overt behaviours of physical education teachers
Although the benefits of autonomy supportive behaviours are now well established in the literature, very few studies have attempted to train teachers to offer a greater autonomy support to their students. In fact, none of these studies has been carried out in physical education (PE). The purpose of this study is to test the effects of an autonomy-supportive training on overt behaviours of teaching among PE teachers. The experimental group included two PE teachers who were first educated on the benefits of an autonomy supportive style and then followed an individualised guidance programme during the 8 lessons of a teaching cycle. Their behaviours were observed and rated along 3 categories (i.e., autonomy supportive, neutral and controlling) and were subsequently compared to those of three teachers who formed the control condition. The results showed that teachers in the experimental group used more autonomy supportive and neutral behaviours than those in the control group, but no difference emerged in relation to controlling behaviours. We discuss the implications for schools of our findings
Setting the stage: social-environmental and motivational predictors of optimal training engagement
In this paper, we will firstly explore the central tenets of SDT. Research that has examined the social-environmental and motivation-related correlates of optimal training, performance and health-related engagement through the theoretical lens of SDT will be reviewed. Drawing from SDT-driven work undertaken in educational, sport and dance settings, we will draw conclusions and suggest future directions from a research and applied perspective
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