451 research outputs found
Mitigation of Ar/K background for the GERDA Phase II experiment
Background coming from the Ar decay chain is considered to be one of
the most relevant for the GERDA experiment, which aims to search of the
neutrinoless double beta decay of Ge. The sensitivity strongly relies on
the absence of background around the Q-value of the decay. Background coming
from K, a progeny of Ar, can contribute to that background via
electrons from the continuous spectrum with an endpoint of 3.5 MeV. Research
and development on the suppression methods targeting this source of background
were performed at the low-background test facility LArGe. It was demonstrated
that by reducing K ion collection on the surfaces of the broad energy
germanium detectors in combination with pulse shape discrimination techniques
and an argon scintillation veto, it is possible to suppress the K
background by three orders of magnitude. This is sufficient for Phase II of the
GERDA experiment
Glial activation in prion diseases is selectively triggered by neuronal PrPSc
Although prion infections cause cognitive impairment and neuronal death, transcriptional and translational profiling shows progressive derangement within glia but surprisingly little changes within neurons. Here we expressed PrP(C) selectively in neurons and astrocytes of mice. After prion infection, both astrocyte and neuron-restricted PrP(C) expression led to copious brain accumulation of PrPSc. As expected, neuron-restricted expression was associated with typical prion disease. However, mice with astrocyte-restricted PrP(C) expression experienced a normal life span, did not develop clinical disease, and did not show astro- or microgliosis. Besides confirming that PrPSc is innocuous to PrP(C)-deficient neurons, these results show that astrocyte-born PrPSc does not activate the extreme neuroinflammation that accompanies the onset of prion disease and precedes any molecular changes of neurons. This points to a nonautonomous mechanism by which prion-infected neurons instruct astrocytes and microglia to acquire a specific cellular state that, in turn, drives neural dysfunction
KATANA - a charge-sensitive triggering system for the SRIT experiment
KATANA - the Krakow Array for Triggering with Amplitude discrimiNAtion - has
been built and used as a trigger and veto detector for the SRIT TPC at
RIKEN. Its construction allows operating in magnetic field and providing fast
response for ionizing particles, giving the approximate forward multiplicity
and charge information. Depending on this information, trigger and veto signals
are generated. The article presents performance of the detector and details of
its construction. A simple phenomenological parametrization of the number of
emitted scintillation photons in plastic scintillator is proposed. The effect
of the light output deterioration in the plastic scintillator due to the
in-beam irradiation is discussed.Comment: 14 pages, 11 figure
Recommended from our members
Alterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma
Abstract: Psychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors in germ cells. Initial evidence suggested that sperm RNA is causally linked to the transmission of symptoms induced by traumatic experiences. Here, we show that alterations in long RNA in sperm contribute to the inheritance of specific trauma symptoms. Injection of long RNA fraction from sperm of males exposed to postnatal trauma recapitulates the effects on food intake, glucose response to insulin and risk-taking in adulthood whereas the small RNA fraction alters body weight and behavioural despair. Alterations in long RNA are maintained after fertilization, suggesting a direct link between sperm and embryo RNA
Russell-names: an introduction to Millian descriptivism
This essay studies the semantic properties of what I call Russell-names. Russell-names bear intimate semantic relations with descriptive conditions, in consonance with the main tenets of descriptivism. Yet, they are endowed with the semantic properties attributed to ordinary proper names by Millianism: they are rigid and non-indexical devices of direct reference. This is not an essay in natural language semantics, and remains deliberately neutral with respect to the question whether any among the expressions we ordinarily classify as proper names behave as Russell-names. Its aim is rather that of casting a new light on the traditional debate about descriptivism on the one hand, and, on the other, what is commonly understood as a radically anti-descriptivist approach. From the viewpoint of descriptivism, the conceivability of Russell-names provides welcome relief from the pressure exerted by considerations at odds with a flaccid and/or indexical treatment of proper names. Conversely, from a Millian standpoint, the conceivability of Russell-names indicates that the Millian stance, far from providing a meagre picture of names as ‘mere tags’, is at least in principle consistent with the recognition of their semantic bonds with richer descriptive material. The Appendix provides a formal treatment of Russell-names within a model theoretic semantics for indexical intensional languages, developed within an original ‘double-context’ framework
A novel experimental setup for rare events selection and its potential application to super-heavy elements search
The paper presents a novel instrumentation for rare events selection which was tested in our research of short-lived super-heavy elements production and detection. The instrumentation includes an active catcher multi-elements system and dedicated electronics. The active catcher located in the forward hemisphere is composed of 63 scintillator detection modules. Reaction products of damped collisions between heavy-ion projectiles and heavy-target nuclei are implanted in the fast plastic scintillators of the active catcher modules. The acquisition system trigger delivered by logical branch of the electronics allows to record the reaction products which decay via the alpha-particle emissions or spontaneous fission which take place between beam bursts. One microsecond wave form signal from FADCs contains information on heavy implanted nucleus as well as its decays
Characterization of 30 Ge enriched Broad Energy Ge detectors for GERDA Phase II
The GERmanium Detector Array (GERDA) is a low background experiment located
at the Laboratori Nazionali del Gran Sasso in Italy, which searches for
neutrinoless double beta decay of Ge into Se+2e. GERDA has
been conceived in two phases. Phase II, which started in December 2015,
features several novelties including 30 new Ge detectors. These were
manufactured according to the Broad Energy Germanium (BEGe) detector design
that has a better background discrimination capability and energy resolution
compared to formerly widely-used types. Prior to their installation, the new
BEGe detectors were mounted in vacuum cryostats and characterized in detail in
the HADES underground laboratory in Belgium. This paper describes the
properties and the overall performance of these detectors during operation in
vacuum. The characterization campaign provided not only direct input for GERDA
Phase II data collection and analyses, but also allowed to study detector
phenomena, detector correlations as well as to test the strength of pulse shape
simulation codes.Comment: 29 pages, 18 figure
Background free search for neutrinoless double beta decay with GERDA Phase II
The Standard Model of particle physics cannot explain the dominance of matter
over anti-matter in our Universe. In many model extensions this is a very
natural consequence of neutrinos being their own anti-particles (Majorana
particles) which implies that a lepton number violating radioactive decay named
neutrinoless double beta () decay should exist. The detection
of this extremely rare hypothetical process requires utmost suppression of any
kind of backgrounds.
The GERDA collaboration searches for decay of Ge
(^{76}\rm{Ge} \rightarrow\,^{76}\rm{Se} + 2e^-) by operating bare detectors
made from germanium with enriched Ge fraction in liquid argon. Here, we
report on first data of GERDA Phase II. A background level of
cts/(keVkgyr) has been achieved which is the world-best if
weighted by the narrow energy-signal region of germanium detectors. Combining
Phase I and II data we find no signal and deduce a new lower limit for the
half-life of yr at 90 % C.L. Our sensitivity of
yr is competitive with the one of experiments with
significantly larger isotope mass.
GERDA is the first experiment that will be background-free
up to its design exposure. This progress relies on a novel active veto system,
the superior germanium detector energy resolution and the improved background
recognition of our new detectors. The unique discovery potential of an
essentially background-free search for decay motivates a
larger germanium experiment with higher sensitivity.Comment: 14 pages, 9 figures, 1 table; ; data, figures and images available at
http://www.mpi-hd.mpg/gerda/publi
- …