Complexity in forecasting and predictive models

Te challenge of this special issue has been to know the state of the problem related to forecasting modeling and the creation of a model to forecast the future behavior that supports decision making by supporting real-world applications. Tis issue has been highlighted by the quality of its research work on the critical importance of advanced analytical methods, such as neural networks, sof computing, evolutionary algorithms, chaotic models, cellular automata, agent-based models, and fnite mixture minimum squares (FIMIX-PLS).info:eu-repo/semantics/publishedVersio

Retraction: C-reactive protein in aortic valve disease

<p>Abstract</p> <p>A preliminary version of a review article was published in error on 16 October 2006.</p> <p>The correct version of the article had previously been published in <it>Cardiovascular Ultrasound</it>.</p> <p>The authors have agreed that the preliminary version should be retracted.</p

C-reactive protein in aortic valve disease

Aortic Valve Disease, includes a range of disorder severity from mild leaflet thickening without valve obstruction, "aortic sclerosis", to severe calcified aortic stenosis. It is a slowly progressive active process of valve modification similar atherosclerosis for cardiovascular risk factors, lipoprotein deposition, chronic inflammation, and calcification. Systemic signs of inflammation, as wall and serum CRP, similar to those found in atherosclerosis, are present in patients with degenerative aortic valve stenosis and may be expression of a common disease, useful in monitoring of stenosis progression

A perspective on architectural re-engineering

Continuous evolution towards very large, heterogeneous, highly dynamic computing systems entails the need for sound and flexible approaches to deal with system modification and re-engineering. The approach proposed in this paper combines an analysis stage, to identify concrete patterns of interaction in legacy code, with an iterative re-engineering process at a higher level of abstraction. Both stages are supported by the tools CoordPat and Archery, respectively. Bi-directional model transformations connecting code level and design level architectural models are defined. The approach is demonstrated in a (fragment of a) case study.This work is funded by the ERDF through the Programme COMPETE and by FCT, the Portuguese Foundation for Science and Technology, under contract FCOMP-01-0124-FEDER-028923

On the Structure of Dark Matter Halos at the Damping Scale of the Power Spectrum with and without Relict Velocities

We report a series of high-resolution cosmological N-body simulations designed to explore the formation and properties of dark matter halos with masses close to the damping scale of the primordial power spectrum of density fluctuations. We further investigate the effect that the addition of a random component, v_rms, into the particle velocity field has on the structure of halos. We adopted as a fiducial model the Lambda Warm Dark Matter cosmology with a non-thermal sterile neutrino mass of 0.5 keV. The filtering mass corresponds then to M_f = 2.6x10^12 M_sun/h. Halos of masses close to M_f were simulated with several million of particles. The results show that, on one hand, the inner density slope of these halos (at radii <~0.02 the virial radius Rvir) is systematically steeper than the one corresponding to the NFW fit or to the CDM counterpart. On the other hand, the overall density profile (radii larger than 0.02Rvir) is less curved and less concentrated than the NFW fit, with an outer slope shallower than -3. For simulations with v_rms, the inner halo density profiles flatten significantly at radii smaller than 2-3 kpc/h (<~0.010-0.015Rvir). A constant density core is not detected in our simulations, with the exception of one halo for which the flat core radius is ~1 kpc/h. Nevertheless, if ``cored'' density profiles are used to fit the halo profiles, the inferred core radii are ~0.1-0.8 kpc/h, in rough agreement with theoretical predictions based on phase-space constrains, and on dynamical models of warm gravitational collapse. A reduction of v_rms by a factor of 3 produces a modest decrease in core radii, less than a factor of 1.5. We discuss the extension of our results into several contexts, for example, to the structure of the cold DM micro-halos at the damping scale of this model.Comment: 13 pages, 6 figures, accepted for publication in The Astrophysical Journa

Four Phosphonium-based Ionic Liquids. Synthesis, Characterization and Electrochemical Performance as Electrolytes for Silicon Anodes

Herein, we describe the synthesis, characterization and electrochemical performance of four phosphonium-based ionic liquids (ILs) as electrolytes, Physicochemical properties such as viscosity, density, ionic conductivity, and thermal stability of ILs and conventional organic solvent ethylene carbonate (EC)/diethyl carbonate (DEC) were experimentally determined at different temperatures. All ILs showed thermal stability greater than 300 degrees C, surpassing the stability of the conventional organic solvent, whose flash points were 145 and 23 degrees C for EC and DEC, respectively. Nevertheless, at room temperature, all ILs are much more viscous than EC/DEC. The composite Si -[P-2224][FSI] (triethyl-n-butylphosphonium bis(fluoromethylsulfonyl)imide) and Si-EC/DEC anodes exhibit initial specific capacities at 0.15 A/g of 2409 and 2631 mAh/g, respectively. This demonstrates that despite the inferior transport properties of ILs, short alkyl-substituted phosphonium ILs like [P-2224][FSI] are potentially competitive for the new generation of electrolytes for LIBs. NMR, DSC, TGA, and galvanostatic discharged/charged were used as characterization techniques.Peer reviewe

DABCO-customized nanoemulsions: characterization, cell viability and genotoxicity in retinal pigmented epithelium and microglia cells

Quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and of quinuclidine surfactants were used to develop oil-in-water nanoemulsions with the purpose of selecting the best long-term stable nanoemulsion for the ocular administration of triamcinolone acetonide (TA). The combination of the best physicochemical properties (i.e., mean droplet size, polydispersity index, zeta potential, osmolality, viscoelastic properties, surface tension) was considered, together with the cell viability assays in ARPE-19 and HMC3 cell lines. Surfactants with cationic properties have been used to tailor the nanoemulsions surface for site-specific delivery of drugs to the ocular structure for the delivery of TA. They are tailored for the eye because they have cationic properties that interact with the anionic surface of the eye.Portuguese Science and Technology Foundation (FCT) from the Ministry of Science and Technology (MCTES), European Social Fund (FSE) of the EU, for the scholarship SFRH/BD/130555/2017 granted to A. R. Fernandes, and for the projects UIDB/04469/2020 (CEB strategic fund) and UIDB/04033/2020 (CITAB), co-funded by European Funds (PRODER/COMPETE) and FEDER, under the Partnership Agreement PT2020info:eu-repo/semantics/publishedVersio

Human Metapneumovirus Infections during COVID-19 Pandemic, Spain

We describe an unusual outbreak of respiratory infections caused by human metapneumovirus in children during the sixth wave of COVID-19 in Spain, associated with the Omicron variant. Patients in this outbreak were older than usual and showed more hypoxia and pneumonia, longer length of stay, and greater need for intensive care.This study was partially funded by FIS (Fondo de Investigaciones Sanitarias-Spanish Health Research Fund), grant nos. PI06/0532, PI09/0246, PI12/0129, PI18CIII/00009, PI21CIII/00019, and PI21/00377.S