513 research outputs found

    A landscape forensic investigation of the 2021 flood in the Ahr Valley, Germany

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    The Ahr River experienced a catastrophic flood in July 2021, damaging or destroying nearly every home and piece of infrastructure in the valley. Though the river has had serious floods in history, contemporary methods to measure risk failed to account for the qualitative descriptions available and instead referenced a limited qualitative data set that has been collected since 1947. This drastically underdimensioned the risk of flooding for the Ahr during low pressure system "Berndt", which led to approximately €40 billion in damages in the region and the deaths of 135 people in the Ahr Valley alone. A comprehensive plan for disaster risk reduction is necessary but still completely lacking nearly a year after the disaster. The understanding of what is needed to reduce risk has developed through history, with several paradigms that underwent major shifts in how we see nature, spaces, and people as having a role. These paradigms are used to understand the benefits and limitations of planning concepts in each, so that an optimal risk reduction plan can be produced for the Ahr Valley reconstruction.M-GL

    Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus

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    There are several autoimmune and rheumatic diseases affecting different organs of the human body. Multiple sclerosis (MS) mainly affects brain, rheumatoid arthritis (RA) mainly affects joints, Type 1 diabetes (T1D) mainly affects pancreas, Sjogren’s syndrome (SS) mainly affects salivary glands, while systemic lupus erythematosus (SLE) affects almost every organ of the body. Autoimmune diseases are characterized by production of autoantibodies, activation of immune cells, increased expression of pro-inflammatory cytokines, and activation of type I interferons. Despite improvements in treatments and diagnostic tools, the time it takes for the patients to be diagnosed is too long, and the main treatment for these diseases is still non-specific anti-inflammatory drugs. Thus, there is an urgent need for better biomarkers, as well as tailored, personalized treatment. This review focus on SLE and the organs affected in this disease. We have used the results from various rheumatic and autoimmune diseases and the organs involved with an aim to identify advanced methods and possible biomarkers to be utilized in the diagnosis of SLE, disease monitoring, and response to treatment

    Estetisk lesing og lesestrategier- Et bidrag for økt estetisk lesing på småtrinnet

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    Master´s thesis in Primary Teacher Educatio

    Ta steget – en studie av kvinner og deres vei til egen bedrift

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    Masteroppgave i bedriftsøkonomi – Universitetet i Nordland, 201

    Hva er den teoretiske forankringen til det utviklingsstøttende tilknytningsprinsipp, og hvilke implikasjoner har dette for barnevernets tiltaksarbeid?

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    Det ble i 2012 gitt ut Norges offentlige utredninger, nr. 5, Bedre beskyttelse av barns utvikling (NOU 2012:5). Her ble det lagt frem flere anbefalinger som kunne bidra til å bedre barnevernets praksis. Denne oppgaven ser nærmere på noen av forslagene til NOU 2012:5, herunder forslaget om å innføre det utviklingsstøttende tilknytningsprinsipp. Oppgavens problemstilling er: Hva er den teoretiske forankringen til det utviklingsstøttende tilknytningsprinsipp, og hvilke implikasjoner har dette for barnevernets tiltaksarbeid? Oppgaven har todelt problemstilling og i første del gjennomføres en teori- og litteraturstudie for å presentere og drøfte det teoretiske grunnlaget for det utviklingsstøttende tilknytningsprinsipp. For å besvare andre del av problemstillingen er det gjennomført en dokumentanalyse av høringsuttalelsene til NOU 2012:5 for å vise hvordan det nye prinsippet kan ha implikasjoner for barnevernets tiltaksarbeid. Nøkkelord: barnevern, NOU 2012:5, tilknytningsteori, det utviklingsstøttende tilknytningsprinsipp, dokumentanalys

    Hvordan kan friskfaktorene ledelse og arbeidsglede bidra til langtidsfriske medarbeidere?

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    Studentarbeid i økonomi og ledelse (bachelorgrad) - Universitetet i Nordland, 201

    Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus

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    There are several autoimmune and rheumatic diseases affecting different organs of the human body. Multiple sclerosis (MS) mainly affects brain, rheumatoid arthritis (RA) mainly affects joints, Type 1 diabetes (T1D) mainly affects pancreas, Sjogren’s syndrome (SS) mainly affects salivary glands, while systemic lupus erythematosus (SLE) affects almost every organ of the body. Autoimmune diseases are characterized by production of autoantibodies, activation of immune cells, increased expression of pro-inflammatory cytokines, and activation of type I interferons. Despite improvements in treatments and diagnostic tools, the time it takes for the patients to be diagnosed is too long, and the main treatment for these diseases is still non-specific anti-inflammatory drugs. Thus, there is an urgent need for better biomarkers, as well as tailored, personalized treatment. This review focus on SLE and the organs affected in this disease. We have used the results from various rheumatic and autoimmune diseases and the organs involved with an aim to identify advanced methods and possible biomarkers to be utilized in the diagnosis of SLE, disease monitoring, and response to treatment

    Economic Gain vs. Ecological Pain—Environmental Sustainability in Economies Based on Renewable Biological Resources

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    There are two main international strategies concerning how to ensure a sustainable environment: one is to develop a globally bio-based economy, or bioeconomy, to meet the increased demand of goods and products to maintain our well-being and to reduce climate change. On the other hand, there is an aim to decrease the negative impacts on nature and natural habitats to conserve and maintain ecosystems and control the loss of biodiversity. There is a trade-off between these two strategies; as we increase the commitment to the bioeconomy by intensifying biomass production, we will simultaneously challenge biodiversity through the increased pressure on, and the utilization of, biological raw materials. Here, we first review and discuss the challenges and opportunities in terrestrial and marine ecosystems for the production of biomass for the bioeconomy. We focus on the trade-offs between economic sustainability on one hand, and environmental sustainability and resilience on the other hand. We conclude with a discussion of the various bioeconomy strategies. Finally, we present a conceptual model on how to sustainably develop the bioeconomies (by introducing the concept of optimizing the economic gain/ecological pain ratio) to be able to manage the biodiversity in a sustainable way.publishedVersio
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