Il ruolo della scuola nel contrasto alla violenza di genere e le opportunità offerte dal programma operativo nazionale

Relating on recent gender equality and gender opportunities laws and regulations, thispaper will deepen gender education’s relevance in the Educational system, relying onthe outcomes of the questionnaire addressed to gather data on gender education in Italianschools, provided by For School: skills and learning environments 2014-2020, NationalOperational Programme (NOP).Gender-based violence’s preventative measures survey allowed to focus on best practices’indicators: temporal and educational continuity, schoolteachers training, communitykey stakeholders’collaboration, development of specific instruments to promoteinvolved actors self-audit and reflectiveness.Obiettivo di questo lavoro è proporre una riflessione sull’educazione di genere nellescuole, con riferimento in particolare alle azioni di contrasto alla violenza di genere, anchealla luce della recente normativa. Le osservazioni qui presentate si basano sull’analisi deidati di un questionario rivolto alle scuole, realizzato da INDIRE per conto dell’Autorità diGestione del PON “Per la scuola: Competenze e ambienti per l’apprendimento” finalizzatoa monitorare i progetti realizzati dalle scuole su tali tematiche. La rilevazione sui progettidi prevenzione e di contrasto della violenza di genere ha consentito di individuare degliindicatori di buona pratica: la continuità temporale ed educativa dei progetti; la formazionedei docenti; il coinvolgimento dei soggetti del territorio; l’uso di strumenti per favorire lariflessività e l’autovalutazione

The GAPS Programme with HARPS-N at TNG. XV. A substellar companion around a K giant star identified with quasi-simultaneous HARPS-N and GIANO measurements

Context. Identification of planetary companions of giant stars is made difficult because of the astrophysical noise, that may produce radial velocity variations similar to those induced by a companion. On the other hand any stellar signal is wavelength dependent, while signals due to a companion are achromatic. Aims: Our goal is to determine the origin of the Doppler periodic variations observed in the thick disk K giant star TYC 4282-605-1 by HARPS-N at the Telescopio Nazionale Galileo (TNG) and verify if they can be due to the presence of a substellar companion. Methods: Several methods have been used to exclude the stellar origin of the observed signal including a detailed analysis of activity indicators and bisector and the analysis of the photometric light curve. Finally, we have conducted an observational campaign to monitor the near-infrared (NIR) radial velocity with GIANO at the TNG in order to verify whether the NIR amplitude variations are comparable with those observed in the visible. Results: Both optical and NIR radial velocities show consistent variations with a period at 101 days and similar amplitude, pointing to the presence of a companion orbiting the target. The main orbital properties obtained for our giant star with a derived mass of M = 0.97 ± 0.03M☉ are M_Psini = 10.78 ± 0.12M_J; P = 101.54 ± 0.05 days; e = 0.28 ± 0.01 and a = 0.422 ± 0.009 AU. The chemical analysis shows a significant enrichment in the abundance of Na I, Mg I, Al I, and Si I while the rest of the analyzed elements are consistent with the solar value demonstrating that the chemical composition corresponds with an old K giant (age = 10.1 Gyr) belonging to local thick disk. Conclusions: We conclude that the substellar companion hypothesis for this K giant is the best explanation for the observed periodic radial velocity variation. This study also shows the high potential of multi-wavelength radial velocity observations for the validation of planet candidates. Based on observations collected at the Italian Telescopio Nazionale Galileo (TNG), operated on the island of La Palma by the Fundación Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de Los Muchachos of the Instituto de Astrofísica de Canarias, in the frame of the programme Global Architecture of Planetary Systems (GAPS)

The GAPS Programme at TNG. XXVIII. A pair of hot-Neptunes orbiting the young star TOI-942

Context. Young stars and multi-planet systems are two types of primary objects that allow us to study, understand, and constrain planetary formation and evolution theories. Aims: We validate the physical nature of two Neptune-sized planets transiting TOI-942 (TYC 5909-319-1), a previously unacknowledged young star (50-20+30 Myr) observed by the TESS space mission in Sector 5. Methods: Thanks to a comprehensive stellar characterization, TESS light curve modeling and precise radial-velocity measurements, we validated the planetary nature of the TESS candidate and detected an additional transiting planet in the system on a larger orbit. Results: From photometric and spectroscopic observations we performed an exhaustive stellar characterization and derived the main stellar parameters. TOI-942 is a relatively active K2.5V star (log R'HK = -4.17 ± 0.01) with rotation period Prot = 3.39 ± 0.01 days, a projected rotation velocity v sin i⋆ = 13.8 ± 0.5 km s-1, and a radius of ~0.9 R⊙. We found that the inner planet, TOI-942 b, has an orbital period Pb = 4.3263 ± 0.0011 days, a radius Rb = 4.242-0.313+0.376 R⊕, and a mass upper limit of 16 M⊕ at 1σ confidence level. The outer planet, TOI-942 c, has an orbital period Pc = 10.1605-0.0053+0.0056 days, a radius Rc = 4.793-0.351+0.410 R⊕, and a mass upper limit of 37 M⊕ at 1σ confidence level. Based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated by the Fundación Galileo Galilei (FGG) of the Istituto Nazionale di Astrofisica (INAF) at the Observatorio del Roque de los Muchachos (La Palma, Canary Islands, Spain). The authors became aware of a parallel effort on the characterization of TOI-942 by Zhou et al. (2021) in the late stages of the manuscript preparations. The submissions are coordinated, and no analyses or results were shared prior to submission

Immaginario di genere: pratiche educative = Imagery of gender: educational practices

In this work we present some reflections on the relationship between education and gender issues. In particular, we will focus on the role of school in deconstructing imaginaries linked to stereotyped views of the masculine and feminine

Synthesis and Biological Evaluation of Quinoxaline Derivatives for PET Imaging of the NMDA Receptor

Due to the biological complexity of the N-methyl-d-aspartate receptor (NMDAR), the development of a positron emission tomography radiotracer for the imaging of NMDAR has met with limited success. Recent studies have established the presence of GluN2A subunit of the NMDAR in the heart and its role in the regulation of intracellular calcium levels. In our efforts to develop an imaging agent for the GluN2A subunit, we designed three new compounds based on a quinoxaline scaffold. The synthesis of the analogues was based on a two-step Kabachnik–Fields reaction in sequence with Suzuki cross-coupling and acid hydrolysis. They exhibited comparable high binding affinity values below 5 nm. A two-step radiolabeling procedure was successfully developed for the synthesis of [18F]1. [18F]1 was obtained in a modest overall radiochemical yield of 5.5 ± 4.2%, a good specific radioactivity of 254 ± 158 GBq/μmol, and a radiochemical purity > 99%. While compounds 2 and 3 showed comparable binding affinity towards NMDAR, sluggish radiolabeling, prevented their further evaluation. For [18F]1, in vitro autoradiography on rat heart slices demonstrated heterogeneous but unspecific accumulation, whereas for the brain a high in vitro specificity towards NMDAR, could be demonstrated

Design, Synthesis, and Pharmacological Characterization of Indole-3-ylacetamides, Indole-3-yloxoacetamides, and Indole-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists

In our search for new cannabinoid receptor modulators, we describe herein the design and synthesis of three sets of indole-based ligands characterized by an acetamide, oxalylamide, or carboxamide chain, respectively. Most of the compounds showed affinity for CB2 receptors in the nanomolar range, with Ki values spanning 3 orders of magnitude (377−0.37 nM), and moderate to good selectivity over CB1 receptors. Their in vitro functional activity as inverse agonists was confirmed in vivo in the formalin test of acute peripheral and inflammatory pain in mice, in which compounds 10a and 11e proved to be able to reverse the effect of the CB2 selective agonist COR16

Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor

Two recently reported hit compounds, COR627 and COR628, underpinned the development of a series of 2-(acylamino)thiophene derivatives. Some of these compounds displayed significant activity in vitro as positive allosteric modulators of the GABAB receptor by potentiating GTPγS stimulation induced by GABA at 2.5 and 25 μM while failing to exhibit intrinsic agonist activity. Compounds were also found to be effective in vivo, potentiating baclofen-induced sedation/hypnosis in DBA mice when administered either intraperitoneally or intragastrically. Although displaying a lower potency in vitro than the reference compound GS39783, the new compounds 6, 10, and 11 exhibited a higher efficacy in vivo: combination of these compounds with a per se nonsedative dose of baclofen resulted in shorter onset and longer duration of the loss of righting reflex in mice. Test compounds showed cytotoxic effects at concentrations comparable to or higher than those of GS39783 or BHF177

Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.

Three heterocyclic systems were selected as potential bioisosteres of the amide linker for a series of 1,6-disubstituted-4-quinolone-3-carboxamides, which are potent and selective CB2 ligands that exhibit poor water solubility, with the aim of improving their physicochemical profile and also of clarifying properties of importance for amide bond mimicry. Among the newly synthesized compounds, a 1,2,3-triazole derivative (1-(adamantan-1-yl)-4-[6-(furan-2-yl)-1,4-dihydro-4-oxo-1-pentylquinolin-3-yl]-1H-1,2,3-triazole) emerged as the most promising in terms of both physicochemical and pharmacodynamic properties. When assayed in vitro, this derivative exhibited inverse agonist activity, whereas, in the formalin test in mice, it produced analgesic effects antagonized by a well-established inverse agonist. Metabolic studies allowed the identification of a side chain hydroxylated derivative as its only metabolite, which, in its racemic form, still showed appreciable CB2 selectivity, but was 150-fold less potent than the parent compound