Impaired mesial synchronization in temporal lobe epilepsy

Objective: Temporal lobe epilepsy is commonly associated with synchronous, hyper-synchronous and des-synchronous activity. The aim of the present work is to explore synchronization activity in both mesial areas in temporal lobe epileptic patients during the interictal state. Methods: Using a cluster technique, we analyzed 17 temporal lobe epilepsy patients’ records of foramen ovale electrodes activity during the inter-ictal state. Results: There exists a clear tendency in the mesial area of the epileptic side to be organized as isolated clusters of electrical activity as compared with the contra-lateral side, which is organized in the form of large clusters of synchronous activity. The number of desynchronized areas is larger in the epileptic side than in the contra-lateral side in 16 out of 17 temporal lobe epileptic patients. Conclusions: The mesial area responsible for the seizures is less synchronous than the contra-lateral; the different kind of synchronous organization accounts for a lower synchronization activity at the epileptic side, suggesting that this lack of synchronous cluster organization would favour the appearance of seizures. Significance: Our results shed new light regarding synchronization issues in temporal lobe epilepsy and also it would help in reducing drastically the time of study.Fil: Ortega, Guillermo José. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Peco, Iván Herrera. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; EspañaFil: Sola, Rafael G.. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; EspañaFil: Pastor, Jesús. Universidad Autonoma de Madrid. Hospital Universitario de la Princesa; Españ

The Process Controller for the LHCb On-LIne Farm

The Process Controller is a tool of the LHCb FMC (Farm Monitoring and Control System) in charge of keeping a list of applications up and running on the farm nodes. It tipically runs on a few control PCs each one watching ~200 farm nodes and performs its task by maintaining the list of scheduled applications for each controlled farm node and by interacting with the Task Manager Servers running on the farm nodes to start processes, to obtain the notification of process termination, to re-spawn the terminated processes (if requested) and to stop processes. Processes can be added to or removed from the scheduled application list for one or more nodes by means of DIM commands, while DIM services provide the list of scheduled applications for each controlled farm node together with their properties, the number of re-spawns and the re-spawn times

The Power Manager for the LHCb On-Line Farm

The Power Manager is a tool of the LHCb FMC (Farm Monitoring and Control System) which allows - in an OS-independent manner and without requiring expensive network-controlled power distributors - to switch the farm nodes on and off, and to monitor their physical condition: power status (on/off), temperatures, fan speeds and voltages. The Power Manager can operate on farm nodes whose motherboards and network interface cards implement the IPMI (Intelligent Platform Management Interface) specifications, version 1.5 or subsequent, and copes with several IPMI limitations

Co-creation Processes Contributing to the Societal Impact of Science: Contributions from the Net4Impact Network

La participación ciudadana a lo largo del desarrollo de los proyectos de investigación ha demostrado aumentar el impacto social de la ciencia. Los procesos de cocreación promueven un impacto social más significativo al alinear la investigación con las necesidades sociales. En los últimos años se han identificado importantes avances en materia de participación ciudadana en la ciencia. Sin embargo, todavía existen importantes retos que limitan la interacción de la ciudadanía con las creaciones científicas. Este artículo recoge algunas de las aportaciones de la red Net4Impact frente a estos retos. Concretamente, analizamos los procesos de cocreación desarrollados por proyectos que han demostrado impacto social. Este estudio cualitativo se basa en el análisis de Webinars, reuniones con investigadores de diferentes áreas científicas y en el Análisis de Contenido Comunicativo. Como resultado, este trabajo ofrece seis ejemplos de impacto social en tres áreas científicas: ciencias sociales, humanidades e ingeniería. Además, se analizan las características e implicaciones de los distintos procesos de cocreación desarrollados por estos proyectos exitosos

Local step-flow dynamics in thin film growth with desorption

Desorption of deposited species plays a role in determining the evolution of surface morphology during crystal growth when the desorption time constant is short compared to the time to diffuse to a defect site, step edge or kink. However, experiments to directly test the predictions of these effects are lacking. Novel techniques such as \emph{in-situ} coherent X-ray scattering can provide significant new information. Herein we present X-ray Photon Correlation Spectroscopy (XPCS) measurements during diindenoperylene (DIP) vapor deposition on thermally oxidized silicon surfaces. DIP forms a nearly complete two-dimensional first layer over the range of temperatures studied (40 - 120 $^{\circ}$C), followed by mounded growth during subsequent deposition. Local step flow within mounds was observed, and we find that there was a terrace-length-dependent behavior of the step edge dynamics. This led to unstable growth with rapid roughening ($\beta>0.5$) and deviation from a symmetric error-function-like height profile. At high temperatures, the grooves between the mounds tend to close up leading to nearly flat polycrystalline films. Numerical analysis based on a 1 + 1 dimensional model suggests that terrace-length dependent desorption of deposited ad-molecules is an essential cause of the step dynamics, and it influences the morphology evolution.Comment: 21 pages, 9 figures, and one tabl

Storage Infrastructure at the INFN LHC Tier-1

In this paper we will describe the Storage Infrastructure of the INFN-CNAF Tier-1, used to store data of High Energy Physics experiments, in particular those operating at the Large Hadron Collider

Realfood and cancer: analysis of the reliability and quality of YouTube content

This study analyzes the quality and reliability of videos related to nutrition and cancer on YouTube. Study Design: An observational, retrospective, cross-sectional, time-limited study analyzing activity on the social network YouTube was proposed. Methods: The information from the videos was extracted through an API search tool, using the NodeXL software. The criteria to select the videos on YouTube were the keywords “real food”, “realfood”, and “cancer” and the hashtags #realfood and #cancer were present, videos in English and videos available on 1 December 2022. Results: The DISCERN value in the total number of videos viewed was 2.25 (±0.88) points, indicating low reliability. The videos uploaded by HRU represented only 20.8%. Videos suggesting that the use of foods defined as “real food” could cure cancer without the intervention of any other treatment accounted for 12.5%. Videos that provided external links to scientific/technical evidence verifying the information represented only 13.89% of the total number of videos. Of these videos, 70% corresponded to HRU. The DISCERN value for videos from HRU users was 3.05 (0.88), a value that reflects a good reliability of videos from these users. Conclusions: This study provides information on the content and quality of the videos that we can find on YouTube. We found videos of non-health users who do not base their content on any scientific evidence, with the danger that this entails for the population, but it also highlights that the videos published by HRU have greater reliability and quality, being better perceived by the population, so it is important to encourage healthcare professionals and health institutions to share verified information on YouTube.This research was funded by Fundación Banco Santander and Fundación Alfonso X el Sabio, grant number 1014011. Partial funding for open access charge: Universidad de Málag

Steel cathodic protection afforded by zinc, aluminium and zinc/aluminium alloy coatings in the atmosphere

Zinc has traditionally been the metallic material most widely used to protect steel against atmospheric corrosion due to its ability to afford cathodic protection to steel in all types of natural atmospheres. In recent decades, aluminium and zinc/aluminium alloy coatings have been used instead of zinc in certain atmospheric applications. Although these coatings present some advantages over zinc, they are not able to cathodically protect steel substrates in all types of natural atmospheres. The present paper assesses the cathodic protection afforded by Al (flame spraying), Al/13 Si (hot dipping), 55Al/Zn (hot dipping), Zn/15Al (flame spraying), Zn/5Al (hot dipping), Zn (hot dipping), Zn (discontinuous hot dipping) and Zn (electroplating). Aluminium and aluminium-rich alloy coatings (55%Al/Zn) provide cathodic protection to the steel substrate only in atmospheres that are highly contaminated with chloride ions (>100 mg Cl- m-2 day-1) where these coatings become active. © 2004 Elsevier B.V. All rights reserved.Peer Reviewe

TRY plant trait database - enhanced coverage and open access

Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives

Time to focus on outcome assessment tools for childhood vasculitis

Childhood systemic vasculitides are a group of rare diseases with multi-organ involvement and potentially devastating consequences. After establishment of new classification criteria (Ankara consensus conference in 2008), it is now time to establish measures for proper definition of activity and damage in childhood primary vasculitis. By comparison to adult vasculitis, there is no consensus for indices of activity and damage assessment in childhood vasculitis. Assessment of disease activity is likely to become a major area of interest in pediatric rheumatology in the near future. After defining the classification criteria for primary systemic childhood vasculitis, the next step was to perform a validation study using the original Birmingham vasculitis activity score as well as the disease extent index to measure disease activity in childhood vasculitis. Presently, there are efforts in place to develop a pediatric vasculitis activity score. This paper reviews the current understanding about the assessment tools (i.e., clinical features, laboratory tests, radiologic assessments, etc.) widely used for evaluation of the disease activity and damage status of the children with vasculitis