Growth strategies in mature destinations: Linking spatial planning with product development

To rejuvenate a destination means to develop growth strategies whilst in a phase of maturation or stagnation. Stagnation tendencies have been prevalent in Alpine tourism since the 1980’s. In recent years, mature destinations in the Alps have attempted to maintain their appeal by defining and inventing new products and promotions rather than by further market penetration. The rapid (spatial) growth of tourism enterprises in the 1960’s and 1970’s in the Alpine destination South Tyrol led to restrictive spatial legislation and as a result, greatly limited the quantitative and qualitative development capacities of hotel businesses in these mature destinations. Consequently, the entrepreneurs in South Tyrol and the surrounding region often perceive spatial planning as a restrictive instrument limiting the growth and strategic planning and development of their enterprises. In 2007, after a period of stagnation, the South Tyrolean legislature opened up possibilities of quantitative growth for tourism enterprises, but connected it with an obligatory spatial planning and strategy concept for the entire municipality. Consequently, the municipality has to justify the declaration of new tourism zones by demonstrating the potential for growth in tourism. The aim of this paper is to demonstrate, by way of the three South Tyrolean municipalities, that spatial planning and strategic tourism development are not necessarily conflictive but that spatial planning, in combination with tourism planning and product development, can be a pro-active and creative tool with an important role in developing and implementing growth in mature destinations. As such, the scope of both spatial planning and product development have been jointly defined and tested in a case study

The structural stabilization of the κ three-way junction by Mg(II) represents the first step in the folding of a group II intron

Folding of group II introns is characterized by a first slow compaction of domain 1 (D1) followed by the rapid docking of other domains to this scaffold. D1 compaction initiates in a small subregion encompassing the κ and ζ elements. These two tertiary elements are also the major interaction sites with domain 5 to form the catalytic core. Here, we provide the first characterization of the structure adopted at an early folding step and show that the folding control element can be narrowed down to the three-way junction with the κ motif. In our nuclear magnetic resonance studies of this substructure derived from the yeast mitochondrial group II intron Sc.ai5γ, we show that a high affinity Mg(II) ion stabilizes the κ element and enables coaxial stacking between helices d′ and d′′, favoring a rigid duplex across the three-way junction. The κ-element folds into a stable GAAA-tetraloop motif and engages in A-minor interactions with helix d′. The addition of cobalt(III)hexammine reveals three distinct binding sites. The Mg(II)-promoted structural rearrangement and rigidification of the D1 core can be identified as the first micro-step of D1 foldin

On the fate of singularities and horizons in higher derivative gravity

We study static spherically symmetric solutions of high derivative gravity theories, with 4, 6, 8 and even 10 derivatives. Except for isolated points in the space of theories with more than 4 derivatives, only solutions that are nonsingular near the origin are found. But these solutions cannot smooth out the Schwarzschild singularity without the appearance of a second horizon. This conundrum, and the possibility of singularities at finite r, leads us to study numerical solutions of theories truncated at four derivatives. Rather than two horizons we are led to the suggestion that the original horizon is replaced by a rapid nonsingular transition from weak to strong gravity. We also consider this possibility for the de Sitter horizon.Comment: 15 pages, 3 figures, improvements and references added, to appear in PR

Energy in Generic Higher Curvature Gravity Theories

We define and compute the energy of higher curvature gravity theories in arbitrary dimensions. Generically, these theories admit constant curvature vacua (even in the absence of an explicit cosmological constant), and asymptotically constant curvature solutions with non-trivial energy properties. For concreteness, we study quadratic curvature models in detail. Among them, the one whose action is the square of the traceless Ricci tensor always has zero energy, unlike conformal (Weyl) gravity. We also study the string-inspired Einstein-Gauss-Bonnet model and show that both its flat and Anti-de-Sitter vacua are stable.Comment: 18 pages, typos corrected, one footnote added, to appear in Phys. Rev.

Extended Gravity Theories and the Einstein-Hilbert Action

I discuss the relation between arbitrarily high-order theories of gravity and scalar-tensor gravity at the level of the field equations and the action. I show that $(2n+4)$-order gravity is dynamically equivalent to Brans-Dicke gravity with an interaction potential for the Brans-Dicke field and $n$ further scalar fields. This scalar-tensor action is then conformally equivalent to the Einstein-Hilbert action with $n+1$ scalar fields. This clarifies the nature and extent of the conformal equivalence between extended gravity theories and general relativity with many scalar fields.Comment: 12 pages, Plain Latex, SUSSEX-AST-93/7-

KULTURNI TURIZAM KAO KONKURENTNI ČIMBENIK U MEDITERANSKOM TURIZMU - Komparativna studija japanskog i njemačkog izvornog tržišta za talijansku kulturnu baštinu

The Mediterranean region is a delicate area of living, exposed to severe trouble that may be caused even by minor influences, e.g. military conflicts. Therefore, it is necessary to search for useful long-term solutions for tourism in the countries of this region. Due to the abundance of cultural assets, cultural tourism becomes ever more important. On the other hand, the weak points of product development and marketing become apparent in spite of great demand. This empirical study determines the needs of people potentially interested in visiting Italy with the example of the source markets in Japan and in Germany, particularly considering cultural tourism with specific consideration of castles and stately homes. Having determined these needs, it will be possible to show the required consequences for product development and marketing at a local, regional, national and international level.Mediteran je osjetljivo područje za život, izloženo ozbiljnom problemu koji može biti izazvan i neznatnim utjecajem npr. vojnim konfliktima. Zbog toga je potrebno tražiti korisna dugoročna rješenja za turizam u zemljama tog područja. Zbog obilja kulturnog bogatstva kulturni turizam postaje još važniji. S druge strane, slabe točke razvoja proizvoda i marketinga bivaju očevidni unatoč velikoj potražnji. Ova empirijska studija utvrđuje potrebe ljudi, potencijalno zainteresiranih da posjete Italiju s primjerom izvornih tržišta Japana i Njemačke, osobito u svezi kulturnog turizma sa specifičnim naglaskom dvoraca i otmjenih obiteljskih kuća. Nakon što smo utvrdili te potrebe biti će moguće pokazati potrebna djelovanja za razvoj proizvoda i marketinga na lokalnoj, područnoj, nacionalnoj i međunarodnoj razini

Hospitality entrepreneurs managing quality of life and business growth

The hospitality industry is dominated by small- and medium-sized enterprises (SMEs).They are often led by entrepreneurs who face the challenge of simultaneously managing business decisions and their own wellbeing. The competitiveness of tourism destinations often depends on these entrepreneurs and therefore understanding their motivations and work patterns is critical. Research on individual wellbeing increasingly builds on the concept of quality of life (QoL). Hospitality and tourism literature so far predominantly focused on investigating QoL for tourists and residents, rather than for entrepreneurs’ QoL, even though being key stakeholders in the hospitality industry. Therefore, this study explores the factors influencing hospitality entrepreneurs’ quality of life (“HE-QoL”) and how these relate to business growth. Results of a 380 hospitality entrepreneurs’ survey identify six distinct factors of HE-QoL. Two groups of HE-QoL are identified with significant differences in fitness level activity, entrepreneurial competencies and business growth. Findings lead to recommendations to reduce stress to improve HE-QoL, and to develop entrepreneurial competencies, which help to cope with entrepreneurial challenges. Tourism destinations and politics can support hospitality entrepreneurs in these actions by creating conditions that foster social exchange in regional communities and trust in political and economic stability

Destination Design: A heuristic case study approach to sustainability-oriented innovation

The landscape of research outputs in tourism planning is fragmented and multi-disciplinary. Design as a meta-discipline has the power to integrate sectoral thought and inject creativity, non-linear thought and transdisciplinarity into planning processes, particularly when tackling sustainability challenges. This paper defines Destination Design as a novel framework capable of evolving the concepts of spatial and participatory planning using the design thinking cognitive style to address sustainability paradoxes. The features of are explored through the unique case study of sustainability-oriented innovation in the Dolomites UNESCO World Heritage Site. Results show that design thinking can be invaluable for pioneering pro-sustainability initiatives. Further, creative forms of engagement might encourage the acceptance and support of local transformations, but are difficult to implement

Ineffective off-label use of recombinant activated factor VII in a case of bone-marrow transplantation-related gastrointestinal bleeding

BACKGROUND: For patients with a normal coagulation system, who experience serious bleeding, sound evidence for recombinant activated factor VII (rFVIIa) as an effective haemostatic agent is only scarcely available so far from controlled clinical trials. In systematic reviews on the clinical use of rFVIIa, treatment failures were only rarely reported. CASE PRESENTATION: We present a 45-year old, Caucasian male with persistent intestinal bleeding due to enterocolitis associated with cytomegalovirus infection and acute graft-versus-host-disease. He had received allogeneic peripheral blood stem cell transplantation from an unrelated HLA-identical donor because of chronic myelogenous leukaemia diagnosed two years earlier. Bleeding started at day 18 after transplantation with bloody diarrhea, which was treated with multiple transfusions of fresh frozen plasma, platelet, and red blood cell concentrates, and continued relentlessly, despite all efforts, including continued transfusions, high-dose prednisolone, broad antibiotic and antiviral coverage, and tranexamic acid. Recombinant FVIIa was started at boluses of 90–120 μg/kg every 4–8 hours. Despite more than 10 doses, recurrent severe bleeding progressed to refractory shock, multiorgan failure and death. CONCLUSIONS: Little can be concluded from single case reports of clinical improvement, because publication bias in favour of positive effects is likely. Our case suggests that rFVIIa is not a panacea, in particular for severe bleeding after bone-marrow transplantation. As long as rigorous, controlled studies or comprehensive registries are lacking, conventional interventions remain the standard of care in non-haemophilic patients with severe bleeding