El estado del arte de la tecnología al servicio de la construcción

Throughout history, the concept of evolution has been applied in all known domains. Homes may be said to constitute technology inasmuch as they adopt objects, tools and designs geared to fulfilling the most important human aspirations such as comfort, safety, status, rest, harmony, nutrition and so forth. Human beings have always looked to their surroundings to acquire such technology - the technology characteristic of each age. What this article intends to convey, therefore, is how humanity deals with this constant evolution in the context of today’s technologies, as well as the laws of supply and demand in market economies.The integration, application and implementation of a combination of technologies in home architecture is known as domotics, a term widely used but apparently not entirely satisfactory to all concerned. Industry consensus has been reached, however, around the objective of all this evolution, which is none other than to furnish useful applications and services for all the inhabitants of a home or a community.The present article provides an overview of the new concept ”Intelligent environment” and all it entails, discussing origins, contributions, surrounding social environment and a brief description of the various technologies and services available at this time, while stressing the gradual growth of the concept.El concepto de evolución se ha aplicado siempre en todos los ámbitos conocidos a lo largo de nuestra historia. Se podría decir que el hogar es tecnología en cuanto al hecho de que incorpora en la medida de lo posible objetos, herramientas y diseños orientados a los objetivos humanos más importantes como la comodidad, seguridad, status, descanso, convivencia, alimentación, etc. Para conseguir esa tecnología, el ser humano siempre se ha valido del entorno y, por tanto, de la tecnología de cada época. Lo que se pretende dar a conocer es, por tanto, cómo enfoca el ser humano esta constante evolutiva de acuerdo a las tecnologías que conocemos en la actualidad, atendiendo a las ofertas y demandas del mercado.La integración, aplicación y puesta en marcha de la combinación de tecnologías en la arquitectura del hogar, se conoce en la actualidad como Domótica, aunque ni siquiera el término que se maneja parece complacer en cierta medida a los vinculados al sector. Cierto es que en lo que se está de acuerdo es en que el objetivo de toda esta evolución es conseguir aplicaciones y servicios de utilidad para todos los habitantes del hogar o de una comunidad.En este artículo se presenta una visión global sobre todo lo que rodea al nuevo concepto de “Entorno Inteligente”, distinguiendo sus orígenes, aportaciones, el entorno social que lo envuelve, así como la mención a las distintas tecnologías y servicios existentes, siempre destacando el crecimiento progresivo del concepto

Generació de la corba d'oferta a partir de les dades públiques del MIBEL

Research Report, Dept. of Statistics and Operations Research, UPC.Preprin

Potential protective role of reactive astrocytes in the periventricular parenchyma in congenital hydrocephalus

Background Cerebrospinal fluid accumulation in hydrocephalus produces an elevation of intraventricular pressure with pathological consequences on the periventricular brain parenchyma including ischemia, oedema, oxidative stress, and accumulation of metabolic waste products. Here we studied in the hyh mouse, an animal model of congenital hydrocephalus, the role of reactive astrocytes in this clinical degenerative condition. Materials and Methods Wild type and hydrocephalic hyh mice at 30 days of postnatal age were used. Three metabolites related to the oxidative and neurotoxic conditions were analysed in ex vivo samples (glutathione, glutamine and taurine) using High Resolution Magic Angle Spinning (HR-MAS). Glutathione synthetase and peroxidase, glutamine synthetase, kidney-type glutaminase (KGA), and taurine/taurine transporter were immunolocated in brain sections. Results Levels of the metabolites were remarkably higher in hydrocephalic conditions. Glutathione peroxidase and synthetase were both detected in the periventricular reactive astrocytes and neurons. Taurine was mostly found free in the periventricular parenchyma and in the reactive astrocytes, and the taurine transporter was mainly present in the neurons located in such regions. Glutamine synthetase was found in reactive astrocytes. Glutaminase was also detected in the reactive astrocytes and in periventricular neurons. These results suggest a possible protective response of reactive astrocytes against oxidative stress and neurotoxic conditions. Conclusions Astrocyte reaction seems to trigger an anti-oxidative and anti-neurotoxic response in order to ameliorate pathological damage in periventricular areas of the hydrocephalic mice.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. PI15-00619 to AJJ

Método de obtención de un biomaterial

La presente invención está dirigida a un método de obtención de un biomaterial que comprende un soporte de fibras de carbón activado y células de linaje osteocondral, en el que células madre se ponen en contacto con dicho soporte y se cultivan en presencia de suero y ausencia de factores de diferenciación osteogénica y/o condrogénica adicionales. La invención se dirige asimismo al biomaterial así obtenido y a las diferentes aplicaciones médicas de dicho biomaterial.Peer reviewedUniversidad de Granada, Consejo Superior de Investigaciones CientíficasA1 Solicitud de patente con informe sobre el estado de la técnic

Multiobjective RBFNNs Designer for Function Approximation: An Application for Mineral Reduction

Radial Basis Function Neural Networks (RBFNNs) are well known because, among other applications, they present a good perfor- mance when approximating functions. The function approximation prob- lem arises in the construction of a control system to optimize the process of the mineral reduction. In order to regulate the temperature of the ovens and other parameters, it is necessary a module to predict the ¯nal concentration of mineral that will be obtained from the source materials. This module can be formed by an RBFNN that predicts the output and by the algorithm that designs the RBFNN dynamically as more data is obtained. The design of RBFNNs is a very complex task where many parameters have to be determined, therefore, a genetic algorithm that determines all of them has been developed. This algorithm provides sat- isfactory results since the networks it generates are able to predict quite precisely the ¯nal concentration of mineral.Spanish CICYT Project TIN2004-01419European Commission's Research Infrastructures RII3-CT-2003-506079 (HPC-Europa

Glutamate and Brain Glutaminases in Drug Addiction

Glutamate is the principal excitatory neurotransmitter in the central nervous system and its actions are related to the behavioral effects of psychostimulant drugs. In the last two decades, basic neuroscience research and preclinical studies with animal models are suggesting a critical role for glutamate transmission in drug reward, reinforcement, and relapse. Although most of the interest has been centered in post-synaptic glutamate receptors, the presynaptic synthesis of glutamate through brain glutaminases may also contribute to imbalances in glutamate homeostasis, a key feature of the glutamatergic hypothesis of addiction. Glutaminases are the main glutamate-producing enzymes in brain and dysregulation of their function have been associated with neurodegenerative diseases and neurological disorders; however, the possible implication of these enzymes in drug addiction remains largely unknown. This mini-review focuses on brain glutaminase isozymes and their alterations by in vivo exposure to drugs of abuse, which are discussed in the context of the glutamate homeostasis theory of addiction. Recent findings from mouse models have shown that drugs induce changes in the expression profiles of key glutamatergic transmission genes, although the molecular mechanisms that regulate drug-induced neuronal sensitization and behavioral plasticity are not clear.This work was financially supported by Grants RD12/0028/0013 (JM) and RD12/0028/0001 (FRF) of the RTA RETICS network from the Spanish Health Institute Carlos III, Grant SAF2015-64501-R from the Spanish Ministry of Economy and Competitivity (to JM and JMM) and Excellence Grant CVI-6656 (Regional Andalusian government) (to JM)

Total domination in plane triangulations

Preprin

Dimensión métrica y dimensión métrica tolerante en grafos MOP.

En este trabajo estudiamos la dimensión métrica y la dimensión métrica tolerante en grafos periplanos maximales. Concretamente, damos cotas ajustadas de ambos parámetros y caracterizamos los grafos que alcanzan las cotas inferiores.Postprint (author's final draft

Response‐adapted treatment with rituximab, bendamustine, mitoxantrone, and dexamethasone followed by rituximab maintenance in patients with relapsed or refractory follicular lymphoma after first‐line immunochemotherapy: Results of the RBMDGELTAMO08 phase II trial

Background: Consensus is lacking regarding the optimal salvage therapy for patients with follicular lymphoma who relapse after or are refractory to immunochemotherapy. Methods: This phase II trial evaluated the efficacy and safety of response‐adapted therapy with rituximab, bendamustine, mitoxantrone, and dexamethasone (RBMD) in follicular lymphoma patients who relapsed after or were refractory to first‐line immunochemotherapy. Sixty patients received three treatment cycles, and depending on their response received an additional one (complete/unconfirmed complete response) or three (partial response) cycles. Patients who responded to induction received rituximab maintenance therapy for 2 years. Results: Thirty‐three (55%) and 42 (70%) patients achieved complete/unconfirmed complete response after three cycles and on completing induction therapy (4‐6 cycles), respectively (final overall response rate, 88.3%). Median progression‐free survival was 56.4 months (median follow‐up, 28.3 months; 95% CI, 15.6‐51.2). Overall survival was not reached. Progression‐free survival did not differ between patients who received four vs six cycles (P = .6665), nor between patients who did/did not receive rituximab maintenance after first‐line therapy (P = .5790). Median progression‐ free survival in the 10 refractory patients was 25.5 months (95% CI, 0.6‐N/A) and was longer in patients who had shown progression of disease after 24 months of first‐line therapy (median, 56.4 months; 95% CI, 19.8‐56.4) than in those who showed early progression (median, 42.31 months; 95% CI, 24.41–NA) (P = .4258). Thirty‐six (60%) patients had grade 3/4 neutropenia. Grade 3/4 febrile neutropenia and infection were recorded during induction (4/60 [6.7%] and 5/60 [8.3%] patients, respectively) and maintenance (2/43 [4.5%] and 4/43 [9.1%] patients, respectively). Conclusions: This response‐adapted treatment with RBMD followed by rituximab maintenance is an effective and well‐tolerated salvage treatment for relapsed/refractory follicular lymphoma following first‐line immunochemotherapy. Clinical trial registration: ClinicalTrials.gov # NCT01133158