Perovskitas ACoO3 : papel del catión en posición A en las propiedades catalíticas y de superficie

Tesis - Universidad Complutense de Madrid,Facultad de Ciencias Químicas,Departamento de Química Inorgánica, 1990.Depto. de Química InorgánicaFac. de Ciencias QuímicasTRUEProQuestpu

Characterization of the substrate noise spectrum for mixed-signal ICs

© 2005 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes,creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.This paper presents a simplified analytical model of the substrate noise generated by digital circuitry that captures the most relevant frequency domain characteristics and relates them with parameters of the digital circuit and the package. Simulations and experimental results are used to validate the analytical model.Peer ReviewedPostprint (published version

Hybrid chitosan derivative-carbon suport for oxygen reduction reactions

New hybrid chitosan derivative-carbon black was prepared and used as support for Pt nanoparticles. These catalysts improved the activity toward oxygen reduction reaction (ORR), compared with those of commercial Pt/C catalyst. The biopolymer chitosan provided an efficient and sustainable surface nitrogen source associated with the superior performance of the catalysts.Peer reviewe

Design and Implementation of a Prototype Seismogeodetic System for Tectonic Monitoring

This manuscript describes the design, development, and implementation of a prototype system based on seismogeodetic techniques, consisting of a low-cost MEMS seismometer/accelerometer, a biaxial inclinometer, a multi-frequency GNSS receiver, and a meteorological sensor, installed at the Doñana Biological Station (Huelva, Spain) that transmits multiparameter data in real and/or deferred time to the control center at the University of Cadiz. The main objective of this system is to know, detect, and monitor the tectonic activity in the Gulf of Cadiz region and adjacent areas in which important seismic events occur produced by the interaction of the Eurasian and African plates, in addition to the ability to integrate into a regional early warning system (EWS) to minimize the consequences of dangerous geological phenomena

Clinical utility of the hematopoietic precursor cell (HPC) count compared with the CD 34+ cell count in peripheral blood (PB) for the prediction of apheresis performance

El éxito de un trasplante de precursores hematopoyéticas de SP depende de un adecuado número de células CD34+ infundidas, siendo el momento óptimo de la colecta por aféresis clave. Un conteo de células CD34+ en SP > de 10 x 106/l es utilizado como criterio para la realización de aféresis. Las CPHs en SP se correlacionan con las células CD34+ SP, una alternativa rápida (90 segundos), no operador dependiente, económica (USD 9.8) comparado con CD34+ SP que es costosa (USD 110.34) y consume mayor tiempo. Nuestro objetivo fue evaluar la utilidad clínica del conteo de CPHs SP tomando como referencia un conteo de CD 34+ SP > de 10 x 106/l + SP, una alternativa rápida (90 segundos), no operador dependiente, económica (USD 9.8) comparado con CD34 + SP que es costosa (USD 110.34) y consume mayor tiempo. Nuestro objetivo fue evaluar la utilidad clínica del conteo de CPHs SP tomando como referencia un conteo de CD 34.1. FICHA TECNICA PROPUESTA DE INVESTIGACION 9 1.1 RESUMEN DEL PROYECTO 10 1.2 PLANTEAMIENTO DEL PROBLEMA 12 1.3 JUSTIFICACION 14 1.4 ESTADO DEL ARTE 16 1.5 METODOLOGIA 17 1.5.1 TIPO DE ESTUDIO 17 1.5.2 POBLACION 17 1.5.3 CRITERIOS DE INCLUSION 17 1.5.4 CRITERIOS DE EXCLUSION 17 1.6 OBJETIVO GENERAL 18 1.6.1 OBJETIVO ESPECIFICOS 18 1.7 CONSIDERACIONES ETICAS 19 1.8 PACIENTES Y METODOS 20 1.8.1 POBLACION 20 1.8.2 REGIMENES DE MOVILIZACION 21 1 8.3EVALUACIÓN DE LA MOVILIZACIÓN DE 21 PRECURSORES HEMATOPOYÉTICOS 1.8.4 MEDICIÓN DE CPHS 22 1.8.5 ANÁLISIS ESTADISTICO 22 1.9. RESULTADOS 23 1.10 DISCUSION 28 1.11 BIBLIOGRAFÍA 29EspecializaciónThe success of a transplant of hematopoietic precursors of SP depends on an adequate number of CD34+ cells infused, being the optimal moment of collection by apheresis key. A CD34+ cell count in SP > 10 x 106/l is used as a criterion for performing apheresis. HPCs in SP correlate with CD34+ SP cells, a fast (90 seconds), non-operator dependent, inexpensive (USD 9.8) alternative compared to CD34+ SP that is expensive (USD 110.34) and more time consuming. Our objective was to evaluate the clinical usefulness of counting SP hCcs taking as reference a count of CD 34+ SP > 10 x 106/l + SP, a fast alternative (90 seconds), non-operator dependent, cheap (USD 9.8) compared with CD34 + SP which is expensive (USD 110.34) and more time consuming. Our objective was to evaluate the clinical usefulness of the SP CPH count, taking a CD 34 count as a reference

Influencia del sistema de control zonificado en la combinación de un suelo radiante refrescante con un fancoil de conductos

La aerotermia está siendo promovida como solución en el sector residencial tanto para la producción de agua caliente sanitaria como para la climatización con instalaciones con agua, reemplazando a la energía solar térmica y los equipos de expansión directa. Este estudio presenta el análisis, desde el punto de vista del confort térmico y el consumo de energía, de un sistema de control zonificado aplicado a una instalación de suelo radiante y fancoil de conductos, comparado con un sistema de suelo radiante y fancoils individuales. El sistema de control incluye el uso eficiente combinado de ambas unidades terminales. La capacidad de refrigeración del suelo refrescante está limitada y en climas cálidos es necesario el uso del fancoil para asegurar el confort térmico y combatir la carga latente de la zona. El sistema se ha modelado en Trnsys17 y el caso de estudio se ha aplicado a una vivienda residencial y en diferentes zonas climáticas

Public healthcare costs associated with long-term exposure to mixtures of persistent organic pollutants in two areas of Southern Spain: A longitudinal analysis

Background: Polychlorinated biphenyls and organochlorine pesticides are persistent organic pollutants (POPs) that had been banned or restricted in many countries, including Spain. However, their ubiquity still poses environmental and human health threats. Objective: To longitudinally explore public healthcare costs associated with long-term exposure to a mixture of 8 POPs in a cohort of residents of two areas of Granada Province, Southern Spain. Methods: Longitudinal study in a subsample (n = 385) of GraMo adult cohort. Exposure assessment was performed by analyzing adipose tissue POP concentrations at recruitment. Average primary care (APC) and average hospital care (AHC) expenditures of each participant over 14 years were estimated using the data from their medical records. Data analyses were performed by robust MM regression, weighted quantile sum regression (WQS) and G-computation analysis. Results: In the adjusted robust MM models for APC, most POPs showed positive beta coefficients, being Hexachlorobenzene (HCB) significantly associated (beta 1.87; 95% Confidence interval (95%CI): 0.17, 3.57). The magnitude of this association increased (beta: 3.72; 95%CI: 0.80, 6.64) when the analyses were restricted to semirural residents, where p-HCH was also marginally-significantly associated to APC (beta: 3.40; 95%CI: -0.10, 6.90). WQS revealed a positive but non-significant mixture association with APC (beta: 0.14; 95%CI: -0.06, 0.34), mainly accounted for by p-HCH (54%) and HCB (43%), that was borderline-significant in the semi-rural residents (beta: 0.23; 95%CI: -0.01, 0.48). No significant results were observed in G-Computation analyses. Conclusion: Long-term exposure to POP mixtures might represent a modifiable factor increasing healthcare costs, thus affecting the efficiency of the healthcare systems. However, and owing the complexity of the potential causal pathways and the limitations of the present study, further research is warranted to fully elucidate ascertain whether interventions to reduce human exposure should be considered in healthcare policies.CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Spain PI16/01858 PI18/01573 PI20/01568European CommissionRamon y Cajal Program (Ministerio de Economia, Industria y Competitividad, Spain) RYC-2016-20,155PFIS (Instituto de Salud Carlos III, Spain) FI17/00310Universidad de Granada/CBU

Recurrent genetic variants and prioritization of variants of uncertain clinical significance associated with hereditary breast and ovarian cancer in families from the Region of Murcia

© 2023 the author(s). This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Advances in Laboratory Medicine. To access the final edited and published work see https://doi.org/10.1515/almed-2023-0103Objectives Hereditary breast and ovarian cancer (HBOC) follows an autosomal dominant inheritance pattern of cancer susceptibility genes. The risk of developing this disease is primarily associated with germline mutations in the BRCA1 and BRCA2 genes. The advent of massive genetic sequencing technologies has expanded the mutational spectrum of this hereditary syndrome, thereby increasing the number of variants of uncertain clinical significance (VUS) detected by genetic testing. Methods A prevalence study of HBOC was performed within 2,928 families from the Region of Murcia, in southeastern Spain. Genetic testing enabled the identification of recurrent pathogenic variants and founder mutations, which were mainly related to the BRCA1 and BRCA2 genes. VUS testing was performed using a prioritization algorithm designed by our working group. Results Variants c.68_69del, c.212+1G>A, and c.5123C>A were detected in 30 % of BRCA1 carriers, whereas exon 2 deletion concurrent with c.3264dupT, c.3455T>G and c.9117G>A variants were found in 30 % of BRCA2 carriers. A total of 16 VUS (15 %) were prioritized. Conclusions The genotype-phenotype correlation observed in our study is consistent with the scientific literature. Furthermore, the founder effect of c.1918C>T (BRCA1) and c.8251_8254del (ATM) was verified in the Murcian population, whereas exon 2 deletion (BRCA2) was proven to be a Spanish founder mutation. Our algorithm enabled us to prioritize potentially pathogenic VUS that required further testing to determine their clinical significance and potential role in HBOC

Altruismo y exclusión social

[ES]Este proyecto va dirigido al estudio de los conceptos y los patrones de la exclusión social desde una perspectiva económica. Desde el punto de vista teórico, se pretende plantear modelos que analicen las implicaciones del altruismo en relación a la lucha contra situaciones de pobreza y exclusión social, profundizando en el estudio con las herramientas que proporciona la economía experimental. Desde el punto de vista empírico, se analizan los factores que han llevado a retrocesos en la dimensión de pobreza y exclusión social de la estrategia Europa 2020. Los indicadores AROPE se basan únicamente en el recuento de excluidos y, en consecuencia, no incorporan el grado de intensidad de la exclusión que es la base de los indicadores multidimensionales de la pobreza como el IPM. Por ello, se plantea dar definiciones alternativas de medidas que permitan caracterizar la sensibilidad de los indicadores de pobreza y exclusión social, integrando en la medición la proporción de excluidos con la intensidad de la exclusión. Se pretende identificar patrones de exclusión y grupos de especial riesgo, estudiando la contribución de los posibles factores causales