2,241 research outputs found
Advocating Affordable Housing in New Hampshire: The Amicus Curiae Brief of the American Planning Association in Wayne Britton v. Town of Chester
In June 1990, The American Planning Association, a national Washington, D.C. based non-profit association of 27,000 professional planners, elected and appointed planning officials, and citizens interested in improving urban and rural planning filed this amicus curiae brief with the New Hampshire Supreme Court. The case on appeal is Wayne Britton v. Town of Chester, No. 85-E-342 (N.H. Super. Ct. June 27, 1989), brought by a builder/developer and low-income plaintiffs in need of affordable housing in Chester, New Hampshire
Book Reviews
Wesleyan Perspectives on the New Creation
M. Douglas Meeks, ed.
Nashville: Kingswood,
2004, 200 pp., paper, 2004, 25.00
Reviewed by Elaine A. Heath
The Evangelical Moment: The Promise of an American Religion
By Kenneth J. Collins
Grand Rapids: Baker Academic Press
2005, 288 pp., paper, 22.99
Reviewed by Nathan Crawford
Theology as History and Hermeneutics: A Post-Critical Evangelical Conversation with Contemporary Theology
Laurence W. Wood
Lexington: Emeth Publisher
2004, 261 pp.
Reviewed by Nathan Crawford
Resistance and Theological Ethics
Ronald H. Stone and Robert L. Stivers, eds.
Lanham, Maryland: Roman & Littlefield Publishers
2004, ri, 334 pp. paper, 28.95
Reviewed by Joerg Rieger
The Ripple Church: Multiply Your Ministry by Parenting New Churches
Phil Stevenson
Indianapolis, IN: Wesleyan Publishing House
2004. pp. 186, 35.00
Reviewed by John N. Oswalt
God is Not Religious, Nice, One of Us, an American, a Capitalist
D. Brent Laytham, ed.
Grand Rapids, Michigan: Press.
2004, 152 pp., paper, 19.95
Reviewed by Charles M. Woo
Extracurricular Activities and Disadvantaged Youth: A Complicated - But Promising - Story
Increased political and research interest in extracurricular activities stems, in part, from the claim that these programs especially benefit disadvantaged youth. However, little literature has synthesized studies across types of disadvantage to assess this claim. This article reviews research on disadvantaged youth in extracurricular programs, including differences by gender, socioeconomic status, race/ethnicity, and immigrant status. Our review reveals a promising, if complicated, picture. Although disadvantaged youth are less likely to participate in extracurricular activities, they often experience greater benefits, depending on the risk status and activity type. Evidence clearly supports expanding access to extracurricular programs for disadvantaged youth
Collective excitations of Bose-Einstein condensed gases at finite temperatures
We have applied the Popov version of the Hartree-Fock-Bogoliubov (HFB)
approximation to calculate the finite-temperature excitation spectrum of a
Bose-Einstein condensate (BEC) of Rb atoms. For lower values of the
temperature, we find excellent agreement with recently-published experimental
data for the JILA TOP trap. In contrast to recent comparison of the results of
HFB--Popov theory with experimental condensate fractions and specific heats,
there is disagreement of the theoretical and recent experimental results near
the BEC phase transition temperature.Comment: 4 pages, Latex, with 4 figures. More info at
http://amo.phy.gasou.edu/bec.htm
The accuracy of diagnostic coding for acute kidney injury in England - a single centre study.
BACKGROUND: Acute kidney injury (AKI) is an independent risk factor for mortality and is responsible for a significant burden of healthcare expenditure, so accurate measurement of its incidence is important. Administrative coding data has been used for assessing AKI incidence, and shows an increasing proportion of hospital bed days attributable to AKI. However, the accuracy of coding for AKI and changes in coding over time have not been studied in England. METHODS: We studied a random sample of admissions from 2005 and 2010 where ICD-10 code N17 (acute renal failure) was recorded in the administrative coding data at one acute NHS Foundation Trust in England. Using the medical notes and computerised records we examined the demographic and clinical details of these admissions. RESULTS: Against a 6.3% (95% CI 4.8-7.9%) increase in all non-elective admissions, we found a 64% increase in acute renal failure admissions (95% CI 41%-92%, p < 0.001) in 2010 compared to 2005. Median age was 78 years (IQR 72-87), 11-25% had a relevant pre-admission co-morbidity and 64% (55-73%) were taking drugs known to be associated with AKI. Over both years, 95% (91-99%) of cases examined met the Kidney Disease: Improving Global Outcomes criteria for AKI. CONCLUSIONS: Patients with hospital admissions where AKI has been coded are elderly with multiple co-morbidities. Our results demonstrate a high positive predictive value of coding data for a clinical diagnosis of AKI, with no suggestion of marked changes in coding of AKI between 2005 and 2010.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are
VESPA: software to facilitate genomic annotation of prokaryotic organisms through integration of proteomic and transcriptomic data
<p>Abstract</p> <p>Background</p> <p>The procedural aspects of genome sequencing and assembly have become relatively inexpensive, yet the full, accurate structural annotation of these genomes remains a challenge. Next-generation sequencing transcriptomics (RNA-Seq), global microarrays, and tandem mass spectrometry (MS/MS)-based proteomics have demonstrated immense value to genome curators as individual sources of information, however, integrating these data types to validate and improve structural annotation remains a major challenge. Current visual and statistical analytic tools are focused on a single data type, or existing software tools are retrofitted to analyze new data forms. We present Visual Exploration and Statistics to Promote Annotation (VESPA) is a new interactive visual analysis software tool focused on assisting scientists with the annotation of prokaryotic genomes though the integration of proteomics and transcriptomics data with current genome location coordinates.</p> <p>Results</p> <p>VESPA is a desktop Javaâą application that integrates high-throughput proteomics data (peptide-centric) and transcriptomics (probe or RNA-Seq) data into a genomic context, all of which can be visualized at three levels of genomic resolution. Data is interrogated via searches linked to the genome visualizations to find regions with high likelihood of mis-annotation. Search results are linked to exports for further validation outside of VESPA or potential coding-regions can be analyzed concurrently with the software through interaction with BLAST. VESPA is demonstrated on two use cases (<it>Yersinia pestis </it>Pestoides F and <it>Synechococcus </it>sp. PCC 7002) to demonstrate the rapid manner in which mis-annotations can be found and explored in VESPA using either proteomics data alone, or in combination with transcriptomic data.</p> <p>Conclusions</p> <p>VESPA is an interactive visual analytics tool that integrates high-throughput data into a genomic context to facilitate the discovery of structural mis-annotations in prokaryotic genomes. Data is evaluated via visual analysis across multiple levels of genomic resolution, linked searches and interaction with existing bioinformatics tools. We highlight the novel functionality of VESPA and core programming requirements for visualization of these large heterogeneous datasets for a client-side application. The software is freely available at <url>https://www.biopilot.org/docs/Software/Vespa.php</url>.</p
Identification of Widespread Adenosine Nucleotide Binding in Mycobacterium tuberculosis
SummaryComputational prediction of protein function is frequently error-prone and incomplete. In Mycobacterium tuberculosis (Mtb), âŒ25% of all genes have no predicted function and are annotated as hypothetical proteins, severely limiting our understanding of Mtb pathogenicity. Here, we utilize a high-throughput quantitative activity-based protein profiling (ABPP) platform to probe, annotate, and validate ATP-binding proteins in Mtb. We experimentally validate prior in silico predictions of >240 proteins and identify 72 hypothetical proteins as ATP binders. ATP interacts with proteins with diverse and unrelated sequences, providing an expanded view of adenosine nucleotide binding in Mtb. Several hypothetical ATP binders are essential or taxonomically limited, suggesting specialized functions in mycobacterial physiology and pathogenicity
A Novel, Enriched Population Pharmacokinetic Model for Recombinant Factor VIII-Fc Fusion Protein Concentrate in Hemophilia A Patients
Background The currently published population pharmacokinetic (PK) models used for PK-guided dosing in hemophilia patients are based on clinical trial data and usually not externally validated in clinical practice. The aim of this study was to validate a published model for recombinant factor VIII-Fc fusion protein (rFVIII-Fc) concentrate and to develop an enriched model using independently collected clinical data if required. Methods Clinical data from hemophilia A patients treated with rFVIII-Fc concentrate (Elocta) participating in the United Kingdom Extended Half-Life Outcomes Registry were collected. The predictive performance of the published model was assessed using mean percentage error (bias) and mean absolute percentage error (inaccuracy). An extended population PK model was developed using nonlinear mixed-effects modeling (NONMEM). Results A total of 43 hemophilia A patients (FVIII Conclusion We concluded that the existing rFVIII-Fc population PK model is valid for patients >= 12 years. However, it is not reliable in younger patients. Our alternative model, constructed from real world patient data including children, allows for better description of patients >= 5 years
Periodic Emission from the Gamma-ray Binary 1FGL J1018.6-5856
Gamma-ray binaries are stellar systems containing a neutron star or black
hole with gamma-ray emission produced by an interaction between the components.
These systems are rare, even though binary evolution models predict dozens in
our Galaxy. A search for gamma-ray binaries with the Fermi Large Area Telescope
(LAT) shows that 1FGL J1018.6-5856 exhibits intensity and spectral modulation
with a 16.6 day period. We identified a variable X-ray counterpart, which shows
a sharp maximum coinciding with maximum gamma-ray emission, as well as an
O6V((f)) star optical counterpart and a radio counterpart that is also
apparently modulated on the orbital period. 1FGL J1018.6-5856 is thus a
gamma-ray binary, and its detection suggests the presence of other fainter
binaries in the Galaxy.Comment: Contact authors: R.H.D. Corbet, M. Kerr, C.C. Cheun
Slow development of woodland vegetation and bird communities during 33 years of passive rewilding in open farmland
Passive rewilding is a potential tool for expanding woodland cover and restoring biodiversity by abandoning land management and allowing natural vegetation succession to occur. Land can be abandoned to passive rewilding deliberately or due to socio-economic change. Despite abandonment being a major driver of land use change, few have studied the long-term outcomes for vegetation and biodiversity in Western Europe. Studies are also biased towards sites that are close to seed sources and favourable to woodland colonisation. In this case-study, we reconstruct a time series of passive rewilding over 33 years on 25 ha of former farmland that had been subject to soil tipping, far from woodland seed sources. Natural colonisation by shrubs and trees was surveyed at three points during the time series, using field mapping and lidar. Breeding birds were surveyed at three time points, and compared with surveys from nearby farmland. Results showed that natural colonisation of woody vegetation was slow, with open grassland dominating the old fields for two decades, and small wetlands developing spontaneously. After 33 years, thorny shrub thickets covered 53% of the site and former hedgerows became subsumed or degraded, but trees remained scarce. However, the resulting habitat mosaic of shrubland, grassland and wetland supported a locally distinctive bird community. Farmland bird species declined as passive rewilding progressed, but this was countered by relatively more wetland birds and an increase in woodland birds, particularly songbirds, compared to nearby farmland. Alongside biodiversity benefits, shrubland establishment by passive rewilding could potentially provide ecosystem services via abundant blossom resources for pollinators, and recreation and berry-gathering opportunities for people. Although closed-canopy woodland remained a distant prospect even after 33 years, the habitat mosaic arising from passive rewilding could be considered a valuable outcome, which could contribute to nature recovery and provision of ecosystem services
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