Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia

International audienc

Tumor Evolution and Therapeutic Choice Seen through a Prism of Circulating Tumor Cell Genomic Instability

Circulating tumor cells (CTCs) provide an accessible tool for investigating tumor heterogeneity and cell populations with metastatic potential. Although an in-depth molecular investigation is limited by the extremely low CTC count in circulation, significant progress has been made recently in single-cell analytical processes. Indeed, CTC monitoring through molecular and functional characterization may provide an understanding of genomic instability (GI) molecular mechanisms, which contribute to tumor evolution and emergence of resistant clones. In this review, we discuss the sources and consequences of GI seen through single-cell analysis of CTCs in different types of tumors. We present a detailed overview of chromosomal instability (CIN) in CTCs assessed by fluorescence in situ hybridization (FISH), and we reveal utility of CTC single-cell sequencing in identifying copy number alterations (CNA) oncogenic drivers. We highlight the role of CIN in CTC-driven metastatic progression and acquired resistance, and we comment on the technical obstacles and challenges encountered during single CTC analysis. We focus on the DNA damage response and depict DNA-repair-related dynamic biomarkers reported to date in CTCs and their role in predicting response to genotoxic treatment. In summary, the suggested relationship between genomic aberrations in CTCs and prognosis strongly supports the potential utility of GI monitoring in CTCs in clinical risk assessment and therapeutic choice

V(D)J recombination process and the Pre-B to immature B-cells transition are altered in Fanca−/− mice

International audienc

Whole exome sequencing identifies a new mutation in the SLC19A2 gene leading to thiamine‐responsive megaloblastic anemia in an Egyptian family

International audienc

Thrombopoietin-Increased DNA-PK-Dependent DNA Repair Limits Hematopoietic STEM and Progenitor CELL Mutagenesis in Response to Irradiation

54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta, GA, DEC 08-11, 2012International audienceno abstrac

Thrombopoietin increases dna repair and limits hematopoietic stem cell long-term injury and mutagenesis in response to dna damage

ISEH 41st Annual Scientific Meeting of the Society-for-Hematology-and-Stem-Cells, Amsterdam, NETHERLANDS, AUG 23-26, 2012International audienceno abstrac

FANCD2 functions as a critical factor downstream of MiTF to maintain the proliferation and survival of melanoma cells

International audienc

Mycorrhizal colonization of Daucus carota and Calamagrostis epigejos growing on post-mining heap and its role in oxidative stress

tekst w j. pol. i ang.Celem pracy było zbadanie poziomu kolonizacji mikoryzowej korzeni Daucus carota i Calamagrostis epigejos, rosnących na zwale pogórniczym oraz określenie roli mikoryzy arbuskularnej w ograniczaniu stresu oksydacyjnego w roślinach. Aby obniżyć poziom kolonizacji mikoryzowej i określić rolę grzybów arbuskularnych w stresie oksydacyjnym, część roślin została jednorazowo potraktowana fungicydem Amistar 250 SC (Syngenta, Polska), w postaci oprysku (286 l/ha)