478 research outputs found
Reading versus the Red Bull: Cultural Constructions of Democracy and the Public Library in Cold War Wisconsin
From the Garden Club: Rural Women Writing Community
Review of: "From the Garden Club: Rural Women Writing Community," by Charlotte Hogg
How to Host a Data Competition: Statistical Advice for Design and Analysis of a Data Competition
Data competitions rely on real-time leaderboards to rank competitor entries
and stimulate algorithm improvement. While such competitions have become quite
popular and prevalent, particularly in supervised learning formats, their
implementations by the host are highly variable. Without careful planning, a
supervised learning competition is vulnerable to overfitting, where the winning
solutions are so closely tuned to the particular set of provided data that they
cannot generalize to the underlying problem of interest to the host. This paper
outlines some important considerations for strategically designing relevant and
informative data sets to maximize the learning outcome from hosting a
competition based on our experience. It also describes a post-competition
analysis that enables robust and efficient assessment of the strengths and
weaknesses of solutions from different competitors, as well as greater
understanding of the regions of the input space that are well-solved. The
post-competition analysis, which complements the leaderboard, uses exploratory
data analysis and generalized linear models (GLMs). The GLMs not only expand
the range of results we can explore, they also provide more detailed analysis
of individual sub-questions including similarities and differences between
algorithms across different types of scenarios, universally easy or hard
regions of the input space, and different learning objectives. When coupled
with a strategically planned data generation approach, the methods provide
richer and more informative summaries to enhance the interpretation of results
beyond just the rankings on the leaderboard. The methods are illustrated with a
recently completed competition to evaluate algorithms capable of detecting,
identifying, and locating radioactive materials in an urban environment.Comment: 36 page
The dynamical association between physical activity and affect in the daily life of individuals with ADHD
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
Background:
Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events.
Methods:
The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627).
Findings:
Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92).
Interpretation:
These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention
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