Screening and assessment of polyneuropathy in adult patients and the effect of folic acid administration on the course of neuropathy

Background: Multiple nerves damage (polyneuropathy) characterized by symmetrical sensory symptoms, such as numbness, paraesthesia, pain, andweakness predominantly in distal parts and pathophysiology depends on the underlying disease. Folic acid, (vitamin B9) deficiency causes many neurodegenerative and cerebrovascular diseases. Supplementation enhances neurodevelopment and provides neuroprotection in someneurological diseases by growth, differentiation and regeneration of the CNS.Methods: Prospective open-label study included 60 patients visiting at tertiary care hospital of either sex with an age range between 18 to 70 years. We evaluated the role of folic acid in the course of neuropathy in all enrolled patients using various neuropathy scores like diabetic neuropathy symptom questionnaire, survey of autonomic symptoms questionnaire, neuropathy deficit (or disability) score, standardized nerve conduction studies and cardiac autonomic reflex test.Results: NCV in the diabetic and alcoholic patients was statistically significant in almost all motor and sensory nerves in both upper and lower limb. In epileptic patients, was more significant in the lower limb in both motor and sensory nerves. In nutritional deficient patients was significant in only 2 nerves. In the diabetic patient, we also observed significance in DNS questionnaire (0.017).Conclusions: Since folate is effective, cheap, treatment and, devoid of apparent toxicity for this obscure, chronic, neurological disorders would be agent justified. A significant improvement in the results was seen majorly in diabetic group, thus can be included for them

Reconsidering Traditional Medicinal Plants to Combat COVID-19

COVID – 19 is a deadly disease, caused by a novel coronavirus (SARS-CoV-2) that is rapidly spreading across the globe and causing many fatalities. WHO (World Health Organization) has declared this disease as pandemic. Currently the disease has no treatment available in the form of medicine or vaccine. Ayurveda is an ancient Indian system of medicine, been practiced in India for nearly 5000 years and relies majorly on plants for its formulations. These herbal formulations and immunity boosters may show us the path to come up with a broad-spectrum antiviral product, which is the need of the hour. In this review, we have selected plants like Phyllanthus spp., Andrographis paniculata, Curcuma longa, Zingiber officinale, Glycyrrhiza glabra, and Withania somnifera with reported antiviral properties. While others like Tinospora cordifolia and Emblica officinalis that have immunity boosting properties.  The exact mechanisms of action for all the plants may not be clear as per modern medicine, but their history of safe use is in place

SELF CARE TO FEEL BEST DURING MENSTRUATION (RAJASWALA PARICHARYA): THE IMPACT OF LIFESTYLE MODIFICATION THAT ENHANCE FERTILITY

Out of various Paricharya mentioned in Ayurveda, Rajaswala Paricharya holds an important one. The Charya or code of conduct mentioned for a Rajaswala stree is termed as Rajaswala Parichara. Due to changing lifestyle, physical and mental stress, Mithya Aahar, Woman in reproductive age groups suffer from various conditions related to menstrual cycle like dysmenorrhoea, menorrhagia, irregular menses, PCOS, endometriosis, adenomyosis which increase incidence of infertility also Rajaswala charya is the most neglected part in the society. Acharyas mentioned Aaharas and Charyas which are indicated and contracted for maintaining the health. By the concept of Shuddha Shukra & Shuddha Aartava in the formation of Garbha its very clear that concept of Supraja Jananam i.e., healthy progency begins at the very level of preconceptional care or even before to that in the form of Rajaswala Paricharya. If it followed during menstruation it will get relief from conditions of menstrual abnormalities, infertility and to gain better healthy life of woman

Study of the Phase Transition Phenomenon in SrTe under Pressure

The phase transition pressure and volume collapse of SrTe have been studied. A three body interaction potential (TBIP) model is developed to study the high pressure phase transition of present compound having NaCl (B1) structure at room temperature. This model includes the long range Columbic, three body interaction forces, short range overlap forces operative up to next nearest neighbors and zero point energy effects.  It is found that the inclusion of zero point energy effects has improved the results. Keywords: Phase transition, volume collapse, three body interaction and zero point energy

Prolactin level in umbilical cord blood of newborn and its relation to respiratory distress syndrome

Background: Production of lower concentrations of prolactin in fetus is considered as one of the major contributor for the development of respiratory distress syndrome (RDS) in newborns considerably in pregnants with maternal complications. Hence the present study was conducted with the objective to measure the serum level of cord blood prolactin in normal pregnancy and in pregnancy with maternal complications and its association with development of RDS in newborn.Methods: In this prospective study of 100 women, 28 with normal pregnancy (Group A) and 72 with abnormal pregnancies (Group B) were included in the study. Umbilical cord blood was collected and serum prolactin level was estimated using radio-immuno assay. The obtained values were correlated with prevalence of RDS in neonates and maternal complications.Results: The average age of pregnant women participated in Group A was 26 years and Group B was 27 years. In Group A 2 babies with birth weight of 2001-3000 gm had a cord serum prolactin level of 216±137.8 ng/mL developed RDS. In Group B the level of prolactin was 285±276 and 326±132 ng/mL in 4 RDS babies with birth weight of <1000 gm and 1000-2000 gm respectively. It was observed that cord serum prolactin levels had no correlation with the mode of delivery, sex of newborn, steroid therapy. In Group A, 2 neonates developed RDS which were of gestational age between 32-35 weeks with mean prolactin level of 216 ng/ml, while in Group B, 1 neonate with gestational age less than 32 weeks and mean prolactin level of 480 and 4 neonates of 32-35 weeks with mean prolactin level of 266 ng/mL developed RDS. Out of 27 mothers with complications of PIH, 3 developed RDS. 1 case each from IUGR and twins developed RDS respectively.Conclusions: The risk of RDS is less in newborn with high prolactin level than in newborns with low prolactin levels. So prolactin might have a role in fetal lung maturation

Development and Valiation of Stability Indicating Chromatographic Methods for Drugs Used in Bacterial Infection Diseases Applying Experimental Design

This study was motivated by the fact that certain food poisonings and harmful microorganisms in ethanol and water determine roselle (Hibiscus sabdariffa), rosemary (Rosmarinus officinalis), clove (Syzygium aromaticum), and thyme (Thymus vulgaris). is to exhibit the capacity to eliminate Least inhibitory focuses (MICs) of different plant extricates against Gram-positive microorganisms (Bacillus cereus, Staphylococcus aureus), Gram-negative microscopic organisms (Escherichia coli, Enteritidis, Vibrio parahaemolyticus, Pseudomonas aeruginosa) and parasites (Candida albicans) and antibacterial impacts were explored. It is dissolved and measured using the agar well dispersion technique. The concentrate showed antimicrobial efficacy against the microorganisms and yeast used in the tests. Both pHint reduction and cell layer hyperpolarization indicated that the plant extract had a profound effect on the membranes of Gram-positive and Gram-negative microorganisms. Overall, plant extracts have significant potential as unique regular food additives due to their antibacterial properties

Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial

Background. Pediatric tuberculous meningitis (TBM) commonly causes death or disability. In adults, high-dose rifampicin may reduce mortality. The role of fluoroquinolones remains unclear. There have been no antimicrobial treatment trials for pediatric TBM. Methods. TBM-KIDS was a phase 2 open-label randomized trial among children with TBM in India and Malawi. Participants received isoniazid and pyrazinamide plus: (i) high-dose rifampicin (30 mg/kg) and ethambutol (R30HZE, arm 1); (ii) high-dose rifampicin and levofloxacin (R30HZL, arm 2); or (iii) standard-dose rifampicin and ethambutol (R15HZE, arm 3) for 8 weeks, followed by 10 months of standard treatment. Functional and neurocognitive outcomes were measured longitudinally using Modified Rankin Scale (MRS) and Mullen Scales of Early Learning (MSEL). Results. Of 2487 children prescreened, 79 were screened and 37 enrolled. Median age was 72 months; 49%, 43%, and 8% had stage I, II, and III disease, respectively. Grade 3 or higher adverse events occurred in 58%, 55%, and 36% of children in arms 1, 2, and 3, with 1 death (arm 1) and 6 early treatment discontinuations (4 in arm 1, 1 each in arms 2 and 3). By week 8, all children recovered to MRS score of 0 or 1. Average MSEL scores were significantly better in arm 1 than arm 3 in fine motor, receptive language, and expressive language domains (P < .01). Conclusions. In a pediatric TBM trial, functional outcomes were excellent overall. The trend toward higher frequency of adverse events but better neurocognitive outcomes in children receiving high-dose rifampicin requires confirmation in a larger trial. Clinical Trials Registration. NCT02958709

SURVEY PAPER ON WIFI COMMUNITY ON ANDROID PHONES

With the development of wireless communication, the popularity of android phones, the increasing of social networking services, mobile social networking has become a hot research topic. Personal mobile devices have become ubiquitous and an inseparable part of our daily lives. These devices have evolved rapidly from simple phones and SMS capable devices to Smartphone’s and now with android phones that we use to connect, interact and share information with our social circles. The Smartphone’s are used for traditional two-way messaging such as voice, SMS, multimedia messages, instant messaging or email. Moreover, the recent advances in the mobile application development frameworks and application stores have encouraged third party developers to create a huge number of mobile applications that allow users to interact and share information in many novel ways. In this paper, we elaborate a flexible system architecture based on the service-oriented specification to support social interactions in campus-wide environments using Wifi. In the client side, we designed a mobile middleware to collect social contexts such as the messaging, creating group, accessing emails etc. The server backend, on the other hand, aggregates such contexts, analyses social connections among users and provides social services to facilitate social interactions. A prototype of mobile social networking system is deployed on campus, and several applications are implemented based on the proposed architecture to demonstrate the effectiveness of the architecture

Using Social Media To Gain Business Value

As  the  competition  for  Business  is  growing  day  by day   the   owners   are   concerned   about   the   growth   of   their business.Social   networking  has  become  one  of  the   most important   parts   of   our   daily   life   as   it   enables   us   to communicate  with  a  lot  of  people.  Social  networking  sites  are created  to  assist  in  online  networking.It  is  also  is  a  platform where our creations and thoughts are presented to a huge lot of masses.Online  social  media  represent  a  fundamental  shift  of how information is being produced, transferred and consumed. User  generated  content  in  the  form  of  blog,  posts,  comments, and tweets  establishes a connection between the producers and the consumers of information. Tracking the pulse of the  social media outlets, enables companies to gain feedback and insight in how to improve and market products better. For consumers, the   abundance   of   information   and   opinions   from   diverse sources  helps  them  tap  into  the  wisdom  of  crowds,  to  aid  in making more informed  decisions [1] Social  media  platform (SM) in particular comprises a flourishing  new  set  of  viral  marketing  mechanism  that  are growing  exponentially.  More  and  more  companies  are  using SM because they know it works[1]. How much they spend and how  long  they  continue  to  spend  it  will  depend  on  how efficient SM proves to be in the long run. The measurement of social  media  effectiveness  or  ROI  (Return  on  Investment)  is the key  factor  in  the  long  term  success  of  SM  marketing  and management program.[1] The   proposed   system   will   calculate   the   gain   of business by using social media as a platform.General Terms Business, Social Media, Information, ROI, Marketin

CuO (Copper Oxide) Thin Films by Successive Ionic Layer Adsorption and Reaction (SILAR): A Sustainable Approach for Solar-Driven Methylene Blue (MB) Degradation

The paper investigates the solar photodegradation of Methylene Blue dye using copper oxide (CuO) thin films synthesized by the Successive Ionic Layer Adsorption and Reaction (SILAR) method. The structural, morphological, and optical characteristics of the CuO thin films have been investigated by employing a variety of methods, such as Fourier transform Infrared (FTIR) spectroscopy, UV-Vis spectroscopy, Scanning electron microscopy (SEM), and X-ray diffraction (XRD). The outcomes showed that CuO thin films with excellent surface shape and a highly crystalline nature had been successfully deposited. Methylene Blue was subjected to solar radiation during its photodegradation process, and the outcomes showed a significant decrease in the dye's concentration over time. To maximize the photo degradation process, the effects of other experimental factors were also assessed, such as the starting concentration of MB, the quantity of CuO thin film, number of SILAR cycles and the pH of the solution. Good photocatalytic activity is demonstrated by CuO thin films produced using the SILAR approach in the solar photodegradation of methylene blue. The development of affordable and ecologically friendly wastewater treatment technology that can use sun energy to break down persistent organic contaminants is affected by these findings