People in different age groups show different hip-joint morphology

It has been suggested that the distribution of the subchondral bone density may be regarded as the expression of the long-term effective stress in a joint, and previous results indicate the regularity of the distribution of subchondral bone density as a function of the passing demands made upon a joint. Computed tomography-osteoabsorptiometry has been developed to visualize the area distribution of subchondral mineralization in the major joints in vivo. The purpose of this study was to display the distribution of subchondral bone density in the acetabular cup of patients of different ages. Computer tomography data files of hip joints of 27 patients (18–89 years) were used. Density ranges, image analysis, and area presentation of the distribution of subchondral mineralization are presented. The maximal subchondral mineralization in young persons is found both in the ventral and dorsal part of the acetabular roof. In older people, however, the densest areas are most often found at the zenith of the acetabulum. These morphological results could be well explained by the experimental results of other authors who found a joint incongruity in young persons with contact areas in the ventral and dorsal part of the acetabulum. With advancing age a decrease in incongruence is found, leading to an increased stress in the dome, i.e. in the area where degenerative changes are often found

FIRA: Instrument of Regulation or Vote-Maximization?

The establishment of the Foreign Investment Review Agency can be explained on the basis that such a screening instrument was the most efficient instrument to deal with the problem of foreign direct investment in Canada. However, Jacques Pauwels argues that FIRA was created not for the efficient regulation of foreign direct investment but for political purposes; that is, FIRA provided the Trudeau government with considerable vote-maximizing possibilities. Moreover, Pauwels suggests that Mulroney\u27s introduction of the Investment Canada Act, replacing FIRA with Investment Canada, can similarly be explained

FIRA: Instrument of Regulation or Vote-Maximization?

The establishment of the Foreign Investment Review Agency can be explained on the basis that such a screening instrument was the most efficient instrument to deal with the problem of foreign direct investment in Canada. However, Jacques Pauwels argues that FIRA was created not for the efficient regulation of foreign direct investment but for political purposes; that is, FIRA provided the Trudeau government with considerable vote-maximizing possibilities. Moreover, Pauwels suggests that Mulroney\u27s introduction of the Investment Canada Act, replacing FIRA with Investment Canada, can similarly be explained

Multiscale assimilation of Advanced Microwave Scanning Radiometer-EOS snow water equivalent and Moderate Resolution Imaging Spectroradiometer snow cover fraction observations in northern Colorado

Eight years (2002–2010) of Advanced Microwave Scanning Radiometer–EOS (AMSR-E) snow water equivalent (SWE) retrievals and Moderate Resolution Imaging Spectroradiometer (MODIS) snow cover fraction (SCF) observations are assimilated separately or jointly into the Noah land surface model over a domain in Northern Colorado. A multiscale ensemble Kalman filter (EnKF) is used, supplemented with a rule-based update. The satellite data are either left unscaled or are scaled for anomaly assimilation. The results are validated against in situ observations at 14 high-elevation Snowpack Telemetry (SNOTEL) sites with typically deep snow and at 4 lower-elevation Cooperative Observer Program (COOP) sites. Assimilation of coarse-scale AMSR-E SWE and fine-scale MODIS SCF observations both result in realistic spatial SWE patterns. At COOP sites with shallow snowpacks, AMSR-E SWE and MODIS SCF data assimilation are beneficial separately, and joint SWE and SCF assimilation yields significantly improved root-mean-square error and correlation values for scaled and unscaled data assimilation. In areas of deep snow where the SNOTEL sites are located, however, AMSR-E retrievals are typically biased low and assimilation without prior scaling leads to degraded SWE estimates. Anomaly SWE assimilation could not improve the interannual SWE variations in the assimilation results because the AMSR-E retrievals lack realistic interannual variability in deep snowpacks. SCF assimilation has only a marginal impact at the SNOTEL locations because these sites experience extended periods of near-complete snow cover. Across all sites, SCF assimilation improves the timing of the onset of the snow season but without a net improvement of SWE amounts

Information system support in construction industry with semantic web technologies and/or autonomous reasoning agents

Information technology support is hard to find for the early design phases of the architectural design process. Many of the existing issues in such design decision support tools appear to be caused by a mismatch between the ways in which designers think and the ways in which information systems aim to give support. We therefore started an investigation of existing theories of design thinking, compared to the way in which design decision support systems provide information to the designer. We identify two main strategies towards information system support in the early design phase: (1) applications for making design try-outs, and (2) applications as autonomous reasoning agents. We outline preview implementations for both approaches and indicate to what extent these strategies can be used to improve information system support for the architectural designer

Pairing-excitation versus intruder states in 68Ni and 90Zr

A discussion on the nature of the 0+ states in 68Ni (Z=28, N=40) is presented and a comparison is made with its valence counterpart 90Zr (Z=40, N=50). Evidence is given for a 0+ proton intruder state at only ~2.2 MeV excitation energy in 68Ni, while the analogous neutron intruder states in 90Zr reside at 4126 keV and 5441 keV. The application of a shell-model description of 0+ intruder states reveals that many pair-scattered neutrons across N=40 have to be involved to explain the low excitation energy of the proton-intruder configuration in 68Ni.Comment: 10 pages, 2 figures, 1 tabl

The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma

peer reviewedNeurokinin A (NKA) causes bronchoconstriction in asthmatic patients. In vitro both NK1 and NK2 receptors can mediate airway contraction. Moreover in guinea pigs, NK3 receptors facilitate cholinergic neurotransmission. Dual tachykinin NK1/NK2 receptor antagonism results in prevention of NKA-induced bronchoconstriction. We have now examined the effect of a single dose of the triple tachykinin receptor antagonist CS-003 on NKA-induced bronchoconstriction in asthmatics. A double blind, crossover, placebo-controlled trial in 16 mild asthmatics was performed. One single dose of CS-003 (200 mg, solution in distilled water) or matched placebo was given orally on the assessment days. NKA-provocation tests were performed pre-dose and 1, 8 and 24h after dosing. There was a significant shift to the right of the dose-response curve at 1 and 8 h after intake of CS-003. PC20 was not reached in 12/16 patients at 1 h post-dose and in 5/16 patients at 8h post-dose. This did not occur under placebo treatment. A single dose of 200 mg CS-003 protected significantly against NKA-induced bronchoconstriction at 1 and 8 h post-dose in mild asthmatics. (c) 2005 Elsevier Ltd. All rights reserved

A New Snail-Eating Turtle of the Genus Malayemys Lindholm, 1931 (Geoemydidae) from Thailand and Laos

We describe a snail-eating turtle, Malayemys isan sp. nov., from the Mekong River Basin in northeastern Thailand (Nong Bua Lamphu, Nong Khai and Udon Thani provinces) and the adjacent Vientiane area in Laos. The new species is readily distinguishable from M. subtrijuga by its two (vs. six to nine) nasal stripes, and from both M. subtrijuga and M. macrocephala by its thin, often discontinuous, infraorbital stripe that never reaches the loreal seam. This geographically-restricted new species is sold in several food markets throughout the species‟ distribution and is in urgent need of conservation measures

Interoperability for the design and construction industry through semantic web technology

The domain of architecture, engineering and construction (AEC) has experienced significant improvements with the advent of building information modelling (BIM) applications, which allow AEC specialists to model all information concerning a building design into one three-dimensional building model. Much of these improvements are however generated by the mere availability of such an environment, whereas many more improvements were expected by achieving an appropriate interoperability of information. We are investigating why such an interoperability is not reached fully and consider the semantic web as an alternative approach to reach the targeted interoperability. In this paper, an AEC description framework based on semantic web technology is presented and compared to the BIM approach, after which we indicate how it might solve the issue of interoperability more appropriately. Our evaluation of this investigation indicates the semantic web approach as a valid alternative approach, although considerably more research is needed to show it capable of providing the targeted interoperability of information in the AEC domain