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Technical Review of Residential Programmable Communicating Thermostat Implementation for Title 24-2008
Ionization of hydrogen atoms by electron impact at 1eV, 0.5eV and 0.3eV above threshold
We present here triple differential cross sections for ionization of hydrogen
atoms by electron impact at 1eV, 0.5eV and 0.3eV energy above threshold,
calculated in the hyperspherical partial wave theory. The results are in very
good agreement with the available semiclassical results of Deb and Crothers
\cite{DC02} for these energies. With this, we are able to demonstrate that the
hyperspherical partial wave theory yields good cross sections from 30 eV
\cite{DPC03} down to near threshold for equal energy sharing kinematics.Comment: 6 pages, 9 figure
The Influence of Exercise Dose, Exercise Intensity, and Weight Loss and Change in C-Reactive Protein in Sedentary Overweight Women
Objective: To examine the effect physical activity included in a weight loss program has on high sensitivity C-reactive protein (hs-CRP) levels in sedentary overweight women.
Design, Setting, and Participants: This study examined the change in hs-CRP in overweight and obese women in response to a 6 month behavioral weight loss program. The parent study was a randomized trial involving 201 sedentary overweight women who participated in a weight control program, with data from 182 subjects available for this secondary analysis.
Methods: Participants were randomly assigned to 1 of 4 exercise groups based on energy expenditure (1000kcal/week or 2000 kcal/week) and intensity (vigorous vs. moderate). Groups included: vigorous intensity/high dose; vigorous intensity/moderate dose; moderate intensity/moderate dose; and moderate intensity/high dose. Participants were prescribed an energy restricted diet consisting of 1200 kcal/day or 1500 kcal/day and daily dietary fat intake between 20%-30% of total energy intake.
Results: There were no statistically significant differences between dose of exercise, moderate vs. high, (F=0.330, p=0.58) or level of intensity, moderate vs. vigorous (F=0.118, p=0.731) for change in hs-CRP. However, there was a significant decrease in hs-CRP from baseline to 6 months (F=25.553, p<0.0004); there was a significant 3 way interaction between energy expenditure, intensity, and Pre/Post differences (F=4.035, p=0.035), post hoc analysis revealed a significant decrease in hs-CRP in the moderate/high (p<0.0004) and vigorous/moderate groups (p=004). The results were unchanged after controlling for the change in body weight, body fatness, or body distribution. The change in hs-CRP was not significantly correlated with the change in body weight, percent body fat, waist circumference, or self-reported physical activity. hs-CRP at 6 months was correlated with 6 month measures of weight, BMI, percent body fat, and fat distribution (p<0.0004).
Conclusions: hs-CRP was reduced in overweight and obese women in response to a 6 month weight loss intervention that included a prescribed reduction in energy intake and a prescribed increase in exercise with a significant reduction in the moderate intensity/high dose and vigorous intensity/moderate dose groups. Further research is needed to determine what effect exercise and or weight loss may have on markers of inflammation
The Enantioselective Construction of Tetracyclic Diterpene Skeletons with Friedel-Crafts Alkylation and Palladium-catalyzed Cycloalkenylation Reactions
Due to the profound extent to which natural products inspire medicinal chemists in drug discovery, there is demand for innovative syntheses of these often complex materials. This article describes the synthesis of tricarbocyclic natural product architectures through an extension of the enantioselective Birch-Cope sequence with intramolecular Friedel-Crafts alkylation reactions. Additionally, palladium-catalyzed enol silane cycloalkenylation of the tricarbocyclic structures afforded the challenging bicyclo[3.2.1]octane C/D ring system found in the gibberellins and the ent-kauranes, two natural products with diverse medicinal value. In the case of the ent-kaurane derivative, an unprecedented alkene rearrangement converted four alkene isomers to one final product
University space planning and space-type profiles
Universities planning the provision of space for their teaching requirements need to do so in a fashion that reduces capital and maintenance costs whilst still providing a high-quality level of service. Space plans should aim to provide sufficient capacity without incurring excessive costs due to over-capacity. A simple measure used to estimate over-provision is utilisation. Essentially, the utilisation is the fraction of seats that are used in practice, or the ratio of demand to supply. However, studies usually find that utilisation is low, often only 20–40%, and this is suggestive of significant over-capacity. Our previous work has provided methods to improve such space planning. They identify a critical level of utilisation as the highest level that can be achieved whilst still reliably satisfying the demand for places to allocate teaching events. In this paper, we extend this body of work to incorporate the notions of event-types and space-types. Teaching events have multiple ‘event-types’, such as lecture, tutorial, workshop, etc., and there are generally corresponding space-types. Matching the type of an event to a room of a corresponding space-type is generally desirable. However, realistically, allocation happens in a mixed space-type environment where teaching events of a given type are allocated to rooms of another space-type; e.g., tutorials will borrow lecture theatres or workshop rooms. We propose a model and methodology to quantify the effects of space-type mixing and establish methods to search for better space-type profiles; where the term “space-type profile” refers to the relative numbers of each type of space. We give evidence that these methods have the potential to improve utilisation levels. Hence, the contribution of this paper is twofold. Firstly, we present informative studies of the effects of space-type mixing on utilisation, and critical utilisations. Secondly, we present straightforward though novel methods to determine better space-type profiles, and give an example in which the resulting profiles are indeed significantly improved. <br/
Assessment of Dose-dependent Endocrine and Immune Responses to Simulated Ionizing Radiation
The hypothalamic-pituitary-adrenal axis can regulate immune responses to counteract stressful stimuli in maintaining homeostasis within the body. Cosmic ionizing radiation is an innate risk within the space environment and it is known to cause direct DNA damage and indirectly impact cellular function, transduction, and communication processes. Assessment of different physiological systems and their interactions are important to consider for mitigation strategies in spaceflight. The degree of ionizing radiation and relative biological effectiveness is an open question as it pertains to immune and endocrine responses. Therefore, this study will assess the dose-dependent responses of immunity and adrenal function to cosmic ionizing radiation. For this, male and female C57 BL/6J mice were exposed to simulated, simplified five-ion galactic cosmic ray (GCR) radiation at 5cGy, 15cGy, and 50cGy. Blood and tissues were collected two-weeks post exposure and inflammatory biomarkers and hormone biochemical pathways were characterized by whole transcriptome RNA sequencing. Results displayed differential transcriptomic profiles for each condition and sex, indicating complex responses and networks are generated from different doses of ionizing radiation. Careful consideration of unique profiles highlights the current need for personalized medicine requirements for astronauts exposed to similar doses on exploration missions. Supported by the NASA Human Research Program (HRP) Human Factors Behavioral Performance Element Grant 18 18FLAG 2 0028 and Embry-Riddle Aeronautical University startup funding
Miniaturized data loggers and computer programming improve seabird risk and damage assessments for marine oil spills in Atlantic Canada
Obtaining useful information on marine birds that can aid in oil spill (and other hydrocarbon release) risk and damage assessments in offshore environments is challenging. Technological innovations in miniaturization have allowed archival data loggers to be deployed successfully on marine birds vulnerable to hydrocarbons on water. A number of species, including murres (both Common, Uria aalge, and Thick-billed, U. lomvia) have been tracked using geolocation
devices in eastern Canada, increasing our knowledge of the seasonality and colony-specific nature of their susceptibility to oil on water in offshore hydrocarbon production areas and major shipping lanes. Archival data tags are starting to resolve questions around behaviour of vulnerable seabirds at small spatial scales relevant to oil spill impact modelling, specifically to determine the duration and frequency at which birds fly at sea. Advances in data capture methods using voice activated software have eased the burden on seabird observers who are collecting
increasingly more detailed information on seabirds during ship-board and aerial transects. Computer programs that integrate seabird density and bird behaviour have been constructed, all with a goal of creating more credible seabird oil spill risk and damage assessments. In this paper, we discuss how each of these technological and computing innovations can help define critical inputs into seabird risk and damage assessments, and when combined, can provide a more realistic understanding of the impacts to seabirds from any hydrocarbon release
An unidentified Fermi source emitting radio bursts in the Galactic bulge
We report on the detection of radio bursts from the Galactic bulge using the
real-time transient detection and localization system, realfast. The pulses
were detected commensally on the Karl G. Jansky Very Large Array during a
survey of unidentified Fermi -ray sources. The bursts were localized to
subarcsecond precision using realfast fast-sampled imaging. Follow-up
observations with the Green Bank Telescope detected additional bursts from the
same source. The bursts do not exhibit periodicity in a search up to periods of
480s, assuming a duty cycle of < 20%. The pulses are nearly 100% linearly
polarized, show circular polarization up to 12%, have a steep radio spectral
index of -2.7, and exhibit variable scattering on timescales of months. The
arcsecond-level realfast localization links the source confidently with the
Fermi -ray source and places it nearby (though not coincident with) an
XMM-Newton X-ray source. Based on the source's overall properties, we discuss
various options for the nature of this object and propose that it could be a
young pulsar, magnetar, or a binary pulsar system.Comment: Submitted to The Astrophysical Journa
The Host Galaxy and Redshift of the Repeating Fast Radio Burst FRB 121102
The precise localization of the repeating fast radio burst (FRB 121102) has
provided the first unambiguous association (chance coincidence probability
) of an FRB with an optical and persistent radio
counterpart. We report on optical imaging and spectroscopy of the counterpart
and find that it is an extended ()
object displaying prominent Balmer and [OIII] emission lines. Based on the
spectrum and emission line ratios, we classify the counterpart as a
low-metallicity, star-forming, AB mag dwarf galaxy at a
redshift of , corresponding to a luminosity distance of 972 Mpc.
From the angular size, the redshift, and luminosity, we estimate the host
galaxy to have a diameter kpc and a stellar mass of
, assuming a mass-to-light ratio between 2 to
3. Based on the H flux, we estimate the star
formation rate of the host to be and a
substantial host dispersion measure depth .
The net dispersion measure contribution of the host galaxy to FRB 121102 is
likely to be lower than this value depending on geometrical factors. We show
that the persistent radio source at FRB 121102's location reported by Marcote
et al (2017) is offset from the galaxy's center of light by 200 mas and
the host galaxy does not show optical signatures for AGN activity. If FRB
121102 is typical of the wider FRB population and if future interferometric
localizations preferentially find them in dwarf galaxies with low metallicities
and prominent emission lines, they would share such a preference with long
gamma ray bursts and superluminous supernovae.Comment: 12 pages, 3 figures, Published in ApJ Letters. V2: Corrected mistake
in author lis
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