An Environmental Analysis of Illinois Coal Entry into the Transportation Market

Using Illinois coal in transportation has varied environmental consequences. This study calculated the total CO2 emissions from gasoline and eight other vehicle propulsion methods (VPMs) involving Illinois coal. VPMs of Ultra Super Critical electrical cycle (USC), Integrated Gasification Combined electrical Cycle (IGCC), Pulverized coal in a Sub-Critical electrical cycle (PSC), and electricity from a hydrogen fuel cell emitted the lowest CO2. VPMs using Illinois coal to produce ethanol, butanol, and IGCC/ethanol emitted CO2 comparable to gasoline. The VPM of Fischer-Tropsch (FT) diesel emitted the most CO2. It was concluded that energy efficiency and CO2 offset from agricultural growth and by-products were the most influential factors of CO2 emissions

Towards a class library for mission planning

The PASTEL Mission Planning System (MPS) has been developed in C++ using an object-oriented (OO) methodology. While the scope and complexity of this system cannot compare to that of an MPS for a complex mission one of the main considerations of the development was to ensure that we could reuse some of the classes in future MPS. We present here PASTEL MPS classes which could be used in the foundations of a class library for MPS

Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury.

Acute kidney injury (AKI) can be fatal and is a well-defined risk factor for the development of chronic kidney disease. Group 2 innate lymphoid cells (ILC2s) are innate producers of type-2 cytokines and are critical regulators of homeostasis in peripheral organs. However, our knowledge of their function in the kidney is relatively limited. Recent evidence suggests that increasing ILC2 numbers by systemic administration of recombinant interleukin (IL)-25 or IL-33 protects against renal injury. Whilst ILC2s can be induced to protect against ischemic- or chemical-induced AKI, the impact of ILC2 deficiency or depletion on the severity of renal injury is unknown. Firstly, the phenotype and location of ILC2s in the kidney was assessed under homeostatic conditions. Kidney ILC2s constitutively expressed high levels of IL-5 and were located in close proximity to the renal vasculature. To test the functional role of ILC2s in the kidney, an experimental model of renal ischemia-reperfusion injury (IRI) was used and the severity of injury was assessed in wild-type, ILC2-reduced, ILC2-deficient, and ILC2-depleted mice. Surprisingly, there were no differences in histopathology, collagen deposition or mRNA expression of injury-associated (Lcn2), inflammatory (Cxcl1, Cxcl2, and Tnf) or extracellular matrix (Col1a1, Fn1) factors following IRI in the absence of ILC2s. These data suggest the absence of ILC2s does not alter the severity of renal injury, suggesting possible redundancy. Therefore, other mechanisms of type 2-mediated immune cell activation likely compensate in the absence of ILC2s. Hence, a loss of ILC2s is unlikely to increase susceptibility to, or severity of AKI

TiO2/MoO2 nanocomposite as anode materials for high power Li-ion batteries with exceptional capacity

Nanoparticles of molybdenum(IV) oxide (MoO 2 ) and a TiO 2 /MoO 2 nanocomposite were synthesised via a continuous hydrothermal synthesis process. Both powders were analysed using XRD, XPS, TEM, and BET and evaluated as active materials in anodes for Li-ion half-cells. Cyclic voltammetry and galvanostatic charge/discharge measurements were carried out in the potential window of 0.1 to 3.0 V vs. Li/Li+. Specific capacities of ca. 350 mAh g -1 were obtained for both materials at low specific currents (0.1 A g -1 ); TiO 2 /MoO 2 composite electrodes showed superior rate behaviour & stability under cycling (compared to MoO 2 ), with stable specific capacities of ca. 265 mAh g -1 at a specific current of 0.5 A g -1 and ca. 150 mAh g -1 after 350 cycles at a specific current of 2.5 A g -1 . The improved performance of the composite material, compared to MoO 2 , was attributed to a smaller particle size, improved stability to volume changes (during cycling), and lower charge transfer resistance during cycling. Li-ion hybrid electrochemical capacitors using TiO 2 /MoO 2 composite anodes and activated carbon (AC) cathodes were evaluated and showed excellent performance with an energy density of 44 Wh kg -1 at a power density of 600 W kg -1

Reducing recurrent stroke: Methodology of the motivational interviewing in stroke (MIST) randomized clinical trial

Rationale Recurrent stroke is prevalent in both developed and developing countries, contributing significantly to disability and death. Recurrent stroke rates can be reduced by adequate risk factor management. However, adherence to prescribed medications and lifestyle changes recommended by physicians at discharge after stroke is poor, leading to a large number of preventable recurrent strokes. Using behavior change methods such as Motivational Interviewing early after stroke occurrence has the potential to prevent recurrent stroke. Aims and/or hypothesis The overall aim of the study is to determine the effectiveness of motivational interviewing in improving adherence to medication and lifestyle changes recommended by treating physicians at and after hospital discharge in stroke patients 12 months poststroke to reduce risk factors for recurrent stroke. Design Recruitment of 430 first-ever stroke participants will occur in the Auckland and Waikato regions. Randomization will be to intervention or usual care groups. Participants randomized to intervention will receive four motivational interviews and five follow-up assessments over 12 months. Nonintervention participants will be assessed at the same time points. Study outcomes Primary outcome measures are changes in systolic blood pressure and low-density lipoprotein levels 12 months poststroke. Secondary outcomes include self-reported adherence and barriers to prescribed medications, new cardiovascular events (including stroke), changes in quality of life, and mood. Discussion The results of the motivational interviewing in stroke trial will add to our understanding of whether motivational interviewing may be potentially beneficial in the management of stroke and other diseases where similar lifestyle factors or medication adherence are relevant

Precise wave-function engineering with magnetic resonance

Controlling quantum fluids at their fundamental length scale will yield superlative quantum simulators, precision sensors, and spintronic devices. This scale is typically below the optical diffraction limit, precluding precise wave-function engineering using optical potentials alone. We present a protocol to rapidly control the phase and density of a quantum fluid down to the healing length scale using strong time-dependent coupling between internal states of the fluid in a magnetic field gradient. We demonstrate this protocol by simulating the creation of a single stationary soliton and double soliton states in a Bose-Einstein condensate with control over the individual soliton positions and trajectories, using experimentally feasible parameters. Such states are yet to be realized experimentally, and are a path towards engineering soliton gases and exotic topological excitations.This work was supported by the Australian Research Council (ARC) Centre of Excellence for Engineered Quantum Systems (Project No. CE110001013), the Australian Postgraduate Award Scheme, and ARC Grants No. DP1094399, No. DP130101613, and No. FT120100291

Sustaining entrepreneurial business: a complexity perspective on processes that produce emergent practice

This article examines the management practices in an entrepreneurial small firm which sustain the business. Using a longitudinal qualitative case study, four general processes are identified (experimentation, reflexivity, organising and sensing), that together provide a mechanism to sustain the enterprise. The analysis draws on concepts from entrepreneurship and complexity science. We suggest that an entrepreneur’s awareness of the role of these parallel processes will facilitate their approaches to sustaining and developing enterprises. We also suggest that these processes operate in parallel at multiple levels, including the self, the business and inter-firm networks. This finding contributes to a general theory of entrepreneurship. A number of areas for further research are discussed arising from this result

IM Normae: The Death Spiral of a Cataclysmic Variable?

We present a study of the orbital light curves of the recurrent nova IM Normae since its 2002 outburst. The broad "eclipses" recur with a 2.46 hour period, which increases on a timescale of 1.28(16)x10^6 years. Under the assumption of conservative mass-transfer, this suggests a rate near 10^-7 M_sol/year, and this agrees with the estimated /accretion/ rate of the postnova, based on our estimate of luminosity. IM Nor appears to be a close match to the famous recurrent nova T Pyxidis. Both stars appear to have very high accretion rates, sufficient to drive the recurrent-nova events. Both have quiescent light curves which suggest strong heating of the low-mass secondary, and very wide orbital minima which suggest obscuration of a large "corona" around the primary. And both have very rapid orbital period increases, as expected from a short-period binary with high mass transfer from the low-mass component. These two stars may represent a final stage of nova -- and cataclysmic-variable -- evolution, in which irradiation-driven winds drive a high rate of mass transfer, thereby evaporating the donor star in a paroxysm of nova outbursts.Comment: PDF, 30 pages, 3 tables, 6 figures; accepted, in press, ApJ; more info at http://cbastro.org

Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization

Islet transplantation is an efficacious therapy for type 1 diabetes; however, islets from multiple donor pancreata are required, and a gradual attrition in transplant function is seen. Here, we manufactured human umbilical cord perivascular mesenchymal stromal cells (HUCPVCs) to Good Manufacturing Practice (GMP) standards. HUCPVCs showed a stable phenotype while undergoing rapid ex vivo expansion at passage 2 (p2) to passage 4 (p4) and produced proregenerative factors, strongly suppressing T cell responses in the resting state and in response to inflammation. Transplanting an islet equivalent (IEQ):HUCPVC ratio of 1:30 under the kidney capsule in diabetic NSG mice demonstrated the fastest return to normoglycemia by 3 days after transplant: Superior glycemic control was seen at both early (2.7 weeks) and later stages (7, 12, and 16 weeks) versus ratios of 1:0, 1:10, and 1:50, respectively. Syngeneic islet transplantation in immunocompetent mice using the clinically relevant hepatic portal route with a marginal islet mass showed that mice transplanted with an IEQ:HUCPVC ratio of 1:150 had superior glycemic control versus ratios of 1:0, 1:90, and 1:210 up to 6 weeks after transplant. Immunodeficient mice transplanted with human islets (IEQ:HUCPVC ratio of 1:150) exhibited better glycemic control for 7 weeks after transplant versus islet transplant alone, and islets transplanted via the hepatic portal vein in an allogeneic mouse model using a curative islet mass demonstrated delayed rejection of islets when cotransplanted with HUCPVCs (IEQ:HUCPVC ratio of 1:150). The immunosuppressive and proregenerative properties of HUCPVCs demonstrated long-term positive effects on graft function in vivo, indicating that they may improve long-term human islet allotransplantation outcomes