Anti-CTLA-4 (CD 152) monoclonal antibody-induced autoimmune interstitial nephritis

Targeted immune-modulating agents are entering clinical practice in many specialties, providing novel therapeutic possibilities but introducing new potential toxicities. We present the first reported case, to our knowledge, of immune-mediated nephritis following the administration of Tremelimumab (CP-675, 206), an anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibody. High-dose steroid therapy led to a rapid improvement in renal function, avoiding the need for renal replacement therapy.Peer reviewe

Influence of Container Color, Media Depth, and Subsequent Light Availability on Stem Elongation of Longleaf Pine

Nathan G. Bolner is an undergraduate student in the School of Agricultural Sciences and Forestry at Louisiana Tech University. D. Paul Jackson is an Assistant Professor in the School of Agricultural Sciences and Forestry at Louisiana Tech Universit

Strong Authentication for Web Services using Smartcards

The popularity of the Internet and the variety of services it provides has been immense. Unfortunately, many of these services require the user to register and subsequently login to the system in order to access them. This has resulted in the user having to remember a multitude of username and password combinations in order to use the service securely. However, literature has clearly demonstrated this is not an effective approach, as users will frequently choose simple passwords, write them down, share them or use the same password for multiple systems. This paper proposes a novel concept where Internet users authenticate to web services (service providers) by the use of a smartcard – taking away any requirement for the user to provide credentials. The smartcard is useful in this context as it is a trusted device that is capable of applying cryptography in a tamper resistant environment. The development of the concept is based upon an extension to Authentication Authorisation Infrastructure (AAI) models, where a trusted authority (Identity Provider) will provide and manage the smart card to end-users. In devices such as mobile phones, a smartcard is already present (e.g. the SIM) to facilitate this and it is envisaged such a card could also be produced for desktop environments – similarly to what many banks are currently implementing

Short-term disturbance by a commercial two-dimensional seismic survey does not lead to long-term displacement of harbour porpoises

Peer reviewedPublisher PD

4-π-Photocyclization of 1,2-Dihydropyridazines: An Approach to Bicyclic 1,2-Diazetidines with Rich Synthetic Potential.

The 4-π-photocyclization of a range of 1,2-dihydropyridazines is described, generating bicyclic 1,2-diazetidines in high yields on multigram scale. The key bicyclic 1,2-diazetidines are versatile synthetic intermediates and were easily converted into a range of novel derivatives, including functionalized 1,2-diazetidines, cyclobutenes, cyclobutanes, and 1,3-dienes

A Knock-In Mouse Model for the R120G Mutation of αB-Crystallin Recapitulates Human Hereditary Myopathy and Cataracts

An autosomal dominant missense mutation in αB-crystallin (αB-R120G) causes cataracts and desmin-related myopathy, but the underlying mechanisms are unknown. Here, we report the development of an αB-R120G crystallin knock-in mouse model of these disorders. Knock-in αB-R120G mice were generated and analyzed with slit lamp imaging, gel permeation chromatography, immunofluorescence, immunoprecipitation, histology, and muscle strength assays. Wild-type, age-matched mice were used as controls for all studies. Both heterozygous and homozygous mutant mice developed myopathy. Moreover, homozygous mutant mice were significantly weaker than wild-type control littermates at 6 months of age. Cataract severity increased with age and mutant gene dosage. The total mass, precipitation, and interaction with the intermediate filament protein vimentin, as well as light scattering of αB-crystallin, also increased in mutant lenses. In skeletal muscle, αB-R120G co-aggregated with desmin, became detergent insoluble, and was ubiquitinated in heterozygous and homozygous mutant mice. These data suggest that the cataract and myopathy pathologies in αB-R120G knock-in mice share common mechanisms, including increased insolubility of αB-crystallin and co-aggregation of αB-crystallin with intermediate filament proteins. These knock-in αB-R120G mice are a valuable model of the developmental and molecular biological mechanisms that underlie the pathophysiology of human hereditary cataracts and myopathy