Depositional and Structural Challenges of the Wilcox Lobo Natural Gas Trend, South Texas

To increase understanding and utilization of gas resources in the Wilcox Lobo play of South Texas, this report reviews current geological knowledge of the Lobo trend. An additional objective of this report is to identify areas where advancements in geological understanding could lead to substantial improvements in efficient development of the Wilcox Lobo trend natural gas resource. According to published accounts, Lobo sandstones formed in a variety of depositional environments in both shallow and deep marine waters. During and after deposition, the Lobo experienced repeated episodes of erosion, faulting, and diagenesis. Thus, accurate prediction of reservoir sandstone attributes is difficult, and this difficulty is cited by operators as a significant challenge to efficiently targeting the remaining gas resource. Knowledge that would aid in the emergence of this resource includes information on sandstone correlation and accurate zone identification, depositional systems and facies interpretations, controls on fault pattern variability, and, to a lesser extent, recognition of diagenetic patterns and faults and fractures that are below seismic resolution. Geologic challenges of the Lobo trend are opportunities for targeting increasingly smaller and more difficult-to-detect compartments with advanced technology.Bureau of Economic Geolog

Results of 2018–2019 assessment of Thuja occidentalis populations at the Fox River Fen

▷Collected seed from mature individuals of Thuja occidentalis at Trout Park and Chicago Junior School, as well as 3 control sites for comparison ▷Measured seed set, seed weight, and seed morphology to determine site variability ▷Conducted germination trials in growth chambers under incremental salt concentrations to determine the effect of salt on seed germination ▷Conducted periodic soil samples over the span of 1 year to assess salt levels at Trout Park and Chicago Junior School ▷Found differences between Trout Park and Chicago Junior School for reproductive metrics and soil salt levels, but not for germinationIllinois State Toll Highway Authorityunpublishednot peer reviewedOpe

Hydrogeology and Hydrochemistry of the Falls City Uranium Mine Tailings Remedial Action Project, Karnes County, Texas

Oxidized uranium ore deposits were discovered in the Deweesville sandstone (also referred to as the Stones Switch; Bunker and MacKallor [1973]) in the Falls City region in the 1950s. Uranium was mined and milled in the small community of Deweesville by Susquehanna-Western, Inc. (SWI) from April 1961 to August 1973. Tailings composed of sediment residue from the sulfuric acid milling process and residual sulfuric acid solutions were disposed of in six ponds on the outcrop of the Deweesville, within the mined-out uranium pits in the Deweesville, and on the outcrop of the Conquista, creating a set of large tailings impoundments (figs. 1.1 and 1.2). From 1978 to 1982 Solution Engineering, Inc. (SEI) conducted a secondary recovery of the remaining uranium in the tailings piles by in situ leaching. In 1984, the ponds on top of two of the tailings piles were spray evaporated and a clay cap was placed over the piles to prevent additional percolation of water through the piles and into the underlying aquifers. Acidic tailings solutions have been recharging the underlying aquifers since initial tailings disposal and may still be leaking into these aquifers. Several hydrogeologic investigations have been conducted to assess whether there has been groundwater contamination from the tailings. Early studies were conducted by Turk, Kehle and Associates (1976), and Ford, Bacon & Davis Utah (1978, 1981). Each of these studies included only minor investigations of the hydrogeology and hydrochemistry of the site and, in general, underestimated the extent of contamination from the site. Investigations conducted by the U.S. Department of Energy (DOE) from 1985 to 1991 have since revealed the true extent of contamination (U.S. Department of Energy, 1991).Bureau of Economic Geolog

Effect of Genetic Variation in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin

The identification and validation of gene–gene interactions is a major challenge in human studies. Here, we explore an approach for studying epistasis in humans using a Drosophila melanogaster model of neonatal diabetes mellitus. Expression of the mutant preproinsulin (hINSC96Y) in the eye imaginal disc mimics the human disease: it activates conserved stress-response pathways and leads to cell death (reduction in eye area). Dominant-acting variants in wild-derived inbred lines from the Drosophila Genetics Reference Panel produce a continuous, highly heritable distribution of eye-degeneration phenotypes in a hINSC96Y background. A genome-wide association study (GWAS) in 154 sequenced lines identified a sharp peak on chromosome 3L, which mapped to a 400-bp linkage block within an intron of the gene sulfateless (sfl). RNAi knockdown of sfl enhanced the eye-degeneration phenotype in a mutant-hINS-dependent manner. RNAi against two additional genes in the heparan sulfate (HS) biosynthetic pathway (ttv and botv), in which sfl acts, also modified the eye phenotype in a hINSC96Y-dependent manner, strongly suggesting a novel link between HS-modified proteins and cellular responses to misfolded proteins. Finally, we evaluated allele-specific expression difference between the two major sfl-intronic haplotypes in heterozygtes. The results showed significant heterogeneity in marker-associated gene expression, thereby leaving the causal mutation(s) and its mechanism unidentified. In conclusion, the ability to create a model of human genetic disease, map a QTL by GWAS to a specific gene, and validate its contribution to disease with available genetic resources and the potential to experimentally link the variant to a molecular mechanism demonstrate the many advantages Drosophila holds in determining the genetic underpinnings of human disease

The Lantern Vol. 69, No. 2, Spring 2002

• What was Said in the Court of Riong • Bailan Pies (Dancing Feet) • Canard • Vernacular City • Saturday Night Motorcycles • The Muse • I Stuffed my Face in the Herbs • Jacob\u27s Nightingale • At Tracey\u27s • Ona Time, a Rhym-mer • For Yo Yo Ma\u27s Encore • Two Minutes from Earl\u27s Court Tube Station • For Two • Bald • This Year\u27s Love • The Dimmer Switch • Tickertape • Imaginary Highway • First Kiss and Related Terrors • Hairball • His Hobbies • Spaghetti Dinnerhttps://digitalcommons.ursinus.edu/lantern/1160/thumbnail.jp

The Grizzly, October 11, 2000

University Students Disappointed by Rally • Ruhe\u27s \u27Athens\u27 with Ursinus Faces is a Work of Art • Homecoming 2000: Alumni Remember Collegeville Days • Food Critics Speak up at Dining Services Meeting • New Prof. has Students all Shook up...Over Shakespeare?! • Brodbeck Residents Take it to Extreme • French Officials Approve Morning-After Pill • Should Patients\u27 Drug Use be Confidential? • Nearing Fall Break, Freshmen High on UC Experience • The Wrong-Way Geese • Best Buddies: Offering Friendship, Making a Difference • Opinions: New Breed of Grizzly at Ursinus College; Abortion Pill Provides Pause for Debate; Pro-Life Sends Wrong Message; Is Bioengineering Ethical?; Ursinus Students React to Israeli-PLO Clashes; Presidential Debate Shows Just how Mediocre Politics can be; Defending Al Gore • Battle of the Bands Rocks in Reimert • Harpoon Louie\u27s a World Away from Wismer • Poetry Slam on Campus in November • Bears Maul Blue Jays • Women\u27s Rugby Roughed Up by Hawks • Binge Drinking Growing Problem on College Campuses • Roofies: Date Rape Drug More Popular, Dangerous Than Ever • Men\u27s Soccer Downs Aggies • New Coaches Bring Promise to Programs • Matty Earns McIntyre Award • Lowell\u27s Lone Goal Leads Bears to OT win Over Davidson Coll. • Lady Bears Struggle to go on Offensive • Volleyball Stomps the Sciences; Drops two CC Matches • Annual Alumni Lacrosse Match Ends in tie • Leadership in Adventure: ESS Class Molds Leaders Through Sporthttps://digitalcommons.ursinus.edu/grizzlynews/1475/thumbnail.jp

The relationship between salivary C-reactive protein and cognitive function in children aged 11-14 years: Does psychopathology have a moderating effect?

Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11- 14 years and explored the moderating effect of psychopathology. The study utilised data from an established longitudinal investigation of children recruited from the community (N=107) that had purposively over-sampled individuals experiencing psychopathology (determined using questionnaires). CRP was measured in saliva samples and participants completed assessments of cognition (memory and executive function) and psychopathology (internalising and externalising symptoms and psychotic-like experiences). Linear regression models indicated that higher salivary CRP was associated with poorer letter fluency (β=-0.24, p=0.006) and scores on the inhibition (β=-0.28, p=0.004) and inhibition/switching (β=-0.36, p<0.001) subtests of the colour-word interference test, but not with performance on any of the memory tasks (working, visual, and verbal memory tasks). Results were largely unchanged after adjustment for psychopathology and no significant interactions between CRP and psychopathology were observed on any cognitive measure. Our findings provide preliminary evidence that elevated salivary CRP is associated with poorer cognitive function in early life, but that this association is not moderated by concurrent psychopathology. These findings have implications for early intervention strategies that attempt to ameliorate cognitive deficits associated with emerging psychiatric disorders. Further research is needed to determine whether salivary CRP levels can be used as a valid marker of peripheral inflammation among healthy adolescents

Developing an intervention to increase REferral and uptake TO pulmonary REhabilitation in primary care in patients with chronic obstructive pulmonary disease (the REsTORE study): mixed methods study protocol.

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease associated with breathlessness, inability to exercise, frequent infections, hospitalisation and reduced quality of life. Pulmonary rehabilitation (PR), providing supervised exercise and education, is an effective and cost-effective treatment for COPD but is significantly underused. Interventions to improve referral and uptake have been tested and some positive results reported. However, interventions are diverse and no clear recommendations for practice can be made. This study aims to understand the challenges to referral and uptake in primary care, where most referrals originate, and to develop a flexible toolkit of resources to support referral and uptake to PR in primary care in the UK. METHODS AND ANALYSIS: This is a mixed methods study informed by normalisation process theory and burden of treatment theory. In the first phase, general practitioners, practice nurses and PR providers will be invited to complete an online survey to inform a broad exploration of the topic areas. In phase 2 interviews and focus groups will be conducted with patients, healthcare professionals (HCP) in primary care, PR providers and commissioners to gain an in-depth understanding of the issues and needs. Toolkit development in phase 3 will draw together the learning from phases 1 and 2 and employ an iterative development process to build the toolkit jointly with patients and HCPs. It will be tested in primary care for usability and acceptability. ETHICS AND DISSEMINATION: The study has ethical and Health Research Authority approval (Research Ethics Committee reference number 17/EE/0136). It is registered with the International Standard Registered Clinical/Social Study Number (ISRCTN) registry (trial ID: ISRCTN20669629, assignment date 20 March 2018, trial start date 1 April 2016). Dissemination will be aimed at patients, carers/families, service providers, commissioners and national interest groups. Methods will include conferences, presentations, academic publications and plain English reports and will be supported by the British Lung Foundation. TRIAL REGISTRATION NUMBER: ISRCTN20669629 ; Pre-results.This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Research for Patient Benefit (RfPB) Programme (grant reference number PB-PG-1215-20034)

Developing an intervention to increase REferral and uptake TO pulmonary REhabilitation in primary care in patients with chronic obstructive pulmonary disease (the REsTORE study): mixed methods study protocol

Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease associated with breathlessness, inability to exercise, frequent infections, hospitalisation and reduced quality of life. Pulmonary rehabilitation (PR), providing supervised exercise and education, is an effective and cost-effective treatment for COPD but is significantly underused. Interventions to improve referral and uptake have been tested and some positive results reported. However, interventions are diverse and no clear recommendations for practice can be made. This study aims to understand the challenges to referral and uptake in primary care, where most referrals originate, and to develop a flexible toolkit of resources to support referral and uptake to PR in primary care in the UK. Methods and analysis: This is a mixed methods study informed by normalisation process theory and burden of treatment theory. In the first phase, general practitioners, practice nurses and PR providers will be invited to complete an online survey to inform a broad exploration of the topic areas. In phase 2 interviews and focus groups will be conducted with patients, healthcare professionals (HCP) in primary care, PR providers and commissioners to gain an in-depth understanding of the issues and needs. Toolkit development in phase 3 will draw together the learning from phases 1 and 2 and employ an iterative development process to build the toolkit jointly with patients and HCPs. It will be tested in primary care for usability and acceptability