Action observation in the modification of postural sway and gait: Theory and use in rehabilitation

The discovery of cortical neurons responsive to both the observation of another individual’s movement and one’s own physical movement has spurred scientists into utilising this interplay for rehabilitation. The idea that humans can quickly transfer motor programmes or refine existing motor strategies through observation has only recently gained interest in the context of gait rehabilitation but may offer significant promise as an adjunctive therapy to routine balance training. This review is the first dedicated to action observation in postural control or gait in healthy individuals and patients. The traditional use of action observation in rehabilitation is that the observer has to carefully watch pre-recorded or physically performed actions and thereafter imitate them. Using this approach, previous studies have shown improved gait after action observation in stroke, Parkinson’s disease and knee or hip replacement patients. In healthy subjects, action observation reduced postural sway from externally induced balance perturbations. Despite this initial evidence, future studies should establish whether patients are instructed to observe the same movement to be trained (i.e., replicate the observed action(s)) or observe a motor error in order to produce postural countermeasures. The best mode of motor transfer from action observation is yet to be fully explored, and may involve observing live motor acts rather than viewing video clips. Given the ease with which action observation training can be applied in the home, it offers a promising, safe and economical approach as an adjunctive therapy to routine balance training

A closed-form solution to estimate uncertainty in non-rigid structure from motion

Semi-Definite Programming (SDP) with low-rank prior has been widely applied in Non-Rigid Structure from Motion (NRSfM). Based on a low-rank constraint, it avoids the inherent ambiguity of basis number selection in conventional base-shape or base-trajectory methods. Despite the efficiency in deformable shape reconstruction, it remains unclear how to assess the uncertainty of the recovered shape from the SDP process. In this paper, we present a statistical inference on the element-wise uncertainty quantification of the estimated deforming 3D shape points in the case of the exact low-rank SDP problem. A closed-form uncertainty quantification method is proposed and tested. Moreover, we extend the exact low-rank uncertainty quantification to the approximate low-rank scenario with a numerical optimal rank selection method, which enables solving practical application in SDP based NRSfM scenario. The proposed method provides an independent module to the SDP method and only requires the statistic information of the input 2D tracked points. Extensive experiments prove that the output 3D points have identical normal distribution to the 2D trackings, the proposed method and quantify the uncertainty accurately, and supports that it has desirable effects on routinely SDP low-rank based NRSfM solver.Comment: 9 pages, 2 figure

Summary of the CKM 2010 Working Group on Rare Decays

Rare decays were essential in the discovery of the CKM mechanism of flavour and CP violation and are highly sensitive probes of physics beyond the Standard Model. In this summary the current status and future prospects of experimental measurements and the Standard Model theory predictions of various rare B, D and K decay observables are discussed. The specific new physics sensitivities of each mode are also briefly reviewed

Experimental observation of extreme multistability in an electronic system of two coupled R\"{o}ssler oscillators

We report the first experimental observation of extreme multistability in a controlled laboratory investigation. Extreme multistability arises when infinitely many attractors coexist for the same set of system parameters. The behavior was predicted earlier on theoretical grounds, supported by numerical studies of models of two coupled identical or nearly identical systems. We construct and couple two analog circuits based on a modified coupled R\"{o}ssler system and demonstrate the occurrence of extreme multistability through a controlled switching to different attractor states purely through a change in initial conditions for a fixed set of system parameters. Numerical studies of the coupled model equations are in agreement with our experimental findings.Comment: to be published in Phys. Rev.

A review of standard pharmacological therapy for adult asthma - Steps 1 to 5

The aim of pharmacological therapy for asthma is to improve symptoms and lung function and minimise the risk of asthma attacks. The intensity of treatment is based on the level of asthma control and the potential risk of future deterioration. In the British asthma guidelines, treatments are divided into Step One to Five, with each Step signifying a need for an increase in therapy in response to symptoms or to prevent exacerbations. Treatments comprise of inhaled or systemic medications. Inhaled therapy includes short-acting and long-acting medication to improve symptoms and inhaled corticosteroids which reduce airway inflammation. Systemic treatments include medications which act on specific biological pathways, such as the leukotriene or IgE pathways, or systemic corticosteroids. In choosing a particular therapy, treatment benefits are balanced by the potential risks of medication-related adverse effects. This review will provide a practical guide to the key pharmacological therapies for adult asthma at Steps One to Five based on British guidelines and consider future options for new treatments

Electronic monitoring of adherence to inhaled medication in asthma

The main treatment of asthma is inhaled corticosteroids. However adherence to these medications in asthma is often poor, with low adherence associated with excessive health care costs and an increased risk of emergency room visits and mortality. Although various methods are used to indirectly assess adherence, all have significant limitations whether used in clinical or research practice. The recent development of electronic monitoring devices (EMDs) for use with inhalers presents an exciting opportunity to easily and accurately measure inhaler adherence. This article summarises the current devices available; for each device features and limitations are considered, followed by a review of both the current clinical literature and data on reliability and accuracy. An overall summary is also provided to aid comparison of capabilities between devices and future issues pertaining to the use of EMDs are discussed, including barriers to adoption, stakeholder involvement, novel methods of communicating adherence data, recording of data and cloud storage. Finally key areas that still require investigation are highlighted