47,335 research outputs found
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A Multilayer Monte Carlo Model for the Investigation of Optical Path and Penetration Depth at Different Perfusion States of the Colon
There is a great interest in monitoring the oxygen supply delivered to the colon. Insufficient oxygen delivery may lead to hypoxia, sepsis, multiorgan dysfunction and death. For assessing colonic perfusion, more information and understanding is required relating to the light-interaction within the colonic tissue. A multilayer Monte Carlo model of a healthy human colon has been developed to investigate the light-tissue behavior during different perfusion states within the mucosal layer of the colon. Results from a static multilayer model of optical path and reflectance at two wavelengths, 660 nm and 880 nm, through colon tissue, containing different volume fractions of blood with a fixed oxygen saturation are presented. The effect on the optical path and penetration depth with varying blood volumes within the mucosa for each wavelength has been demonstrated. The simulation indicated both wavelengths of photons penetrated similar depths, entering the muscularis layer
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The circulatory impact of dust from dust profile assimilation
We present results from a reanalysis of temperatures, dust columns and dust vertical profiles focussing on the assimilation, distribution and transport of dust in the martian atmosphere. The assimilation of dust vertical information in particular is a valuable technique which has been shown to be of vital importance to a successful assimilation of the martian atmosphere, with the vertical representation of the dust distribution having a critical effect on assimilation results generally.
Atmospheric dust is a key driver of the martian circulation. Dust-induced heating and cooling is a potential feedback mechanism for dust lifting, for example, and can modify the circulation to either enhance or suppress dust storm activity. Accurately representing its complex spatial and temporal distribution is therefore crucial for understanding Mars’ atmospheric dynamics and transport
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Development of an intraluminal intestinal photoplethysmography sensor
Intestinal ischemia is a serious medical condition and can lead to life threatening sepsis. Currently, there are no reliable techniques available for directly monitoring intestinal viability for prolonged periods of time, and intraoperatively, the majority of the surgeons still rely on subjective methods, such as visual inspection to assess viability of the intestine. The development of an intraluminal optical sensor for monitoring intestinal viability is being proposed. The sensor will continuously monitor changes in blood volume and oxygen saturation. The developed reflectance photoplethysmography/pulse oximetry sensor comprises of two emitters (red and infrared) and a photodiode. A photoplethysmography processing and data acquisition system was also utilized. The prototype sensor was evaluated in a pilot study in the buccal mucosa of 12 healthy volunteers, given the locations similarity to the intestinal mucosa and its easy accessibility. Good quality photoplethysmography signals with high signal-to-noise ratio were acquired from the buccal mucosa in all the volunteers. Preliminary blood oxygen saturation values from the intraluminal sensor were in broad agreement with the standard finger pulse oximeter probes
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The effects of optical sensor-tissue separation in endocavitary photoplethysmography
Objective: Intestinal anastomotic failure that occurs mainly due to ischaemia is a serious risk in colorectal cancer patients undergoing surgery. Surgeons continue to rely on subjective methods such as visual inspection to assess intestinal viability during surgery and there are no clinical tools to directly monitor viability postoperatively. A dual-wavelength reflectance optical sensor has been developed for continuous and dynamic monitoring of intestinal viability via the intestinal lumen. Maintaining direct contact between the sensor and the inner intestinal wall can be difficult in an intraluminal design, therefore impacting on signal acquisition and quality. This paper investigates the effect of direct contact versus variable distances between the sensor and the tissue surface of the buccal mucosa as a surrogate.
Approach: The in vivo study involved 20 healthy volunteers to measure the effect of optical sensor-tissue distances on the ability to acquire photoplethysmography signals and their quality. Signals were acquired from the buccal mucosa at five optical sensor-tissue distances.
Main results: Distances between 0 mm (contact) to 5 mm were the most optimal, producing signals of high quality and signal-to-noise ratio, resulting in reliable estimations of the blood oxygen saturation. Distances exceeding 5 mm compromised the acquired signals, and were of poor quality, thereby unreliably estimating the blood oxygen saturation.
Significance: The developed optical sensor proved to be reliable for acquiring photoplethysmography signals for cases where distances between the optical sensor-tissue may arise during the assessment of intraluminal intestinal viability
Phase transitions driven by L\'evy stable noise: exact solutions and stability analysis of nonlinear fractional Fokker-Planck equations
Phase transitions and effects of external noise on many body systems are one
of the main topics in physics. In mean field coupled nonlinear dynamical
stochastic systems driven by Brownian noise, various types of phase transitions
including nonequilibrium ones may appear. A Brownian motion is a special case
of L\'evy motion and the stochastic process based on the latter is an
alternative choice for studying cooperative phenomena in various fields.
Recently, fractional Fokker-Planck equations associated with L\'evy noise have
attracted much attention and behaviors of systems with double-well potential
subjected to L\'evy noise have been studied intensively. However, most of such
studies have resorted to numerical computation. We construct an {\it
analytically solvable model} to study the occurrence of phase transitions
driven by L\'evy stable noise.Comment: submitted to EP
Submillimeter polarisation and magnetic field properties in the envelopes of proto-planetary nebulae CRL 618 and OH 231.8+4.2
We have carried out continuum and line polarisation observations of two
Proto-planetary nebulae (PPNe), CRL 618 and OH 231.8+4.2, using the
Submillimeter Array (SMA) in its compact configuration. The frequency range of
observations, 330-345 GHz, includes the CO(J=3-2) line emission. CRL 618 and OH
231.8+4.2 show quadrupolar and bipolar optical lobes, respectively, surrounded
by a dusty envelope reminiscent of their AGB phase. We report a detection of
dust continuum polarised emission in both PPNe above 4 sigma but no molecular
line polarisation detection above a 3 sigma limit. OH 231.8+4.2 is slightly
more polarised on average than CRL 618 with a mean fractional polarisation of
4.3 and 0.3 per cent, respectively. This agrees with the previous finding that
silicate dust shows higher polarisation than carbonaceous dust. In both
objects, an anti-correlation between the fractional polarisation and the
intensity is observed. Neither PPNe show a well defined toroidal equatorial
field, rather the field is generally well aligned and organised along the polar
direction. This is clearly seen in CRL 618 while in the case of OH 231.8+4.2,
the geometry indicates an X-shaped structure coinciding overall with a
dipole/polar configuration. However in the later case, the presence of a
fragmented and weak toroidal field should not be discarded. Finally, in both
PPNe, we observed that the well organised magnetic field is parallel with the
major axis of the 12CO outflow. This alignment could indicate the presence of a
magnetic outflow launching mechanism. Based on our new high resolution data we
propose two scenarios to explain the evolution of the magnetic field in evolved
stars.Comment: 11 pages, 8 figures and 1 table. Accepted for publication in the
Monthly Notices of the Royal Astronomical Societ
A new array for the study of ultra high energy gamma-ray sources
The design and operation of a 32 x 1 10 to the 15th power sq m array of scintillation detectors for the detection of 10 to the 15th power eV cosmic rays is described with an expected angular resolution of 1 deg, thus improving the present signal/background ratio for gamma ray sources. Data are recorded on a hybrid CAMAC, an in-house system which uses a laser and Pockel-Cell arrangement to routinely calibrate the timing stability of the detectors
Symptomatic adrenal insufficiency during inhaled corticosteroid treatment
Symptomatic adrenal insufficiency, presenting
as hypoglycaemia or poor weight
gain, may occur on withdrawal of corticosteroid
treatment but has not previously
been reported during inhaled corticosteroid
treatment. This case series illustrates
the occurence of clinically
significant adrenal insufficiency in asthmatic
children while patients were on
inhaled corticosteroid treatment and the
unexpected modes of presentation. General
practitioners and paediatricians need
to be aware that this unusual but acute
serious complication may occur in patients
treated
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